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1 of symptoms was 12.8 years (SD: 15.3), a non-significant reduction of 0.6 years (95% CI: -2, 0.8; p-v
3 d nonstimulant medications led to clinically significant reductions of 14.93 to 24.60 absolute points
5 ed sample study demonstrated a statistically significant reduction of 40% in 24 h BC concentrations w
7 (0.90) in the placebo group, representing a significant reduction of 68% (difference -2.75 dB, 95% C
8 meters compared with baseline and promoted a significant reduction of A. actinomycetemcomitans and P.
9 istration at the pre-amyloid stage, led to a significant reduction of Abeta deposition and downstream
10 eed to be genetically inactivated to cause a significant reduction of activity-evoked release at two
11 erm sustained weight loss is associated with significant reduction of AF burden and maintenance of si
12 ction of liver inflammation accompanied by a significant reduction of alanine aminotransferase levels
14 n therapy with defibrillators demonstrated a significant reduction of all-cause mortality when compar
15 Micro-computed tomography analysis showed significant reduction of alveolar bone loss in the CCL2
16 treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compa
17 mitral valve (MV) annular geometry, we found significant reduction of anterior-posterior (-0.31 +/- 0
19 ables controlled CAR dimerization and (ii) a significant reduction of antigen-binding affinities to i
23 can children had a normal FEV1/FVC ratio but significant reductions of approximately 0.5 z-scores ( a
24 ts addition, at higher level tested (25%): a significant reduction of around 30% for yoghurt bread an
25 The combination of VMI and MAR facilitates a significant reduction of artifacts adjacent to intracran
27 pocampus and cortex, respectively, induced a significant reduction of BACE1 substrates processing and
28 SP-A/SP-B(N)-treated infected mice showed significant reduction of bacterial burden, enhanced neut
29 best compound (13a) was as low as 4 nM with significant reduction of bacterial resistance to the com
31 Bland-Altman analyses revealed a clinically significant reduction of bias when results were reported
34 ative anti-TNF therapy was associated with a significant reduction of both 12-month risks of endoscop
35 n of synapses as its depletion resulted in a significant reduction of both NMDA receptor (NMDAR) and
36 or its downstream target Mxi1 resulted in a significant reduction of c-Myc and Id1 ( approximately 7
38 h DES was safe but was not associated with a significant reduction of cardiac events at 3-year follow
39 ctosamine in T. cruzi-infected mice led to a significant reduction of cardiac fibrosis and inflammati
41 d the role of ccf-mtDNA in PD, identifying a significant reduction of ccf-mtDNA in PD patient cerebro
43 is of tumor-infiltrating leukocytes revealed significant reduction of CD8(+) T cells in the tumors of
46 ared to supplementation, which resulted in a significant reduction of cell growth and loss of phenoty
48 electrospray (ESI)-FTICR is supported by the significant reduction of chlorophyll and its related met
49 ement in endothelial function accompanied by significant reduction of circulating intercellular adhes
52 more, the most active ColH inhibitor shows a significant reduction of collagen degradation in an ex v
53 rway epithelial cell line model demonstrated significant reduction of cytokine expression relevant to
56 ues above these thresholds could result in a significant reduction of decomposition and mineralizatio
57 n shown that a similar program resulted in a significant reduction of delirium incidence and duration
59 wly discovered protease inhibitors yielded a significant reduction of dengue and West Nile virus tite
60 eatment with ezogabine, subjects exhibited a significant reduction of depressive symptoms (Montgomery
62 nd anti-LTB antibody responses and conferred significant reduction of diarrhea compared to phosphate-
64 the Src kinase inhibitor PP2 resulted in the significant reduction of disinhibited synaptic currents
66 eukotriene receptor antagonism resulted in a significant reduction of early, diabetes-induced retinal
67 PP transgenic mice treated with NIR showed a significant reduction of endogenous Abeta at CNS synapse
68 on of nonrisk allele promoter activity and a significant reduction of endogenous GUCY1A3 expression.
69 cedent hypoglycemia with placebo resulted in significant reductions of epinephrine, norepinephrine, g
70 PET/CT and whole-body SPECT/CT resulted in a significant reduction of equivocal readings compared wit
71 he intronic mutation, showed a statistically significant reduction of exon X-containing Cep290 transc
72 ent with an anti-Neo1 antibody resulted in a significant reduction of experimental hepatic ischemia a
75 consequence of the frameshift variant and a significant reduction of expression was also observed in
77 trated a synergistic loss of body weight and significant reductions of fat mass, blood glucose, and l
79 or at both 3,13-positons of chlorin exhibit significant reduction of fluorescence in polar solvents.
80 d after digestion of fortified bread and the significant reduction of free amino groups confirm the p
82 of TDP-43-induced proteinopathy, there is a significant reduction of futsch mRNA at the NMJ compared
83 of avacincaptad pegol 2 mg and 4 mg led to a significant reduction of GA growth in eyes with AMD over
85 sociation due to osmotic stress results in a significant reduction of Galphaq/phospholipase Cbeta-med
86 demonstrate that Smox-deficient mice exhibit significant reductions of gastric spermidine levels and
87 nts who underwent deferoxamine therapy had a significant reduction of GLC (from 0.64 mug/g +/- 0.29 t
88 T2 or SETDB1 in growing oocytes and achieved significant reduction of global H3K9me2 or H3K9me3 level
91 deletion of both Nap1 and Chz1 resulted in a significant reduction of H2A.Z deposition at promoters a
92 found DNA motifs at particular loci and the significant reduction of H3K27ac levels validated the re
93 that the sdg8 deletion is associated with a significant reduction of H3K36me3, preferentially toward
95 r an in vivo model of angiogenesis, showed a significant reduction of haemoglobin content (54.2%) in
97 od cells from affected individuals exhibited significant reductions of HES1 and NOTCH3 expression ref
100 gitudinal study showed that cART resulted in significant reductions of HIV-specific effector antibody
101 sing a polarized microscope, demonstrating a significant reduction of ice crystal size induced by CCH
102 nsive BP treatment was not associated with a significant reduction of ICH expansion (relative risk, 0
106 case load and growing expertise, there was a significant reduction of in-hospital mortality to 4.8% (
107 2 month follow-up, YAM was associated with a significant reduction of incident suicide attempts (odds
112 btaining the ultralong PK profile was also a significant reduction of insulin receptor affinity.
113 techniques, but both techniques resulted in significant reduction of interface fluid during the proc
115 silencing the human gene TRAM2 resulted in a significant reduction of intracellular bacterial load wh
117 reatment for 3 months may be associated with significant reduction of IPA without influencing mortali
118 443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and R
119 evodopa challenge, 5 mg eltoprazine caused a significant reduction of L-DOPA-induced dyskinesias on a
122 ssigned to omega-3 fatty acids experienced a significant reduction of left ventricular systolic volum
125 runcated version of EXP-1 resulted in both a significant reduction of liver burden and delayed blood-
126 ) carbon tetrachloride-treated mice showed a significant reduction of liver fibrosis compared to carb
128 e mosquito bite challenge, leading to a more significant reduction of liver-stage burden and even a l
135 the corresponding yeast mutation result in a significant reduction of m(7)G46 methylation of specific
136 rthritis, where this biased agonist afforded significant reduction of macroscopic and histological pa
137 different capacities allowed elimination or significant reduction of manpower, labor, and time with
143 act-based spatial statistics analysis showed significant reductions of mean diffusivity within the wh
146 H. pylori eradication was associated with a significant reduction of miR-124a-3 methylation only in
147 ltiple localizations is associated with more significant reduction of mortality and dementia than a s
148 e severity subgroup meta-analysis revealed a significant reduction of mortality in the intermediate-
149 phenotypic correction was associated with a significant reduction of mutant Krt75 mRNA in the skin g
150 functional mitral regurgitation experienced significant reduction of MV annular dimensions, which wa
151 validate the efficacy, but it did not show a significant reduction of myocardial ischemia and angina
155 th the Ro5-3335 small molecule resulted in a significant reduction of neovascular tufts in oxygen-ind
156 of MTA biomass in the field was linked to a significant reduction of net C uptake (-13%) of the enti
161 se models, overexpression of Sox2 leads to a significant reduction of Notch1 and Notch2 transcripts,
162 extracellular domain mutations, we observed significant reduction of NOTCH1 expression, suggesting i
165 ant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group
166 ive organ development in males, resulting in significant reduction of oviposition periods and fecundi
167 A promoter, and KDM5B knockout resulted in a significant reduction of P110alpha and PIP3 levels and s
168 of patients with multiple sclerosis showed a significant reduction of P2RY12, a marker expressed in h
169 ates the WNT/calcium pathway associated with significant reduction of p38-MAPK (p38-mitogen-activated
171 monstrated CNS penetration in a PK study and significant reduction of parasitemia in four out of the
172 Reformulated OxyContin was associated with a significant reduction of past-month abuse after its intr
176 quent professional prophylaxis brought about significant reduction of plaque and resolution of gingiv
177 polyinosinic:polycytidylic acid and found a significant reduction of plaque size in NK-cell-deficien
178 sion inflammatory cell accumulation, we find significant reductions of plasma and AAA lesion IL6 expr
179 ministration of intravenous LA resulted in a significant reduction of platelet reactivity compared wi
181 te-induced macrophage depletion results in a significant reduction of portal fibrosis and portal hype
183 with the benzimidazole inhibitor exhibited a significant reduction of pristane-dependent induction of
185 ed central and effector T cell memory, and a significant reduction of pro-tumorigenic M2 macrophages.
186 MHCII deficiency in pDCs was associated with significant reductions of proatherogenic T cell-derived
187 l apheresis in patients with AD, there was a significant reduction of proinflammatory lipids, circula
189 n mice results in myelination defects with a significant reduction of protein levels of proteolipid p
190 odies prevent and reverse PH in rats through significant reduction of pulmonary arterial inflammation
192 owder diffraction and FTIR analyses showed a significant reduction of QC crystallinity upon formulati
193 Stress-CMR strategy was associated with a significant reduction of radiation exposure and cumulati
194 ocalization in the cytoplasm, thus mediating significant reduction of RAS-GTP levels and of cell clon
195 and prevents dystrophic pathology through a significant reduction of regeneration, necrosis and fibr
196 ntral striatum) showed significant or nearly significant reductions of regional binding potential in
197 Repeated administration of A-705253 caused significant reductions of relapse-like excessive alcohol
199 e to either AMD or DME comorbidity, showed a significant reduction of RGC axon fiber layer thickness,
200 confirmed for 12 SQ-HDM, with statistically significant reductions of rhinitis symptoms and medicati
202 elated optic neuropathy in AD by OCT, with a significant reduction of RNFL thickness (p = 0.038), mor
203 uce disease symptomology of RKNs in vivo via significant reduction of root-galls on tomato (Solanum l
205 eizure outcome was estimated on the basis of significant reduction of seizure frequency at the first
206 ariant scoring problems, thus resulting in a significant reduction of sensitivity and precision.
208 increased recipient survival and resulted in significant reduction of serum transaminases, bilirubin,
209 fecal metabolome of EF-fed infants showed a significant reduction of several metabolites including l
210 er tonne of suspended solids treated, with a significant reduction of sludge mass (80% reduction of w
212 increase in crumb hardness at time 0 while a significant reduction of staling was observed only at 5d
214 hree-dimensional reconstructions uncovered a significant reduction of stem cell niches and progenitor
215 In addition, PCP-treated animals showed a significant reduction of striatal A(2A)R-D(2)R heteromer
216 ownstream FAK/Akt signaling concomitant with significant reduction of stromal invasion and spontaneou
217 ptin-resistant diet-induced obese mice, show significant reductions of sympathetic innervation of sub
218 eemed their interventions as successful with significant reduction of symptoms irrespective of AF.
220 unction and hyaloid vasculature, we observed significant reduction of talin1 expression, a regulator
221 g, the tax was associated with statistically significant reductions of taxed beverage purchases at 3
223 with overexpression of dFMRP resulting in a significant reduction of TDP-43 in the aggregate fractio
225 ith ongoing islet autoimmunity resulted in a significant reduction of TFH precursors in peripheral bl
226 aralogs in Nicotiana benthamiana resulted in significant reduction of TGB1 accumulation in the nucleu
227 The spin transition is associated with a significant reduction of the aggregate VP/VS via the agg
228 ior to 3-AP and 3-AP-Me treatment leads to a significant reduction of the antiproliferative propertie
229 iet, Gucy1a3(-/-)/Ldlr(-/-) mice exhibited a significant reduction of the atherosclerotic plaque size
232 for catalytic activation, since it allows a significant reduction of the barrier of the initial (and
233 ding to Scheimpflug-based CATCRP result in a significant reduction of the CAant and CATCRP, but do no
234 n of myocardial FA uptake in atATGL-KO and a significant reduction of the cardiac hypertrophic respon
236 with state-of-the-art algorithms and with a significant reduction of the computational complexity.
237 by suppression of leukemic cell growth and a significant reduction of the doxorubicin IC50 value.
238 AMs on the electrode surface, resulting in a significant reduction of the electron transfer resistanc
239 human kallikrein 5 transgenic mouse revealed significant reduction of the global proteolytic activity
240 ia additional ethenylene linker results in a significant reduction of the HOMO-LUMO gap and an enhanc
241 tein signal, to normalize the spectra allows significant reduction of the impact of measurement-to-me
242 rug resistance that can be associated with a significant reduction of the intracellular platinum conc
243 tion of CPU-GPU processing, which leads to a significant reduction of the likelihood calculation time
245 e O1 antigen of C. turicensis cells caused a significant reduction of the membrane potential which is
248 The placebo group, in contrast, displayed a significant reduction of the N400 repetition effect afte
249 LOD) of 10 ng/mL (400 pM), attributed to the significant reduction of the net charge of JR2EC upon di
251 valirudin regimen remained associated with a significant reduction of the primary endpoint after mult
253 cit is likely caused, at least in part, by a significant reduction of the radial processes projecting
255 onses against individual ebolaviruses and no significant reduction of the responses compared to that
256 In hospitalized adults with Covid-19, no significant reduction of the risk of unfavorable outcome
257 erebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum
258 C activity by bile acids is accompanied by a significant reduction of the single-channel current ampl
259 Such arrangement is accompanied by a very significant reduction of the source temperature, in prin
260 d across all cornea layers and resulted in a significant reduction of the targeted protein expression
262 e and can achieve favourable outcomes with a significant reduction of the treatment burden compared t
263 use models, 4LB5 administration results in a significant reduction of the tumor volume without eviden
264 We attribute the improved emission to a significant reduction of the work function rather than a
266 he planar 2,2'-biaceanthrylene system showed significant reductions of the optical gaps (1 eV) and re
269 nd whey protein concentrate contributed to a significant reduction of their immunoreactive epitopes.
270 and knockdown mutants of these genes showed significant reduction of their root elongation response
272 ite in the human T cell line CEM demonstrate significant reduction of TNF and LTA mRNA synthesis and
273 s a model system, we show that MDP induced a significant reduction of total and mitochondrial reactiv
274 ardiac output optimization protocol led to a significant reduction of total isovolumic time with conc
280 armacokinetic properties, and demonstrates a significant reduction of tumor growth in vivo on A375 xe
282 commercially processed and prepared foods, a significant reduction of US sodium intake could occur.
283 concerns regarding overuse of OPs, allowing significant reduction of use without compromising effica
284 n affected-female-derived fibroblasts showed significant reduction of USP9X level, confirming the los
285 ubglottic secretion suctioning resulted in a significant reduction of ventilator-associated pneumonia
291 oximal external region peptides) resulted in significant reduction of virus neutralization, suggestin
293 ubjects, HCMV+ subjects in sample 1 showed a significant reduction of volume in six regions (p(uncorr
294 t not the duration of stimulation, induced a significant reduction of volume in the caudate, pallidum
295 suggested that nhx5 nhx6 knockouts showed a significant reduction of VSR binding to both cargoes.
296 s with VT recurrence, CA still resulted in a significant reduction of VT burden, with 31 (53%) patien
297 tients with VT recurrences, CA resulted in a significant reduction of VT burden, with 8 (50%) having
298 s with IP linTT1-D(KLAKLAK)2-NWs resulted in significant reduction of weight of peritoneal tumors and
299 With this small sample size, we observed significant reduction of white blood cell and absolute l