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1 sms, and nonequilibrium effects in a dynamic signaling cascade.
2 the ultimate effector protein of this stress signaling cascade.
3 icant role of Y954 in influencing downstream signaling cascade.
4 rmacologically tractable Prion Protein (PrP) signaling cascade.
5 is, and the mitogen-activated protein kinase signaling cascade.
6 reases ENaC activity independent of the RAAS signaling cascade.
7 echanisms, proliferative pathway and the Wnt signaling cascade.
8 T303 in the DCT of mouse kidney via the PTH signaling cascade.
9 ferentiation depends on a Dll4-Jag1-EphrinB2 signaling cascade.
10 t links Ras family members with the MAPK/ERK signaling cascade.
11 N) classically counteracts the PI3K/AKT/mTOR signaling cascade.
12 potent and selective antagonist of the CCR3 signaling cascade.
13 tune a fast reactive but potentially harmful signaling cascade.
14 tumor by inhibiting the NF-kappaB-IL-6-STAT3 signaling cascade.
15 ly regulated by TORC1 through the Rim15-Ume6 signaling cascade.
16 SG formation by inhibiting the PKR-triggered signaling cascade.
17 activity of the RTK-RAS-RAF and RTK-PI3K-AKT signaling cascade.
18 edgehog (HH) paracrine system as a candidate signaling cascade.
19 ity-dependent, non-apoptotic Bax/Bak-caspase signaling cascade.
20 orylates multiple proteins in the checkpoint signaling cascade.
21 survival by exerting dual effects on the BCR signaling cascade.
22 Mtb gains survival advantage through ATM-Akt signaling cascade.
23 promote Treg-cell generation through the BMP signaling cascade.
24 nism, coupled with the insulin receptor (IR) signaling cascade.
25 the mitogen-activated protein kinase (MAPK) signaling cascade.
26 d to identify additional players in the cAMP-signaling cascade.
27 tively disrupting a previously unappreciated signaling cascade.
28 ion of ATM-FOXO3a association and downstream signaling cascade.
29 -alpha and induced a PI3K/PDK1/PKA-dependent signaling cascade.
30 a dominant astrocyte-mediated glutamatergic signaling cascade.
31 latelets, an essential component of the ITAM-signaling cascade.
32 lly affect processes downstream of the auxin signaling cascade.
33 on to output a specific cell lineage through signaling cascades.
34 neural repair but does not pin down specific signaling cascades.
35 y nutrient-sensing mechanisms and cell death signaling cascades.
36 ized properties to help orchestrate multiple signaling cascades.
37 y in vivo and alters multiple immune-related signaling cascades.
38 ch several are found on proteins involved in signaling cascades.
39 sine receptor subtypes that induce different signaling cascades.
40 otic mitogen-activated protein kinase (MAPK) signaling cascades.
41 n through activation of FGFR4 and downstream signaling cascades.
42 g with activated downstream protein kinase B signaling cascades.
43 ly through convergence of multiple perturbed signaling cascades.
44 inase (IKK)/nuclear factor-kappaB (NFkappaB) signaling cascades.
45 bind to phosphothreonine (pThr) residues in signaling cascades.
46 t/beta-catenin and noncanonical Wnt/Ror2/Jnk signaling cascades.
47 h include activating several proteolytic and signaling cascades.
48 tegy to restore balance to these hyperactive signaling cascades.
49 nodine receptor and Ulk-1-PERK and AMPK-mTOR signaling cascades.
50 s stomatal closure via multifarious cellular signaling cascades.
51 ell surface receptors to activate downstream signaling cascades.
52 /p50) is involved in both NF-kappaB and MAPK signaling cascades.
53 enzymatic activities, which initiate various signaling cascades.
54 h) by the Hh ligands relieves suppression of signaling cascades.
55 ma-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades.
56 classical receptor tyrosine kinase-activated signaling cascades.
57 y, integrates multiple inputs from different signaling cascades.
58 essions, post-translation modifications, and signaling cascades.
59 the mitogen-activated protein kinase and AKT signaling cascades.
60 strating the transduction of a repertoire of signaling cascades.
61 nd act as scaffolds to enhance intracellular signaling cascades.
62 multiple levels of NF-kappaB, STAT and AP-1 signaling cascades.
63 t-pathogen interaction through activation of signaling cascades.
64 ers of DNA replication and of the DNA damage-signalling cascade.
65 al components of the non-canonical NF-kappaB signalling cascade.
66 pects of plant development through a complex signalling cascade.
67 s on the microenvironment and interdependent signalling cascades.
68 cover two crucial properties of the core SAC signaling cascade: (1) a cellular limit on the maximum a
70 ernal negative charge of the cell triggers a signaling cascade activating an innate immune response c
71 ption, the Fzr-ubiquitinated H2B (H2Bub)-Myc signaling cascade also positively regulates the transcri
72 gh this canonical pathway is the predominant signaling cascade, alternative pathways also affect ethy
73 er cancer treatment: targeting the ErbB/MAPK signaling cascade and (2) establish the utility of canin
74 the cytoplasm downstream of Fzd7 in the Wnt signaling cascade and APC mutations activate Wnt/beta-ca
75 ing p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WAS
76 sponse to IL-15, CD122+Macs activate the ERK signaling cascade and enhance production of proinflammat
79 nrelated receptors can change the downstream signaling cascade and regulate neuronal growth through a
80 romotes cell proliferation by activating AKT signaling cascades and augmenting cell cycle progression
81 naling, which cooperated with other cellular signaling cascades and cytoskeletal remodeling to suppor
85 te to deregulation of critical developmental signaling cascades and inflammatory responses following
86 change detection may be important in diverse signaling cascades and multiple biological contexts.
88 erved role of SlBBX gene family in the light signalling cascade and identified putative members affec
89 network of ion channels initiates left-sided signalling cascades and differential gene expression is
90 e kinases, activates various proinflammatory signaling cascades, and concomitantly stimulates Wnt and
91 , depending on behavioral context, G-protein-signaling cascades, and DA neuron efferent targets, high
94 esponse to genotoxic stress, multiple kinase signaling cascades are activated, many of them directed
95 embryos of unknown sex, whether BDNF-induced signaling cascades are altered when early and recycling
96 Our discovery highlights this NAC42-NPF6.1 signaling cascade as a strategy for high NUE and yield b
97 hate-mediated signaling and calcineurin-NFAT signaling cascade as important biological process associ
98 entify activation of the NF-kappaB/LIF/STAT3 signaling cascade as involved in inducing antibody-media
99 least in part, via inhibition of TLR4/MyD88 signaling cascade as well as inactivation of NLRP3 infla
101 ecular mechanisms underlying their effect on signal cascades associated with tumorigenesis, and summa
102 of radiation dose fractionation on the KLF2 signaling cascade at early time points (up to 24 h).
103 Extracellular Signal-Regulated Kinase (ERK)-signaling cascade at the most proximal step of effector
106 L5 (HY5) represents a major hub in the light-signaling cascade both under visible and UV-B light.
107 ha-actin cytoskeleton and classic fibrogenic signaling cascades, but also emphasize the relationship
108 mplicated in the regulation of critical cell-signaling cascades, but most OTUs functions remain to be
109 terferons (IFNs) activate similar downstream signaling cascades, but unlike type I IFNs, type III IFN
110 actors to the DNA damage site, initiation of signaling cascades, chromatin remodeling, cell-cycle che
111 STATEMENT At the neuronal membrane, protein signaling cascades consisting of ion channels and metabo
112 , such as the Notch, WNT, Hedgehog and Hippo signalling cascades, continues to be pursued across mult
113 ne evasion strategies but also of the immune signaling cascades controlling antiviral immunity and th
114 athway represents one of the best-understood signaling cascades controlling epithelial morphogenesis.
117 in interacting proteins control inflammatory signaling cascades could provide new pathways for therap
118 sm in which cholesterol depletion triggers a signaling cascade, culminating with contraction impairme
119 ion factor downstream of the RAS-RAF-MEK-ERK signaling cascade directly transactivates the xCT promot
120 mily that signal via the BMP receptor (BMPR) signaling cascade, distinct from canonical TGF-beta sign
121 ement is facilitated through a switch in the signaling cascade downstream of CaSR (i.e., from the PI3
123 and mammalian target of rapamycin-dependent signaling cascade downstream of Toll-like receptors (TLR
124 ath pathway mediated by the RIPK1-RIPK3-MLKL signaling cascade downstream of tumor necrosis factor al
125 rative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate
126 g assays, and inhibition of LRP6 or critical signaling cascades downstream of LRP6, including JNK and
128 ns similar to Mp1p can severely disturb host signaling cascades during proinflammatory responses by r
129 SPRTN activates the ATR-CHK1 phosphorylation signalling cascade during physiological DNA replication
131 ography, we found that loss of this critical signaling cascade exaggerated the vasoconstrictor respon
132 This redox-auxin-strigolactone systemic signaling cascade facilitates eCO(2) -induced AMF symbio
134 ctor receptor (EGFR), and activates cellular signaling cascades for host invasion, cytoskeletal remod
136 ke receptors (TLRs) coupled to intracellular signaling cascades function as central elements of innat
139 sms by which they can be coupled to neuronal signaling cascades highlights the desirability of contin
141 , we identified a dysregulated miR-486/DOCK3 signaling cascade in dystrophin-deficient muscle, which
142 indings establish the role of GBP2/Stat3/FN1 signaling cascade in GBM invasion and suggest GBP2 may s
144 study has uncovered a novel PKCbeta-Lyn-Pyk2 signaling cascade in primary monocytes that regulates MC
145 macrophages that activate the intracellular signaling cascade in response to pathogenic stimuli.
147 the AWC neurons are thought to deploy a cGMP signaling cascade in the detection of and response to AW
149 ncing broadly implicates TrkB.T1 in the PI3K signaling cascades in a ligand-independent fashion.
151 n the one hand, the virus highjacks cellular signaling cascades in order to support its propagation;
152 Growing evidence implicates altered mTORC1 signaling cascades in the pathophysiology of depression,
153 hway, which is the most frequently activated signalling cascade in GB, have so far only shown limited
154 r that activates an evolutionarily conserved signalling cascade in response to biotic and abiotic str
155 shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mamma
156 various harmful factors that engage diverse signalling cascades in neurons; thus, therapeutic approa
158 n PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK, AKT and PAK1 a
159 f post-transcriptional regulation of the ECF signaling cascade, including the previously reported pos
160 R can also act in a variety of intracellular signaling cascades independently of RAS in the renal med
161 at the endosomal pathway is required for the signaling cascade initiated by BDNF and its receptors at
162 ion has addressed early steps in the insulin signaling cascade, insulin resistance in obesity seems t
163 and that its role depends on activation of a signaling cascade involving apoptosis signaling kinase 1
164 rch in the mouse embryo have revealed that a signaling cascade involving the Bone Morphogenic Protein
165 sa, expression of the T3SS is regulated by a signaling cascade involving the proteins ExsA, ExsC, Exs
166 state cancer cells that an early step in the signal cascade is direct action on the cell membrane pot
171 The epidermal growth factor receptor (EGFR) signaling cascade is known to drive cell migration and p
172 g of the structural elements regulating this signaling cascade is limited, hindering structure-based
175 ically, our data indicate that the NF-kappaB signaling cascade is significantly upregulated in Nlrx1(
179 plicate p38 and Jun kinases and MEF2C in the signal cascade leading to ionotropic glutamate receptor
180 ues by binding with cytokines to transduce a signaling cascade leading to gene transcription in cells
181 interferon genes (STING), which activates a signaling cascade leading to the production of type I in
182 d FPR2/ALX receptors and the downstream AMPK signaling cascade, leading to macrophage skewing, dampen
183 utation results in dysregulation of the cAMP signaling cascade, leading to upregulation of phosphodie
184 ogy, suggesting that modulation of glutamate signaling cascades may offer novel therapeutic potential
185 a novel non-cell autonomous neuroprotective signaling cascade mediated through PI3K that requires re
186 signaling but also neomorphic, as it enables signaling cascades not canonically mediated by JAK1.
187 e governed in part by complex interconnected signaling cascades occurring between stromal and tumor c
191 RasGRF2), upstream regulators of the Ras-ERK signaling cascade, on cocaine self-administration (SA) i
193 sible as being key effectors within the PTEN signalling cascade, other genes required meticulous func
194 mRNA and miRNA gene annotation information, signaling cascade pathways and direct cancer association
195 Thus, our results highlight that alternative signaling cascades play a predominant role in the resist
196 on kinase re-wiring and the redeployment of signalling cascades previously associated with endocrine
199 model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) and Ras protein
201 rugs can tune rather than completely inhibit signaling cascades, providing information on the relatio
202 Here we show that TLR4 activation induces a signalling cascade recruiting TRAF6 and TBK-1, while TBK
205 We further found that the Fzr-H2Bub-Myc signaling cascade regulating endoreplication progression
207 phasis is given to the trigger molecules and signaling cascades regulating exit from host cells.
208 lant pathogen Agrobacterium tumefaciens, the signalling cascades regulating the activity of this secr
209 ial gene and protein expression profiles for signaling cascades related to neuroendocrine and inflamm
213 STING pathway is an essential innate immune signaling cascade responsible for the sensing of aberran
214 for ligands targeting orphan GPCRs since the signaling cascade(s) of the majority of these receptors
215 statement and synaptic enlargement through a signaling cascade selectively in D1-expressing neurons r
218 disruption of S100A8/A9 and their downstream signaling cascade suppress MI-induced granulopoiesis and
219 ts whereby reexposure to cocaine activates a signaling cascade that alters synaptic strength in the N
220 and promotes activation of an SRC-dependent signaling cascade that controls YAP nuclear shuttling.
221 electins also trigger an immunoreceptor-like signaling cascade that converts integrin alphaLbeta2 to
222 ound that components of a G(12/13)-dependent signaling cascade that culminates in activation of the H
223 Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an
224 the levels of pluripotency factors through a signaling cascade that includes epidermal growth factor
225 n-R plants constitutively activate an immune signaling cascade that induces temperature-sensitive res
226 eic acids during viral infection activates a signaling cascade that induces type I and type III IFNs
227 ts receptor AstAR1 activate a neuroendocrine signaling cascade that initiates metamorphosis, similar
228 ustains a mast cell and macrophage-dependent signaling cascade that is amenable for the treatment of
230 mbined with overexpression of EGFR induces a signaling cascade that leads to hyperactivation of NFkB
231 aining adaptor protein (TIRAP), triggering a signaling cascade that leads to innate immune responses.
232 port a previously unknown Ca(2+)-CaMKK2-AMPK signaling cascade that protects stalled forks from degra
236 in the ER, resulting in the activation of a signaling cascade that restores proper homeostasis in th
237 nitiation of the feedforward chemoattractant signaling cascade that results in neutrophil swarms.
239 idopsis (Arabidopsis thaliana), triggering a signaling cascade that shares some similarities to respo
240 ppo pathway of multicellular organisms, is a signaling cascade that triggers node dispersal, CR assem
241 ooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibiti
242 taining protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment
243 YSLTR2 -> GNAQ/11 -> PLCbeta act in a linear signaling cascade that, via protein kinase C (PKC), acti
244 ng to nucleic acids, these proteins initiate signaling cascades that activate host defense responses.
245 ough our work, we have now identified 2 main signaling cascades that are activated during MRP-induced
246 gnals, like activation of specific genes and signaling cascades that enable cells to adapt to their p
247 al step for the initiation of the downstream signaling cascades that guide various cellular mechanism
250 lial cell (EC) adaptation by activating gene-signaling cascades that promote endothelial migration, g
252 pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton,
253 e postsynaptic neuron and trigger downstream signaling cascades that regulate the synaptic state.
254 lation as a tractable tool for modulation of signaling cascades that rely on calcium as a transductio
256 erated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robu
257 dulated by additional inhibition of the PI3K signalling cascade, there is no apparent benefit of bloc
258 other Syk-coupled CLRs, including Dectin-1, signaling cascade through DC-ASGPR did not trigger NF-ka
260 ergic receptors in these neurons initiates a signaling cascade through which Gi-protein reduces cAMP
262 This work describes how C1P activates a signaling cascade to dynamically regulate P-glycoprotein
264 s from canonical activation of the NF-kappaB signaling cascade to increase PLPP3 expression through n
265 This induces the conserved left-sided Nodal signaling cascade to initiate asymmetric organogenesis.
266 ferentially signal through the canonical BMP signaling cascade to instruct inflammatory-type LCs and
268 tilized ovules and developing seeds initiate signaling cascades to coordinate and promote the growth
269 show that OXT recruits several intracellular signaling cascades to induce protein synthesis, which me
270 ases in AMP/ATP ratio by activating multiple signaling cascades to overcome the energetic deficiency.
271 h specific machinery that initiates discrete signaling cascades to produce a localized response.
272 pattern recognition and triggers downstream signaling cascades to promote inflammation and immune de
273 ted receptors can integrate their individual signaling cascades toward a nonadditive effect and thus
275 ptor proteins that orchestrate transmembrane signaling cascades triggered by the 7-transmembrane G pr
277 s that differentially inhibit these discrete signaling cascades, understanding the source and signali
278 ivity, a shift from PKA to ERK intracellular signaling cascades upon D1R activation, and a reduction
279 G protein-coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (be
281 e therapeutic effect may arise from only one signalling cascade, whereas the other pathway may mediat
282 emical or physical perturbations via complex signaling cascades which can simultaneously affect multi
283 of tumors is dependent on a pro-inflammatory signaling cascade, which begins with the disruption of e
285 stimulation of the beta1-adrenoreceptor (AR) signaling cascade, which leads to activation of cAMP-dep
286 ress hormone abscisic acid (ABA) initiates a signaling cascade, which leads to increased H(2)O(2) and
287 axial length of the eye occurs via a complex signaling cascade, which originates in the retina and pr
288 mitotic progression by interfering Mps1-MAP4 signaling cascade, which results in an extended infectio
289 at can block the Hh pathway along its entire signaling cascade, which, in light of emerging drug resi
290 y amplifying the infection-induced host cell signaling cascade, which, in turn, induces the nuclear t
291 with IAVs leads to the induction of complex signaling cascades, which apparently serve two opposing
292 dence that Shp1 regulates the TCR and Slamf6 signaling cascades, which have been suggested to promote
294 -apoptotic activities of JNK1/2 and MAPK p38 signaling cascades while partially downregulated the pro
295 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essential functions in d
296 e same time as validating and dissecting the signalling cascade with more precision than is possible
297 therapies owing to an established network of signalling cascades with functional redundancy, which pr
298 from embryonic stem cells also hinders these signaling cascades, with detrimental effects on cell sur