ライフサイエンスコーパス: silencer element

1 ed DNA binding motif (the Neuron Restrictive Silencer Element).

2 the persistence of CDP/cut binding to the LF silencer element.

3 element and a separate, pro-T-cell-specific silencer element.

4 l border is established by the newly defined silencer element.

5 d a sequence resembling a neuron-restrictive silencer element.

6 cantly enhanced the repressive effect of the silencer element.

7 ttern of a specific set of genes via the RE1 silencer element.

8 -wide identification and characterization of silencer elements.

9 rs some resemblance to known neuron-specific silencer elements.

10 the combined effects of a series of upstream silencer elements.

11 exonic splicing enhancer and exonic splicing silencer elements.

12 licing events by the recognition of splicing silencer elements.

13 ree distinct enhancer types, and one or more silencer elements.

14 d 37 SRE sets that include both enhancer and silencer elements.

15 es spanning the distance between the E and I silencer elements.

16 es genes subject to control by Mad-dependent silencer elements.

17 er activity, suggesting this region contains silencer elements.

18 is able to bind both the 5' and 3' enhancer silencer elements; a point mutation of the single overla

19 and show that it contains a transcriptional silencer element acting on both the AWT1 and WT1-AS prom

20 he 549 bp pp52 promoter and acted as an anti-silencer element against the pp52 NRE, but lacked any in

21 (ASO) that blocks an SMN2 intronic splicing silencer element and efficiently promotes exon 7 inclusi

22 maining independent causal variant disrupt a silencer element and putatively increase ESR1 and RMND1

23 which acts positively in the presence of the silencer element and, thus, is referred to as an antisil

24 The silencing is mediated by cis-acting silencer elements and is thought to require the formatio

25 promoter is kept in a repressed state by the silencer elements and other normally active CAP-dependen

26 Rap1p binds to silencer elements and telomeric repeats in yeast, where

27 ed the inter-relationship between the UGCAUG silencer elements and the previously identified intronic

28 ferentiated chondrocytes; 2) an adenine-rich silencer element, and 3) an enhancer cis element functio

29 ure analyses to demonstrate that the two HMR silencer elements are in close proximity and functionall

30 tone 3'-UTR motif and the neuron-restrictive silencer element, as well as striking examples of novel

31 domain protein Oct-1 recognized the A/T-rich silencer element at multiple sites in gel mobility shift

32 region has previously been shown to act as a silencer element at the endogenous locus.

33 is divergence is a result of a pdm2-specific silencer element at the pdm2 promoter that receives repr

34 A silencer element (at -319) binds the repressor ZBP-89.

35 -binding protein, is able to interact with a silencer element (BE) in the gamma interferon (IFN-gamma

36 Deletion analysis located a strong silencer element between nucleotides -244 and -80, and a

37 Kruppel-like repressor protein is vimentin's silencer element binding factor.

38 n of DBH promoter activity did not require a silencer element but was prevented by overexpression of

39 functionally confirmed four enhancer and two silencer elements by performing luciferase reporter assa

40 2, the mutated and destabilized G-quadruplex silencer element can be reinstated by the addition of G-

41 r with GAL4-binding sites (UAS(G)) replacing silencer elements, causing the silencer to become anchor

42 Here we identify a conserved exonic splicing silencer element (CE(16)) in E16 that interacts with hnR

43 Strong silencer elements contained a novel CT-rich motif, often

44 odel is presented as to how this Sp1-binding silencer element contributes to the megakaryocyte-specif

45 ntaining exon IIIb and the intronic splicing silencer element demonstrate PTB-mediated repression of

46 he NHE III(1) element has been shown to be a silencer element for c-MYC transcription upon formation

47 form a G-quadruplex structure that acts as a silencer element for c-MYC transcriptional control.

48 lex structure that is a critical part of the silencer element for this promoter.

49 ion of the minimal promoter and the upstream silencer elements FROG, TOAD, and the A+T-rich Oct-1/Oct

50 located 5' of the previously identified B29 silencer elements, FROG and TOAD.

51 bp pp52 promoter and functioned as an active silencer element in a position and orientation independe

52 Loss of the silencer element in ADLD identifies a role for non-codin

53 the mechanism that selectively activates the silencer element in GSCs.

54 e predominant G-quadruplex structure of this silencer element in potassium solution by NMR.

55 transfection experiments, the existence of a silencer element in the 5'-flanking region of the human

56 We show that the transcriptional silencer element in the bam gene integrates Dpp control

57 lation of Cx36 requires a neuron-restrictive silencer element in the Cx36 gene promoter, and the down

58 troversial; to examine it we deleted the CD4-silencer element in the germ line of a mouse using a com

59 It is thought that the silencer element in the human aromatase gene may functio

60 In this study, we characterized a silencer element in the human interleukin-3 gene promote

61 her "neuronal" genes with neuron-restrictive silencer elements in SCLCs.

62 ar ribonucleoprotein (hnRNP) A/B proteins to silencer elements in the exon and that down-regulation o

63 large-scale identification of transcription silencer elements, indicating their importance in homeos

64 ulates bam expression directly since the bam silencer element is a strong binding site for the Drosop

65 ment does not enhance gene activity when the silencer element is absent and thus cannot be viewed as

66 ents associated with CD44 identified a novel silencer element leading to the direct transcriptional r

67 ancer sequencers were more prevalent and the silencer elements less prevalent in all exons compared w

68 l analyses show that SNP rs2494737 maps to a silencer element located within AKT1, a member of the PI

69 s by a separate RNA and that the replication silencer element, located within RIV, defines the templa

70 , we showed here that the neuron-restrictive silencer element (NRSE) of MOR functions as a critical r

71 sly, we reported that the neuron-restrictive silencer element (NRSE) of mu opioid receptor (MOR) func

72 L1 gene and showed that a neural restrictive silencer element (NRSE) was critical for preventing ecto

73 could demonstrate that a neuron restrictive silencer element (NRSE) was implicated in transcriptiona

74 We found that a neural restrictive silencer element (NRSE) within the second intron prevent

75 otif with homology to the neuron-restrictive silencer element (NRSE) within this fragment.

76 21-bp element called the neuron-restrictive silencer element (NRSE).

77 ic DNA motif known as the neuron-restrictive silencer element (NRSE).

78 a DNA element called the neuron-restrictive silencer element (NRSE).

79 pecific DNA sequence (RE1/neuron-restrictive silencer element [NRSE]) present in their regulatory reg

80 RSF DNA-binding sequence (neuron restrictive silencer element [NRSE]), in vitro and in vivo, reduced

81 etal globin genes, including the deletion of silencer elements, of genes encoding noncoding RNA, and

82 xtaposition to one another, and enhancer and silencer elements operate over large distances to regula

83 ilent mating-type locus lacking a functional silencer element or at a telomere in a strain in which t

84 Deletion of the neuron-restrictive silencer element partially relieved the suppression of p

85 Finally, a strong silencer element (PCS1) (between -162 and -82) and two p

86 m the repressor element 1/neuron-restrictive silencer element previously described in other neural ge

87 osition of the IFN-gamma promoter close to a silencer element previously identified in our laboratory

88 Loss of expression requires a silencer element previously shown to be controlled by BM

89 restricted to neurons in the brain contain a silencer element (RE1/NRSE) that limits transcription in

90 nase A was localized to a neuron-restrictive silencer element/repressor element 1 (NRSE/RE-1) sequenc

91 binds to the DNA element, neuron-restrictive silencer element/repressor element-1.

92 We have previously described a cis-acting silencer element required for repressing transcription o

93 Systematic analysis of cis-regulatory silencer elements reveals their chromatin features and g

94 recognition element (p33RE), the replication silencer element (RSE), and the 3'-terminal minus-strand

95 We have previously identified a silencer element (S1) that is situated between promoters

96 uggest that the binding of CDP/cut to the LF silencer element serves to suppress basal promoter activ

97 ia reactivation of the ThPOK transcriptional silencer element (Sil(ThPOK)).

98 Southwestern blot analysis confirm that the silencer element specifically binds a protein.

99 gradient via a conserved Schnurri/Mad/Medea silencer element (SSE) unlike NEEs at brk, sog, rho, and

100 er is adjacent to a potentially novel exonic silencer element that contains a 13-nucleotide imperfect

101 Furthermore, we identified a novel silencer element that facilitated the function of GATA2

102 lines and mouse models, we have identified a silencer element that is lost in ADLD patients and that

103 ndrocyte-specific transcription enhancer and silencer elements that are consistent with the sequence

104 n gene is regulated by multiple promoter and silencer elements that are GC-rich and exhibit considera

105 pression module" and identified enhancer and silencer elements that are likely to be responsible for

106 catabolite gene activator protein (CAP) and silencer elements that are located upstream and downstre

107 8 kilobase pairs (kb)) revealed enhancer and silencer elements that contribute significantly to trans

108 , Mad and Medea, binds with high affinity to silencer elements that repress brinker and bag of marble

109 tic stem and progenitor cell (HSPC)-specific silencer element (the Gata1 methylation-determining regi

110 rate that the Fab-7' deletion also removes a silencer element, the iab-7 PRE, which maps to a differe

111 ent-transfection assays, we have localized a silencer element to a region between -128 and -480 bp up

112 eterodimerizes with ZBP-89 when bound to the silencer element to yield a DNA-protein complex whose mo

113 n, by enabling distal regulatory enhancer or silencer elements to directly interact with proximal pro

114 des methods to identify "tissue regeneration silencer elements" (TRSEs) with the potential to reduce

115 Our examples include a particular Dpp Silencer Element upstream of insect brinker genes, in co

116 This repression is mediated by silencer elements upstream and downstream of the exon.

117 nt through subsequent mitoses, even when the silencer element was excised.

118 nsfection of promoter deletion constructs, a silencer element was found between nucleotides -260 and

119 A novel silencer element was identified within the ind enhancer

120 A strong silencer element was observed between -638 and -220.

121 Since it appears to overcome the effect of a silencer element, we refer to it as an antisilencer elem

122 The silencer elements were able to block enhancement from a

123 These motifs, including Neuron Restrictive Silencer Element, were missed in recent comparative geno

124 completely override the effect of different silencer elements when fused to a heterologous promoter.

125 its 5'-flanking region a neural restrictive silencer element which may govern neuron-specific expres

126 cruits chromatin-modifying complexes to RE1 'silencer elements', which are associated with hundreds o

127 Until now, the silencer element, which shuts down vimentin synthesis in

128 s further revealed that SF-1 can bind to the silencer element with an affinity comparable with ERR al

129 A silencer element within the first intron of the CD4 gene

130 enable detection of functional enhancer and silencer elements within a large genome.

131 cating these two motifs as the principal B29 silencer elements within these regions.