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1 hine (ligands that bind to both dopamine and sigma receptors).
2 eptide Y), were screened for activity at the sigma receptor.
3 with the same molecular weight as the cloned sigma receptor.
4 o proposed that PCP may induce c-fos via the sigma receptor.
5 ial cells through the binding to its cognate sigma receptor.
6 F10 murine melanoma cells, which express the sigma receptor.
7  thus was blocked by antagonists for CCR2 or sigma receptor.
8 nels are modulated by a single population of sigma receptors.
9 ere conducted to test for the involvement of sigma receptors.
10 ling behavior, indicating the involvement of sigma receptors.
11 inity drug binding site similar to mammalian sigma receptors.
12 GluN2B affinity but limited selectivity over sigma receptors.
13  major questions that remain in the study of sigma receptors.
14 transduction mechanisms of NPY receptors and sigma receptors.
15 matches the reported binding specificity for sigma receptors.
16                                              Sigma receptor 1 (sigmaR1) is expressed abundantly in th
17  regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1).
18 atory activities by activating signaling via sigma receptor 1, inositol-requiring enzyme-1alpha (IRE1
19          One promising target of METH is the sigma receptor, a chaperone protein located on the membr
20 ies or affinities of 5-HT(1), muscarinic, or sigma receptors across these strains, suggesting that de
21                          Other mechanisms of sigma receptor action may involve interaction with ankyr
22 ine release and basal efflux is dependent on sigma receptor activation.
23          In contrast, haloperidol, and other sigma receptor-active agents, were relatively inactive a
24 tuted analogues were shown to have increased sigma receptor affinity and represent the most potent an
25 ues were synthesized and optimized for their sigma receptor affinity and selectivity.
26                                              sigma receptor affinity was recorded using receptor mate
27                                     In vitro sigma-receptor affinity measurements indicate these comp
28 compare mechanisms by which the prototypical sigma receptor agonist (+)-pentazocine, and the proposed
29                 In the presence of 10 microM sigma-receptor agonist BD737 or 10 microM sigma-receptor
30 cytes without receptors were unresponsive to sigma receptor agonists, ruling out inhibition through a
31  In this review, we revisit past research on sigma receptors and discuss the interpretation of these
32           Recently, molecules active at both sigma receptors and NMDA receptor sites were investigate
33 5 = Br, R3 = C2H5) exhibited potency at both sigma receptors and NMDA receptor sites; 27b also showed
34 vel of G-protein activation, suggesting that sigma receptors and NPY receptors do not represent a com
35 hereas the precise molecular mechanism(s) of sigma receptors and their involvement in cancer cell bio
36                                   The sigma (sigma) receptor and its agonists have been implicated in
37 y site or state of the dopamine transporter, sigma receptors, and their potential roles in modulating
38                 Unilateral injections of the sigma receptor antagonist BD-1063 prior to METH administ
39 zole (rimcazole) has been characterized as a sigma receptor antagonist that binds to the dopamine tra
40  attenuated by pretreatment of mice with the sigma receptor antagonist.
41 oM sigma-receptor agonist BD737 or 10 microM sigma-receptor antagonist haloperidol, the distribution
42 on [(3)H]dopamine release is not reversed by sigma receptor antagonists.
43  that this enhancement is reversed by sigma (sigma) receptor antagonists.
44 affected by micromolar concentrations of the sigma-receptor antagonists Dup734 or haloperidol.
45                                              Sigma receptors are known to be expressed in a variety o
46                                              Sigma receptors are unique endoplasmic reticulum protein
47                                              Sigma receptors bind a diverse group of chemically unrel
48 quirements of a molecule necessary to elicit sigma receptor binding activity.
49                                 Variation in sigma receptor binding labeled by [3H]nemonapride was st
50 125I]IPBS in guinea pig brain membranes with sigma receptor binding ligands confirmed its sigma pharm
51 ese results demonstrate the potential use of sigma receptor binding ligands in non-invasive diagnosti
52 el halogenated arylsulfonamides (HAS) as new sigma receptor binding tumor imaging agents is described
53                                          The sigma-receptor binding affinity of (19)F-FBZA was determ
54  displayed the highest selectivity over both sigma receptors but was very fast metabolized in vitro.
55 s involving HDACs (histone deacetylases) and sigma receptors by employing modern approaches based on
56 ogether, the data suggest that modulation of sigma receptors can mitigate methamphetamine-induced cyt
57                            However, the only sigma receptor characterized at the molecular level has
58 ity appears to correlate with differences in sigma receptor coupling rather than levels of expression
59 10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive mann
60 hibited very high potency for binding to the sigma receptors (e.g.28).
61 SH-SY5Y cells are suitable for investigating sigma receptor effects and whether any sigma receptors p
62        To further evaluate the properties of sigma receptors, especially sigma-1 and sigma-2 subtypes
63  ligands used here are known to bind also to sigma receptors, experiments were conducted to test for
64     Altogether, these findings show that the sigma receptor has a key role in METH dysregulation of d
65                                              sigma receptors have been found to be frequently up-regu
66 heterogeneous and their function is unknown, sigma receptors have been proposed as potential targets
67                                              sigma Receptors have been the focus of extensive studies
68 a) receptor ligands may share a putative NPY/sigma receptor in rat brain.
69 mma S binding, suggesting a broader role for sigma receptors in modulating G-protein-coupled receptor
70              Radioligand binding results for sigma receptors indicated that the structure of the amin
71                                          The sigma receptor is a novel protein that mediates the modu
72 s study, we show that a very high density of sigma receptors is also expressed in an androgen-indepen
73 dentity of the endogenous ligands for sigma (sigma) receptors is unknown, neuropeptide Y (NPY) has be
74 ggest that interactions between METH and the sigma receptor lead to oxidative species (most likely su
75 es demonstrated the ability of the selective sigma receptor ligand N-phenethylpiperidine oxalate (AC9
76 (+)-pentazocine, and the proposed endogenous sigma receptor ligand NPY regulate potassium-stimulated
77  sulpiride (dopamine receptor ligand), PPAP (sigma receptor ligand) and haloperidol (mixed dopaminerg
78  assess the effect of SR 31742A, a selective sigma receptor ligand, on N-methyl-d-aspartate (NMDA) an
79 orted tumour-selective killing by the sigma (sigma) receptor ligand rimcazole.
80                                    Using the sigma-receptor ligand anisamide as an example, we descri
81                               Beginning with sigma receptor ligands and expanding to other drugs from
82             Thus, physiological responses to sigma receptor ligands are mediated by a protein with th
83               Recent work has indicated that sigma receptor ligands can modulate potassium channels.
84 owever, despite ongoing clinical trials with sigma receptor ligands for multiple conditions, relative
85                     To study whether NPY and sigma receptor ligands have an inverse agonism at this p
86                                              Sigma receptor ligands inhibited current through two dis
87                                          The sigma receptor ligands N-allylnormetazocine (SKF10047),
88                                          The sigma receptor ligands pentazocine and SKF10047 modulate
89                   In rat neurohypophysis the sigma receptor ligands SKF10047, pentazocine, and ditoly
90   The phenylethylene diamines are a class of sigma receptor ligands with excellent selectivity over o
91                 Fifteen candidate endogenous sigma receptor ligands, including biogenic amines (e.g d
92 d to the purported neuroprotective action of sigma receptor ligands.
93 ggested that neuropeptide Y (NPY) and sigma (sigma) receptor ligands may share a putative NPY/sigma r
94 ], have been identified as new potent sigma (sigma) receptor ligands.
95 we did not see an inverse agonism of NPY and sigma-receptor ligands at the putative NPY/sigma recepto
96              Since no significant effects by sigma-receptor ligands on NPY-induced G-protein activati
97 d sigma-receptor ligands at the putative NPY/sigma receptor measured at the level of G-protein activa
98                                 Release of a sigma receptor-mediated brake on apoptosis may offer a n
99              These experiments indicate that sigma receptor-mediated signal transduction is membrane
100 e used to investigate the mechanism by which sigma receptors modulate K+ channels in peptidergic nerv
101 clamp technique was used to demonstrate that sigma receptors modulate K+ channels in rodent neurohypo
102                                        Thus, sigma receptors modulate opioid transduction without inf
103                                              Sigma receptors modulated voltage-gated K+ channels (Kv1
104 udies using glutamate and KCl and identify a sigma receptor modulation of functional NMDA responsiven
105         For the first time, a combination of sigma receptor moieties and a NO photodonor is reported,
106 e NO under visible light and possess overall sigma receptor nanomolar affinity, with one of them (8b)
107                                              sigma Receptors, once considered a class of opioid recep
108  study the regulation of dopamine release by sigma receptors or by NPY receptors, but this population
109 ins, the specific physiopathological role of sigma receptors (oRs) has been deeply investigated.
110 m (RES) and anisamide (AA) for targeting the sigma receptor over-expressed in H460 human lung cancer
111 vel hybrid compounds that conjugate a sigma (sigma) receptor pharmacophore and a nitric oxide (NO) ph
112                                          The sigma receptor photoprobe iodoazidococaine labelled a pr
113      Iodoazidococaine (IAC), a high affinity sigma receptor photoprobe, produced a similar inhibition
114 The sub-cellular distribution studied in the sigma receptor positive human H460 lung cancer cells ind
115 ating sigma receptor effects and whether any sigma receptors present are of the subtype responsive to
116 with the same molecular mass (26 kDa) as the sigma receptor protein identified by cloning.
117                        The exact function of sigma receptors remains to be elucidated.
118                   METH-induced activation of sigma receptors results in oxidation of a cysteine resid
119 h as fibroblasts, epithelial cells, and even sigma receptor-rich neurons are resistant to the apoptot
120                                          Yet sigma receptor selective antagonists, but not agonists,
121 independent effects on channels suggest that sigma receptors serve as auxiliary subunits to voltage-g
122                                              Sigma receptors (sigmaRs) are nonopioid, nonphencyclidin
123               The present study investigated sigma receptor signal transduction by reconstituting res
124 unt of specific binding for dopaminergic and sigma receptor sites was observed.
125 -diazaspiro[4.4]nonane derivatives as potent sigma receptor (SR) ligands, associated with analgesic a
126 idol, a multifunctional D2-like dopamine and sigma receptor subtype antagonist, has neuroprotective p
127  of these compounds at the sigma1 and sigma2 sigma receptor subtypes.
128                                       Sigma (sigma) receptor subtypes, sigma(1) and sigma(2), are tar
129 expression and functional changes by cocaine/sigma receptor system may provide insights into the deve
130  of D(2) receptors were independent of final sigma receptor systems because the final sigma agonist (
131 o further define the molecular physiology of sigma receptors, their involvement in the cellular patho
132                                              Sigma receptors thus modulate ion channels by a novel tr
133 odent microglia through translocation of the sigma receptor to the lipid raft microdomains of the pla
134 dothelial cells through the translocation of sigma receptor to the plasma membrane, followed by phosp
135 14 cells (a tumor cell line known to express sigma receptors) to investigate the role of the 26-kDa p
136  density (1.0-1.5 million receptors/cell) of sigma receptors was also reported in a human androgen-de
137       Association between Kv1.4 channels and sigma receptors was demonstrated by coimmunoprecipitatio
138         The particularly rich hit subset for sigma receptors was expanded with two focused library se
139 ]24b (Ki = 0.78 nM for VAChT, 1200-fold over sigma receptors) was successfully synthesized and evalua
140 have an inverse agonism at this putative NPY/sigma receptor, we measured their effects on G-protein a
141                                          The sigma receptor, which modulates voltage-gated K+ channel
142 NPY as an endogenous ligand for a subtype of sigma receptor with characteristics different from Y1, Y
143 ty experiments suggested a structure for the sigma receptor with two cytoplasmic termini and two memb
144 nhibition of voltage-activated K+ current by sigma receptors would be expected to enhance the secreti

 
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