ライフサイエンスコーパス: silence

1 In the presence of the target the probe is "silenced".

2 se have been shifted to ectopic locations or silenced.

3 ntary motion detector neurons T4 and T5 were silenced.

4 ties that are either complement competent or silenced.

5 s regarding their recruitment and role in Xi silencing.

6 appaB Relish expression was increased by osa silencing.

7 stance results from heterochromatin-mediated silencing.

8 modification, which is associated with gene silencing.

9 vide a powerful system for studying Polycomb silencing.

10 ritical is the process of gene repression or silencing.

11 synthetic transacting siRNA vectors for gene silencing.

12 g small non-coding RNA (ncRNA) mediated gene silencing.

13 that are related to both gene activation and silencing.

14 ing for heterochromatin maintenance and gene silencing.

15 irion pp71 levels reduce fitness but promote silencing.

16 e mechanisms involved in its transcriptional silencing.

17 omatin-modifying activities involved in gene silencing.

18 lipolysis, and impairment of GSIS after ATGL silencing.

19 ational epigenetic inheritance (TEI) of gene silencing.

20 for sustained, long-term gene expression or silencing.

21 mation that is thought to contribute to gene silencing.

22 n unanticipated mechanism for heritable gene silencing.

23 the transcription machinery, leading to its silencing.

24 nd guide Argonaute proteins to mediate their silencing.

25 mutations result in impaired shRNA-mediated silencing.

26 or piRNA-directed TE de novo methylation and silencing.

27 chromosome inactivation prevents biallelic X silencing.

28 an ancestral role of this mark in transposon silencing.

29 al Argonaute that are both required for gene silencing.

30 ed genes, in contrast, bore the signature of silencing.

31 rovides insights into RNA-mediated chromatin silencing.

32 ograft mouse model showed around 15-20% ITCH silencing 48 hours after transfection.

33 Tx in nonhuman primates (NHPs) (baboons) by silencing a gene (caspase-3) responsible for induction o

34 Silencing adipose triglyceride lipase (ATGL) in human ps

35 identification of MafK as modulator of IRF8 silencing, affecting chromatin architecture.

36 suppression is abolished if DG expression is silenced, again demonstrating the central role of this r

37 s act as single-entity transfection and gene silencing agents and have been used as lead therapeutic

38 ternating 3' U and G nucleotides become gene-silencing agents.

39 rotein combined with TP53 and RB1 transcript silencing alleviated induced arrest in TP53+/+ cells.

40 saw each training object again, presented in silence along with a new object from the same category.

41 ATG7 silencing also reduced thrombin-mediated EC permeability

42 ging, we found that miR-671-5p more potently silenced an axis of CDR1as and its antisense transcript,

43 eral miRNAs and other categories of sRNAs in silenced and overexpression lines, in agreement with its

44 Silencing and chromatin immunoprecipitation experiments

45 scription factor coordinates heterochromatic silencing and male germline maturation.

46 t precludes histone turnover to promote gene silencing and preserve epigenetic stability of heterochr

47 ltransferase that is required for transposon silencing and RNA interference in Caenorhabditis elegans

48 We have identified the gene conferring the silencing and show it to encode a sirtuin-type histone d

49 aset of plants, several rules governing gene silencing, and a series of computational models of the b

50 cal and functional mapping, gene expression, silencing, and editing.

51 Gene silencing approaches confirmed the regulatory role of HI

52 ploits the prosurvival output of transiently silencing APT in the presence of 2-fluoroadenine, thereb

53 Our findings identify LSD1-mediated enhancer silencing as a cell-intrinsic epigenetic feedback mechan

54 cium FLIPR, and short hairpin RNA-based gene-silencing assays.

55 Silencing AVIL nearly eradicated glioblastoma cells in c

56 e upstream Hippo tumor suppressor pathway is silenced, but efforts to pharmacologically inhibit YAP1

57 ransposons and endogenous viral elements are silenced by ADARs [adenosine deaminases acting on double

58 While previously known to be silenced by CHD4, the fetal globin genes are exposed her

59 evels but also increased expression of genes silenced by EZH2, such as E-cadherin, which suppresses e

60 the gene functions, each candidate gene was silenced by injecting the target dsi-RNA to female Cx. p

61 CARM1 promotes MAD2L2 silencing by driving the switch from the SWI/SNF complex

62 ts are suppressed by strong and constitutive silencing by miR159.

63 Greater understanding of gene silencing by promoter hypermethylation in anal carcinoge

64 Gene silencing by RNA interference (RNAi) has emerged as a po

65 ll migration and invasion in vitro, and GBP2 silencing by RNA interference exhibits opposite effects.

66 Likewise, silencing cct2 gene expression by ~50% caused other CCT

67 Galc-silenced cells displayed altered sphingolipid metabolism

68 nical distribution of PRC2 activity and lack silenced chromatin like embryonic progenitors.

69 tion, and defects in G(1)-S progression upon silencing circ-MDM2 Our results on the initial character

70 Finally, MEK5 silencing combined with focal irradiation causes strong

71 component of the miRNA-dependent RNA-induced silencing complex (RISC).

72 the host plant's Argonaute (AGO)/RNA-induced silencing complex for virulence.

73 Target recruitment to RNA-induced silencing complex was assessed by using anti-Argonaute2

74 1 (AGO1; a key component of microRNA-induced silencing complex) as a crucial regulator in hypoxia-ind

75 ce of ATM in miR-181c-associated RNA-induced silencing complex.

76 d thrombopoietin receptor to the RNA-induced silencing complex; downregulated these genes in the lung

77 Silencing components of the complement-like system throu

78 al approaches, including siRNA-mediated gene silencing, confocal microscopy, and subcellular fraction

79 s upstream of the SD, sRNA-mediated enhancer silencing could be a common mode of gene regulation.

80 epidermal differentiation and epigenetically silences critical genes involved in keratinocyte differe

81 his mechanism of suppressing regeneration by silencing damage-responsive enhancers at multiple loci c

82 LincNMR silencing decreases dNTP levels, while exogenous dNTPs r

83 red for piRNA biogenesis but piRNA-dependent silencing: deps-1 mutants fail to produce the secondary

84 of Dnmt3a and Dnmt3b resulted in failure to silence developmental genes.

85 male mice exhibiting RFRP neuron ablation or silencing did not exhibit the stress-induced suppression

86 nal studies with gene-overexpressed and gene-silenced DLBCL cell lines showed that expression of NANO

87 uired for RNAi-mediated post-transcriptional silencing, downstream of small RNA production.

88 of mice to arouse during hypercapnia, as did silencing DR(Sert) terminals in the PBel.

89 occurs when transcription of the FXN gene is silenced due to an excessive expansion of GAA repeats in

90 lement located in its 5' end, to induce gene silencing during X-chromosome inactivation.

91 in foreign genes, bacteria must overcome the silencing effects of H-NS.

92 To maximize the silencing efficacy of gene targets, we created vectors t

93 of the fly's illusory percept by selectively silencing either T4 or T5 neurons.

94 MR had identical cell-cycle requirements for silencing establishment, with no apparent contribution f

95 is and pain, such that ET(A)R activation and silenced ET(B)R expression result in increased carcinoge

96 Polycomb repressive complex 2 (PRC2) silences expression of developmental transcription facto

97 Silencing expression of RNA-directed RNA polymerases RdR

98 example is the conserved bacterial ribosome silencing factor (RsfS) that binds to uL14 protein onto

99 posed of nucleosome arrays that are bound by silencing factors.

100 nciding with the loss of promoter epigenetic silencing factors.

101 ycomb repressive complex 2 to epigenetically silence FLOWERING LOCUS C (FLC) during vernalization, is

102 SAP2 silencing fully restores mortality of the mosquitoes, wh

103 Further, silencing furin reduced tumor cell migration and invasio

104 Polycomb group (PcG) proteins silence gene expression by chemically and physically mod

105 ucleic acids to identify target molecules or silence genes involved in disease pathways.

106 n remodeling of specific loci to permanently silence genes that are not essential for the differentia

107 chment sites correspond to transcriptionally silenced genes with GO enrichment for neuronal function

108 gramming and derepression of developmentally silenced genes.

109 L2A is required to stabilize heterochromatin silencing genome-wide, likely by preventing replicative

110 n GSCs, abundant Pcl inhibits PRC2-dependent silencing globally, while in nurse cells Pcl declines an

111 Silencing glutamate favored goal-directed behaviors and

112 By contrast, overexpressing or silencing GmMYB29A1 decreased glyceollin I accumulation

113 preferentially reduced by anaesthesia and by silencing higher visual areas.

114 assessed the potential of Host-Induced Gene Silencing (HIGS) approach to target the Colletotrichum g

115 rent understanding of this host-induced gene silencing (HIGS) process as a defense mechanism during n

116 EBP1 associates with ribosomes and that EBP1 silencing hinders ribosomal RNA processing.

117 it is shown that, when EZH2 is functionally silenced, HR+, CARM1-high, high-grade serous ovarian can

118 The Human Silencing Hub (HUSH) complex is necessary for epigenetic

119 FOSL1 silencing impaired LPS-induced in vitro HPMEC angiogenes

120 FBP1 is universally silenced in both human and murine liver tumours.

121 etting was revealed when plants individually silenced in their expression (and their binary combinati

122 nerative cell causes reduced heterochromatic silencing in both bicellular and mature pollen.

123 A to Spen and results in strictly local gene silencing in cis.

124 We used 3 human beta cell models (YIPF5 silencing in EndoC-betaH1 cells, YIPF5 knockout and muta

125 mediated gene editing and RNAi-mediated gene silencing in human cells, here we analyzed the consequen

126 Deletion of XRN1 impaired gene silencing in N. castellii, and this impaired silencing w

127 show that H3K27me3 is not required for their silencing in non-2i conditions.

128 es may similarly contribute to germline gene silencing in other organisms.

129 PXN silencing in ovarian cancer mouse models reduced angioge

130 lar movement of these siRNAs to reinforce TE silencing in sperm.

131 Finally, TNFR1 silencing in the PVN inhibits elevated blood pressure in

132 urvival and relevant tumour markers, and its silencing in vivo drastically decreased tumour developme

133 Conversely, its genetic silencing increases melanoma cell proliferation and redu

134 expression and TKI sensitivity, whereas SOX2 silencing induced vimentin, but suppressed BCL2L11, expr

135 atic RNAs, and block spreading of H3K9me and silencing into actively transcribed regions.

136 Silencing is attributed to a 1:1 double stranded (ds) co

137 Our results suggest that PRC2-dependent silencing is developmentally regulated by accessory prot

138 ow that Polycomb Repressive Complex 2 (PRC2) silencing is genetically required by FCA to repress FLC

139 x strands that comprise the SNA lead to gene silencing is not understood.

140 Silencing Klf10 also sensitized primary hepatocytes to a

141 Silencing Lcn2 expression worsens metabolic dysfunction

142 Concomitantly, XPR1 silencing led to intracellular P(i) accumulation and a p

143 ructural analysis revealed that exocyst gene silencing led to the striking appearance of novel electr

144 ns to repurpose powerful antiviral chromatin silencing machinery for sex chromosome dosage compensati

145 DNA methylation is a major silencing mechanism of transposable elements (TEs).

146 anscription factor binding requires specific silencing mechanisms to ensure lineage fidelity.

147 anaphase onset, it must promptly respond to silencing mechanisms.

148 ntimiR to miR-370-3p into heart failure mice silences miR-370-3p and restores HCN4 mRNA and protein a

149 Silencing MMP3 significantly reduced S100A9-mediated cel

150 gene target sequence in tandem with the APT silencing motif.

151 pecies small RNAs are used by host plants to silence mRNAs in pathogens.

152 Here, we show that silencing netrin-1 in the adult substantia nigra of mice

153 ion, using chemogenetic tools to selectively silence newly formed connections in behaviorally recover

154 Silencing NOX1 using NOX1-specific siRNA mitigated radia

155 ar dominance (ND) consists of the reversible silencing of 35S/45S rDNA loci inherited from one of the

156 Strikingly, deletion or epigenetic silencing of an ERV-derived enhancer suppresses cell gro

157 Furthermore, we predict that the silencing of anti-SWR interneurons can trigger SWRs.

158 to decipher mechanisms that drive epigenetic silencing of AP-2gamma target genes are a critical area

159 ion between this epigenetic modification and silencing of Avr1b.

160 exhibits strong dwarfism and cell death, and silencing of both genes via RNA interference also leads

161 D1/5 phosphorylation and gene expression and silencing of CAV-1 and DNM2 diminishes LDL-mediated ALK-

162 itro, both overexpression of mutant COPA and silencing of COPA induced STING-dependent IFN signaling.

163 re-related antigen (HBcrAg) as surrogates of silencing of covalently closed circular DNA (cccDNA), to

164 P2J2 in cardiac cells, we performed targeted silencing of CYP2J2 expression in human adult ventricula

165 Genetic silencing of DCC prodeath activity in a BRAF(V600E) mous

166 cally directed deletion or acute optogenetic silencing of DR(Sert) neurons dramatically increased the

167 However, silencing of DvABCB2 which is highly homologous to DvABC

168 an observation that was confirmed by genetic silencing of EBP.

169 Silencing of eIF3e reduced the intracellular levels of t

170 ot formulations was also demonstrated by the silencing of endogenous genes that encode two subunits o

171 Silencing of endogenous UBR5 induced MYC protein express

172 We propose that PRC2-mediated silencing of enhancers involved in cell differentiation

173 d propose that the developmentally regulated silencing of ESRRB triggers the selective inactivation o

174 Importantly, CRISPR-mediated silencing of Foxp3 transcription, but not protein expres

175 Chemogenetic silencing of GC impaired task performance.

176 portant epigenetic mechanism responsible for silencing of gene expression in animal development and c

177 hrin-dependent using chemical inhibitors and silencing of gene expression.

178 EZH2 expression results in the silencing of genes that suppress tumor formation and met

179 Silencing of H. schachtii ACC by RNAi induced similar ph

180 This mechanism involves the silencing of H3K27me3 writers, activity of H3K27me3 eras

181 cognizes' H3K27me3 specifically and enforces silencing of H3K27me3-demarcated genes in mammalian cell

182 ts for compounding hypermethylation and gene silencing of hemizygous tumor suppressor genes (TSG), we

183 atment ameliorated Th17-induced EAU, whereas silencing of IL-24 in Th17 cells enhanced disease.

184 ge induces L13a/GAIT-dependent translational silencing of inflammatory genes in response to HFD as an

185 Silencing of JMJD2B prevented the EndMT-induced reductio

186 Silencing of JMJD2B reduced TGF-beta2-induced expression

187 Silencing of LAMR abrogated these effects.

188 epended on top-down feedback as chemogenetic silencing of lateral OFC neurons disrupted reversal lear

189 In vivo silencing of Mcl and Mincle or blockade of their endogen

190 genetic editing and simultaneous epigenetic silencing of multiple ERVs, we demonstrate that ERV dere

191 netic phenomena that involve transcriptional silencing of one parental allele.

192 Both reactivation of telomerase and silencing of p53 rescued hepatocyte formation in telomer

193 pressive chromatin marks and transcriptional silencing of piRNA targets.

194 e the secondary endo-siRNAs required for the silencing of piRNA targets.

195 we identified a functional role of Nup93 in silencing of Polycomb target genes and in spatial foldin

196 Silencing of Rab9 or Rab11 GTPases, which are involved i

197 rtitioning solely to non-raft domains, while silencing of SNX19 impaired D(1) R function in RPTCs.

198 Small interfering RNA-mediated silencing of SOCS1 and SOCS3 in macrophage and T cells,

199 ure models of human OCCC, we find that shRNA silencing of SPINK1 sensitizes tumor cells to anoikis an

200 tone hyper-acetylation, and Sirtuin-mediated silencing of starvation-induced subtelomeric domains.

201 aneous activity guides the strengthening and silencing of synapses which underlies tonotopic map refi

202 27 (H3K27) methylation to mediate epigenetic silencing of target genes.

203 Silencing of the PttCLE47 gene expression affected later

204 data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal ca

205 As potential mechanisms involved in the silencing of the two miR-15/16 loci, we identified a gen

206 ed a genetic loss of miR-15a and miR-15b and silencing of these two loci by methylation.

207 Silencing of this intronic circular RNA in pancreatic is

208 culture models revealed that siRNA-mediated silencing of TMPRSS13 expression decreases proliferation

209 Chemogenetic silencing of TRPV1-expressing afferents or rostral ventr

210 altered PRMT5 expression to transcriptional silencing of tumor-suppressing miRNAs in lymphoma cells

211 Additionally, virus-induced gene silencing of two trichomes preferentially expressed cand

212 Chemogenetic silencing of USV-responsive neurons in TeA impairs audit

213 e anti-Rac1-GTP antibody, which is lost upon silencing of vimentin expression.

214 shown to be a positive regulator of HR since silencing of VuPOB1 expression in transgenic B301 roots

215 1, that is essential for the methylation and silencing of young transposable elements.

216 Silencing of ZNF529 in human hepatoma cells results in u

217 We find that TADs are lost as genes become silenced on the paternal X chromosome but linger in regi

218 h not from NOX2 knockout mice) and from NOX4-silenced or catalase-overexpressing INS-1E cells.

219 In orthotopic and syngeneic mouse models, silencing or inactivating IRIS in TNBC cells lowered the

220 Silencing or inhibiting Ca/calmodulin kinase II (CaMKII)

221 LAMTOR1 silencing or mTOR inhibition restores autophagy and indu

222 ive islet oscillations and that electrically silencing or optically ablating these cells suppresses c

223 We show that silencing, or gene inactivation, of endothelial Tie-2 re

224 was rescued by concurrent knockdown of CD44v Silencing p53 phenocopied the loss of ZMAT3 with respect

225 and restoration of NRF2 levels after SARRAH silencing partially rescues the reduction in cell viabil

226 n in the absence of mutations disrupting the silencing pathway.

227 esults identify a role for AGO1 and AGO4 RNA-silencing pathways in low-oxygen signaling in Arabidopsi

228 igning and expressing the VIGS constructs to silence Phytoene desaturase (PDS) or a ribosomal protein

229 etic wound bed with TWIST1 overexpression or silencing (piLenti-TWIST1-shRNA-GFP), respectively, furt

230 1B2 mutant and fruit-specific PHYA- or PHYB2-silenced plants, we demonstrated that biosynthesis of th

231 Their silencing promotes faster regeneration and increases cel

232 non-coding (spliceosomal) small nuclear RNA, silences proximal PASs and its inhibition with antisense

233 ida) are caused by post-transcriptional gene silencing (PTGS) of the key enzyme of anthocyanin biosyn

234 Genetically silencing Purkinje cell neurotransmission blocks the for

235 Finally, silencing PVN TNFR1 prevented the increase in systolic b

236 These results demonstrate that while silencing Rab27a and TRAF3IP2 each inhibited tumor growt

237 ld influence phenotype through unstable gene silencing rather than DNA change(6,7).

238 of horizontally acquired MGE-encoded genes, silencing recessive alleles if the recipient bacterium a

239 lease from the haematopoietic niche via Mcp1 silencing reduced leukocytes in the diseased heart, impr

240 bodies (MVBs) by chemical inhibitors or gene silencing reduced MDV titers and cell-to-cell spread.

241 agonists OPC31260 and Tolvaptan, or V2R gene silencing reduced wound closure and cell viability of 78

242 Consistent with this, PHF19 silencing reduces cell proliferation, while promotes inv

243 ile Nup93 associates primarily with Polycomb-silenced regions.

244 which one ancestral rDNA set is selected for silencing remain unclear.

245 e an integral role for H1 linker histones in silencing repetitive elements in mouse embryonic stem ce

246 It is unclear if that silence requires minimum H3K27me3 levels and how the mar

247 TaNPR1 homologues via virus-induced gene co-silencing resulted in enhanced resistance to stem rust.

248 co-activator with a PDZ-binding domain (TAZ) silencing results in reduced ZIKV replication, indicatin

249 Functional experiments following H19X silencing revealed that H19X was an obligatory factor fo

250 GB1 translocation (CC1-KO->WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stress

251 e Avr1b locus in a naturally occurring Avr1b-silenced strain but not in an Avr1b-expressing strain, s

252 RNA-sequencing screening coupled with gene silencing studies identified ATF3 as the driver of this

253 ystem would be useful for overexpression and silencing studies of target genes to regulate the yield

254 NOX4 silencing suppressed Ca(2+) oscillations, and the patch-

255 the autophagy pathway, thereby affecting the silencing suppression activity of p3.

256 bP3IP, was shown to interact with p3, an RNA-silencing suppressor protein encoded by Rice stripe viru

257 ay function as a nuclear effector of MILI to silence TEs by DNA methylation.

258 gated siRNAs is the remarkable durability of silencing that can persist for months in preclinical spe

259 SPs are central chromatin regulators of gene silencing that establish immune cell identity and functi

260 expression in trans via piRNA-mediated gene silencing that is essential for embryonic development.

261 ough which double-stranded RNA molecules can silence the gene carrying the same code as the particula

262 cell lines with ITCH siRNA could effectively silence the ITCH expression, and result in the stabiliza

263 that G9a-derived dimethylated H3K9 (H3K9me2) silenced the expression of the Hippo pathway kinase LATS

264 of fear memory as tested 1 d later, whereas silencing the VTA-central amygdala (CeA) projection had

265 piRNAs in humans is posttranscriptional mRNA silencing, their functions are similar to what we have d

266 d by sensory neurons in the uterus(2-4), and silences these neurons and their postsynaptic ascending

267 establish H1 as a critical regulator of gene silencing through localized control of chromatin compact

268 Gene silencing through RNAi has been used successfully in a b

269 genetic axis, regulated by autocrine IL6, to silence TNFalpha expression.

270 each inhibited tumor growth and metastasis, silencing TRAF3IP2 is more effective; targeting TRAF3IP2

271 PEN and chromatin, Xist-2kb did not robustly silence transcription, whereas a 5.5-kb Xist transgene r

272 on, whereas a 5.5-kb Xist transgene robustly silenced transcription and read through its polyadenylat

273 polycomb repressive complex 2 (PRC2), which silences transcription through trimethylation of histone

274 cover the neuronal corepressor for element-1-silencing transcription factor (CoREST) is upregulated u

275 ence has linked the transcription factor RE1-silencing transcription factor (REST) to PD and also Alz

276 in A)-mediated decreased host REST/NRSF (RE1-silencing transcription factor/neuron-restrictive silenc

277 racting RNAs (piRNAs) guide PIWI proteins to silence transposons but, after birth, most post-pubertal

278 epressive histone mark, H3K9me2, that mainly silences transposons in heterochromatic regions.

279 in redundancy with symmetric methylation in silencing transposons and to regulate the expression of

280 Functionally, enhanced ROS in Angpt2-silenced tumor cells reduced colonization potential in v

281 ease of dysfunctional mitochondria in Angpt2-silenced tumor cells, thereby resulting in enhanced reac

282 Silencing ventral P-FNs prevented flies from selecting a

283 enorhabditis elegans activates RNAi-directed silencing via induction of a pathway homologous to the m

284 romoters of genes downregulated after SARRAH silencing via RNA-DNA triple helix formation and cardiom

285 RNA and expressed through virus-induced gene silencing (VIGS) or synthetic transacting siRNA vectors

286 APL1-MeAPL5) and employed virus induced gene silencing (VIGS) to show that MeAPL3 is the key isoform

287 Silencing VMNCCKBR neurons also impaired the counterregu

288 Finally, silencing VTA dopamine neurons, or their axon terminals

289 silencing in N. castellii, and this impaired silencing was attributable to multiple functions of Xrn1

290 In primary UCB, GULP1 silencing was more prevalent in muscle-invasive UCB comp

291 ng small pharmacological inhibitors and gene silencing, we established an association between MDV-RB1

292 Using GABA(A)R subunit expression and silencing, we identified that the GABA(A)R subunit combi

293 Transfection and silencing were performed in Caco2 cells.

294 HT depletion, and optogenetic activation and silencing were performed.

295 and DON content in harvested kernels, while silencing WFhb1-1 in Qfhb1-carrier wheat resulted in a s

296 that 6mA in T. vaginalis is associated with silencing when present on genes.

297 replicative fitness but, strikingly, impede silencing, whereas low virion pp71 levels reduce fitness

298 NAs are also broadly required for transposon silencing, whereas piRNAs are largely dispensable.

299 PTEN silencing with CRISPR/dCas9 epigenetic editing may provi

300 Silencing ZMAT3 increased inclusion of CD44 variant exon