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1 of the RAS-mitogen-activated protein kinase signaling pathway.
2 A (PKA), a known node in the beta-adrenergic signaling pathway.
3 monogenic disorders associated with the mTOR signaling pathway.
4 (CLR) Dectin-1- and Dectin-2-mediated CARD9 signaling pathway.
5 tion of the Target of Rapamycin (TOR) kinase signaling pathway.
6 ignaling and hyperstimulation of the insulin signaling pathway.
7 , a downstream effector in the canonical Wnt signaling pathway.
8 nic events associated with the hedgehog (hh) signaling pathway.
9 hat are essential components of the JAK-STAT signaling pathway.
10 ting the involvement of a non-canonical Tgfb signaling pathway.
11 molecular mechanisms that modulate the Notch signaling pathway.
12 splice forms in the Toll-like receptor (TLR) signaling pathway.
13 PSCs, at least in part, via ROS-mediated Src signaling pathway.
14 downstream effector of beta(2) -adrenoceptor signaling pathway.
15 activated by the canonical beta3-adrenergic signaling pathway.
16 f transcription factors of the innate immune signaling pathway.
17 ermediate beta-ADP-heptose by the ALPK1/TIFA signaling pathway.
18 ses, placing ethylene epistatic to the auxin signaling pathway.
19 ase Notum is a negative regulator of the Wnt signaling pathway.
20 CK6-correlated genes in the WNT/beta-catenin signaling pathway.
21 the IL-2/STAT5, TNF/NF-kappaB, and IFN-gamma signaling pathways.
22 akpoints and with the activation of specific signaling pathways.
23 nd as possible scaffolds for coordination of signaling pathways.
24 zyingly complex biochemical processes called signaling pathways.
25 and LIF interleukin-6 family cytokine (LIF) signaling pathways.
26 astic overgrowth fueled by mis-regulation of signaling pathways.
27 roliferation and apoptosis, and on pertinent signaling pathways.
28 ose associated with RAR and Wnt/beta-catenin signaling pathways.
29 t also explain the operation of other immune signaling pathways.
30 A variety of techniques exist for inferring signaling pathways.
31 were also identified based on the conserved signaling pathways.
32 aminergic, glutamatergic, and neuroendocrine signaling pathways.
33 /STAT1, (b) ASPP2, and (c) HDAC1/GADD45alpha signaling pathways.
34 re and is under discussion to be involved in signaling pathways.
35 plication and inhibit a variety of antiviral signaling pathways.
36 IL-6, TNF, HGF, VEGF, and EGF), ATM and p53 signaling pathways.
37 ng that PPR30 and mTERF9 are involved in ROS signaling pathways.
38 DUB that controls key cellular functions and signaling pathways.
39 chemokine production via triggering multiple signaling pathways.
40 ed by impairing regulatory T cell associated signaling pathways.
41 expression by distinct SMS- and MYC-mediated signaling pathways.
42 by negatively regulating multiple oncogenic signaling pathways.
43 dback control is a universal feature of cell signaling pathways.
44 y activation of both SAPK (p38/JNK) and GCN2 signaling pathways.
45 pects of causation with respect to the Notch signalling pathway.
46 rmity via a largely unexplored plant nuclear signalling pathway.
47 and differentiation, and in IGF and TGFbeta signalling pathways.
48 biological interactions reflecting receptor signalling pathways.
49 , adhesion and migration properties and cell signalling pathways.
51 ikely via the modulation of Wnt/beta-catenin signaling pathway, a key signaling pathway involved in m
52 tral to understanding the function of a cell signaling pathway, aberration of which often leads to fa
53 ine motifs and is present in a wide range of signaling pathways across different evolutionary taxa.
54 ting that TrkA is an important player in the signaling pathway activated by eotaxin-1 during eosinoph
55 , is dispensable for both ligand-independent signaling pathway activation and ligand-responsive signa
56 cytometric analysis of monocyte subsets and signaling pathway activation patterns in conventional mo
57 n dependent on Erk1/2, p38 MAPK and PI3K-Akt signaling pathway activation, thereby regulating cemento
58 for the exploration of tissue secretions and signalling pathway activation as well as the oxidative s
59 nd mutations leading to excessive pro-growth signaling pathway activations frequently occurs in cance
61 endogenous intracellular targets, modulating signaling pathway activity, and controlling binding to p
62 the reversible binding interactions used by signaling pathways affect the relationship between noise
65 tif (TAZ) are the key mediators of the Hippo signaling pathway and are essential for cardiac regenera
66 taII, functions in the B cell receptor (BCR) signaling pathway and contributes to B cell development.
67 are negative regulators of the Ras/Raf/MAPK signaling pathway and involved in regulation of organoge
69 osteogenesis of rat BMSCs through the STAT3 signaling pathway and restrains the osteoclastogenesis o
70 us research entailing the importance of this signaling pathway and the organismal processes that it i
71 ir host transcripts in the modulation of key signaling pathways and disease progression, adding new p
72 ever, a detailed description of the relevant signaling pathways and functional TFs (transcription fac
73 t PG specifically inhibits NF-kappaB and Akt signaling pathways and promotes accelerated cell death i
74 l to affect protein expression and molecular signaling pathways and should be consistently reported.
77 lases are a vital element within ADP-ribosyl signaling pathways and they hold the potential for novel
79 f pathogens by macrophages engages conserved signalling pathways and transcription factors to coordin
80 diated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the myogeni
81 th MAP3K4, an upstream regulator of the MAPK signaling pathway, and regulates its transcription in ci
82 aired AM crawling via the type II interferon signaling pathway, and this greatly increased secondary
83 nal microbiome (including specific microbes, signaling pathways, and microbiota-related metabolites)
84 morphology, neurotransmission, postsynaptic signaling pathways, and neural circuitry to propose a mu
85 l GSK-3 (glycogen synthase kinase 3) and Akt signaling pathways, and normalized dysregulation of both
86 pathways, transcriptional networks, hormone signaling pathways, and plant developmental processes.
87 y impaired, and activation of MAPKs and PI3K signaling pathways are delayed in P2-deficient mouse bon
89 ) levels are elevated, mTOR and IRF/IFN-beta signaling pathways are enhanced, leading to cellular sen
90 ern recognition receptors, internal cellular signaling pathways are induced to ultimately fend off th
95 analysis revealed pro-inflammatory cytokine signaling pathways as dysregulated, and this was further
96 Evolutionary conservation of the core Hh signaling pathway, as well as conservation of epithelial
97 critical for the induction of the JAK-STAT3 signaling pathway, as well as the A2 reactive astrocyte
98 heme were critical for most proinflammatory signaling pathways, as the antioxidant N-acetyl-l-cystei
99 , WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI(3)K,
101 anding of the dynamic interplay of molecular signaling pathways at critical phases of palate developm
102 ever, the mechanism by which the adiponectin signaling pathway attenuates colon cancer risk remains t
103 h is focused on finding a globally expressed signaling pathway, because it has been proposed that the
104 oblasts and early activation of pro-fibrotic signaling pathways before adverse ventricular remodeling
105 y activate G protein-coupled receptor (GPCR) signaling pathways beneficial in treating a disease, whi
106 tivation of the Galpha(q/11)-coupled calcium-signaling pathway, beta-arrestin recruitment, and mitoge
108 at activation of the non-canonical NF-kappaB signalling pathway by AZD5582 results in the induction o
110 mutations in APC, a key component in the Wnt signalling pathway, can bias neutral drift and can also
111 en mediated an increase in Hey2 in the NOTCH signaling pathway, causing downregulation of the transcr
112 n) that alter inflammatory cell function and signalling pathways characteristic of AKI, and tested th
113 endorepellin activates the canonical stress signaling pathway consisting of PERK, eIF2alpha, ATF4, a
114 ptor 4-regulated cytokines, immune cells and signalling pathways - contributes to the pathogenesis of
115 w cellular mechanics affects the instructive signaling pathways controlling cell fate is poorly under
116 he RAS family of small GTPases that regulate signaling pathways controlling cell proliferation, diffe
117 e macrophages from patients with IPF and the signaling pathways controlling CXCL13 gene expression in
118 changes coincided with greater activation of signalling pathways controlling muscle growth and greate
119 model that the amino acid and growth factor signaling pathways converge on the Rag GTPase to inhibit
121 yo and indicate that impairment of the Hippo signaling pathway could be a molecular cause for early h
123 current state of knowledge of the different signalling pathways coupled to the IL-4R complexes and e
124 ng to the promoters of genes in the TGF-beta signaling pathway decreased significantly with age and w
125 Here, we report that the activation of PKA signaling pathway decreases the unitary conductance of a
126 showing that noise plays a positive role in signaling pathways, demonstrating that noise is essentia
127 beta3-integrin, FAK and cofilin constitute a signaling pathway downstream of MMP activation that is i
128 content release, we sought to elucidate the signaling pathway downstream of PAR4 activation that lea
129 compromised the ability of Sts-1 to suppress signaling pathways downstream of both the TCR and the De
133 cific to each tissue source, to identify key signalling pathways driving fibrosis and to screen for a
134 e show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically
136 act-free domain, nuclear expression of Hippo signalling pathway effectors and restricted expression o
137 lysis revealed that TFEB regulates apoptotic signaling pathways, especially apoptosis inhibitor B-cel
139 to predict upstream regulators and affected signaling pathways following arsenite and antimonite tre
140 signaling have yet been identified, and the signaling pathways for cGAMP have been inferred to displ
142 uromodulatory activity, define mechanisms of signalling pathways from the gut microbiota to the brain
143 is model, indicating that the HilD-dependent signaling pathway functions within the complex milieu of
144 transcriptome confirms that core UV-B stress signaling pathway genes are conserved and upregulated in
145 hanges of core liver functions and canonical signaling pathways governing development at both mRNA an
149 r tyrosine kinase (MET) and Wnt/beta-catenin signaling pathways has been observed in advanced and met
151 d agonists, preferentially targeting various signaling pathways, have the potential to become drug ca
152 he cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients w
153 d that multiple genes of the IL-12/IFN-gamma signaling pathway (IL12B, IL12RB2, TYK2, IFNGR1, JAK1, a
154 le, an overview is provided of the different signaling pathways implicated in cardiomyocyte prolifera
157 by an increased activation of the NF-kappaB signaling pathway in bone marrow and BM-MSC of DeltaNC16
158 results uncover a role for the beta-catenin signaling pathway in fine tuning the granulocytic produc
159 so investigated the role of Wnt/beta-catenin signaling pathway in IL-1beta induced inflammation in ch
161 me and establishes the importance of the WNT signaling pathway in the mTORC1-driven lung phenotype.
162 ysis approach can separate each of the three signaling pathways in a straightforward single-step anal
163 tations in G protein-coupled receptor (GPCR) signaling pathways in cancer are more prominent than was
167 and mitogen-activated protein kinase (MAPK) signaling pathways in intestinal and hepatic cells, resp
168 different LEPR types and activating distinct signaling pathways in intestinal and hepatic cells.
172 rize evidence that overactivation of SMAD2/3 signaling pathways in MDSs causes anemia due to impaired
173 ncer of activated B cells (NF-kappaB) as key signaling pathways in NFKBIZ/IkappaBzeta regulation.
174 mechanisms integrating light and temperature signaling pathways in plants remain poorly understood.
177 measure changes in the activity of two cell signaling pathways in the same living cells in tissues.
179 osomes act as platforms for a new phagocytic signalling pathway in which FcgammaR activation recruits
180 n understanding the insulin receptor and its signalling pathways in cancer, and a number of lessons h
181 nerate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body
182 y circuit connecting RPW8.1 and the ethylene-signaling pathway, in which RPW8.1 enhances ethylene sig
183 ned activity of phosphorylated components of signaling pathways including p-Mef2c, which causes Hspb7
184 This signature represents an intersection of signaling pathways including Smads, TGF-beta, and vitami
185 that RET drives a multifaceted intracellular signaling pathway, including key signaling intermediates
186 l inflammatory responses and immune response signaling pathways, including NF-kB signaling, IL-6 sign
187 n epigenetic therapy with a noncanonical WNT signaling pathway inhibitor has the potential to eradica
188 on elongation and suggest that translational signaling pathways intricately interact to regulate neur
189 of Wnt/beta-catenin signaling pathway, a key signaling pathway involved in multiple cancer types.
190 re known to participate in cell cycle and in signaling pathways involved in neurodegeneration and can
191 te immune cells and show that the underlying signaling pathway involves Nedd4-2-mediated Wnt3a ubiqui
192 ass IIa HDAC nuclear translocation through a signaling pathway involving direct HDAC5 tyrosine 642 ph
197 an hepatocyte growth factor receptor (c-MET) signaling pathway is dysregulated in several malignancie
199 astid-to-nucleus communication by retrograde signaling pathways is essential for fine-tuning of respo
200 y human diseases, and modulating activity of signaling pathways is often the preferred therapeutic st
201 ght how the precise coordination of multiple signaling pathways is required for the successful format
202 of bioactive chemicals in terms of targeted signaling pathways is the essential first step in evalua
203 gs show that TEAD4, an effector of the Hippo signaling pathway, is essential for the establishment of
204 BRAF kinase, a critical effector of the ERK signaling pathway, is hyperactivated in many cancers.
205 se for disorders affecting the RAS-MAPK cell-signaling pathway (known as RASopathies) (30% of the gen
206 etylation changes are linked to AML-relevant signaling pathways like EGF/EGFR and Wnt/Hedgehog/Notch.
207 inhibitors of kinases in the B-cell receptor signaling pathway, like Bruton tyrosine kinase and phosp
208 is highly integrated with defense and stress signaling pathways, meaning that plants will be able to
209 ation from stem cells utilized classical RGC signaling pathways mimicking retinal development in vivo
211 conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal
212 abilities of opioids to activate downstream signaling pathways normally depend on the binding betwee
213 findings indicate that vitreous activate the signaling pathway of phosphoinositide 3-kinase (PI3K)/Ak
214 ons between proteins in complex networks and signaling pathways of the cell (e.g. the Hippo pathway).
217 a gene network, including components of the signalling pathways of auxin, brassinosteroids (BRs) and
218 ation trajectories identify highly conserved signaling pathways, pharmacological targeting of which s
220 sm involving PDGFRB and associated oncogenic signalling pathways (PI3K-AKT/ERK), which may also invol
221 Activation of the WNT/beta-catenin (CTNNB1) signaling pathway plays a critical role in colorectal ca
222 The mechanistic target of rapamycin (mTOR)-signaling pathway plays a key role in nutrient sensing a
223 istic target of rapamycin complex 1 (mTORC1) signaling pathway, potentially leading to a range of pos
224 nbiased discovery approach to identify novel signaling pathways programming sepsis-induced deviant lu
225 indings define a mechanism by which the same signaling pathway promotes both autonomous muscle growth
226 ls through G-protein coupled receptors, this signalling pathway provides an interesting therapeutic t
227 ed cell death process is mediated by several signalling pathways (referred to as intrinsic and extrin
231 etic inhibition of the endothelial RAS-MAPK1 signaling pathway rescued hepatic vascular cavernoma for
233 ells do not depend on type I IFN or on IL-22 signaling, pathways responsible for protection against a
234 c mutations in factors governing the hypoxia signaling pathway, resulting in metabolic dysregulation,
235 sequent repression of PKA dysregulates these signaling pathways, resulting in increased intracellular
236 encoding proteins at known steps of the PIX signaling pathway show defects at muscle cell boundaries
237 daria are known to contain complex apoptotic signaling pathways, similar to those in vertebrates, the
238 , we find the stress-responsive p38 MAPK-MK2 signaling pathway stabilizes ARE mRNAs by phosphorylatio
239 of hepatic mRNA associated with inflammatory signaling pathways, steatosis, and increased collagen de
240 ies and biologics acting on various stemness signaling pathways, surface markers, efflux transporters
241 otein response (UPR) is a conserved adaptive signaling pathway that governs protein folding, secretio
244 on were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms a
245 eir response is tightly regulated by complex signaling pathways that all start with stimulus percepti
246 nd by influencing the activities of multiple signaling pathways that are known to regulate HF stem ce
247 dies of model organisms defined intersecting signaling pathways that converge to promote HSC emergenc
248 gence for calcium-related and lipid-mediated signaling pathways that coordinate conoid protrusion, mi
249 selection in genes related to metabolic and signaling pathways that could be evidence of environment
251 6, 9, and 10 are critical modulators of cell signaling pathways that promote SNc DA neuron survival a
252 ified by editing) as an approach to identify signaling pathways that regulate dendritic branching dow
255 ge polarization and the interactions between signaling pathways that regulate the pathogenesis of UC
256 phenoloxidase activation, or at the upstream signaling pathways that regulate these immune effectors.
257 lta-catenin, subject to a glutamate-mediated signaling pathway, that assists in balancing the branchi
258 example Dopamine-PKA-CREB and GABA-PKC-CREB signaling pathways, the biotypes were oppositely dysregu
259 ndividually in the context of their distinct signaling pathways, the mechanism that determines which
260 previously known to interact with serotonin signaling pathways: the disulfide-bridged 2,5-diketopipe
261 wing to concomitant activation of cell death signalling pathways; these cells are poised to apoptose
262 ing AAI and suggests that targeting the TrkA signaling pathway to inhibit eosinophil recruitment may
263 thus acts as an upstream kinase of the CREB signaling pathway to regulate the transcription function
264 duces stromal activation of the canonical Hh signaling pathway to suppress tumor growth and metastase
265 r environment and act on hormone systems and signaling pathways to alter physiological homeostasis.
266 oth the amino-acid-sensing and growth factor signaling pathways to control TORC1 activity through the
267 r sac of the lung is dependent upon multiple signaling pathways to coordinate cell growth, migration,
268 ion between the IFN-alpha/beta and IFN-gamma signaling pathways to optimize antiviral IFN-gamma activ
269 d, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce representative cytokines (
270 phoma subtypes, malignant B cells hijack AgR signaling pathways to promote their own growth and survi
271 r demonstrate the potential of targeting 20E signaling pathways to reduce malaria parasite infection
273 ammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability.
275 binds to a protein in the type I interferon signaling pathway Tyk2 and inhibits the expression of ge
276 brosis, and about the precise mechanisms and signalling pathways underlying the autophagy response in
277 DANs and maintain normal function of the DA signaling pathway via regulating microglia-mediated neur
279 des finding key components of the interferon signaling pathway, we discovered a new restriction facto
280 dition to known components of the interferon signaling pathway, we found that replication termination
282 onents of the Fibroblast Growth Factor (FGF) signaling pathway were enriched in nascent myotubes in D
287 l failure through activation of the BMP/SMAD signaling pathway when administered under mild metabolic
288 rix to tendon cells, thereby triggering cell signaling pathways which lead to adaptive regulation of
289 , and transforming growth factor beta (TGFB) signaling pathway, which is often altered in colorectal
290 distinctive eotaxin-mediated TrkA-dependent signaling pathway, which, in addition to other TrkA-acti
291 e responses are under the control of complex signaling pathways, which are still poorly understood.
292 ent models suggest that activating G protein signaling pathways while avoiding phosphorylation of the
293 Q displays profound signaling bias for Gq/11 signaling pathways while escaping beta-arrestin-mediated
294 n about the evolutionary roots of this major signaling pathway, will shed light on the origins of reg
295 riventricular endothelial cells house a GABA signaling pathway with direct implications for psychiatr
296 types of data corresponding to the EPA's AR signaling pathway with proprietary software, Assay Centr
297 Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development,
298 acts as an activation signal by triggering a signaling pathway within responding macrophages by direc
300 se specificity is crucial to the fidelity of signaling pathways, yet many pathways use the same kinas