ライフサイエンスコーパス: signature

1 egative correlation with Myc transcriptional signature.

2 did not have the characteristics of a robust signature.

3 ive drugs on the basis of the target's redox signature.

4 ground to largely abrogate this distinct APA signature.

5 tex, but with a strikingly specific regional signature.

6 cterized by the acquisition of a SiglecF(hi) signature.

7 the DD distribution is an important network signature.

8 vere disease had elevated levels of all four signatures.

9 ubtype was characterized by mesenchymal gene signatures.

10 titution and 17 small insertion-and-deletion signatures.

11 orocarbons were measured to establish source signatures.

12 y transmission electron microscopy and Raman signatures.

13 ignature as well as gut- and spleen-specific signatures.

14 ess prominently explored than for prognostic signatures.

15 ent in event-free survival in its graduating signatures.

16 y and systemic strains with distinct genomic signatures.

17 , functionally confirming OL transcriptional signatures.

18 on and of saturation remanence magnetization signatures.

19 of CSCs with specific metabolic and stemness signatures.

20 ween gene expression spatial patterns and FC-signatures.

21 cell histone methylation and functional gene signatures.

22 riptional perturbations from gene expression signatures.

23 disturbing the ambient-mantle stable-isotope signatures.

24 patients with VRL had no common genome-wide signatures.

25 olzeta translesion polymerase, yields COSMIC signature 3 observed in BRCA1/BRCA2-mutant breast cancer

26 enriched in tissue reparative growth factor signature A, whereas the profiles of those with who deve

27 A previously identified biopsy gene signature accurately predicted TOL versus non-TOL in 12/

28 ts with a median follow-up of 346 days, this signature achieved a PPV of 50% (95% confidence interval

29 m forest modeling to identify differences in signatures across subject groups.

30 o directly access and download any subset of signatures across the entire library independent from th

31 se of infection show an early transcriptomic signature akin to that of established T central memory c

32 haracterized common and unique transcriptome signatures among CTE, CTE/AD, and AD.

33 High-throughput screening and gene signature analyses frequently identify lead therapeutic

34 Gene signature analysis confirmed the lymphocyte infiltration

35 Mutational signature analysis revealed age- and gender-related muta

36 lustering, gene set analysis, and expression signature analysis.

37 identified a 3491-gene MMC9 transcriptional signature and identified 2 transcriptionally distinct SI

38 We established a biomarker signature and multiple protein ratios that differentiate

39 orrelation with other environmental exposure signatures and a field effect in NATs.

40 ed model to estimate the correlation between signatures and clinical and demographical phenotypes.

41 integration, characterized by unique cancer signatures and clinical characteristics.

42 tained immunologic and endothelial biomarker signatures and decreased long-term physical function and

43 ciations between thalamic glial histological signatures and ensuing release of Iba-1 and GFAP into th

44 We highlight signatures and patterns of rNMPs, including sites within

45 By comparing these gene signatures and validated markers to HIO ECs, we find tha

46 ffectively capture these progression-related signatures, and that carcinoma-specific signatures are p

47 4-knockout showed virtually opposite genomic signatures, and their putative target genes play an impo

48 However, many signatures are of unknown cause.

49 ated signatures, and that carcinoma-specific signatures are predictive of survival for human breast c

50 tions reveal that the measured spectroscopic signature arises from defect-induced pseudo-localized ph

51 bgroups have activated DNA repair-associated signature as a prominent late mutational process, wherea

52 tissues revealed a tissue-resident MBC gene signature as well as gut- and spleen-specific signatures

53 cing factors exhibit similar gene expression signatures as samples with coding mutations in these gen

54 rements further reveal weak antilocalization signatures as well as breaking of fourfold spin-valley s

55 ted with etoposide exhibit the same mutation signature, as do cells that overexpress the wild-type pr

56 n of a baseline intrahepatic transcriptional signature associated with response to GS-9688 treatment

57 yses can be used to identify novel microbial signatures associated with diabetes and support the need

58 e are able to identify concordant peripheral signatures associated with prevalent AD arising from lip

59 es strong increases in inflammatory cytokine signatures associated with redox dependent induction of

60 ncreased levels of FOXP3 and gene expression signatures associated with tolerance induction.

61 Acute/chronic insomnia-related signature bacteria also showed correlations with these p

62 A potential molecular signature based on oncomirs from SEVs (caf-miR-205, caf-

63 A gene expression signature based on over-represented TFs correlated with

64 le syndrome with intellectual disability and signature brain and congenital abnormalities.

65 s not an aneuploidy-specific gene-expression signature but the result of normalizing the gene-express

66 e elimination of past transposition increase signatures by natural selection, we performed a laborato

67 rehensive catalogue of perturbation-response signatures by utilizing a diverse collection of perturba

68 tify eight processes, including a mutational signature caused by exposure to melphalan.

69 FA exhibited a disease-specific metabolomic signature compared with both control subjects and asthma

70 ested miRNAs are affected by T2DM, while the signature composed by miR-146a, -320a, -422a, and -451a

71 ccRCC shows a gene expression signature consistent with adipogenesis, and the phosphol

72 The signature constructed using the seven features had 98% [

73 Here we show that similar transcriptional signatures correlate with increased bacterial loads and

74 n and interferon-gamma (IFN-gamma) signaling signatures correspond most highly with clinical response

75 These signatures could not be detected in either a pediatric o

76 ells identified a core oxidative stress gene signature coupled to coagulation and glutathione-pathway

77 This signature, decreased by ICS/LABA treatment was enriched

78 investigated for their Si, B, and Sr isotope signatures (delta(30)Si, delta(11)B, and (87)Sr/(86)Sr,

79 The main tidal signature depends predominantly on the equation of state

80 Moreover, the spectra and signatures derived from yeast were detectable in lung ca

81 Currently, prognostic gene-expression signatures do not exist for all cancer types, and most d

82 Our signatures driven by CpGs in intergenic regions that sho

83 induction of a specific DNA hypomethylation signature during development, after which Tregs persist

84 er cohort, FGFR4-induced and FGFR4-repressed signatures each predicted overall survival.

85 rong enrichment in inflammation-related gene signatures, elevated expression of pro-inflammatory tumo

86 This signature enables precise mapping of core fragility regi

87 n the sample matrices, considering that such signatures encode the history and circumstances of the r

88 Notably, this signature enriched for targets of Yes-associated protein

89 1(pos)) with unique remission transcriptomic signatures enriched in negative regulators of inflammati

90 , we found that both AEC- and NEC-based DNAm signatures exerted a lower classification error than the

91 iduals with higher similarity to deletion FC-signatures exhibit worse cognitive and behavioral sympto

92 rate that this configuration is a structural signature for a ubiquitous class of receptors in the pla

93 demonstrate the effectiveness of the Census signature for both stages.

94 rprisingly, among HPV-negative cases, a gene signature for HPV status was predictive of survival, eve

95 hile the probability of wideband emission (a signature for inertial cavitation) was than 1%.

96 -sequencing studies have defined a molecular signature for microglia under homeostasis.

97 domains (BGRD) on chromatin as an epigenetic signature for oncogenes.

98 omputational approach to identify an optimal signature for short-term risk of active tuberculosis and

99 zation has been shown to provide interesting signatures for detecting the presence of geological mate

100 ification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is

101 authors sought to identify unique proteomic signatures for patients with HF with reduced ejection fr

102 nvironments have a distinct representational signature from both scene and object views in visual cor

103 In this work, we therefore introduced the ts signature from Len LAIV into Cal/09.

104 ive explanation of the observed experimental signatures from a model of polydisperse hard spheres wit

105 ative interpretation of induced polarization signatures from brine-filled rock formations with conduc

106 treamlined by the integration of non-trivial signatures from discordant paired-end alignments, split-

107 We demonstrate that signatures from discrete subpopulations of cortical exci

108 bile MPCs correlating with osteogenesis, and signatures from immobile MPCs with adipogenesis.

109 Importantly, the investigation of gene signatures from inflammatory-CAFs and differentiated-PVL

110 The electrolyte exhibits unique vibrational signatures from stimulated Raman spectroscopy.

111 It has been demonstrated how process signatures from the PAT tools across various batches and

112 lgorithm capable of identifying radionuclide signatures from weak sources in the presence of a high r

113 Cas10 is the signature gene for type III CRISPR-Cas surveillance comp

114 We use the computational tool DSGRN (Dynamic Signatures Generated by Regulatory Networks) to explore

115 or copy-number variations and able to run on signatures generated from RNA-Seq or ATAC-Seq data.

116 resent high potency to reverse expression of signature genes for further experimental testing of thei

117 LAM(CORE) cells expressing signature genes included known LAM markers such as PMEL,

118 Transcript abundance of C(4)-CAM signature genes was shown to be a useful indicator of th

119 ional burden/T cell-inflamed gene expression signature (GES) or high immunosuppressive tumor microenv

120 y for constructing and optimizing predictive signatures has been less prominently explored than for p

121 The signature identified cancer patients prior to a clinical

122 therapy graduates with one or more of these signatures if and when it has an 85% Bayesian predictive

123 ed sulfur to produce the positive delta(34)S signature in arc settings.

124 ction of a proinflammatory and proadipogenic signature in endothelium, pericytes, and mesenchyme.

125 We confirm this altered lipid signature in human HCC and show a positive correlation o

126 lity of using the EVLP platform to study miR signature in human lungs in response to CI/EVR.

127 Furthermore, an RA-responsive gene signature in human monocytes correlates with an immunosu

128 c effectors, consistent with an observed Tfh signature in T1D.

129 e study, we aimed to define a serum glycomic signature in the first week after liver transplantation

130 ized by high prevalence of APOBEC mutational signature in younger females and over-representation of

131 disease result in unique histone methylation signatures in affected cell populations, including repre

132 tumours revealed that the genomic alteration signatures in Chinese patients were markedly distinct fr

133 ofiling detected distinct immune and barrier signatures in lesional and nonlesional AD and psoriasis

134 We identified blood RNA signatures in mice infected with an ULD or a conventiona

135 th or without immobilization identifies gene signatures in mobile MPCs correlating with osteogenesis,

136 of environmental carcinogen-like mutational signatures in older females.

137 to better understand the relevance of these signatures in pancreatic neoplasms.

138 a have revealed differential DNA methylation signatures in proxy tissues that are associated with rep

139 confirm the assignment of specific spectral signatures in the live cell spectra, SERS data were coll

140 We identified transcriptional signatures in the lymph nodes associated with difference

141 et genes are marked by permissive epigenomic signatures in the naive state, indicating that they are

142 dated the clinical profiles for all three CT signatures in the replication sample.

143 to the absence of radiological and chemical signatures in the sample matrices, considering that such

144 r detect outlier-free genetic and epigenetic signatures in various complex diseases and their develop

145 ncies of copy number alterations, mutational signatures in whole exome, and tumor mutational burden i

146 e "common aneuploidy gene-expression" (CAGE) signature, in which many ESR genes are oppositely regula

147 Gene-specific phenotypic signatures included associations of SCN1A with "complex

148 al function but also show distinct molecular signatures indicative of enhanced fatty acid metabolism

149 )He OIB exhibit anomalous (182)W-an isotopic signature inherited during the earliest history of Earth

150 Displacement loops (D-loops) are signature intermediates formed during homologous recombi

151 tations or copy number alterations, mutation signatures, intratumor heterogeneity, pathway alteration

152 sthma in children, particularly inflammatory signatures involving the air spaces.

153 In patients with RA, the IFN signature is characterised by up-regulation of SIGLEC1 (

154 A broad T(h)1/T(h)2/T(h)17 inflammatory signature is detected in the periphery and in the skin.

155 We show that the CAGE signature is not an aneuploidy-specific gene-expression

156 Perhaps the most well established candidate signature is the P3b event-related potential, a late slo

157 hological analysis integrated with molecular signatures is then required to advance our understanding

158 Hydrosalpinx was absent in all TOC and p53 signature lesions at transvaginal US.

159 gnant neoplasms, and two (1.4%) isolated p53 signature lesions.

160 any ligands were predicted based on sequence signatures, ligands of shorter sequences have not been i

161 Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with th

162 p=0.27), especially if they had an IFNgamma signature lower than the median (HR 0.88 [95% CI 0.40-1.

163 Forty-nine gene signatures (modules) for differentially stimulated macro

164 Whole-exome sequencing identified UV-signature mutations in multiple genes, including NOTCH1-

165 udy was to evaluate whether MV pre-operative signature (number, cellular origin, procoagulant phenoty

166 Here, using gene expression signatures obtained from mouse cell types, we deconvolut

167 The comparison between gene signatures obtained from the in vitro model (CS vs. air)

168 us across tissues provided a transcriptional signature of 248 genes.

169 e short-lived ones (1-10 s) are the temporal signature of a low fidelity catalytic pathway.

170 rotation) on body recognition, a behavioral signature of a specialized mechanism for body perception

171 on indispensable for 77% of the induced gene signature of alternative polarization, including its aut

172 Finally, a genetic signature of autophagy had negative prognostic value in

173 We also identified a temporal signature of blood proteins that was significantly diffe

174 geusia, constitutes the earliest EHR-derived signature of COVID-19.

175 say, each sample is labeled with a different signature of emission wavelengths and mixed with other s

176 Chemical signature of femoral pore secretions is important for in

177 -bet axis in suppressing the transcriptional signature of immature NK cells.

178 geographic genetic structure and the genetic signature of multiple postglacial recolonisation events,

179 10,000 years (p = 0.0082), consistent with a signature of polygenic adaptation driven primarily by th

180 ot in the sequence of S that also displays a signature of positive selection and may have implication

181 In order to capture the metabolic signature of proliferating hepatocytes, we applied state

182 Translocated genes, in contrast, bore the signature of silencing.

183 omena, the electronic transport and magnetic signature of the heterointerface are significantly alter

184 d-dynamics in the weak coupling regime, is a signature of the passive parity-time ([Formula: see text

185 We have previously shown that the ts residue signature of the Russian A/Leningrad/17/57 H2N2 LAIV (Le

186 ng time distributions of each molecule are a signature of the system's state.

187 This molecular signature of vulnerability to stress-induced anhedonia a

188 nd NK cells, allowing immunosurveillance for signatures of "altered self" on target cells, via a memb

189 this cellular characterization with cleavage signatures of 178 proteases highlights proteolytic degen

190 However, the cellular profiles and signatures of aging, as well as those ameliorated by CR,

191 itute, we generated whole brain and regional signatures of AMPAR subunit gene expression in healthy h

192 erformance was partly due to the conspicuous signatures of archetypal raised-leg postures in the acce

193 , with 15-47% of loci exhibiting significant signatures of balancing selection.

194 featuring it as one of the most distinctive signatures of cancer.

195 We introduce dynamic signatures of cells derived from the LD displacement, sp

196 The transcriptomic and proteomic signatures of ChP-CSF organoids reveal a high degree of

197 ds of expression datasets to define extended signatures of distinct breast cancer subtypes.

198 matrix decomposition algorithm learns latent signatures of drugs and side effects that are both repro

199 the number of cell types and transcriptomic signatures of each cell type.

200 ected exploration under L-dopa, while neural signatures of exploration, exploitation and prediction e

201 any of the 188 variants exhibited functional signatures of gene expression regulation or transcriptio

202 formational entropy (S(conf)), we find clear signatures of heterogeneity in the monomeric conformatio

203 hat may benefit the host, as well as genomic signatures of host association and immune system evasion

204 Cancers with HRDetect mutational signatures of HR deficiency had a functional defect in H

205 Unique signatures of in vivo competition in gnotobiotic mice in

206 this competition-as reflected in oculomotor signatures of internal attention-predicts the quality of

207 hen recruited, mean age = 54.9), we test for signatures of loneliness in grey matter morphology, intr

208 These same loci were enriched for signatures of long-term balancing selection in the nativ

209 tion of morphologic and electrophysiological signatures of maladaptive neuronal plasticity; a phenome

210 vely upregulated innate immune response with signatures of nuclear factor-kappaB-dependent, type I an

211 n across species pairs contrast with genomic signatures of past introgression.

212 other nutrients obtained from spectroscopic signatures of peanut seeds.

213 nome has been extensively studied, dynamical signatures of processes such as transcription or DNA rep

214 These findings reveal unique molecular signatures of protective CD8(+) T cells and pave the way

215 delta(13)C signatures of pure-phase CFCs and hydrochlorofluorocarbo

216 seed mass and precipitation that also carry signatures of selection based on F(ST) scans and PCAdapt

217 hese results provide anatomical and temporal signatures of sensory disconnection during sleep and pav

218 To test this, we have measured the signatures of several combination samples containing two

219 We identified classical signatures of stress response in M. inflexa, including m

220 Signatures of strong electron-electron correlations have

221 The far-IR signatures of the discussed studies are summarized in a

222 ed a striking sexual dimorphism in molecular signatures of the dorsal root ganglia (DRG) and spinal c

223 developmental trajectory and transcriptional signatures of the epiblast, primitive endoderm and troph

224 Signatures of these opposing factors were evident across

225 her experiment, we reveal several behavioral signatures of this theoretical account, tying choice sto

226 Imaging signatures of various brain diseases, including schizoph

227 rder that emerged from spectral and chemical signatures over the past decade.

228 ests that the relative abundance of mutation signatures partitions POLE tumors into distinct subgroup

229 led protein composed of several concatenated signature peptides as internal standard.

230 A 76-protein proteomic age signature predicted accumulation of chronic diseases and

231 In melanoma patients, a tumor-intrinsic NGFR signature predicts anti-PD-1 therapy resistance, and NGF

232 Loss of SSD1 recapitulates myriad aneuploidy signatures previously taken as eukaryotic responses.

233 evidence for a distinct microbial diagnostic signature, probably due to heterogeneous host-microbe in

234 of the structural and functional mutational signatures relevant to Mendelian disorders and the prior

235 This signature represents an intersection of signaling pathwa

236 vent type whose current source density (CSD) signature resembled that seen during CA1 SWR, but which,

237 Interrogation of the lipidomics signature revealed abnormal cardiolipin remodeling in di

238 The core disease signature revealed remarkably strong connections to gene

239 The nanodevice then cuts out a signature sequence and uses it as an activator for a "th

240 tant role for the second threonine of the SF signature sequence in the U-type inactivation gating of

241 These motion signatures serve to predict the post-HAA selectivity, an

242 ts uncover a core mRNA-ncRNA transcriptional signature shared by IgG(+) and IgA(+) swMBCs and distinc

243 sory cortical circuits that incorporated the signature short-term synaptic plasticity (STP) profiles

244 Microbiome signatures showed marked shifts in taxonomic levels in p

245 Our viral exposure signature significantly associated with HCC status among

246 BRG1 reexpression induced a gene and protein signature similar to an epithelial cell and gained chrom

247 d intravascular coagulation, with a cytokine signature similar to that of macrophage activation syndr

248 were RNA-sequenced to reveal autism-specific signatures similar to postmortem brain studies, indicati

249 ed with free fatty acids had gene expression signatures similar to those of liver tissues from patien

250 ix types of the strains and their underlying signature SNVs were validated in two subsequent analyses

251 ssible fitness gain conferred by the type VI signature SNVs.

252 restingly, synapse signaling-associated gene signatures (such as synaptotagmins) were commonly down-r

253 Oligodendrocyte signatures suggested impaired axonal myelination and met

254 nent late mutational process, whereas APOBEC signature targeting C>G is activated in the intermediate

255 Btnl expression is required to maintain the signature TCR.Vgamma7(+) IEL phenotype, including specif

256 eggshell and a partly different geochemical signature than those from the egg-bearing layers describ

257 more comprehensive context-based mutational signatures than traditional NMF approaches.

258 In summary, we established a viral exposure signature that can predict HCC among at-risk patients pr

259 c net regression analysis to identify a gene signature that can predict risk of cardiotoxicity.

260 Lack of P2X7 promoted a transcriptional signature that correlated with enhanced cytotoxic T-cell

261 al importance and revealed a unique sequence signature that is potentially responsible for substrate

262 o unmasked a retina-specific gene expression signature that might contribute to CaMKII-dependent reti

263 ulti-systemic disease and provides molecular signatures that are characteristic to the disease proces

264 We characterized mutational signatures that were consistent with those reported befo

265 t with strong ribosome and protein synthesis signatures; these CTCs expressed proliferation and epith

266 ch rendering a unique two-color fluorescence signature to a nucleic acid target representing a clinic

267 By matching the cancer-specific expression signature to compound-induced gene expression profiles f

268 us carbonates and isolate the specific (14)C signature to the lead carbonate.

269 llowed for up to seven different combination signatures to be run at one time.

270 o linear combinations of the individual type signatures to determine the volume ratios of the types.

271 ain tropical and oligotrophic (k-strategist) signatures, to seasonally displace more copiotrophic (r-

272 twork analysis identified FOXM1 and KDM4E as signature transcription factor of AF and NP respectively

273 ting an epithelial-to-mesenchymal transition signature, tumorigenesis proceeds through Wnt-differenti

274 the transplant hospital using shared access signature URL access to Google Maps, and assessed using

275 hift in cuticular hydrocarbons, the chemical signatures used by bees to discriminate colony members f

276 me Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645

277 ophage and "M1"/"M2" ratio by transcriptomic signatures using xCell.

278 y, 10 cases (23.3%) still contained the same signature vh-DNA detected at baseline, indicating the pr

279 For these TFs, a gene expression signature was built to assess their implication in neuro

280 In mainland Europeans, the adaptive signature was detected in haplotype-based analysis but n

281 and perivascular memory T cells, this brain signature was enriched and the surveilling properties of

282 Finally, this signature was increased in COPD patients compared to con

283 The identified murine immune escape signature was reflected in human patients and correlated

284 To define the signature, we performed network deconvolution of transcr

285 To explore the genomic signatures, we comprehensively analyzed 2,492 complete a

286 Using epigenetic signatures, we identified enhancers for each development

287 These signatures were associated with predominantly impaired c

288 workflow revealed that distinctive spectral signatures were detected from different regions of the i

289 ical experimental steps, distinctive roaming signatures were identified.

290 Specifically, eight immune signatures were significantly correlated with a higher p

291 Profound global lymphopenia and a "chemokine signature" were observed in COVID-19 ARDS.

292 types correlated with inhibition of the CSCs signature, which consists of elevated expression of ALDH

293 ound evidence for potential, SIB-specific FC signature, which may point to compensatory neurofunction

294 function, we defined an XBP1s-dependent gene signature, which revealed significant IRE1alpha pathway

295 and a dominant ultraviolet damage mutational signature, which suggested that for the subset of patien

296 s of genes in the basal-like gene expression signature, which were associated with poor prognosis.

297 ion dynamics, produce qualitatively distinct signatures, which can further be used to discern between

298 Two refined signatures with either four (LF2 and BGLF2 IgG, LF2 and

299 gements were linked with univocal mutational signatures, with clusters of point mutations due to kata

300 Moreover, the biomarker gene expression signatures yielded leads for possible new drug candidate