ライフサイエンスコーパス: significance

1 a reaction of great historical and practical significance.

2 inter-point distance to evaluate statistical significance.

3 eric aerosol particles of potentially global significance.

4 1, SE = 0.9), which did not reach study-wide significance.

5 t the associations did not reach statistical significance.

6 nal neurological signs of uncertain clinical significance.

7 i for mitochondrial abundance at genome-wide significance.

8 ile limiting their side effects, is of broad significance.

9 although the HR failed to attain statistical significance.

10 e aimed to assess their long-term prognostic significance.

11 en amount and position with high statistical significance.

12 s (pQTMs) at a stringent Bonferroni level of significance.

13 ariables, and P < 0.05 indicated statistical significance.

14 subtypes of childhood B-ALL, have prognostic significance.

15 uantitative features with potential clinical significance.

16 ell as aggressiveness; 183 reach genome-wide significance.

17 rited methylation variants are of biological significance.

18 ose involving PP2A, assumes greater clinical significance.

19 sed behavioral hyperactivity with borderline significance.

20 0001) but an excess of variants of uncertain significance (24%, P<0.0001), as compared to Whites (pat

21 the originally planned 88% power needed for significance), 4-year overall survival was 77.9% (95% CI

22 ogenic: 31%, excess of variants of uncertain significance: 7%).

23 Yet despite their hydrological significance, a global synthesis of their effects on hyd

24 enes with damaging DNVs that met statistical significance after Bonferroni correction (PTPN11, CHD7,

25 ), these findings would not meet statistical significance (all P > .003).

26 , regularly engages with values such as site significance and allocation of funding that the modern s

27 materials in the pre-historic artifacts, its significance and impact are discussed in this article.

28 Finally, analysis of significance and optimality demonstrates that frameshift

29 We explored the clinical significance and predictive value of trans-ethnic varian

30 om the same parents to determine statistical significance, and it can leverage any black-box multivar

31 few data are available as to the frequency, significance, and management of these cases.

32 This benefit reached statistical significance at 12 days after randomization.

33 itage trend test was used for analysis, with significance at P < .05.

34 There was no statistical significance between AUCs for the macular parameter and

35 Despite its significance, brain-wide quantitative understanding of O

36 (CHIP) and clonal cytopenias of undetermined significance (CCUS).

37 0 years (2.50 +/- 1.00), with no statistical significance detected between the two groups (p-value 0.

38 he amount and type of DNA damage is of great significance for a broad range of clinical and research

39 each case, we discuss (1) the physiological significance for circadian regulation of these processes

40 ons on sustainable mobility and have a wider significance for holistic sustainability governance.

41 ple spacer integration is a rare event which significance for immunity is poorly understood.

42 nt for VSS score (P < 0.0001) and approached significance for itch (P = 0.052).

43 The biological significance for mitochondrial cristae has now, for the

44 e phenomenon described here could have broad significance for predictions of phenotype from genotype.

45 Secukinumab did not meet statistical significance for superiority versus adalimumab in the pr

46 ority of IVIG to placebo reached statistical significance for the primary endpoint for all patients a

47 Of 101 included trials, 12 met statistical significance for their main endpoint, five for increased

48 feature of predator-prey ecology, but their significance has had little impact on the conceptual und

49 Despite its public health significance in Asia, vaccines and specific therapeutics

50 ocated in the gene WWTR1 reached genome-wide significance in association with mental composite score

51 ntial genetic, evolutional, and pathological significance in genome analyses.

52 Dys(-/-) mice, which may have translational significance in HSP-7 patients, both in terms of diagnos

53 c (hetero)biaryls are motifs with increasing significance in ligands, natural products, and biologica

54 ST, PET-based response maintained prognostic significance in patients classified as having progressiv

55 dicate that S. maltophilia may have clinical significance in respiratory infections.

56 Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are

57 The difference, and its significance, in rates of RNFLT change in the UKGTS trea

58 s of freedom" aimed at obtaining statistical significance increases the likelihood of obtaining and p

59 ize for adequate power to detect statistical significance is a crucial step at the design stage for h

60 However, the exploration of RSSH biological significance is challenging due to their instability und

61 on effect are proposed and their statistical significance is estimated by permutation procedures.

62 Although the clinical significance is still under investigation, preclinical d

63 Of special significance is the homodimerization of F-NC, in which t

64 84 known and 18 novel BP loci at genome-wide significance level (P < 5 x 10(-8)).

65 nd BAG3, associated with EF at a genome-wide significance level.

66 rection and another 12 replicated at nominal significance level.

67 lect predictors that meet a priori specified significance level.

68 tatistically rigorous strategy for combining significance levels from multiple methods of driver disc

69 um, allowing improved evaluation of clinical significance, management, and precision medicine in diab

70 Despite its significance, many WAT-related pathophysiogical mechanis

71 ld to find a particular level of family-wise significance may need to be established using separate p

72 comparison with kinetic data demonstrate the significance of 1,5-O...Ch interactions in enantioselect

73 We establish the significance of a sup-optimal paternal low protein diet

74 red in an important insect and emphasize the significance of accounting for an organism's sex when st

75 The significance of activated microglia around motoneurons a

76 However, the true significance of albuminuria has yet to be fully defined.

77 nd (iii) a rigorous statistical test for the significance of all the identified biclusters in any org

78 tissue from a cancer patient highlighted the significance of APE1 exonuclease activity in cancer etio

79 We investigated the significance of arteriolar C4d staining in chronic-activ

80 tistics and ordinal regression to assess the significance of associations and Bonferroni corrected fo

81 ing the direction, strength, and statistical significance of associations for all covariates.

82 ial periods, this raises the question of the significance of bird migration during past periods with

83 events, in each case with evaluation of the significance of candidate signals by extensive simulatio

84 fering a new perspective for the mechanistic significance of CTD length and disorder in transcription

85 nt causal evidence of the two-way functional significance of direct hippocampal-anterior thalamic int

86 is study reveals the biological and clinical significance of dysplastic hematopoiesis in newly diagno

87 dies in various types of cancer point to the significance of epigenetic aging in tumorigenesis and it

88 The biological significance of extracellular vesicles (EVs) as intercel

89 criptomics and network analysis, suggest the significance of genetic diversification for maturation p

90 tunities to better understand the functional significance of genetic variants and to utilize the disc

91 on abilities may help determine the clinical significance of hippocampal hyperactivity throughout the

92 The growing significance of imaging modalities in biology is evident

93 ition for glucose between host and pathogen; significance of infection-induced anorexia; and redefini

94 used iteratively to define the physiological significance of key components and informing targeted fu

95 of type 1 diabetes; however, the physiologic significance of low levels of detectable C-peptide is no

96 The clinical significance of low-titer cryptococcal antigen (CrAg) by

97 ted to an ongoing debate over the ecological significance of lysogeny and other viral life strategies

98 Interpretation of the significance of maternally inherited X chromosome varian

99 The clinical significance of measurement discrepancies was evaluated

100 rnative approach to interpret the functional significance of noncoding somatic mutations in promoting

101 compartmental mask, corroborating biological significance of our annotation of the chromatin compartm

102 We discuss the biological significance of our observation in relation to the aptit

103 The significance of our research is in identifying that the

104 The significance of our research is the demonstration that e

105 The regulatory dynamics and functional significance of putative aging-related heterogeneity are

106 rican strains which conclusively support the significance of recombinations in the serotype-specific

107 The significance of sensory neuron targeting was pursued sub

108 th a brief introduction to contextualize the significance of smart textiles in light of the emerging

109 ) of the mixing process and demonstrated the significance of specific macromolecular interactions tha

110 continuously evolving notions regarding the significance of spontaneous neural activity.

111 The functional significance of such orderly patterning is unknown.

112 (6)A patterns, and we discuss the biological significance of such regulation.

113 In order to address the functional significance of the 'off' component of the proposed mech

114 sults presented here highlight the potential significance of the architecture of GalNAc conjugation f

115 This study underlines the significance of the density, spatial distribution, and g

116 The biological significance of the DHTKD1-encoded 2-oxoadipate dehydrog

117 In this review, we highlight the significance of the EC as a major player in memory proce

118 n this study, we investigated the functional significance of the HCND.

119 radical were used to investigate the kinetic significance of the hydrogen atom abstraction.

120 test was employed to compute the statistical significance of the improvement in performance observed

121 However, the clinical significance of the kidney's clearance of tubular secret

122 The overall significance of the resulting statistic is evaluated usi

123 Users can investigate functional significance of their genetic alterations across samples

124 elucidating the physiological and ecological significance of these biogenic small molecules.

125 The functional significance of these components in ETI was confirmed by

126 ted tissue damage let us test the functional significance of these effects.

127 The in vivo significance of these exosomes was demonstrated by stere

128 The significance of these features remains unclear.

129 to LDL particles; however, the physiological significance of this interaction remains unknown.

130 tein in CHIKV HVD and defined the biological significance of this interaction.

131 To test the behavioral significance of this MSDB-MHb endocannabinoid signaling,

132 We elucidate the significance of this new culture medium for chronic dise

133 Recent studies suggested the significance of throat and salivary glands as major site

134 This study highlights the significance of understanding and optimizing the effects

135 inally, a discussion on the perspectives and significance of using metal complexes as ER stress-induc

136 es on the matrix and explores its functional significance on chemotactic cell migration.

137 t its taxonomic affinities and its potential significance on our understanding of cetacean brain evol

138 of which reach family-wise error rate (FWER) significance (p < 1.25E-06).

139 dditional loci were identified at suggestive significance (P < 10(-6)): 1q31, 5q23, 6q15, 6q21, 8p21,

140 crease didn't reach the level of statistical significance (P = 0.061).

141 vs. 3%), but it failed to reach statistical significance (P = 0.167).

142 Of clinical significance, patients diagnosed with Chagas disease, ei

143 with the reproductive subtype at genome-wide significance (PRDM2/KAZN, P = 2.2 x 10-10; IQCA1, P = 2.

144 Animal migrations are of global ecological significance, providing mechanisms for the transport of

145 lithium-exposed with unexposed pregnancies, significance remained for any malformation (exposure dur

146 to Intermediate or High (P < 0.001) and this significance remained in multivariable analysis (CCS Int

147 BionoiNet also computes significance scores of pocket atoms, called BionoiScores

148 n of the standard deviations and statistical significance shown in Figure 6 which are not supported b

149 IV/AIDS Program Special Projects of National Significance (SPNS).

150 tion of the thalamic relay for those signals.SIGNIFICANCE STATEMENT A corollary discharge (CD) circui

151 PFC and its control of behavioral responses.SIGNIFICANCE STATEMENT A developmental disruption of pre

152 and transfer of abstract control structures.SIGNIFICANCE STATEMENT A fundamental and defining featur

153 stinct stages in the mammalian visual system.SIGNIFICANCE STATEMENT Abnormal binocular vision and red

154 adding representation of broad task context.SIGNIFICANCE STATEMENT Achieving one's goals requires kn

155 tifaceted role in socially adaptive learning.SIGNIFICANCE STATEMENT Adaptively navigating social inte

156 tic and motivational variables are discussed.SIGNIFICANCE STATEMENT Agency is a central concept in ph

157 consumption of ethanol and palatable fluids.SIGNIFICANCE STATEMENT Alcohol use disorder (AUD) is a m

158 nd smoking-related diseases in human smokers.SIGNIFICANCE STATEMENT Allelic variation in CHRNA3, whic

159 l hypothalamic-brainstem instinctive network.SIGNIFICANCE STATEMENT Although behavioral responses to

160 intracellular observations in these synapses.SIGNIFICANCE STATEMENT Although synaptic dynamics have b

161 takeover supports intact whisker processing.SIGNIFICANCE STATEMENT Amputation, peripheral injury, an

162 tures represented in other neural structures.SIGNIFICANCE STATEMENT An effective threat anticipation

163 ilization of different underlying mechanisms.SIGNIFICANCE STATEMENT Associating relevant target stimu

164 changes in early visual processing in cortex.SIGNIFICANCE STATEMENT Attention is our ability to focus

165 so for high-level object attention in humans.SIGNIFICANCE STATEMENT Attention is the cognitive functi

166 s a function of the level of vesicle release.SIGNIFICANCE STATEMENT Auditory information is encoded b

167 er cognitive ability during late adolescence.SIGNIFICANCE STATEMENT Brain tissue iron is essential to

168 d transmitting retrieved spatial information.SIGNIFICANCE STATEMENT By recording from the human media

169 a prominent role in the development of CIPS.SIGNIFICANCE STATEMENT Calcineurin inhibitors are immuno

170 f astrocytes in brain information processing.SIGNIFICANCE STATEMENT Cardiorespiratory reflexes mainta

171 ffects produced by mu-opioids within the OFC.SIGNIFICANCE STATEMENT Considering that both the orbitof

172 for stress-related disorders like depression.SIGNIFICANCE STATEMENT Depression and other mental disor

173 g this process on sensory and motor circuits.SIGNIFICANCE STATEMENT Disrupted mitochondrial transport

174 fort associated with extraneous task demands.SIGNIFICANCE STATEMENT Domain-general executive processe

175 uring reinstated cocaine by drug-paired cues.SIGNIFICANCE STATEMENT Drug-associated cues precipitate

176 and possibly recruiting different mechanisms.SIGNIFICANCE STATEMENT Early-life stress (ELS) induces l

177 population representation of visual stimuli.SIGNIFICANCE STATEMENT Electrophysiological signals capt

178 gainst the pathologic actions of Abeta in AD.SIGNIFICANCE STATEMENT Elevated levels of beta-amyloid (

179 us-action mappings must be retained and used.SIGNIFICANCE STATEMENT Everyday life requires flexibilit

180 NAc in depression and stress susceptibility.SIGNIFICANCE STATEMENT Existing studies focus on excitat

181 g, spatial judgments, and visual exploration.SIGNIFICANCE STATEMENT Focal damage to the right cerebra

182 o-learn) and to make reward-guided decisions.SIGNIFICANCE STATEMENT Frontal neural networks and the t

183 the size of the RRP contributes to PF-PC LTP.SIGNIFICANCE STATEMENT G-protein-coupled receptors modul

184 esolved harmonics along the auditory pathway.SIGNIFICANCE STATEMENT Harmonic complex tones are ubiqui

185 ly within trials and proactivity across them.SIGNIFICANCE STATEMENT Healthy human behavior requires t

186 ression of tuberal hypothalamic neurogenesis.SIGNIFICANCE STATEMENT Here, we investigated the general

187 f pain generated by nociceptor sensitization.SIGNIFICANCE STATEMENT High-molecular-weight-hyaluronan

188 estructuring memory representations in vmPFC.SIGNIFICANCE STATEMENT How new experiences are transform

189 even interfere with the exploitation thereof.SIGNIFICANCE STATEMENT Human visual perception is determ

190 t on previously extracted low-level features.SIGNIFICANCE STATEMENT In a single fixation, we glean en

191 at will process similar frequencies of sound.SIGNIFICANCE STATEMENT In developing sensory systems, gr

192 temporal and reward structure into decisions.SIGNIFICANCE STATEMENT In everyday life, decisions are i

193 o representations that guide motor responses.SIGNIFICANCE STATEMENT In our natural environment, our s

194 gait and balance, and to prevent falls in PD.SIGNIFICANCE STATEMENT In persons with Parkinson's disea

195 tively different kinds of visual information.SIGNIFICANCE STATEMENT In this article, we characterize

196 account for attentional atypicalities in ASD.SIGNIFICANCE STATEMENT Individuals with autism spectrum

197 d hypothalamic glutamate-dependent signaling.SIGNIFICANCE STATEMENT Inflammation is critical for the

198 temporal coordination of circadian behaviors.SIGNIFICANCE STATEMENT Ion channels are transmembrane pr

199 effective target for beta-based adaptive DBS.SIGNIFICANCE STATEMENT It is known that subthalamic nucl

200 d by unwanted memories of distressing events.SIGNIFICANCE STATEMENT It is typically assumed that forg

201 cognitive systems according to task demands.SIGNIFICANCE STATEMENT It is well established that the h

202 timize discrimination of particular odorants.SIGNIFICANCE STATEMENT Lateral inhibition is a key featu

203 y people learn less from observing outgroups.SIGNIFICANCE STATEMENT Learning from observing others is

204 e the capacity to regenerate OE cells ceases.SIGNIFICANCE STATEMENT Little is known about signals tha

205 processes related to attentional reorienting.SIGNIFICANCE STATEMENT Localizing a touch in space requi

206 -induced impairment of dopamine transmission.SIGNIFICANCE STATEMENT Manganese is a trace element crit

207 ional integrity and localization to synapses.SIGNIFICANCE STATEMENT Menkes and Wilson disease affect

208 ction selectivity in carnivores and primates.SIGNIFICANCE STATEMENT Motion perception is vital for na

209 e type of cerebellar nuclei neurons targeted.SIGNIFICANCE STATEMENT Motor coordination and skilled mo

210 o understand even seemingly simple behaviors.SIGNIFICANCE STATEMENT Motor-guided sensation and percep

211 The sex of animal subjects is unknown.SIGNIFICANCE STATEMENT Nestin, an intermediate filament

212 ool to investigate its underlying mechanisms.SIGNIFICANCE STATEMENT Neural correlates of object recog

213 n in epilepsy and other neurologic disorders.SIGNIFICANCE STATEMENT Neuroinflammation is thought to h

214 ng by orchestrating OB inhibitory activities.SIGNIFICANCE STATEMENT Neuronal morphology and organizat

215 ding GPCR signaling in other neural circuits.SIGNIFICANCE STATEMENT Neurotransmitters signal through

216 used by NMDAR interneuron hypofunction alone.SIGNIFICANCE STATEMENT NMDAR hypofunction in cortical in

217 conditions, leading to pain hypersensitivity.SIGNIFICANCE STATEMENT Noxious stimuli are detected by t

218 tend beyond the network that was manipulated.SIGNIFICANCE STATEMENT Olfaction guides the behavior of

219 working memory coding in prefrontal circuits.SIGNIFICANCE STATEMENT Ongoing delay activity of prefron

220 rd and relapse than MORs on VTA GABA neurons.SIGNIFICANCE STATEMENT Opioid reward has long been belie

221 re different types of memories are retrieved.SIGNIFICANCE STATEMENT Our ability to remember ranges fr

222 abitual fashion by a diverse set of measures.SIGNIFICANCE STATEMENT Our research expands the literatu

223 odulating the pain process at the RAIC level.SIGNIFICANCE STATEMENT Oxytocin is a neuropeptide involv

224 bilities for future therapeutic intervention.SIGNIFICANCE STATEMENT Parkinson's disease (PD) prevalen

225 logy described in different mental disorders.SIGNIFICANCE STATEMENT Parvalbumin-expressing (PV+) inte

226 ls with stress- and trauma-related disorders.SIGNIFICANCE STATEMENT Patients with post-traumatic stre

227 sociated with degraded attentional selection.SIGNIFICANCE STATEMENT People with age-related sensorine

228 unchosen options are by the sensory evidence.SIGNIFICANCE STATEMENT Perceptual decisions require conv

229 isms in shaping responses of individual ANFs.SIGNIFICANCE STATEMENT Phase locking of auditory-nerve-f

230 ine the differentiation of neuronal subtypes.SIGNIFICANCE STATEMENT Predisposition to anxiety disorde

231 enting multiple stimuli in the visual cortex.SIGNIFICANCE STATEMENT Previous studies have shown that

232 ble representations under certain conditions.SIGNIFICANCE STATEMENT Prior work suggested that age-rel

233 tions and recollection of source information.SIGNIFICANCE STATEMENT Recalling past events with detail

234 uting to stress-induced cognitive impairment.SIGNIFICANCE STATEMENT Repeated exposure to stress profo

235 d by a "lonelier" neural self-representation.SIGNIFICANCE STATEMENT Social connection is critical to

236 o enhance neurite outgrowth and regeneration.SIGNIFICANCE STATEMENT SORLA is a transmembrane traffick

237 cular regulation and immunity long after SCI.SIGNIFICANCE STATEMENT Spinal cord injury (SCI) signific

238 r circuit to improve the SMA motor phenotype.SIGNIFICANCE STATEMENT Spinal muscular atrophy (SMA) is

239 neutrophil trafficking to the CP and cortex.SIGNIFICANCE STATEMENT Stroke during the neonatal period

240 granularity may promote memory stabilization.SIGNIFICANCE STATEMENT Studying hippocampal maturation c

241 l activity with excitatory neurotransmission.SIGNIFICANCE STATEMENT Synaptic AMPARs are critical for

242 ur interaction with unfolding sensory events.SIGNIFICANCE STATEMENT Temporal expectation enhances per

243 ween selective processing and gamma-activity.SIGNIFICANCE STATEMENT The ability to focus on the behav

244 s an alternative pathway to refine PC output.SIGNIFICANCE STATEMENT The brain can adapt to varying de

245 be reverted by CB1r manipulation at the SNr.SIGNIFICANCE STATEMENT The cannabinergic system has been

246 ssociated with cerebellum-dependent learning.SIGNIFICANCE STATEMENT The cerebellum contributes to mov

247 at the first stage of cerebellar processing.SIGNIFICANCE STATEMENT The cerebellum plays a key role i

248 as well as functional recovery in adulthood.SIGNIFICANCE STATEMENT The decline of cortical plasticit

249 nt of disorders involving memory impairments.SIGNIFICANCE STATEMENT The dentate gyrus (DG) is importa

250 or define a not yet identified human disease.SIGNIFICANCE STATEMENT The development of novel therapie

251 ly limits its use to unidirectional circuits.SIGNIFICANCE STATEMENT The discovery of anterograde tran

252 ening of transcortical developmental signals.SIGNIFICANCE STATEMENT The endogenous cannabinoid system

253 bfields, in line with computational theories.SIGNIFICANCE STATEMENT The flexibility of episodic memor

254 ormation of neural connectivity in the brain.SIGNIFICANCE STATEMENT The formation of interstitial axo

255 space during a symbolic categorization task.SIGNIFICANCE STATEMENT The hippocampal formation and the

256 er direct experimental data become available.SIGNIFICANCE STATEMENT The hippocampal formation is a cr

257 lity throughout fear learning and extinction.SIGNIFICANCE STATEMENT The hippocampus contains place ce

258 eneration of memory-related network dynamics.SIGNIFICANCE STATEMENT The hippocampus is a part of the

259 EGCs than analogous interneurons in the MOB.SIGNIFICANCE STATEMENT The mouse accessory olfactory sys

260 nd nearly 140 cell types in the mouse retina.SIGNIFICANCE STATEMENT The mouse retina is a leading mod

261 pact on their function in health and disease.SIGNIFICANCE STATEMENT The neuropeptide VGF and its pept

262 n of facilitated glutamate neurotransmission.SIGNIFICANCE STATEMENT The postsynaptic ion and metaboli

263 to opioid seeking after voluntary abstinence.SIGNIFICANCE STATEMENT There are few preclinical studies

264 tion on the CNS sympathetic control circuits.SIGNIFICANCE STATEMENT There is evidence suggesting that

265 beta bursts to speed up movement initiation.SIGNIFICANCE STATEMENT This double-blind sham-controlled

266 in motivational behavior between individuals.SIGNIFICANCE STATEMENT This project serves to determine

267 ated stimuli following acute stress exposure.SIGNIFICANCE STATEMENT This study in rats shows that a s

268 unctional muscle recovery after nerve injury.SIGNIFICANCE STATEMENT This work demonstrates beneficial

269 vels over 24 h, in an RBM3-dependent fashion.SIGNIFICANCE STATEMENT This work is important in several

270 uniform downscaling on the presynaptic side.SIGNIFICANCE STATEMENT To date, compensatory adaptations

271 ating global percepts from separate features.SIGNIFICANCE STATEMENT To generate coherent percepts, se

272 treat cognitive deficits associated with MS.SIGNIFICANCE STATEMENT To identify the neural substrates

273 levels require attention and task relevance.SIGNIFICANCE STATEMENT To react to potentially important

274 r, ensuring long-term photoreceptor survival.SIGNIFICANCE STATEMENT Visual arrestin-1 forms dimers an

275 an important role for behavioral flexibility.SIGNIFICANCE STATEMENT We can flexibly adapt our behavio

276 ithout the need for an oscillatory generator.SIGNIFICANCE STATEMENT We examine how coherent neuronal

277 non-homeostatic paradigm of sleep regulation.SIGNIFICANCE STATEMENT We show that the complex micro-ar

278 ways in which they change across adolescence.SIGNIFICANCE STATEMENT Working memory is a foundational

279 tion, some of our findings may have clinical significance, such as the utility of the pyrimidine (ura

280 M) and monoclonal gammopathy of undetermined significance, suggesting that it is therapy independent.

281 tions of myosin variants of unknown clinical significance that were identified in patients with HCM,

282 Of equal significance, the premises underlying the TOFT offer new

283 In the view of physiological significance, the transition-metal-mediated routes for n

284 Despite their frequency and clinical significance, there is a paucity of randomised, placebo-

285 r new synthetic lethal combination therapies.Significance: These findings highlight agents that targe

286 eventing HCC development in at-risk patients.Significance: These findings provide a novel mechanism r

287 ng yet another mechanism of 53BP1 regulation.Significance: This study provides a novel mechanism of 5

288 dular trichomes of N. tabacum are of pivotal significance to be undertaken.

289 tal asymptomatic finding of limited clinical significance to multiple painful episodes of ureteral ob

290 n of a KCNQ1 variant from variant of unknown significance to pathogenic.

291 ncremental steps, but attributing biological significance to their G protein signalling function stil

292 gm, and progress toward ascribing regulatory significance to this widespread post-translational modif

293 t 18 priority research topics based on their significance, urgency, technical and economic feasibilit

294 individual to date are variants of uncertain significance (VUSs).

295 s of the SSIM were reported, and statistical significance was determined by using the Wilcoxon signed

296 No statistical significance was found on the distance between implant s

297 Level of significance was set at P < 0.05.

298 In testing for causal significance, we found that rhythmic optogenetic activat

299 Similar patterns of variable statistical significance were present within sex and race/ethnic gro

300 concept of monoclonal gammopathy of clinical significance, which can have a large spectrum of manifes