ライフサイエンスコーパス: signaling through

1 Importantly, serotonin signaling through 5-HT4 mimicked the effects of L3740, a

2 cytokines that participates in inflammatory signaling through a canonical receptor pathway.

3 In the absence of Lyn, signaling through a CD11b-Syk-PKCdelta-CARD9 pathway was

4 MSTN and activin A are capable of signaling through a complex of type II and type I recept

5 ll death are all buffered by blocking stress signaling through a genuine tissue-autonomous immune res

6 ing TLR4 signaling and inflammatory cytokine signaling through a negative feedback regulation loop in

7 lays in driving tension-mediated cancer cell signaling through a self-enforcing feedback loop that ex

8 Despite signaling through a shared receptor, there are establish

9 ance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the

10 The equilibrium of signaling through activating and inhibitory receptors di

11 In fact, activin-A signaling through activin-like kinase-4 receptor repress

12 and demineralized pits, suggesting that BMP signaling through ACVR1 regulates osteoclast fusion and

13 process also replicated by upregulating TIE2 signaling through adenovirus-mediated angiopoietin-1 (An

14 ficial metabolic effects are due to enhanced signaling through adipocyte beta3-adrenergic receptors (

15 racrine regulation of MYC protein stability, signaling through AKT and GSK-3beta to increase MYC half

16 electin and enable promotion of pro-survival signaling through AKT/NF-kappaB pathways.

17 MAdCAM signaling through alpha(4)beta(7) costimulates CD4(+) T

18 apacity of the V2 domain of gp120 to mediate signaling through alpha(4)beta(7) likely impacts early e

19 Postsynaptic signaling through alpha1A ARs in PDGFRalpha(+) cells is

20 egulation of FGF3 or HBEGF or increased MAPK signaling through an activating V600E mutation in BRAF.

21 which E4orf4 targets and inhibits DNA damage signaling through an association with PARP-1 for the ben

22 metastatic tumors, when adrenergic stress or signaling through beta-adrenergic receptor is reduced.

23 Stress hormone signaling through beta-adrenergic receptors regulates ma

24 proteins 2/3, indicating that stress hormone signaling through beta-AR shifts actin organization to f

25 Norrin signaling through beta-catenin was required for BRB rest

26 Interestingly, rather than canonical signaling through beta-catenin, signaling via the non-ca

27 n in its latent cavity, allowing promiscuous signaling through both Galpha(s) and Galpha(q) in a dose

28 r engagement, bypassed fusion, and initiated signaling through both TLR7 and TLR9, which was not util

29 Low R:FR light enhances brassinosteroid (BR) signaling through BRASSINOSTEROID SIGNALING KINASE 5 (BS

30 ge in V (mem) increases intracellular Ca(2+) signaling through Ca(2+) influx, via Ca(V)1.2, 1 of L-ty

31 creatic cells is regulated by Ca(2+) and ROS signaling through Ca(2+)-induced structural changes prom

32 Calcium signaling through calcineurin and its major transcriptio

33 activated protein kinase 2) and cofilin, and signaling through CaMKII.

34 erotrimeric G proteins, activates downstream signaling through cAMP and plays important roles in skel

35 ractions can reinforce each other to enhance signaling through canonical downstream second messengers

36 ese studies demonstrate that CCL27 and CCL28 signaling through CCR10 may cooperate with inflammatory

37 Chemokine signaling through CCR3 is a key regulatory pathway for e

38 s responded robustly to adaptive Ab-mediated signaling through CD16.

39 Signaling through CD27 plays a role in T cell activation

40 Instead, signaling through CD27 resulted in the progressive survi

41 ollagen fibrillogenesis and remodeling or by signaling through cell-surface integrin receptors to pro

42 mechanism by which GNE activity might affect signaling through cell-surface receptors.

43 Signaling through cGMP has therapeutic potential in the

44 dy each cell type and found that cue-induced signaling through cofilin phosphorylation occurred only

45 d the ability of ACA-01 to inhibit chemokine signaling through cognate receptors.

46 s CRYs link the circadian clock and JAK-STAT signaling through control of STAT5B phosphorylation, whi

47 otent negative regulator of Wnt/beta-catenin signaling through CRISPR screens.

48 ression requires the activation of NF-kappaB signaling through CTAR1 and CTAR2.

49 This identifies autocrine purinergic signaling, through Cx43 hemichannels, as a critical path

50 ration and extent of potentially deleterious signaling through CysLT(2)R, and it may contribute to th

51 Though biased signaling through D2Rs has been demonstrated, acquiring

52 Disruption of SLAM family receptor signaling through deletion of SAP resulted in impaired t

53 6, that are thought to extinguish checkpoint signaling through dephosphorylation of a checkpoint scaf

54 roach has been lacking for the modulation of signaling through dimeric receptors, such as those for c

55 eny by promoting EGFR membrane targeting and signaling through direct association with EGFR.

56 promotes fibrogenesis by enhancing TGFbeta1 signaling through direct binding with and stabilization

57 show that PRMT5 stimulates WNT/beta-CATENIN signaling through direct epigenetic silencing of pathway

58 ranscription factor constrains canonical Wnt signaling through direct inhibition of beta-catenin/LEF

59 moroids (P < 0.02) by disrupting AKT and ERK signaling through direct interference of small GTPases p

60 e, we show that oncogenic ERG repressed PI3K signaling through direct transcriptional suppression of

61 receptors (GPCRs) are capable of downstream signaling through distinct noncanonical pathways such as

62 s activated RAC2 binds effectors to transmit signaling through effector pathways.

63 ional activation of MYC and WNT/beta-catenin signaling (through either beta-catenin activation or los

64 ygen species (ROS) to promote RIG-I-mediated signaling through enhancement of K63-linked RIG-I ubiqui

65 nd we identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregu

66 directly and dynamically regulates cellular signaling through ERK and Akt in response to ischemic in

67 (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) alpha or beta (

68 Estrogen signaling through estrogen receptor alpha (ER) plays a m

69 mation, it remained unclear whether estrogen signaling through estrogen receptor-alpha (ER-alpha, Esr

70 signaling to affect the balance of hormonal signaling through ethylene interaction with SA and cytok

71 CRISPR screens identified death receptor signaling through FADD and TNFRSF10B (TRAIL-R2) as a key

72 Here, we determined whether beta3-integrin signaling through FAK and cofilin (actin depolymerizatio

73 Hh signaling through FAP cilia regulated the expression of

74 Signaling through FGFR1 is also required to constrain le

75 However, inhibition of integrin signaling through focal adhesion kinase inhibition cause

76 llular domain hyperactivate Wnt/beta-catenin signaling through formation of inactive dimers with endo

77 ell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood.

78 the tumor outcome data, we found that Norrin signaling through FZD4 inhibited growth in ASCL1lo GSCs.

79 of heart failure (HF), induces pathological signaling through G protein betagamma (Gbetagamma) subun

80 ) proteins have emerged as key regulators of signaling through G protein-coupled receptors.

81 unit of a heterotrimeric G protein, mediates signaling through G-protein-coupled receptors (GPCRs).

82 dynamic autophosphorylation with chemotactic signaling through G-protein-coupled receptors.

83 GABAergic signaling through GABA(A) receptors (GABA(A)Rs) expresse

84 We show that WNT signaling through Galphao and PLC-beta results in sustai

85 urves were leftward shifted when the KOR was signaling through Galphaz compared with other Galphai/o

86 d Ggamma, and the mechanisms underlying GPCR signaling through Gbetagamma subunits.

87 Thus, T cell-intrinsic disruption of Fas signaling through genetic engineering represents a poten

88 ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions.

89 NLP-2 promotes movement during lethargus, by signaling through gonadotropin-releasing hormone (GnRH)

90 late designer receptors that mimicked mGluR5 signaling through Gq in nNOS interneurons, we recapitula

91 se production critically depends on enhanced signaling through hepatic glucagon receptors (GCGRs).

92 s fully competent to support Hsp90-dependent signaling through heterologously expressed glucocorticoi

93 d NCoR1 and advance our understanding of how signaling through HRMs affects the major cellular proces

94 t not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppressio

95 mbda cytokines are the exclusive ligands for signaling through IFNLR, it is not known whether genetic

96 nts of trophoblast growth and antiluteolytic signaling through IFNT secretion.

97 Signaling through IGF receptor (IGF1R) activated the pro

98 nstrated that interleukin-1alpha (IL-1alpha) signaling through IL-1R and MyD88 in both stromal and im

99 thylene glycol chains resulting in sustained signaling through IL-2Rbetagamma.

100 ement with these findings, inhibition of Ret signaling through in vivo administration of a highly spe

101 xplore a novel strategy of activating immune signaling through increased micronuclei formation utiliz

102 ctivates AKT and p110-independent JAK2/STAT3 signaling through inducing changes in the phosphorylatio

103 del-CFTR by arginine-dependent, nitric oxide signaling through inhibition of endogenous arginase acti

104 Increased anandamide (AEA) signaling through inhibition of its catabolic enzyme fat

105 Boosting AEA signaling through inhibition of its degradative enzyme,

106 Calcium-mediated signaling through inositol 1,4,5-triphosphate receptors

107 echanistically, MUC5AC potentiated oncogenic signaling through integrin alphavbeta5, pSrc (Y416), and

108 ncreases and promotes aberrant extrasynaptic signaling through ionotropic and metabotropic glutamate

109 To investigate the mechanism by which signaling through IRS-1 and IRS-2 results in differentia

110 cell receptor (TCR) mediates antigen-induced signaling through its associated CD3epsilon, delta, gamm

111 t the ER in ESCRT mutants necessitated TORC2 signaling through its downstream kinase Ypk1, which repr

112 PMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(

113 Particularly, ERK3 is critical for AP-1 signaling through its interaction and regulation of c-Ju

114 s non-cell autonomously and does not require signaling through its intracellular domain.

115 NF-kappaB signaling through its NFKB1-dependent canonical and NFKB

116 Here we show that retinoic acid (RA), signaling through its receptor (RAR), is the trigger for

117 Neuregulin-1 (NRG1) signaling through its tyrosine kinase receptor ErbB4 is

118 LGR5 potentiates WNT/beta-catenin signaling through its unique constitutive internalizatio

119 ytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain HFSC quiescence.

120 the underlying mechanism, which depended on signaling through kinases Syk, PI3K, and AKT2, as well a

121 ly, the beneficial effects were mediated via signaling through KOR because off-target effects were ex

122 Elevated CXCR7 activated MAPK/ERK signaling through ligand-independent, but beta-arrestin

123 Importantly, outside-in signaling through ligand-occupied alphaLbeta2 also requi

124 Ti(0.8)O(2) nanosheets reduced CSC signaling through mechanisms involving suppression of pr

125 se and spleen tyrosine kinase activation and signaling through mechanisms that appeared largely unrel

126 tidic acid (PA) pathway, required for mTORC1 signaling through mechanisms that are not fully understo

127 clathrin-coated vesicle trafficking, defense signaling through membrane lipid metabolism and mucilage

128 UT2 activates SMAD3, which regulates hypoxia signaling through modulating HIF1alpha chromatin-binding

129 inally, we show that Bid impacts necroptotic signaling through modulation of caspase-8-mediated Ripk1

130 so required to maintain lysosomal amino acid signaling through mTORC1 across species.

131 dely proposed that mechanical loads activate signaling through mTORC1 and that this, in turn, promote

132 pSTAT5, indicating that PP2A promotes IL-2R signaling through multiple mechanisms.

133 viduals; variants disrupted secretion and/or signaling through multiple molecular mechanisms.

134 chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets.

135 depends on the integration of extracellular signaling through multiple receptors, including the T-ce

136 ed, many of which were commonly regulated by signaling through multiple TLRs and were involved in the

137 tumors to modulate tyrosine kinase-mediated signaling through mutation of phosphatases such as PTPRH

138 The regulation of the striatum by the GPCR signaling through neuromodulators is essential for its p

139 rch emphasizes the distribution of intention signaling through neuronal populations and shows how man

140 We found that Muc-1 signaling through NF-kappaB increased expression of ICAM

141 cancer cells mediated, at least in part, by signaling through NF-kappaB.

142 s initiated by non-ionotropic (metabotropic) signaling through NMDARs, and in wild-type mice this str

143 zophrenia are the consequence of a deficient signaling through NMDARs.

144 re enriched for Nod1 up-regulated cells, and signaling through Nod1 promotes competitive survival of

145 rgeted combination regimens interfering with signaling through oncogenically rewired pathways provide

146 stimulate G protein-coupled receptor (GPCR) signaling through one intracellular pathway versus anoth

147 ystem, we found that prostaglandin E2 (PGE2) signaling through one of its receptors, Ptger4, was suff

148 Insufficient signaling through one or more of these metabolite-sensin

149 nderstanding of how different opioids affect signaling through opioid receptors; how opioid receptors

150 istic roles in the modulation of profibrotic signaling through opposite effects on MAN1 levels at the

151 Ablation of estrogen signaling through ovariectomy produced nipples with abno

152 fic conditions; however, increasing receptor signaling through overexpression more efficiently reveal

153 uggest a potential connection of TH and PPAR signaling through overlapping ligand recognition and may

154 ociated molecular pattern in plants, and its signaling through P2K1 is important for mounting an effe

155 aled a requirement for noncanonical TGFbetaR signaling through p38MAPK.

156 ants critical for agonist binding and biased signaling through PAR4.

157 we report that NRF2 suppresses hedgehog (Hh) signaling through Patched 1 (PTCH1) and primary ciliogen

158 Aberrant signaling through pathways controlling cell response to

159 n II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq s

160 riphery is critically dependent on tonic TCR signaling through peptide + MHC class I (MHCI) recogniti

161 suggest that activation of endothelial HIF-1 signaling through PHD2 inhibition may offer a novel ther

162 surface receptor ACVR1, which over-activates signaling through phospho-Smad1/5 (pSmad1/5).

163 m of how O-GlcNAcylation activates NF-kappaB signaling through phosphorylation and acetylation is not

164 procally modulated CD40-induced Ras-mediated signaling through PI-3K and Raf-1.

165 GGPP-dependent protein modifications control signaling through PI3Kdelta-AKT-GSK3, which in turn prom

166 e potential (RMP) that is maintained by cAMP signaling through PKA and EPAC.

167 The Semaphorin family of guidance cues, signaling through Plexin receptors, influences the devel

168 n an alternative way to modify glutamatergic signaling through positive allosteric modulation of AMPA

169 Restoration of the diminished 5-HT(2C)R signaling through positive allosteric modulation present

170 strate how the interplay between biochemical signaling through positive feedback, combined with diffu

171 m regulating for M1/M2 phenotype transition, signaling through PPARdelta is necessary for obtaining t

172 al pentraxin 1 from presynaptic terminals by signaling through presynaptic protein tyrosine phosphata

173 d evolutionarily conserved regulation of Wnt signaling through Ral GTPases.

174 Signaling through RAS and the MAPK cascade controls a va

175 Therefore, modulation of Ras signaling through RasGAP likely contributes to, but is n

176 er, VCP overexpression restored pro-survival signaling through regulating alternative splicing altera

177 tolerance to drought stress by affecting ABA signaling through regulating the stability and dynamic l

178 ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRalpha, the ligand-bind

179 tein (RREB1), which sustains Ras/ERK pathway signaling through repressing miR-143/145 expression.

180 avenger receptors on multiple cell types and signaling through Rho GTPases.

181 cesses - inhibiting polymerization-promoting signaling through sequestration of Rac/Rho family GTPase

182 In chronic lymphocytic leukemia (CLL), signaling through several prosurvival B cell surface rec

183 ation, and cytokine secretion in response to signaling through several TLRs.

184 sults indicate that phosphotyrosine-mediated signaling through Shb is essential in EphB2-mediated het

185 forming growth factor beta (TGF-beta and BMP signaling through SMAD members has distinct effects on m

186 on cooperation between canonical TGF-beta(1) signaling through Smad3 and activation of mechanistic ta

187 Repression of Hh-signaling through Smo co-mutation in Tbx5 heterozygotes

188 lia, an organelle essential for canonical Hh signaling through smoothened, a transmembrane protein ta

189 nnexin-1, is regulated by metabotropic NMDAR signaling through Src kinase.

190 nvasion required matrix anchorage as well as signaling through Src, PI3K, and Rac1, and increasingly

191 r Mettl14 loss promoted IFN-gamma-Stat1-Irf1 signaling through stabilizing the Stat1 and Irf1 mRNA vi

192 s during viral infection and have convergent signaling through STAT1.

193 ate IFN-gamma, with autocrine IFN-gamma then signaling through STAT1.

194 IFR as the receptor for ILEI, which mediates signaling through STAT3 to drive both EMT and BCSC forma

195 cells and limits inflammation by suppressing signaling through stimulatory receptors.

196 synthesis of type I interferon and involves signaling through STING, TBK1, and IRF3.

197 iquitin E3 ligases potently control TGF-beta signaling through targeted degradation of key regulatory

198 -infected cells become resistant to TGF-beta signaling through targeting of SMAD3 by miR-UL22-A-3p an

199 ese results provide genetic evidence linking signaling through TBC1D4 to enhanced muscle insulin sens

200 g cyclooxygenase-2, lies downstream of EPHA2 signaling through TGFbeta and is associated with poor pa

201 Overall, these studies indicate that TGFbeta signaling through TGFBR1/ALK5 in the endometrium is requ

202 of the AGPCR fragments stimulates G protein signaling through the action of the tethered-peptide ago

203 cytoplasmic arginine methylation during Wnt signaling through the activity of protein arginine methy

204 Signaling through the adaptor proteins MyD88 and TRIF re

205 he analgesic activity is mediated by kappaOR signaling through the adenylyl cyclase-inhibitory family

206 s, suggesting a paracrine alpha to beta-cell signaling through the beta-cell GLP-1 receptor.

207 ptin regulates fat storage and metabolism by signaling through the brain and peripheral tissues.

208 cytokines like TNFalpha cooperated with MAPK signaling through the c-Jun/AP-1 transcription factor co

209 Differential signaling through the CAR costimulatory domain can alter

210 g disease multiple sclerosis (MS).IMPORTANCE Signaling through the chemokine receptor CXCR2 in oligod

211 al. showed that extracellular DEK activates signaling through the CXCL2 receptor, which in turn enha

212 es lung disease, which is thought to require signaling through the cyclic GMP-AMP synthase (cGAS)-STI

213 this study, we examined the role of dopamine signaling through the D1 receptor via a novel pathway in

214 multiple body size factors are controlled by signaling through the DBL-1 pathway and by DBL-1-indepen

215 s studies demonstrated that manipulating 20E signaling through the direct injection of 20E or the app

216 SPASM sensors also retain signaling through the endogenous G protein milieu.

217 ivates the EGF receptor to induce downstream signaling through the ERK serine/threonine kinase and th

218 CLM may attenuate signaling through the estrogen receptor by reducing leve

219 activation of the IKK complex and subsequent signaling through the extracellular signal-regulated pro

220 FGF19 signaling through the FGFR4/beta-klotho receptor complex

221 ivation with increased lysosome content, but signaling through the fractalkine receptor CX3CR1 is not

222 Wnt signaling through the Frizzled (FZD) family of serpentin

223 Endogenous CIS provides a key brake on signaling through the GM-CSF receptor.

224 response to nutritional signals, in part via signaling through the gut microbiota.

225 a2 mutant axolotls, we found that DNA damage signaling through the H2AX histone variant was deregulat

226 In contrast, this mutant could rescue signaling through the Hippo pathway in cells lacking mul

227 This is because IL-4/IL-13 signaling through the HR inhibits their T cell potential

228 Alpha/beta interferon (IFN-alpha/beta) signaling through the IFN-alpha/beta receptor (IFNAR) is

229 fects of type I IFNs were mediated by direct signaling through the IFN-alpha/beta-receptor (IFNAR), a

230 and reveal a novel role for non-canonical Hh signaling through the induction of chromosomal instabili

231 Here, we report that novel signaling through the intracellularly localized D2R long

232 Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT pathway, leading to the t

233 Here, we show that signaling through the lymphotoxin-beta receptor (LTbetaR

234 AMLs are devoid of NRAS(V12) expression and signaling through the major oncogenic Ras effector pathw

235 llosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.

236 ce hypertrophy via a mechanism that requires signaling through the mechanistic target of rapamycin co

237 tory of excessive alcohol drinking increases signaling through the metabotropic glutamate receptor 5

238 re clock component GIGANTEA (GI) and hormone signaling through the modulation of key components of th

239 but enhances the sustained receptor-mediated signaling through the modulation of the expression of pr

240 tiates G protein-mediated signaling but also signaling through the multifunctional adapter protein be

241 mPR signaling and expand the spectrum of mPR signaling through the multitude of pathways involving AP

242 Instead, it was due to TLR4-dependent signaling through the MyD88-dependent pathway of the inn

243 How neurons of the VTA affect signaling through the NAcc and subsequent dopamine relea

244 ch metabolic activity modulates inflammatory signaling through the NF-kappaB pathway.

245 Innate immune signaling through the NLRP3 inflammasome is activated by

246 g synaptic plasticity.SIGNIFICANCE STATEMENT Signaling through the NMDA receptor (NMDAR) is vitally i

247 We demonstrate that glutamate signaling through the NMDA receptor, cytosolic phospholi

248 molecular pathway that links conformational signaling through the NMDAR to dendritic spine shrinkage

249 rinsic response of MDS HSPCs, which involves signaling through the noncanonical NF-kappaB pathway, pr

250 igand (TRAIL) triggers apoptosis in cells by signaling through the O-glycosylated death receptors (DR

251 onize positive and negative feedbacks on TCR signaling through the other components.

252 ecapitulate the diverse biology seen in IGF1 signaling through the overexpression of multiple IGF1 is

253 switch is driven by FAK kinase activity, and signaling through the p130Cas>c-Jun signaling axis.

254 We found that, like GDNF, signaling through the parental compound Q121 is GFRa1-de

255 We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-A

256 atelet-derived growth factor (PDGF) requires signaling through the phospholipase C (PLC)/protein kina

257 uptake may be the key factor in mediating Pi signaling through the PiT proteins.

258 in cusp pattern formation by modulating Wnt signaling through the positive regulation of Sostdc1.

259 are well documented, including constitutive signaling through the RAF-MEK-ERK proproliferative pathw

260 ctly blocks interaction with Raf and reduces signaling through the Raf/MEK/ERK pathway.

261 Amino acid signaling through the Rag GTPases promotes mTORC1 lysoso

262 eceptor (EGFR) at the cell surface initiates signaling through the RAS-RAF-MAPK/ERK1/2 pathway and re

263 ein has been mainly related to oncogenic ERK signaling through the RAS-SHOC2-PP1 phosphatase complex.

264 or PERK led to hyperactivation and apoptotic signaling through the reciprocal arm, thereby halting tu

265 In vivo activation of PTH signaling through the reestablished Jagged1 and osteopon

266 ne ALDH1A2 Interestingly, classical NFkappaB signaling through the RelA transcription factor was equa

267 -receptor-mediated sodium influx and calcium signaling through the reversal of sodium/calcium exchang

268 These mutations increase mitogenic signaling through the RhoA axis and, therefore, may repr

269 cular chaperones and requires TORC1 activity signaling through the Sfp1 transcription factor.

270 lesterol drives mTORC1 activation and growth signaling through the SLC38A9-NPC1 complex.

271 h muscle and nonmuscle cells is regulated by signaling through the small GTPase Rho and by calcium-ac

272 Previous reports suggest that IL-6 trans-signaling through the soluble IL-6/IL-6R complex is invo

273 y, we show how GI modulates gibberellin (GA) signaling through the stabilization of the DELLA protein

274 Signaling through the T-cell receptor (TCR) is critical

275 essed in murine CD4(+) T cells and regulates signaling through the TCR.

276 PN induces RALDH2 in human APCs by signaling through the TLR1/TLR2 heterodimer.

277 ackcrossing Dysf(-/-) mice with mice lacking signaling through the Toll-Interleukin 1 Receptor Domain

278 hat brain-derived neurotrophic factor (BDNF) signaling through the TrkB receptor plays a critical rol

279 Signaling through the type I IL-1R has recently been sho

280 etal muscle fibrosis, is dependent on intact signaling through the type I IL-1R receptor.

281 otein/lipid phosphatase that blocks PI3K/Akt signaling, through the ERK/cAMP-responsive element-bindi

282 ulators of G protein-coupled receptor (GPCR) signaling through their ability to act as GTPase-activat

283 nd underpin the compartmentalization of cAMP signaling through their targeting to particular protein

284 Signaling through these receptors converged on the adapt

285 Aberrant signaling through this cascade contributes to oncogenesi

286 Signaling through this pathway crucially depends on the

287 I interferon receptor have demonstrated that signaling through this receptor is critical for protecti

288 ation of microglia is dependent on intrinsic signaling through TLR4, as disruption of TLR4 within mic

289 hyperreactivity is neutralized by abrogating signaling through TNF-alpha receptors in vivo in a mouse

290 TNF signaling through TNFR1 p55 was required for upregulatio

291 f sterile inflammation, we demonstrated that signaling through Toll-like receptors (TLRs) paradoxical

292 use these conditions involve proinflammatory signaling through toll-like receptors (TLRs), we examine

293 Mechanistically, MAP1S induces NRF2 signaling through two parallel mechanisms, both resultin

294 Indeed, balanced IgG signaling through type I and type II Fc receptors is req

295 hat brain-derived neurotrophic factor (BDNF) signaling through tyrosine kinase B (TrkB) receptors in

296 a mechanism whereby oncogenic KRAS saturates signaling through unpalmitoylated EGFR, reducing formati

297 DORA2B expression and (b) enhanced adenosine signaling through upregulated ADORA2B induces placental

298 nance, acute and chronic, and that pheromone signaling through V1R receptors is involved in the first

299 tes leukocyte recruitment and activation via signaling through various cell surface receptors.

300 nt and enhances cell adhesion, migration and signaling through vitronectin binding and interactions w