ライフサイエンスコーパス: silencing

1 stance results from heterochromatin-mediated silencing.

2 modification, which is associated with gene silencing.

3 vide a powerful system for studying Polycomb silencing.

4 ritical is the process of gene repression or silencing.

5 synthetic transacting siRNA vectors for gene silencing.

6 g small non-coding RNA (ncRNA) mediated gene silencing.

7 that are related to both gene activation and silencing.

8 ing for heterochromatin maintenance and gene silencing.

9 irion pp71 levels reduce fitness but promote silencing.

10 e mechanisms involved in its transcriptional silencing.

11 omatin-modifying activities involved in gene silencing.

12 lipolysis, and impairment of GSIS after ATGL silencing.

13 ational epigenetic inheritance (TEI) of gene silencing.

14 for sustained, long-term gene expression or silencing.

15 mation that is thought to contribute to gene silencing.

16 n unanticipated mechanism for heritable gene silencing.

17 the transcription machinery, leading to its silencing.

18 nd guide Argonaute proteins to mediate their silencing.

19 target protein expression, genetic loss, and silencing.

20 n of GULP1 is a potential mechanism of GULP1 silencing.

21 scriptional and also in transcriptional gene silencing.

22 inhibited by SOX17 expression and SOX2/SOX9 silencing.

23 nding of the mechanism of H3K27me3-dependent silencing.

24 f Periphilin necessary for HUSH assembly and silencing.

25 lipolysis, and impairment of GSIS after ATGL silencing.

26 mutations result in impaired shRNA-mediated silencing.

27 or piRNA-directed TE de novo methylation and silencing.

28 chromosome inactivation prevents biallelic X silencing.

29 an ancestral role of this mark in transposon silencing.

30 al Argonaute that are both required for gene silencing.

31 ed genes, in contrast, bore the signature of silencing.

32 rovides insights into RNA-mediated chromatin silencing.

33 s regarding their recruitment and role in Xi silencing.

34 appaB Relish expression was increased by osa silencing.

35 ograft mouse model showed around 15-20% ITCH silencing 48 hours after transfection.

36 Tx in nonhuman primates (NHPs) (baboons) by silencing a gene (caspase-3) responsible for induction o

37 Silencing adipose triglyceride lipase (ATGL) in human ps

38 identification of MafK as modulator of IRF8 silencing, affecting chromatin architecture.

39 s act as single-entity transfection and gene silencing agents and have been used as lead therapeutic

40 ternating 3' U and G nucleotides become gene-silencing agents.

41 rotein combined with TP53 and RB1 transcript silencing alleviated induced arrest in TP53+/+ cells.

42 ATG7 silencing also reduced thrombin-mediated EC permeability

43 Using this approach, we measure gene silencing and activation for thousands of domains.

44 Silencing and chromatin immunoprecipitation experiments

45 RISC), which targets mRNAs for translational silencing and degradation as part of the RNA interferenc

46 reader and writer domains were necessary for silencing and DNMT3B was identified as an upstream viral

47 eceptors to intraluminal vesicles for signal silencing and lysosomal degradation.

48 scription factor coordinates heterochromatic silencing and male germline maturation.

49 t precludes histone turnover to promote gene silencing and preserve epigenetic stability of heterochr

50 ltransferase that is required for transposon silencing and RNA interference in Caenorhabditis elegans

51 We have identified the gene conferring the silencing and show it to encode a sirtuin-type histone d

52 aset of plants, several rules governing gene silencing, and a series of computational models of the b

53 ld reduction of miRNAs levels, impaired gene silencing, and characteristic morphological defects, inc

54 cal and functional mapping, gene expression, silencing, and editing.

55 Gene silencing approaches confirmed the regulatory role of HI

56 ploits the prosurvival output of transiently silencing APT in the presence of 2-fluoroadenine, thereb

57 Our findings identify LSD1-mediated enhancer silencing as a cell-intrinsic epigenetic feedback mechan

58 gressively inactivated via Polycomb-mediated silencing as discs mature (Harris et al., 2016).

59 cium FLIPR, and short hairpin RNA-based gene-silencing assays.

60 Silencing AVIL nearly eradicated glioblastoma cells in c

61 CARM1 promotes MAD2L2 silencing by driving the switch from the SWI/SNF complex

62 ts are suppressed by strong and constitutive silencing by miR159.

63 Greater understanding of gene silencing by promoter hypermethylation in anal carcinoge

64 Gene silencing by RNA interference (RNAi) has emerged as a po

65 ll migration and invasion in vitro, and GBP2 silencing by RNA interference exhibits opposite effects.

66 Gene silencing by the SETD5 complex regulates known drug resi

67 ibiting a nuclease that promotes RNA-induced silencing (C3PO).

68 Likewise, silencing cct2 gene expression by ~50% caused other CCT

69 tion, and defects in G(1)-S progression upon silencing circ-MDM2 Our results on the initial character

70 Finally, MEK5 silencing combined with focal irradiation causes strong

71 2 and associated miRNAs form the RNA-induced silencing complex (RISC), which targets mRNAs for transl

72 component of the miRNA-dependent RNA-induced silencing complex (RISC).

73 the host plant's Argonaute (AGO)/RNA-induced silencing complex for virulence.

74 Target recruitment to RNA-induced silencing complex was assessed by using anti-Argonaute2

75 1 (AGO1; a key component of microRNA-induced silencing complex) as a crucial regulator in hypoxia-ind

76 ce of ATM in miR-181c-associated RNA-induced silencing complex.

77 d thrombopoietin receptor to the RNA-induced silencing complex; downregulated these genes in the lung

78 Silencing components of the complement-like system throu

79 al approaches, including siRNA-mediated gene silencing, confocal microscopy, and subcellular fraction

80 s upstream of the SD, sRNA-mediated enhancer silencing could be a common mode of gene regulation.

81 his mechanism of suppressing regeneration by silencing damage-responsive enhancers at multiple loci c

82 LincNMR silencing decreases dNTP levels, while exogenous dNTPs r

83 red for piRNA biogenesis but piRNA-dependent silencing: deps-1 mutants fail to produce the secondary

84 male mice exhibiting RFRP neuron ablation or silencing did not exhibit the stress-induced suppression

85 elegans We show that PLP-1 is essential for silencing different types of transgenes in the germ line

86 uired for RNAi-mediated post-transcriptional silencing, downstream of small RNA production.

87 of mice to arouse during hypercapnia, as did silencing DR(Sert) terminals in the PBel.

88 lement located in its 5' end, to induce gene silencing during X-chromosome inactivation.

89 in foreign genes, bacteria must overcome the silencing effects of H-NS.

90 To maximize the silencing efficacy of gene targets, we created vectors t

91 of the fly's illusory percept by selectively silencing either T4 or T5 neurons.

92 Conversely, silencing endogenous KLHL15 markedly stabilizes these DC

93 MR had identical cell-cycle requirements for silencing establishment, with no apparent contribution f

94 ied the cause of the S-phase requirement for silencing establishment: removal of transcription-favori

95 Silencing expression of RNA-directed RNA polymerases RdR

96 example is the conserved bacterial ribosome silencing factor (RsfS) that binds to uL14 protein onto

97 nciding with the loss of promoter epigenetic silencing factors.

98 posed of nucleosome arrays that are bound by silencing factors.

99 SAP2 silencing fully restores mortality of the mosquitoes, wh

100 Further, silencing furin reduced tumor cell migration and invasio

101 L2A is required to stabilize heterochromatin silencing genome-wide, likely by preventing replicative

102 n GSCs, abundant Pcl inhibits PRC2-dependent silencing globally, while in nurse cells Pcl declines an

103 Silencing glutamate favored goal-directed behaviors and

104 By contrast, overexpressing or silencing GmMYB29A1 decreased glyceollin I accumulation

105 idate two distinct, H1-mediated pathways for silencing heterochromatin.

106 preferentially reduced by anaesthesia and by silencing higher visual areas.

107 assessed the potential of Host-Induced Gene Silencing (HIGS) approach to target the Colletotrichum g

108 rent understanding of this host-induced gene silencing (HIGS) process as a defense mechanism during n

109 EBP1 associates with ribosomes and that EBP1 silencing hinders ribosomal RNA processing.

110 The Human Silencing Hub (HUSH) complex is necessary for epigenetic

111 FOSL1 silencing impaired LPS-induced in vitro HPMEC angiogenes

112 nerative cell causes reduced heterochromatic silencing in both bicellular and mature pollen.

113 A to Spen and results in strictly local gene silencing in cis.

114 We used 3 human beta cell models (YIPF5 silencing in EndoC-betaH1 cells, YIPF5 knockout and muta

115 mediated gene editing and RNAi-mediated gene silencing in human cells, here we analyzed the consequen

116 Deletion of XRN1 impaired gene silencing in N. castellii, and this impaired silencing w

117 show that H3K27me3 is not required for their silencing in non-2i conditions.

118 es may similarly contribute to germline gene silencing in other organisms.

119 PXN silencing in ovarian cancer mouse models reduced angioge

120 lar movement of these siRNAs to reinforce TE silencing in sperm.

121 Finally, TNFR1 silencing in the PVN inhibits elevated blood pressure in

122 urvival and relevant tumour markers, and its silencing in vivo drastically decreased tumour developme

123 Conversely, its genetic silencing increases melanoma cell proliferation and redu

124 expression and TKI sensitivity, whereas SOX2 silencing induced vimentin, but suppressed BCL2L11, expr

125 atic RNAs, and block spreading of H3K9me and silencing into actively transcribed regions.

126 RNA silencing is an essential gene-regulation mechanism in e

127 Silencing is attributed to a 1:1 double stranded (ds) co

128 Our results suggest that PRC2-dependent silencing is developmentally regulated by accessory prot

129 ow that Polycomb Repressive Complex 2 (PRC2) silencing is genetically required by FCA to repress FLC

130 Moreover, CDK6 silencing is more effective than treatment with the dual

131 x strands that comprise the SNA lead to gene silencing is not understood.

132 Maintenance of silencing is then based on a combination of RdDM and RNA

133 Silencing Klf10 also sensitized primary hepatocytes to a

134 Silencing Lcn2 expression worsens metabolic dysfunction

135 Concomitantly, XPR1 silencing led to intracellular P(i) accumulation and a p

136 ructural analysis revealed that exocyst gene silencing led to the striking appearance of novel electr

137 ns to repurpose powerful antiviral chromatin silencing machinery for sex chromosome dosage compensati

138 DNA methylation is a major silencing mechanism of transposable elements (TEs).

139 anscription factor binding requires specific silencing mechanisms to ensure lineage fidelity.

140 anaphase onset, it must promptly respond to silencing mechanisms.

141 Nuclear receptor corepressor 1 (NCoR1) and silencing mediator for retinoid or thyroid-hormone recep

142 Silencing MMP3 significantly reduced S100A9-mediated cel

143 gene target sequence in tandem with the APT silencing motif.

144 Here, we show that silencing netrin-1 in the adult substantia nigra of mice

145 Silencing NOX1 using NOX1-specific siRNA mitigated radia

146 ar dominance (ND) consists of the reversible silencing of 35S/45S rDNA loci inherited from one of the

147 Strikingly, deletion or epigenetic silencing of an ERV-derived enhancer suppresses cell gro

148 Furthermore, we predict that the silencing of anti-SWR interneurons can trigger SWRs.

149 to decipher mechanisms that drive epigenetic silencing of AP-2gamma target genes are a critical area

150 ion between this epigenetic modification and silencing of Avr1b.

151 exhibits strong dwarfism and cell death, and silencing of both genes via RNA interference also leads

152 Silencing of c-SRC or treatment with the c-SRC inhibitor

153 D1/5 phosphorylation and gene expression and silencing of CAV-1 and DNM2 diminishes LDL-mediated ALK-

154 ted neural cells can trigger chromosome-wide silencing of chromosome 21 in Down syndrome patient-deri

155 itro, both overexpression of mutant COPA and silencing of COPA induced STING-dependent IFN signaling.

156 re-related antigen (HBcrAg) as surrogates of silencing of covalently closed circular DNA (cccDNA), to

157 P2J2 in cardiac cells, we performed targeted silencing of CYP2J2 expression in human adult ventricula

158 Genetic silencing of DCC prodeath activity in a BRAF(V600E) mous

159 duction in fly Adar mutants is suppressed by silencing of Dicer-2, which has a RNA helicase domain si

160 cally directed deletion or acute optogenetic silencing of DR(Sert) neurons dramatically increased the

161 However, silencing of DvABCB2 which is highly homologous to DvABC

162 an observation that was confirmed by genetic silencing of EBP.

163 Silencing of eIF3e reduced the intracellular levels of t

164 ot formulations was also demonstrated by the silencing of endogenous genes that encode two subunits o

165 Silencing of endogenous UBR5 induced MYC protein express

166 We propose that PRC2-mediated silencing of enhancers involved in cell differentiation

167 d propose that the developmentally regulated silencing of ESRRB triggers the selective inactivation o

168 Importantly, CRISPR-mediated silencing of Foxp3 transcription, but not protein expres

169 Chemogenetic silencing of GC impaired task performance.

170 portant epigenetic mechanism responsible for silencing of gene expression in animal development and c

171 family protein and implicated in epigenetic silencing of gene expression.

172 hrin-dependent using chemical inhibitors and silencing of gene expression.

173 EZH2 expression results in the silencing of genes that suppress tumor formation and met

174 th a spreading surfactant resulted in strong silencing of GFP transgenes in both species.

175 Overexpression and RNA interference silencing of GmMYB29A2 increased and decreased expressio

176 We showed that the silencing of GRASLND resulted in lower accumulation of c

177 n urothelial carcinoma of the bladder (UCB), silencing of GULP1 facilitated the nuclear accumulation

178 Silencing of H. schachtii ACC by RNAi induced similar ph

179 This mechanism involves the silencing of H3K27me3 writers, activity of H3K27me3 eras

180 cognizes' H3K27me3 specifically and enforces silencing of H3K27me3-demarcated genes in mammalian cell

181 ts for compounding hypermethylation and gene silencing of hemizygous tumor suppressor genes (TSG), we

182 anscription and may partly mediate IFN-alpha silencing of hepadnaviral cccDNA transcription.

183 Silencing of histone deacetylase 8 led to the inhibition

184 atment ameliorated Th17-induced EAU, whereas silencing of IL-24 in Th17 cells enhanced disease.

185 ge induces L13a/GAIT-dependent translational silencing of inflammatory genes in response to HFD as an

186 Silencing of JMJD2B prevented the EndMT-induced reductio

187 Silencing of JMJD2B reduced TGF-beta2-induced expression

188 Silencing of LAMR abrogated these effects.

189 epended on top-down feedback as chemogenetic silencing of lateral OFC neurons disrupted reversal lear

190 In vivo silencing of Mcl and Mincle or blockade of their endogen

191 genetic editing and simultaneous epigenetic silencing of multiple ERVs, we demonstrate that ERV dere

192 in human chordoma cells promotes epigenetic silencing of oncogenic TBXT, alters gene networks critic

193 netic phenomena that involve transcriptional silencing of one parental allele.

194 Both reactivation of telomerase and silencing of p53 rescued hepatocyte formation in telomer

195 pressive chromatin marks and transcriptional silencing of piRNA targets.

196 e the secondary endo-siRNAs required for the silencing of piRNA targets.

197 we identified a functional role of Nup93 in silencing of Polycomb target genes and in spatial foldin

198 Silencing of Rab9 or Rab11 GTPases, which are involved i

199 dditional, dominant repressive mechanism for silencing of repetitive major satellite sequences.

200 rtitioning solely to non-raft domains, while silencing of SNX19 impaired D(1) R function in RPTCs.

201 Small interfering RNA-mediated silencing of SOCS1 and SOCS3 in macrophage and T cells,

202 ure models of human OCCC, we find that shRNA silencing of SPINK1 sensitizes tumor cells to anoikis an

203 tone hyper-acetylation, and Sirtuin-mediated silencing of starvation-induced subtelomeric domains.

204 aneous activity guides the strengthening and silencing of synapses which underlies tonotopic map refi

205 27 (H3K27) methylation to mediate epigenetic silencing of target genes.

206 ng development prevented CpG methylation and silencing of the Dlk1-Dio3 locus, thereby increasing miR

207 Silencing of the PttCLE47 gene expression affected later

208 data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal ca

209 As potential mechanisms involved in the silencing of the two miR-15/16 loci, we identified a gen

210 ed a genetic loss of miR-15a and miR-15b and silencing of these two loci by methylation.

211 Silencing of this intronic circular RNA in pancreatic is

212 culture models revealed that siRNA-mediated silencing of TMPRSS13 expression decreases proliferation

213 Chemogenetic silencing of TRPV1-expressing afferents or rostral ventr

214 revealed enhanced intratumoral necrosis upon silencing of tumor cell Angpt2 expression in the absence

215 altered PRMT5 expression to transcriptional silencing of tumor-suppressing miRNAs in lymphoma cells

216 Additionally, virus-induced gene silencing of two trichomes preferentially expressed cand

217 Chemogenetic silencing of USV-responsive neurons in TeA impairs audit

218 e anti-Rac1-GTP antibody, which is lost upon silencing of vimentin expression.

219 shown to be a positive regulator of HR since silencing of VuPOB1 expression in transgenic B301 roots

220 1, that is essential for the methylation and silencing of young transposable elements.

221 Silencing of ZNF529 in human hepatoma cells results in u

222 In orthotopic and syngeneic mouse models, silencing or inactivating IRIS in TNBC cells lowered the

223 Silencing or inhibiting Ca/calmodulin kinase II (CaMKII)

224 LAMTOR1 silencing or mTOR inhibition restores autophagy and indu

225 ive islet oscillations and that electrically silencing or optically ablating these cells suppresses c

226 elanoma cells was investigated following its silencing or upregulation.

227 We show that silencing, or gene inactivation, of endothelial Tie-2 re

228 was rescued by concurrent knockdown of CD44v Silencing p53 phenocopied the loss of ZMAT3 with respect

229 and restoration of NRF2 levels after SARRAH silencing partially rescues the reduction in cell viabil

230 ns that further our understanding of the RNA silencing pathway in both model and non-model organisms.

231 n in the absence of mutations disrupting the silencing pathway.

232 esults identify a role for AGO1 and AGO4 RNA-silencing pathways in low-oxygen signaling in Arabidopsi

233 genous genes controlled by the germline gene-silencing pathways.

234 etic wound bed with TWIST1 overexpression or silencing (piLenti-TWIST1-shRNA-GFP), respectively, furt

235 even in the absence of caspase-8/10, FLIP(L) silencing promoted p53-induced apoptosis by enhancing PU

236 Their silencing promotes faster regeneration and increases cel

237 ida) are caused by post-transcriptional gene silencing (PTGS) of the key enzyme of anthocyanin biosyn

238 Genetically silencing Purkinje cell neurotransmission blocks the for

239 Finally, silencing PVN TNFR1 prevented the increase in systolic b

240 These results demonstrate that while silencing Rab27a and TRAF3IP2 each inhibited tumor growt

241 ld influence phenotype through unstable gene silencing rather than DNA change(6,7).

242 of horizontally acquired MGE-encoded genes, silencing recessive alleles if the recipient bacterium a

243 lease from the haematopoietic niche via Mcp1 silencing reduced leukocytes in the diseased heart, impr

244 bodies (MVBs) by chemical inhibitors or gene silencing reduced MDV titers and cell-to-cell spread.

245 agonists OPC31260 and Tolvaptan, or V2R gene silencing reduced wound closure and cell viability of 78

246 Consistent with this, PHF19 silencing reduces cell proliferation, while promotes inv

247 which one ancestral rDNA set is selected for silencing remain unclear.

248 sceptibility of gene loci to transcriptional silencing remain unknown.

249 e an integral role for H1 linker histones in silencing repetitive elements in mouse embryonic stem ce

250 TaNPR1 homologues via virus-induced gene co-silencing resulted in enhanced resistance to stem rust.

251 co-activator with a PDZ-binding domain (TAZ) silencing results in reduced ZIKV replication, indicatin

252 Functional experiments following H19X silencing revealed that H19X was an obligatory factor fo

253 On the other hand, silencing RGN in LNCap cells promoted its outgrowth in t

254 nd stability of epimutations driven by small silencing RNAs in the model nematode Caenorhabditis eleg

255 GB1 translocation (CC1-KO->WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stress

256 RNA-sequencing screening coupled with gene silencing studies identified ATF3 as the driver of this

257 ystem would be useful for overexpression and silencing studies of target genes to regulate the yield

258 rapidly disengages from chromatin upon gene silencing, suggesting that active transcription is requi

259 NOX4 silencing suppressed Ca(2+) oscillations, and the patch-

260 the autophagy pathway, thereby affecting the silencing suppression activity of p3.

261 bP3IP, was shown to interact with p3, an RNA-silencing suppressor protein encoded by Rice stripe viru

262 gated siRNAs is the remarkable durability of silencing that can persist for months in preclinical spe

263 SPs are central chromatin regulators of gene silencing that establish immune cell identity and functi

264 expression in trans via piRNA-mediated gene silencing that is essential for embryonic development.

265 Furthermore, although silencing the broader VMN decreased energy expenditure a

266 demonstrated highly efficient use of HIGS in silencing the expression of essential fungal development

267 rbuscular mycorrhizal fungal associations by silencing the Sym-pathway gene NaCCaMK did not affect re

268 of fear memory as tested 1 d later, whereas silencing the VTA-central amygdala (CeA) projection had

269 piRNAs in humans is posttranscriptional mRNA silencing, their functions are similar to what we have d

270 observed transcriptional response to CYP2J2 silencing; these master regulators have been implicated

271 establish H1 as a critical regulator of gene silencing through localized control of chromatin compact

272 Gene silencing through RNAi has been used successfully in a b

273 a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we found that these

274 each inhibited tumor growth and metastasis, silencing TRAF3IP2 is more effective; targeting TRAF3IP2

275 cover the neuronal corepressor for element-1-silencing transcription factor (CoREST) is upregulated u

276 ence has linked the transcription factor RE1-silencing transcription factor (REST) to PD and also Alz

277 in A)-mediated decreased host REST/NRSF (RE1-silencing transcription factor/neuron-restrictive silenc

278 in redundancy with symmetric methylation in silencing transposons and to regulate the expression of

279 Silencing ventral P-FNs prevented flies from selecting a

280 enorhabditis elegans activates RNAi-directed silencing via induction of a pathway homologous to the m

281 romoters of genes downregulated after SARRAH silencing via RNA-DNA triple helix formation and cardiom

282 RNA and expressed through virus-induced gene silencing (VIGS) or synthetic transacting siRNA vectors

283 APL1-MeAPL5) and employed virus induced gene silencing (VIGS) to show that MeAPL3 is the key isoform

284 Silencing VMNCCKBR neurons also impaired the counterregu

285 gain without altering blood glucose levels, silencing VMNCCKBR neurons decreased hIepatic glucose pr

286 Finally, silencing VTA dopamine neurons, or their axon terminals

287 silencing in N. castellii, and this impaired silencing was attributable to multiple functions of Xrn1

288 In primary UCB, GULP1 silencing was more prevalent in muscle-invasive UCB comp

289 ng small pharmacological inhibitors and gene silencing, we established an association between MDV-RB1

290 Using GABA(A)R subunit expression and silencing, we identified that the GABA(A)R subunit combi

291 Transfection and silencing were performed in Caco2 cells.

292 HT depletion, and optogenetic activation and silencing were performed.

293 and DON content in harvested kernels, while silencing WFhb1-1 in Qfhb1-carrier wheat resulted in a s

294 that 6mA in T. vaginalis is associated with silencing when present on genes.

295 replicative fitness but, strikingly, impede silencing, whereas low virion pp71 levels reduce fitness

296 NAs are also broadly required for transposon silencing, whereas piRNAs are largely dispensable.

297 Additionally, virus-induced gene silencing, which is RNA mediated and triggered through h

298 Silencing WISP1 markedly disrupts GSC maintenance, reduc

299 PTEN silencing with CRISPR/dCas9 epigenetic editing may provi

300 Silencing ZMAT3 increased inclusion of CD44 variant exon