ライフサイエンスコーパス: sigma-2 receptor

1 ceptor and discuss the recent cloning of the sigma(2) receptor.

2 opy, demonstrating their specificity for the sigma(2) receptor.

3 known about the mechanisms activated by the sigma(2) receptor.

4 have a high affinity and selectivity for the sigma(2)-receptor.

5 and predicted regulators of the sigma-1 and sigma-2 receptors.

6 acterization of sigma-2 receptor ligands and sigma-2 receptors.

7 fold selectivity for VAChT over sigma(1) and sigma(2) receptors.

8 binding affinity and subtype selectivity for sigma(2) receptors.

9 liver and guinea pig liver membranes and the sigma-2 receptor (18 kDa) in rat liver membranes with hi

10 five different scaffolds known to have high sigma(2) receptor affinity were screened.

11 l metabolite II (sigma-1 receptor antagonist/sigma-2 receptor agonist ligand) obtained by conjugation

12 Sigma-2 receptor agonists have been shown to induce cell

13 We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mech

14 emonstrated high affinities for sigma(1) and sigma(2) receptors and thus failed to show significantly

15 hemical compounds with high affinity for the sigma-2 receptor and showed rapid internalization of the

16 (K(i) = 1.2 nM), excellent selectivity over sigma(2) receptors, and promising logD(7.4) (3.05) and l

17 The sigma(1) and sigma(2) receptors are enigmatic proteins that have attr

18 Sigma-1 and sigma-2 receptors are emerging therapeutic targets.

19 We have reported previously that sigma-2 receptors are expressed in high densities in a v

20 ectively inhibited by ligands with different sigma(2) receptor binding affinities.

21 In vitro cell binding indicated that sigma(2) receptor binding of [(11)C]-(+/-)-7 and [(11)C]

22 romatic substitution patterns on sigma-1 and sigma-2 receptor binding affinity and selectivity.

23 Two sigma(2)-receptor-binding ligands were prepared, from th

24 The identification of the putative sigma-2 receptor-binding site as PGRMC1 should stimulate

25 photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site.

26 sed to study the subcellular localization of sigma-2 receptors by two-photon and confocal microscopy.

27 t 66 P cells had approximately 10 times more sigma 2 receptors/cell than the 66 Q cells from 10-day c

28 The results indicate that sigma-2 receptors colocalize with fluorescent markers of

29 onradioactive) glucose in blood, sigma-1 and sigma-2 receptor expression in the tumor, animal weight,

30 The sigma(2)-receptor has been shown to be upregulated in pr

31 The sigma-2 receptor has been identified as a biomarker in p

32 sigma 1 and sigma 2 receptors have been shown to exist in a number o

33 itting radionuclides, which selectively bind sigma 2 receptors, have the potential to noninvasively a

34 The sigma(2) receptor holds promise for the development of d

35 In this study, the density of sigma 2 receptors in proliferative (P) and quiescent (Q)

36 PET radiotracer for imaging the function of sigma(2) receptors in central nervous system disorders.

37 rs have demonstrated increased expression of sigma-2 receptors in rapidly proliferating tumors and th

38 in isothiocyanate group, irreversibly labels sigma-2 receptors in rat liver; the membrane-bound prote

39 The localization of sigma-2 receptors in several organelles known to have a

40 h ligands displayed strong interactions with sigma(2) receptors indicating poor selectivity towards t

41 The sigma(2) receptor is a potential in vivo target for meas

42 In the case of pancreatic cancer, the sigma-2 receptor is a unique target that triggers apopto

43 ); this also showed the highest affinity for sigma-2 receptors (K(i) 13 nM).

44 ls that both PGRMC1 and SW120, a fluorescent sigma-2 receptor ligand, colocalize with molecular marke

45 ll facilitate functional characterization of sigma-2 receptor ligands and sigma-2 receptors.

46 clusions of previous studies suggesting that sigma-2 receptor ligands should be evaluated as potentia

47 These observations further suggest that sigma-2 receptors may be targets that can be therapeutic

48 ontrast, caspase inhibitors had no effect on sigma-2 receptor-mediated (CB-64D and CB-184) cytotoxici

49 S2R (sigma-2 receptor)/Pgrmc1 (progesterone receptor membrane

50 ents and cancer therapeutics that target the sigma-2 receptor/PGRMC1 complex.

51 sigma(1) and/or sigma(2) receptors play a crucial role in pathological c

52 The involvement of sigma-2 receptors remains unclear.

53 The Sigma-2 receptor (S2R) regulates lipid and protein traff

54 The sigma-2 receptor (S2R), with roles in tumor progression,

55 The sigma 2 receptor (sigma(2)R) was described pharmacologic

56 The sigma 2 receptor (sigma(2)R) was recently identified as

57 d in vitro in human sigma(1)R and guinea pig sigma(2) receptor (sigma(2)R) binding assays.

58 of a new series of isoxazolylpyrimidines as sigma-2 receptor (sigma(2)R) ligands are reported.

59 Sigma 2 receptor (sigma2R) is overexpressed in select ca

60 One particular specific ligand of the sigma-2 receptor, SV119, binds to pancreatic cancer cell

61 ormation regarding the molecular function of sigma-2 receptors that can explain these results.

62 validated as powerful tools for the study of sigma(2) receptors via fluorescence-based techniques.

63 their binding affinities to the sigma-1 and sigma-2 receptors, we show that both photoaffinity label

64 Scatchard analyses of sigma 2 receptors were performed on membrane preparation

65 Binding affinities for sigma(1) and sigma(2) receptors were also determined, and several of

66 aspase-independent apoptotic pathway used by sigma-2 receptors, which is distinct from mechanisms use

67 The sigma-2 receptor, whose gene remains to be cloned, has b

68 yield and specific activity that target the sigma(2) receptor with high affinity and selectivity.