ライフサイエンスコーパス: signaling event

1 onformation that accompany the targeted cell signaling event.

2 elucidate the role of that substrate in the signaling event.

3 ive allosteric modulatory impact on the same signaling event.

4 Neo1 proteolytic cleavage as a key upstream signaling event.

5 filament network turnover induced by GTPase signaling events.

6 ing the extent, and duration of PKA-mediated signaling events.

7 ted in tumorigenesis, immunity, and cellular signaling events.

8 a-chain phosphorylation, and more downstream signaling events.

9 plex through the regulation of metabolic and signaling events.

10 nce readout includes information on multiple signaling events.

11 les of histidine phosphorylation in cellular signaling events.

12 ways that is useful in understanding NETosis signaling events.

13 , a protein complex that mediates downstream signaling events.

14 etermined how Iloprost reverses ADP-mediated signaling events.

15 re the best characterized receptor-regulated signaling events.

16 kinase networks and their influence in cell signaling events.

17 downstream of many migratory and chemotaxis signaling events.

18 istidine kinases that convert red light into signaling events.

19 onent may reflect a general feature of rapid signaling events.

20 en extracellular ATP and JA in intracellular signaling events.

21 hile also providing a conduit for allosteric signaling events.

22 polymerization and activation of downstream signaling events.

23 ed as qualitative markers of tissue ethylene signaling events.

24 coupling between metabolic demand and Ca(2+) signaling events.

25 llination and fertilization and involve many signaling events.

26 e protein 24 (TMEM24) helps coordinate these signaling events.

27 ouple extracellular stimuli to intracellular signaling events.

28 onal consequences of the up- and down-stream signaling events.

29 ids that control diverse cellular downstream signaling events.

30 gulate both gene expression and extranuclear signaling events.

31 s or enable them to regulate other important signaling events.

32 s approach to better characterise downstream signaling events.

33 ers spatio-temporal control over down-stream signaling events.

34 by enhancing oxidative stress and associated signaling events.

35 lized enzymes or to convey specific cellular signaling events.

36 llular antioxidants that also regulate redox signaling events.

37 le entry relies on an orderly progression of signaling events.

38 significance for understanding the cellular-signaling events.

39 e with opsonized S. aureus require different signaling events.

40 tor fAR1 is required for folic acid-mediated signaling events.

41 ghly local or cell-wide physiological Ca(2+) signaling events.

42 t Lys15 (H2AK15ub) and triggering downstream signaling events.

43 atment in UUO kidneys, as are TGF-beta1/Smad signaling events.

44 therefore disrupt sleep via changes in acute signaling events.

45 y and faithfully recapitulate STIM1-mediated signaling events.

46 ing is a feature of many critical biological signaling events.

47 This decreases some, but not all, HP signaling events.

48 beta-arrestins to mediate distinct cellular signaling events.

49 by target RNA features and second messenger signaling events.

50 binding the HH ligand, triggering downstream signaling events.

51 and local elementary InsP(3)-mediated Ca(2+) signaling events.

52 structures that can serve as initiators for signaling events.

53 ion proteins involved in regulating numerous signaling events.

54 (protein kinase A)- and proteasome-dependent signaling events.

55 ing outputs while filtering weak or spurious signaling events.

56 ch as protein-protein interactions and other signaling events.

57 The signaling events activate the transcription factors AP-1

58 Our findings help elucidate the paracrine signaling events activated by a compromised mucosal barr

59 ent, the dynamics and relative importance of signaling events activated immediately downstream of GPC

60 toxin listeriolysin O (LLO) to identify key signaling events activated upon plasma membrane perforat

61 a will clarify molecular mechanisms and CD22 signaling events after BCR activation and revealed sever

62 l cell calcium entry and the calcium-related signaling events also help facilitate several leukocyte-

63 he same receptor can produce highly distinct signaling events and arrestins are a major mediator of t

64 s employed to suppress apoptosis, elicit WNT signaling events and drive naive-type piPSC along the me

65 irst time that HE4 has the ability to affect signaling events and gene expression in multiple cell ty

66 s on how these processes respond to cellular signaling events and how they affect metabolism.

67 utation of Y192 blocks critical TCR-proximal signaling events and impairs thymocyte development in re

68 eading to calcium influx and downstream cell signaling events and neurotoxicity.

69 Skap2 regulates integrin-mediated outside-in signaling events and neutrophil functions.

70 cly available databases to identify upstream signaling events and novel therapeutic targets.

71 POFUT1 inactivation disrupts signaling events and results in excessive angiogenic cel

72 riptional events in chromatin in response to signaling events and suggest a model for regulation of h

73 apses, regulating both pre- and postsynaptic signaling events and synaptic plasticity.

74 findings, with special emphasis on critical signaling events and their potential as therapeutic targ

75 C5aR2 is capable of mediating its own set of signaling events and through these events exerting signi

76 rom the environment to coordinate downstream signaling events and various cellular processes.

77 endent on its known intracellular activation signaling events and was even observed in reconstituted

78 deltaPKC regulates many signaling events and we hypothesized that a docking inhi

79 een used to study a wide range of outside-in signaling events, and it is now well appreciated that ma

80 ellular cAMP levels, restrains cAMP-mediated signaling events, and profoundly inhibits cyst formation

81 ifferent types of cell death, the underlying signaling events, and their unequal ability to trigger a

82 Many cell signaling events are coordinated by intrinsically disord

83 nsion and cytoskeletal mechanics to show how signaling events are coupled to retraction velocity, mem

84 Both RAR and RXR signaling events are implicated in hippocampal synaptic

85 riety of other messengers, and whether these signaling events are interconnected has long remained un

86 Keratocyte TPMDs and their associated signaling events are likely common occurrences following

87 subsets, yet the molecular players in these signaling events are not fully understood.

88 ypothesize that alpha2M*/CS-GRP78-evoked key signaling events are required for transcriptional activa

89 appreciated, it is unclear which downstream signaling events are responsible.

90 se modes is not well understood but waves of signaling events are thought to play an important role i

91 and binding reactions, an important class of signaling event, are needed to determine mechanisms.

92 The underlying signaling events associated with endothelial proinflamma

93 clusters and normalizes ATF4, NRF2, and IRP2 signaling events associated with FRDA.

94 annotation analyses to investigate molecular signaling events associated with toxin-mediated arterial

95 mechanisms of cannabinoid receptor-mediated signaling events at critical stages of fetal brain devel

96 We conclude that cytoskeletal and signaling events at endfeet may be controlled through tr

97 COR-induced signaling events at stomata remain unclear.

98 tween proteins and a plethora of biochemical signaling events based on the development of specific bi

99 y pathogens continuously, and the subsequent signaling events between host and microbe are complex, u

100 arefully orchestrated dialog of adhesion and signaling events between leukocyte and endothelial cell.

101 ry effects result from an array of molecular signaling events between macrophages, dying cells, and o

102 s and a Posterior Medial cortical network in signaling event boundaries.

103 mporal distribution of many molecules during signaling events, but as of yet no methods have been des

104 tors (ORs) convert extracellular messages to signaling events by coupling to the heterotrimeric G pro

105 trigger melanoma cell invasiveness, but the signaling events by which Tspan8 regulates the invasion

106 e to direct inhibition of Dsg, intracellular signaling events causing desmosome destabilization, or b

107 oteins and RNA has been shown to function in signaling events, chromatin organization and transcripti

108 and activator of transcription 3 (STAT3), a signaling event conducive to the intracellular growth of

109 To understand Spry1 regulation of signaling events controlling breast cancer phenotype, we

110 Here, we have studied the early signaling events controlling IBI1-dependent BABA-induced

111 The p53-activated downstream signaling events correlated with suppression of abnormal

112 ggest that modulating VEGFR-1 expression and signaling events could potentially prevent senescence an

113 Signaling events coupling PKA activation and aquaporin-2

114 evious studies have revealed many of the key signaling events critical for recruitment of immune cell

115 ins and inhibits early B-cell receptor (BCR) signaling events critical for survival.

116 The results reveal that CK2 regulates signaling events critical to LID in each of the two main

117 ght on the mechanisms of intracellular Cl(-) signaling events crucial for regulating tissue architect

118 Here we demonstrate that these downstream signaling events depend upon the direct activation of a

119 ference, likely in combination with upstream signaling events, determines NRF member activation under

120 Signaling events downstream of GPVI are influenced by hy

121 ng components downstream of Gq We quantified signaling events downstream of GqPCR activation with FRE

122 appaB activation and associated with altered signaling events downstream of the erythropoietin recept

123 Lck SH2-binding monobody inhibited proximal signaling events downstream of the T-cell receptor compl

124 te broad innate immune and inflammasome-like signaling events, driven in part by stimulator of interf

125 Signaling events driving integrin activation have previo

126 ndrome, but the key pathologic cell type and signaling events driving this distinct phenotype remain

127 that allows for observation of intracellular signaling events during collagen matrix assembly, we inv

128 r the formation of functional cilia, and for signaling events during development.

129 coupling membrane dynamics to the cytosolic signaling events during macropinocytosis of KSHV.

130 results constitute a direct visualization of signaling events during mammalian pre-implantation devel

131 on of BRUCE inhibited multiple ATR-dependent signaling events during replication stress, including ac

132 quote above), 4) perturbation of downstream signaling events ( e.g., PTEN loss or PIK3CA mutation),

133 pressing classic thrombin-induced inside-out signaling events (eg, Akt activation, intracellular calc

134 onse was distinguished from the signature of signaling events elicited by proinflammatory LRP1 ligand

135 elial basement membrane and that they induce signaling events essential for corneal wound healing.

136 s approach identifies new Mec1/ATR-dependent signaling events, expanding our understanding of the DNA

137 This transmembrane signaling event facilitates an interaction between BtuB

138 Mechanistically, silencing MOSPD2 inhibited signaling events following chemokine receptor ligation.

139 of abnormalities, including increased early signaling events following engagement of the TCR.

140 odocytes as a significant contributor to the signaling events following LPS challenge and suggest tha

141 he beta-HPV E6 protein to disrupt DNA repair signaling events following UV exposure.

142 The NLRP3 inflammasome activation is a key signaling event for activation and secretion of pro-infl

143 All viruses must antagonize antiviral signaling events for survival.

144 emonstrated the importance of TLRs and IL-1R signaling events for the establishment of an effective i

145 Ongoing receptor-proximal signaling events from activating NK cell receptors and a

146 neutrophils can orchestrate epithelial cell-signaling events functioning in intestinal repair.

147 molecular mechanisms underlying the cellular signaling events governing water-stress responses, it is

148 mbrane microdomains, while integrin-mediated signaling events have inhibitory effects on the activati

149 distinguishes a SUMO ligase that may mediate signaling events important in PML-NB-mediated intrinsic

150 3 Thr(991)/Thr(1048) phosphorylation - a key signaling event in cell swelling-induced regulatory volu

151 ium signaling in chondrocytes, a fundamental signaling event in chondrocyte metabolic activities.

152 compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-direct

153 levation of cytosolic Ca(2+) is an important signaling event in this process, yet the fundamental mec

154 This signaling event in turn enhances the efficacy of juvenil

155 analyzing and ultimately understanding lipid signaling events in a comprehensive manner.

156 e first genetic dissection of the downstream signaling events in a multicellular eukaryote.

157 control of membrane excitability and Ca(2+) signaling events in beta-cells.

158 species polypharmacology with PZQ modulating signaling events in both host and parasite.

159 olds the potential to discover new facets of signaling events in cellular biology.

160 negative regulation of FcepsilonRI-mediated signaling events in mast cells.

161 ns (TPMDs) in single keratocytes can trigger signaling events in neighboring keratocytes.

162 of GITR inhibited IL-15-mediated activating signaling events in NK cells, which include cell activat

163 ultifunctional kinase that regulates various signaling events in plant defense, growth, light respons

164 Signaling events in spines involve a signaling network c

165 s not known whether selectins induce similar signaling events in T cells.

166 gether, our study shows that the dynamics of signaling events in the BMP, WNT, and NODAL cascade in t

167 ulates protein degradation, trafficking, and signaling events in the cell.

168 Confirming the importance of these signaling events in the context of acute MI, Emc10 stimu

169 degranulation, cytokine secretion, and early signaling events in the FcepsilonRI pathway, including p

170 ls and highlights the importance of studying signaling events in the field for understanding how plan

171 arization into precisely timed intracellular signaling events in the mammalian brain.

172 tory cues), or it may be influenced by local signaling events in the PVN.

173 and cell type-dependent profile of molecular signaling events in the striatum.

174 Hence, signaling events in the UPR, such as activation of the J

175 escence, suggesting a direct role of VEGFR-1 signaling events in this paradigm.

176 ext of recent studies implicating purinergic signaling events in this process.

177 d Ca(2+) channels (VGCCs) regulated critical signaling events in various cell types that are not expe

178 Diverse cellular signaling events, including B cell receptor (BCR) activa

179 rray of stimuli remains elusive, but several signaling events, including cytosolic efflux and influx

180 lants, are involved in several YDA-dependent signaling events, including embryogenesis.

181 which stimulate integrin activation through signaling events, including intracellular Ca(2+) mobiliz

182 Proximal IGF-1R signaling events, including IRS tyrosine phosphorylation

183 the intracellular tail of nephrin initiates signaling events, including recruitment of cytoplasmic a

184 of TNFR1 had no effect on early TNF-induced signaling events, including the rapid activation of NF-k

185 , we found that LMP2A mimics a subset of BCR signaling events, including tyrosine phosphorylation of

186 jor mechanism through which common oncogenic signaling events induce de novo lipid synthesis to promo

187 by our finding that adverse proinflammatory signaling events induced by AT1 receptor activation were

188 The precise downstream signaling events initiated by alphavbeta3 may depend on

189 Resolving how the early signaling events initiated by cell-cell interactions are

190 timal CD8 T cell immunity is orchestrated by signaling events initiated by TCR recognition of peptide

191 Yet the signaling events involved in chronic pancreatitis and pa

192 th factors and small molecules mimicking the signaling events involved in liver regeneration.

193 s barrier disruption, leads to a coordinated signaling events involving cytokines between keratinocyt

194 How cells integrate antagonistic receptor signaling events is enigmatic.

195 t of haloperidol antagonism on D2R metabolic signaling events is largely mediated by acute blockade o

196 During autophagy, signaling events lead to the formation of a cup-shaped s

197 Cellular signaling events leading to immunosuppression in sepsis

198 thrombus formation or by initiating various signaling events leading to metastatic cancer progressio

199 rther show that ARF activation regulates key signaling events leading to migration, we also examined

200 By mimicking key signaling events leading to muscle formation in the embr

201 the key driver of bone lesions in CRMO, the signaling events leading to pathogenic levels of the cyt

202 The impact of TRAF3 on this very early signaling event led to the hypothesis that TRAF3 restrai

203 However, the signaling events linking JAKs to rho small GTPase activa

204 dout makes it difficult to capture transient signaling events (<1 min); 3) The experimental environme

205 ual-receptor tyrosine kinase (RTK)-dependent signaling event, m-SCF/c-Kit and VEGF-A/vascular endothe

206 However, the majority of LMP2A-induced signaling events markedly differed from those induced by

207 sine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP.

208 It is the integration of these signaling events, mediated by an interplay between ROS a

209 c reticulum (ER)-stressed myeloid cells, via signaling events modulated by the protein kinase RNA-lik

210 rs at the surface that trigger intracellular signaling events modulating the cytoskeleton.

211 ding edge, both of which processes are early signaling events necessary for proper epithelial wound h

212 The identity of the signaling events needed for the activation of integrins

213 ating that caveolae formation and downstream signaling events occur through independent mechanisms.

214 with the plasma membrane where KRAS-mediated signaling events occur.

215 In contrast to the signaling events occurring at the plasma membrane, as a

216 otein binding, and allows activation of cell signaling events of HS-deficient cells.

217 hway is a central axis in mediating proximal signaling events of TCR and CD28 engagement in T cells.

218 Focusing on downstream signaling events of the functionally active 84-104 myeli

219 As a consequence, aberrant signaling events often underlie human disease.

220 This approach identified a key signaling event, phosphorylation of a desmosome componen

221 ular nucleotides to adenosine, and adenosine signaling events play additional functional roles in leu

222 nstrate that a complex network of purinergic signaling events plays a key role in these trafficking e

223 ated by its ligand angiotensin II, generates signaling events promoting vascular dysfunction and the

224 These independent signaling events propagated by the different catabolites

225 content in response to stimuli and cellular signaling events, raise questions about how cardiolipin

226 Lipid-mediated signaling events regulate many cellular processes.

227 lular carcinogenesis (HCC), but the upstream signaling events remain poorly defined.

228 ochemical properties of enhancer assembly in signaling events remain poorly understood.

229 in cell division, but many of the underlying signaling events remain unknown.

230 id secretion depended on canonical molecular signaling events responsible for ETEC-induced diarrhea,

231 Second, the spatiotemporal orders of key signaling events reveal a robust pattern of lateral inhi

232 nd MET demonstrates that interruption of key signaling events reveals regulatory 'checkpoints' in the

233 of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA

234 ouped into "physiologically relevant" Ca(2+) signaling events spanning multiple pixels (sparks, waves

235 Despite the importance of MPK proteins in signaling events, specific roles for many Arabidopsis MP

236 However, some early signaling events still occur, such as recruitment of the

237 insurmountably (suppressed agonist Emax) in signaling events such as guanosine 5'-3-O-(thio)triphosp

238 molecular patterns to activate innate immune signaling events, such as bursts of reactive oxygen spec

239 m salt and MRS2365 (5'-diphosphates) in some signaling events, such as extracellular signal-regulated

240 defects not only in known PKCtheta-dependent signaling events, such as nuclear factor kappaB (NF-kapp

241 Early TCR signaling events, such as phosphorylation of zeta-chain-

242 e raft structure and feed-forward downstream signaling events, such as rho and PI3K activation.

243 ependent Lck localization controls early TCR signaling events, such as tyrosine phosphorylation of TC

244 le strand breaks (DSBs) can initiate several signaling events, such as ubiquitination, however the pr

245 7 is a more specific reporter of Ag-specific signaling events than the commonly used CD69 activation

246 These findings identify rapid signaling events that 5 GFs elicit directly in the most

247 earch has focused on the gene expression and signaling events that are modulated by SINE ncRNAs, part

248 existence of a previously unknown branch of signaling events that can regulate the TSC2/mTOR pathway

249 aimed to identify and characterize critical signaling events that control functional and metabolic t

250 However, the signaling events that control NKT sublineage specificati

251 What are the molecular and cellular signaling events that control the aging process and how

252 ing Ca(2+) influx and the ensuing downstream signaling events that drive channel trafficking to the c

253 function of ISG15 and the initial outside-in signaling events that drive ISG15-dependent cytokine sec

254 ages, have disrupted capacity to orchestrate signaling events that function in mucosal repair.

255 uch lectins results in altered intracellular signaling events that inhibit TEpM and differentially af

256 r histocompatibility complex (pMHC) triggers signaling events that initiate T cell responses.

257 However, the upstream signaling events that instigate CCF formation remain unk

258 by a multiplicity of molecular and cellular signaling events that interface with environmental facto

259 ygen species and callose depends on specific signaling events that lead to plasmodesmata closure.

260 e involvement of hormone and ROS in systemic signaling events that lead to systemic acquired acclimat

261 pts to highlight the importance of different signaling events that mediate a beneficial plant microbe

262 based approaches, our work characterizes the signaling events that mediate these two disparate change

263 gy reserves, and possibly triggered indirect signaling events that modified mortality through develop

264 a consequence of both genetic mutations and signaling events that modulate phosphorylation.

265 Animal development is characterized by signaling events that occur at precise locations and tim

266 This study aimed to determine the molecular signaling events that originate from the ICAM-1-mediated

267 s the endothelial cell barrier by triggering signaling events that post-translationally modify pre-ex

268 ular respiration and suppresses pathological signaling events that promote inflammation in asthma.

269 anization of nucleolar architecture, but the signaling events that regulate these responses are large

270 Signaling events that result in the inhibition of glycog

271 d initiate a series of complex intracellular signaling events that result in various immune responses

272 st a negative feedback loop that responds to signaling events that tune active Lck amounts and TCR se

273 ll, this analysis provides new insights into signaling events that underlie metastasis in ovarian can

274 o and in biomaterial scaffolds, but the cell-signaling events that underlie this process are not well

275 CD45 suppressed signaling events that were antigen independent or induce

276 nct tissue-, temporal-, and pathway-specific signaling events, the progression of reproductive aging

277 omics analyses, we identified the downstream signaling events these drugs affect.

278 lfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein in

279 ADP) and subsequent autocrine and paracrine signaling events through nucleotide receptors.

280 ted to serve as a major site for active TRIF signaling events, thus linking phagosomal maturation to

281 results indicate the importance of coupling signaling events to cell mechanics and morphology and ma

282 complex series of endoderm-mesoderm-mediated signaling events to generate the final arborized network

283 o directly visualize thymocyte migration and signaling events, together with a living thymic slice pr

284 ry milieu; however, the relationship between signaling events triggered by excess nutrient levels and

285 This report defines the signaling events underlying Ag-induced chemokine recepto

286 However, signaling events underlying placental adaptations remain

287 We investigated cell-specific signaling events underlying the immunosuppressed phenoty

288 ticipates in intracellular and extracellular signaling events unrelated to metabolism.

289 To portray the serial signaling events, we studied a T-cell-mediated model of

290 These cell-signaling events were dependent on the N-methyl-d-aspart

291 ellates is mediated by complex inter-partner signaling events, where the host cnidarian innate immune

292 ngage concomitant stimulatory and inhibitory signaling events, which act together to promote specific

293 s in suboptimal activation of the downstream signaling events, which correlates with the preferential

294 controlling receptor-mediated intracellular signaling events, which have a central role in Alzheimer

295 o activating their own G protein-independent signaling events, which have been shown to mediate locom

296 antibody responses by linking proximal TACI signaling events with distal immunometabolic transcripti

297 tension, triggering long-lasting downstream signaling events with effects on the sperm's mitochondri

298 sensors, allows precise measurement of these signaling events with high spatial and temporal resoluti

299 rial calcium uniporter coordinates cytosolic signaling events with mitochondrial bioenergetics.

300 s regulate a myriad of essential subcellular signaling events, yet they remain difficult to study in