ライフサイエンスコーパス: sigma

1 to predict the direct targets of ~67% of ECF sigmas.

2 roximately circular area with Gaussian width sigma = 0.06 mum.

3 The sigma 1 receptor (S1R) is a molecular chaperone protein

4 ughnesses (U ~ 1.4 MJ.m(-3)), and strengths (sigma ~ 1 MPa).

5 ts (FTC146, BD1407, F3, F4, and NE100) and 4 sigma(1) agonists ((+)-pentazocine, (+/-)-PPCC, PRE-084,

6 Five sigma(1) antagonists (FTC146, BD1407, F3, F4, and NE100)

7 e derivatives as potent dual ligands for the sigma(1) receptor (sigma(1)R) and the mu-opioid receptor

8 )piperazin-1-yl)ethanone (9k, EST64454) as a sigma(1) receptor (sigma(1)R) antagonist clinical candid

9 Two potent sigma(1) receptor agonists, TC1 and SA4503, showed dose-

10 in the presence or absence of pharmacologic sigma(1) receptor blockade with FTC146.

11 AT, as well as the serotonin transporter and sigma(1) receptors.

12 vity in this test, which was reversed by the sigma(1)R agonist PRE-084.

13 mpound 14u (EST73502) showed MOR agonism and sigma(1)R antagonism and a potent analgesic activity, co

14 s provide evidence that dual MOR agonism and sigma(1)R antagonism may be a useful strategy for obtain

15 providing evidence that dual MOR agonism and sigma(1)R antagonism may be a useful strategy for obtain

16 oxycodone, as expected from the addition of sigma(1)R antagonism, 15au showed local, peripheral acti

17 tent dual ligands for the sigma(1) receptor (sigma(1)R) and the mu-opioid receptor (MOR) are reported

18 otent dual ligands for the sigma-1 receptor (sigma(1)R) and the mu-opioid receptor (MOR) are reported

19 anone (9k, EST64454) as a sigma(1) receptor (sigma(1)R) antagonist clinical candidate for the treatme

20 Sigma-1 and sigma-2 receptors are emerging therapeutic t

21 translation and predicted regulators of the sigma-1 and sigma-2 receptors.

22 Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER)

23 Here, we found that the sigma-1 receptor (Sig-1R), a molecular chaperone, revers

24 e derivatives as potent dual ligands for the sigma-1 receptor (sigma(1)R) and the mu-opioid receptor

25 found that cocaine binding to intracellular sigma-1 receptor (sigma1) initiates this mechanism.

26 Cheap, simple ammonium salts act as sigma-1 receptor agonists and antagonists in vivo and re

27 inding can be used to biochemically define a sigma-1 receptor antagonist.

28 nt clinical deterioration by stimulating the sigma-1 receptor, which regulates cytokine production.

29 e, and fitted a 2-site binding model for the sigma-1 receptor.

30 ium (K(i) 9 nM) showed high affinity for the sigma-1 receptor.

31 otal (gas and particulate) concentrations of Sigma(10)OPAHs were 10.0 +/- 9.2 ng/m(3) in winter and 3

32 Average Sigma(11)OPE gas-phase concentrations were 1.77 +/- 0.84

33 TCiPP1 dominated Sigma(11)OPEs, followed by TnBP and TEP.

34 Sigma(18)NPAH concentrations were typically 1 order of m

35 e yet unknown 2-amino-substituted lambda(3) ,sigma(2) -phosphinines are phosphorus-containing aniline

36 i.e. for the highest cationic size-variance, sigma(2) .

37 The sigma(2) receptor is a potential in vivo target for meas

38 two-photon excitation cross-sections (eta(2)sigma(2) ~ 110GM), further support the evidence for 2PA

39 them, SigG1 features a minimal conserved ECF sigma(2)-sigma(4) architecture and an additional C-termi

40 ); this also showed the highest affinity for sigma-2 receptors (K(i) 13 nM).

41 Sigma-1 and sigma-2 receptors are emerging therapeutic targets.

42 and predicted regulators of the sigma-1 and sigma-2 receptors.

43 Elevated Sigma(24)PFAS concentrations were found in aquatic insec

44 However, the structural mechanism of sigma(28) -dependent promoter recognition remains unchar

45 ere, we report cryo-EM structures of E. coli sigma(28) -dependent transcribing complexes on a complet

46 These structures reveal how sigma(28) -RNAP recognizes promoter DNA through strong i

47 In bacteria, sigma(28) is the flagella-specific sigma factor that tar

48 2.15)Fe(2+) (1.59)Ni(2+) (0.17)Cu(+) (0.04))(Sigma) (=) (3.95)O(5) We further suggest a possible link

49 G1 features a minimal conserved ECF sigma(2)-sigma(4) architecture and an additional C-terminal exten

50 ive selectively yields the respective dihalo-sigma(4),lambda(5)- and tetrahalo-sigma(5),lambda(6)-dia

51 The dihalo-sigma(4),lambda(5)-diazaphospholium triflate salt serves

52 ive dihalo-sigma(4),lambda(5)- and tetrahalo-sigma(5),lambda(6)-diazaphospholium triflate salts.

53 th control and oil-exposed (24 h, 14.5 mug/L Sigma(50)PAH) juvenile mahi-mahi (27-85 mm) could detect

54 herefore, transcription initiation involving sigma(54) differs from other bacterial systems, and yiel

55 e of transcription initiation (sigma(70) and sigma(54)).

56 ulated via the burst size, while that of the sigma(54)-controlled stress response is regulated via th

57 ranscription of class-III flagellar genes in sigma(54)-dependent manner.

58 s characterized by a cooperativity parameter sigma ~6 x 10(-5) and a Gibbs free energy of unfolding o

59 e percent of the samples contained plastics (Sigma(6)plastics) at concentrations of between 0.4 and 2

60 Per-capita mass loads of plastics (Sigma(6)plastics) released were between 8 and 877 g/pers

61 ant plastic detected, contributing to 69% of Sigma(6)plastics.

62 as a distinct family of proteins related to sigma(70) .

63 different mode of transcription initiation (sigma(70) and sigma(54)).

64 genetic analyses show MglA-SspA facilitates sigma(70) binding to DNA to regulate virulence and virul

65 ation may be a general mechanism employed by sigma(70) family factors to enhance transcription from p

66 redistribution of RNA polymerase containing sigma(70) to genomic regions vacated by these proteins.

67 cription activities or when the housekeeping sigma(70) was sequestered, and was only significantly di

68 MglA-SspA assembles with the sigma(70)-associated RNAP holoenzyme (RNAPsigma(70)), fo

69 ransition from low to high expression of the sigma(70)-controlled stress response is regulated via th

70 pe: CRISPRa is effective at a broad range of sigma(70)-family promoters, and an expanded PAM dCas9 al

71 aepsilon) RNA Polymerase (RNAP) core enzyme, sigma(A), a promoter DNA, and the ligand-bound B. subtil

72 extracytoplasmic function sigma factors (ECF sigmas), a major family of bacterial regulators, and det

73 ctions between endocyclic heteroatom and the sigma* acceptor orbitals of the C-M bond.

74 Herein, a series of donor-sigma-acceptor dyes has been prepared in a modular appro

75 tion rates under different supersaturations (sigma, achieved by varying pH 3.3-3.6) and temperatures

76 n caMHB lots relative to those for Oxoid and Sigma-Aldrich broth.

77 manufacturers (Becton, Dickinson; Oxoid; and Sigma-Aldrich) were utilized.

78 A cobalt sigma-alkane complex, [Co(Cy(2) P(CH(2) )(4) PCy(2) )(no

79 KHN, sigma and A/C results were statistically analyzed with A

80 We demonstrate that the direct L-An sigma and pai donations combined with the An-L delta or

81 ameters are incompatible with the concept of sigma and pai metal-ligand overlap.

82 We generated an aligned collection of ECF sigmas and their promoters by leveraging the autoregulat

83 tronically dictated by a balance of Fe-imido sigma- and pai-bonding interactions.

84 ribed to the opposing effect on metal-ligand sigma- and pai-bonding.

85 balanced dual profile (i.e., MOR agonism and sigma antagonism) and a potent analgesic activity, compa

86 veal a newly described control mechanism for sigma-anti-sigma complex formation and establish c-di-GM

87 e iodines mix to give a high-energy in-plane sigma-antibonding orbital as the highest occupied molecu

88 This global survey indicated that some ECF sigmas are conserved global regulators controlling many

89 sh a heteroatomic group 13 ring exhibiting a sigma-aromatic nature concomitant with a three-center tw

90 gh a transition state with Craig-Mobius-like sigma-aromaticity.

91 leveraging the autoregulatory nature of ECF sigmas as a means of promoter discovery and analyzed it

92 Both sigma(B) and sporulation activity increase in a gradient

93 d by a simple mathematical model, increasing sigma(B) expression shifts the peak of sporulation to th

94 of the general stress response sigma factor sigma(B) in individual cells during biofilm development.

95 aking at the top of the biofilm, even though sigma(B) represses sporulation.

96 ation with DFT/MRCI calculations, show that (sigma, B p)->(pai, B p) transitions accelerate the ISC p

97 d, the catalyst has high immunity to typical sigma-base poisons due to the antibonding interactions o

98 ons result in the formal addition of the C-C sigma bond to the main group center either at a single s

99 e in that it lacks the typical Rh(II)-Rh(II) sigma bond, but significant orbital overlap between the

100 eta-alkyl migration steps that break the C-C sigma bond.

101 xes and metal NPs in their reactivity toward sigma-bond activation and functionalization.

102 nesium(I) compounds are reported for the C-C sigma-bond activation of strained alkylidene cyclopropan

103 ery example of transition metal mediated C-C sigma-bond activation reported to date, the reaction occ

104 tivation of H-H, Si-H, and C-H bonds through sigma-bond coordination has grown in the past 30 years f

105 All sigma-bond formations were found to proceed through high

106 an unprecedented chemoselective C(sp(2))-Ar sigma-bond insertion of the alkene.

107 ion (prevalent with B-X electrophiles); (ii) sigma-bond metathesis mediated (prevalent with B-H and B

108 DFT studies suggest a complex assisted sigma-bond metathesis pathway for C(sp(2))-H bond activa

109 d: oxidative addition, heterolytic cleavage, sigma-bond metathesis, electrophilic attack, etc.

110 unctionalization of the strained central C-C sigma-bond of the bicyclo[1.1.0]butyl unit.

111 lting in selective hydrogenolysis of the C-C sigma-bond.

112 ed breakdown of pai-stacking by formation of sigma-bonded polymers.

113 isms were discovered via which the initially sigma-bonded substrate could be converted: oxidative add

114 Homoleptic sigma-bonded uranium-alkyl complexes have been a synthet

115 s energetically preferred over the eta(1) - (sigma-bonded) arrangement, but the Mg must be in a low c

116 metal cations, in which 3-center-2-electron sigma bonding in Ge(2) Zn or Ge(2) Cd triangles plays a

117 ults from Ti-N pai-bonding mixing with N-C-N sigma-bonding of the bent N-C-N framework.

118 gnesium-catalyzed hydrosilylation of the C-C sigma bonds of alkylidene cyclopropanes.

119 nitrogen atom into neighboring electron-poor sigma bonds, with the seven-membered catalyst achieving

120 Ge(9) ligands is provided by six 2c-2e Pd-Ge sigma-bonds and two delocalized 4c-2e sigma-bonds.

121 of such reactions is challenging because C-C sigma-bonds are typically unreactive.

122 lanar fragment consists of three 2c-2e Pd-Ge sigma-bonds attaching Pd atoms to the core Ge atom, whil

123 are limited examples of highly strained C-C sigma-bonds being used in difunctionalization reactions.

124 Difunctionalization reactions of C-C sigma-bonds have the potential to streamline access to m

125 to weaken and facilitate the reaction of C-C sigma-bonds, but there are limited examples of highly st

126 Pd-Ge sigma-bonds and two delocalized 4c-2e sigma-bonds.

127 s, where strongly stabilizing anomeric n(O)->sigma(C-O)(*) interactions are activated.

128 In this conformation, ring sigma(C-O)* orbitals oriented antiperiplanar to the ally

129 Analysis suggests that the 1s-sigma* (C-S) transition in benzothiazine groups accounts

130 bilization of the TS through N(lone-pair) -> sigma*(C-C) "negative hyperconjugation" in diamino-o-car

131 cyclic oxygen lone pair into the antibonding sigma*((C-X)) orbital or the minimization of the dipole-

132 sequence for this transformation involving a sigma complex and oxidative cleavage transition state.

133 y described control mechanism for sigma-anti-sigma complex formation and establish c-di-GMP as the ce

134 trisiloxane, and triphenylsilane to give the sigma-complexes IrH(3)(eta(2)-H-SiR(3)){kappa(2)-cis-P,P

135 played by the two degrees of freedom of the sigma-conjugated bridge on the chromophore optical prope

136 ors incorporating and combining a bridge for sigma-conjugation between the D and A units and a struct

137 the linker substituent, such as the Hammett sigma-constant or electrostatic surface potential.

138 f the ecosystem itself: in mesic ecosystems, sigma decreases in drier years with a higher sensitivity

139 ation in the region 1.2 of initiation factor sigma decreases sensitivity to Urd.

140 ng at a Q binding element (QBE) and adjacent sigma-dependent pause element (SDPE) to yield a Q-loadin

141 m with a dimeric form, usually a spin-paired sigma dimer or a pi dimer (pimer).

142 pic, and theoretical evidence shows that the sigma-dimer contains a weak C(sp(3))-C(sp(3)) bond, but

143 e radicals recombine quantitatively into the sigma-dimer with observable kinetics, but they are oxidi

144 The radical was isolated in the form of its sigma-dimer, which was shown to possess a conformational

145 of RNA slippage and extension requiring the sigma dissociation from the core enzyme.

146 n of the electronic properties and excellent sigma-donating capacity displayed by NHCs allow gold-NHC

147 a demonstrate that a combination of a strong sigma-donating tridentate ligand and a (porphinato)zinc(

148 ino)carbenes (CAACs and CAArCs) are stronger sigma-donors and pai-acceptors than imidazol-2-ylidenes

149 Isonitriles, being competent sigma-donors, show a strong aptitude to form transition-

150 ity (sigma(o) ) and electronic conductivity (sigma(e) ) constitute an important family of electrocata

151 Often MIECs exhibit sufficient sigma(e) but inadequate sigma(o) .

152 B, activators of alginate production AlgU (a sigma(E) orthologue) and AlgR repress CRISPR-Cas activit

153 he adjacent top ring reduces the aryl pai-OH sigma* energy gap with a concomitant enhancement of the

154 ndard deviation of energy level distribution sigma(epsilon) is a Lorentzian function of variable Nsig

155 and fidelity of any QDC characterized by (N, sigma(epsilon)).

156 epresent the strongest (S(f) = 21 mN/tex, or sigma(f) ~ 22 MPa) and stiffest (J = 300 mN/tex, or E ~

157 to bind and sequester a sporulation-specific sigma factor (sigma(WhiG)).

158 nd suggest a functional link between the ECF sigma factor and Phu heme uptake system.

159 out displacement of the promoter recognition sigma factor from the core enzyme.

160 involves signalling through the alternative sigma factor FroR, and does not require known surface se

161 ional control in B. burgdorferi, and address sigma factor function and specificity, we developed an i

162 eptor HasR is required for activation of the sigma factor HasI and upregulation of has operon express

163 This review outlines the prospects of sigma factor in metabolic engineering of cyanobacteria,

164 ls an unprecedented role for a transcription sigma factor in spatially coordinating the negative feed

165 lity of catalase and general stress response sigma factor mutants confirmed the synergy of the three

166 tablishes a model in which the activity of a sigma factor of group ECF56, regulates morphogenesis and

167 hiD interacts with domain 4 of the principal sigma factor of Streptomyces, sigma(HrdB) (sigma(HrdB) (

168 d further characterization of the members of sigma factor regulatory circuits.

169 the promoter specificity of the housekeeping sigma factor RpoD to promoters encoding previously ident

170 ein OspC, likely via the central alternative sigma factor RpoS.

171 sis are known to interact with its principal sigma factor SigA.

172 the activity of the general stress response sigma factor sigma(B) in individual cells during biofilm

173 Here, we show that the alternative sigma factor sigma(I) is essential in the absence of aPB

174 iation network by the regulator BldD and the sigma factor sigma(WhiG) .

175 ezuelae through sequestering the sporulation sigma factor sigma(WhiG) and presents the crystal struct

176 proteins, and the second on the alternative sigma factor sigma(X), which directs the expression of t

177 erminal domain of the sigma70-family primary sigma factor sigmaA of M. tuberculosis containing the co

178 h encodes an extracytoplasmic function (ECF) sigma factor system.

179 gma(V) is an extracytoplasmic function (ECF) sigma factor that is found exclusively in Firmicutes inc

180 bacteria, sigma(28) is the flagella-specific sigma factor that targets RNA polymerase (RNAP) to contr

181 te expression of the general stress response sigma factor, RpoS, through direct interactions with an

182 between c-di-GMP, sigma(WhiG), and its anti-sigma factor, RsiG.

183 nearby promoters in the case of retaining a sigma factor.

184 reinitiation, increases with supplement of a sigma factor.

185 5 components enables us to predict potential sigma-factor regulons, along with various spacer lengths

186 pecificity code of extracytoplasmic function sigma factors (ECF sigmas), a major family of bacterial

187 ctivation for sub-groups of extracytoplasmic sigma factors adding to previous successes on bacterial

188 Extracytoplasmic function (ECF) sigma factors are key transcriptional regulators that pr

189 studies on how gene regulatory proteins and sigma factors exert control of gene expression in B. bur

190 Bacterial extracytoplasmic function sigma factors have emerged as an important group of sign

191 -enabled insights into the vast diversity of sigma factors in bacteria.

192 Due to the significant role of sigma factors in bacterial metabolism, their rational en

193 onse to environmental or developmental cues, sigma factors initiate the transcription of necessary ge

194 say to test how gene regulatory proteins and sigma factors interact with RNA polymerase to direct tra

195 Region 4 of the sigma70-family primary sigma factors is commonly used by transcription factors

196 aL_2 domain, which is characteristic for ECF sigma factors of group ECF56.

197 wo stress responses that depend on bacterial sigma factors with different mode of transcription initi

198 tial expression of extracytoplasmic function sigma factors, components of the type IX secretion syste

199 obacterial genomes typically encode multiple sigma factors, effective execution of metabolic engineer

200 ext of putative regulators of cyanobacterial sigma factors.

201 Sigma (sigma) factors are key regulatory proteins that control

202 lta(34)S was usually better than +/-0.2 mUr (sigma) for analytes containing at least 100 pmol of S.

203 the delocalized electrons in the part of the sigma-framework of the B(4) unit, as well as the conjuga

204 After outlier removal, the LMS (Lambda-Mu-Sigma) function within R's GAMLSS package was used to pr

205 through H-atom or hydride transfer from the sigma-H(2) adducts.

206 n complexation induces a polarisation of the sigma hole of ChB and XB heteroditopic receptor donors a

207 zed by cooperative, multidentate, convergent sigma-hole donors, as shown by molecular dynamics simula

208 n substantially increased affinity through a sigma-hole interaction.

209 the appearance of positively charged areas (sigma-holes) on the surface of the iodine substituents i

210 dissociation constant (K(d) ) for the SvWhiD-sigma(HrdB) (4) complex as ~0.7 mum, consistent with a r

211 l sigma factor of Streptomyces, sigma(HrdB) (sigma(HrdB) (4)).

212 on with O(2) and NO when SvWhiD was bound to sigma(HrdB) (4), consistent with protection of the clust

213 the principal sigma factor of Streptomyces, sigma(HrdB) (sigma(HrdB) (4)).

214 e, we show that the alternative sigma factor sigma(I) is essential in the absence of aPBPs.

215 s reveals that cells unable to activate this sigma(I) stress response acquire gain-of-function mutati

216 -dependent wall synthesis are compensated by sigma(I)-dependent upregulation of an MreB homolog, MreB

217 sensitivity to dryness; in xeric ecosystems, sigma increases in drier years with a lower sensitivity

218 ves of the carbene (R != H) are sensitive to sigma inductive effects.

219 Consequently, a dominant pai-sigma* interaction in the amino substituted analogue loc

220 tion of the bicyclobutonium cation 8N by C-C sigma-interactions and the t-butyl group amounts to 10.8

221 nic structure analyses revealed weak C-H->Co sigma-interactions, augmented by dispersive stabilizatio

222 d coincident with increasing cleavage of Pro-sigma(K) , and the FS ATP concentration does not decline

223 , an intramembrane protease that cleaves Pro-sigma(K) , releasing sigma(K) into the MC.

224 n the MC ATP level was not necessary for Pro-sigma(K) cleavage by SpoIVFB, based on analysis of mutan

225 plasm, but the role of ATP in regulating Pro-sigma(K) cleavage has been unclear, as has the impact of

226 otease that cleaves Pro-sigma(K) , releasing sigma(K) into the MC.

227 also demonstrates a novel signature mapping (SigMa) method for rapid and unbiased processing of compl

228 hilicity scale, which compares n-, pai-, and sigma-nucleophiles.

229 s) that display high oxide ion conductivity (sigma(o) ) and electronic conductivity (sigma(e) ) const

230 s exhibit sufficient sigma(e) but inadequate sigma(o) .

231 xceptional bulk transport properties, with a sigma(o) among the highest for known MIECs, but also hig

232 2) O(3-) (delta) (BSCF) exhibits exceptional sigma(o) and electrocatalytic activity.

233 ng challenge to develop MIECs with both high sigma(o) and stability under device operation conditions

234 films show that the electrical conductivity (sigma) of the FAPI thin film is 5.2 x 10(-7) S/cm, which

235 scopy, determining the mode of dimerization (sigma- or pai-dimer) by UV-vis spectroscopy and X-ray cr

236 dinated amide are required to occupy a 3c-4e sigma* orbital which is too high in energy to be reachab

237 e transfer (CT) to the adsorbate antibonding sigma* orbital.

238 sses were 0.15 and 0.18 [Formula: see text] (sigma: particle diameter), respectively, and were isotro

239 se transition sequence from a BCC phase to a sigma phase was observed by increasing annealing tempera

240 packing phases in PBIs, including A15 phase, sigma phase, dodecagonal quasicrystalline (DQC) phase, a

241 n-canonical soft matter Frank-Kasper A15 and sigma phases.

242 1 activity is controlled by the cognate anti-sigma protein RsfG, encoded by a co-transcribed sigG1-ne

243 Protein tyrosine phosphatase sigma (PTPsigma, PTPRS), a receptor for PNNs, interacts

244 ther found that protein tyrosine phosphatase sigma (PTPsigma, PTPRS), receptor for CSPGs, interacts w

245 regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1).

246 atory activities by activating signaling via sigma receptor 1, inositol-requiring enzyme-1alpha (IRE1

247 s involving HDACs (histone deacetylases) and sigma receptors by employing modern approaches based on

248 results suggest that Urd may directly target sigma region 1.2, which allosterically controls the reco

249 y controls the recognition of -10 element by sigma region 2.

250 ation of the iron import machinery through a sigma regulator are unclear.

251 e C-terminal CSS domain (CCSSD) of PupR, the sigma regulator in the Pseudomonas capeferrum pseudobact

252 e regulated intramembrane proteolysis of the sigma regulator, ultimately resulting in transcriptional

253 signals to the cytoplasm via inner-membrane sigma regulators.

254 ve hyphae into spores by arming a novel anti-sigma (RsiG) to bind and sequester a sporulation-specifi

255 s that the observed electrical conductivity (sigma(RT) <= 1.3 x 10(-2) S/cm) is enabled by hole and e

256 n on the activity of RssB and built the RssB-sigma(S) complex model.

257 ation site - D58 is at the interface of RssB-sigma(S) complex.

258 ted by RssB which maintains minimal level of sigma(S) during exponential growth but then elevates sig

259 And IraD-RssB complex is preferred over RssB-sigma(S) in solution, regardless of the phosphorylation

260 e mechanism of anti-adaptors preventing RssB-sigma(S) interaction remains elusive.

261 Regulation of bacterial stress responding sigma(S) is a sophisticated process and mediated by mult

262 Controlled proteolysis of sigma(S) is regulated by RssB which maintains minimal le

263 during exponential growth but then elevates sigma(S) level while facing stresses.

264 daptor protein IraD has higher affinity than sigma(S) to RssB and its binding interface on RssB overl

265 ing interface on RssB overlaps with that for sigma(S).

266 ossesses a two-tier mechanism for regulating sigma(S).

267 58 would weaken the interaction of RssB with sigma(S).

268 Sigma (sigma) factors are key regulatory proteins that c

269 trengths of these noncovalent intramolecular sigma-sigma interactions via temperature-dependent nucle

270 This enabled de novo prediction of ECF sigma specificity, which we combined with a statisticall

271 s (f (L) = 0.25 - 0.33) situated between the sigma-sphere phase and hexagonally close-packed cylinder

272 nhibition involving the regulatory domain of sigma subunit, and potentially pinpoint a novel target f

273 ams were used for 3-point flexural strength (sigma) test.

274 lles to a succession of Frank-Kasper phases (sigma to C14 to C15) upon the addition of minority-block

275 Here, the PA values for several sigma-type carbon-centered pyridine-based monoradicals a

276 sigma(V) is an extracytoplasmic function (ECF) sigma fac

277 structural and molecular parameters lead to sigma- versus pai-dimerization.

278 the pai-dimers lead to improved forecasts of sigma- vs pai-dimerization mode, and suggest that a bala

279 was the lowest with GA pH 5 (p<0.001), while sigma was not significantly affected by the experimental

280 25 years later that the Group IV alternative sigmas were described as a distinct family of proteins r

281 k by the regulator BldD and the sigma factor sigma(WhiG) .

282 gh sequestering the sporulation sigma factor sigma(WhiG) and presents the crystal structure of a tern

283 sent the structure of the RsiG-(c-di-GMP)(2)-sigma(WhiG) complex, revealing an unusual, partially int

284 ntercalated c-di-GMP dimer bound at the RsiG-sigma(WhiG) interface.

285 quester a sporulation-specific sigma factor (sigma(WhiG)).

286 cture of a ternary complex between c-di-GMP, sigma(WhiG), and its anti-sigma factor, RsiG.

287 RsiG binds c-di-GMP in the absence of sigma(WhiG), employing a novel E(X)(3)S(X)(2)R(X)(3)Q(X)

288 at c-di-GMP is essential for RsiG to inhibit sigma(WhiG).

289 ; 2) an association between an i-modulon and sigmaS, whose regulatory role was previously undefined;

290 as ReB(2) O(-) is linear (C(infinityv) , (3) Sigma(-) ) with an electron-precise Re=B triple bond, [R

291 ectionality and sensitivity of isohydricity (sigma) with respect to the interannual variation of dryn

292 We found that ComD, sigma(X) and DprA stably co-localize at one pole in comp

293 ed without information about the data errors sigma(x) and sigma(y), are equivalent to the recommended

294 Through this polar DprA targeting function, sigma(X) mediates the timely shut-off of the pneumococca

295 ocalize at one pole in competent cells, with sigma(X) physically conveying DprA next to ComD.

296 d the second on the alternative sigma factor sigma(X), which directs the expression of the DprA prote

297 ponse function, linear or nonlinear, for any sigma(xi) and sigma(yi).

298 -magnetic field-Hall conductivity (E(F)-B(z)-sigma(xy)) and Fermi energy-electric field-Hall conducti

299 -electric field-Hall conductivity (E(F)-E(z)-sigma(xy)) phase diagrams clearly exhibit oscillatory be

300 formation about the data errors sigma(x) and sigma(y), are equivalent to the recommended best approac

301 , linear or nonlinear, for any sigma(xi) and sigma(yi).