ライフサイエンスコーパス: simplification

1 TGF-beta signaling coincident with alveolar simplification.

2 than the existing approach based on food web simplification.

3 structural features through two-dimensional simplification.

4 ont lineages secondarily underwent flagellar simplification.

5 es, but also extreme physiologic and genomic simplification.

6 egimen considering a regimen modification or simplification.

7 NNRTI-containing regimen and want a regimen simplification.

8 y means other than reformulation and regimen simplification.

9 that important information is lost in their simplification.

10 t the KPR model for non-equilibrium topology simplification.

11 tion an important tool especially for sample simplification.

12 ied strategies and outcomes of kinetic model simplification.

13 ow equilibrium, resulting in global topology simplification.

14 sole determinant of non-equilibrium topology simplification.

15 perience virologic failure by 48 weeks after simplification.

16 resent a model of adolescent-onset dendritic simplification.

17 type IIA enzymes), does not exhibit topology simplification.

18 ment in fast processing, this is a dangerous simplification.

19 shift in response to agricultural landscape simplification.

20 ion of either Foxf1 or c-Kit caused alveolar simplification.

21 in vivo cloning offers potential for greater simplification.

22 r well-informed decision making during model simplifications.

23 have been eliminated through the use of two simplifications.

24 owever, 2 key complications arise from these simplifications.

25 anoparticle sizing techniques through design simplifications.

26 e speakers lose features due to a process of simplification?

27 As the principal simplification, a generic spectrum of the constituent pa

28 displays efficient non-equilibrium topology simplification activity, and for E. coli topoisomerase I

29 poisomerases that span the range of topology simplification activity.

30 This simplification allows the emergence of a realistic troph

31 Simplification, altered connectivity, and mimicking of t

32 manipulation have become a valuable tool for simplification and automation of molecular biology proto

33 e with high fidelity and promise substantial simplification and concatenation of photonic quantum cir

34 Extensive parallel gene divergence during simplification and constraint leading to CM suggest a de

35 prediction methods, data diversity hindered simplification and generalization.

36 In terms of precipitation, both landscape simplification and increases in non-natives appeared to

37 nalysis of this connection between landscape simplification and insecticide use by examining cross-se

38 Here we show that the simplification and intensification of these systems and

39 nsitivity, quantification readout, procedure simplification and multi-functionalization of paper-base

40 The molecular mechanisms leading to synaptic simplification and neuronal apoptosis in human immunodef

41 and provides a rational basis for treatment simplification and optimization.

42 dominant-negative form of MBP20 led to leaf simplification and partly suppressed the increased leaf

43 erized by lung injury, resulting in alveolar simplification and reduced pulmonary function.

44 While simplification and reductionism are necessary to underst

45 t without increasing the number of patterns, simplification and referential relation linking play a k

46 hippocampal and cortical neurons resulted in simplification and retraction of dendritic arbors, witho

47 Simplification and rigidization led to fragments with hi

48 nowledging that the proposed view is still a simplification and should not be taken as a rigorous mod

49 Key components included the simplification and standardization of pressure ulcer-spe

50 Further simplification and standardization of these technologies

51 ng alone is insufficient to explain topology simplification and that the 'exit gate' may be an import

52 e comparability and effectiveness of various simplifications and approximations of existing frailty p

53 A number of existing models rely on simplifications and do not take into account F-actin fra

54 o II (type IIA enzymes that exhibit topology simplification), and Methanosarcina mazei topo VI and Su

55 Abeta-induced dystrophic neurites, dendritic simplification, and dendritic spine loss in both neurons

56 y, reproducibility, usability, assay process simplification, and incorporation of portable time-resol

57 ected by intensive agricultural use, trophic simplification, and invasive species.

58 The weekend effect is a simplification, and just one of several patterns of week

59 astin fiber organization, decreased alveolar simplification, and preserved lung function in mice reac

60 h as low analysis times, miniaturization and simplification, and single use.

61 In some contexts, default rules, simplification, and social norms have had even larger ef

62 magnetization transfers results in spectral simplification, and therefore larger protein assemblies

63 g therapy include convenience, tolerability, simplification, anticipation of potential new drug inter

64 The new chemotype ensued from a molecular simplification approach applied to our previously report

65 y activity and selectivity was proven by the simplification approach by removing a methyl group at th

66 he validity of the tQSSA and for its various simplifications are also of relevance at low molecule nu

67 n the 3D reality of the jellyfish and the 2D simplification, as well as the rigidity of the time vary

68 ed to hyperoxia as neonates display alveolar simplification associated with a reduced number of alveo

69 The simplification associated with transcriptomic profiling

70 analytical and general model resulting from simplifications assuming small phenotypic variance.

71 ferulate biosynthesis appears to be an over-simplification, at least in alfalfa, and additional enzy

72 tial community composition change and forest simplification beyond this century.

73 sults point to a general process of topology simplification by local reconnection, with applications

74 There are various approaches for large data simplification by scaling its dimensions down that play

75 fully characterize the pathways of topology simplification by type-II topoisomerases in terms of sta

76 To forecast how landscape simplification can affect bees, we conducted a replicate

77 A useful simplification can elucidate the core dynamics of a syst

78 experiment further suggested that landscape simplification can lead to greater interference among pr

79 experiment therefore depends on the level of simplification chosen, not the size of the number factor

80 prehensive lipidomics analysis by separation simplification" (CLASS), and the other in which all lipi

81 ard time-resolved fluorometer, a substantial simplification compared to the protocols currently in pl

82 ur model resolves the paradox of topological simplification concomitant with chromosome 'condensation

83 dour intensity of the mixture and that aroma simplification concomitantly implies an increase in the

84 d (4) interface with professionals, (Routine simplification, condition specific education, and acknow

85 The simplifications considered offer a more functional metho

86 marked airway hyperresponsiveness, alveolar simplification, decreased lung compliance, and decreased

87 vious experimental implementations have used simplifications dependent on knowing the factors in adva

88 We review two mathematical approaches to simplification, dimensionality reduction and the maximum

89 know surprisingly little about how landscape simplification-driven changes in network structure impac

90 pping to fix problems, forcing functions and simplification, enhanced visual cues, and cautious use o

91 tissue culture methods need optimization and simplification for efficiency and minimization of time i

92 ysis (FBA) framework has provided conceptual simplifications for genome-scale dynamic analysis at ste

93 he land plant genome, revealing a phenotypic simplification from the complex ancestors envisaged by t

94 Against this background of overall simplification, genes conserved in multiple outcrossing

95 biological system and that the evidence for simplification gives us a language with which to phrase

96 llinator networks observed along a landscape simplification gradient to elucidate how changes in netw

97 Surprisingly, food web simplification had no effect on the growth of A. opacum

98 Traditionally, simplification has been imposed by training animals to e

99 Basal animals are surprisingly complex and simplification has been rampant in animal evolution.

100 temporal perspective suggests that landscape simplification has inconsistent effects on insecticide u

101 ain or whether it is the result of secondary simplification has until now been hindered by lack of fo

102 We demonstrate that model simplifications (i.e. factorizations of the likelihood f

103 intestinal dysbiosis and increased alveolar simplification in a murine hyperoxia model.

104 (119-113 Ma) and suggest that outflow tract simplification in actinopterygians is compatible with a

105 terized histologically by alveolar-capillary simplification in animal models, it is clinically define

106 lytical imperatives were sought: (1) overall simplification in data acquisition and analysis and (2)

107 lect strand passages that result in topology simplification in much larger DNA molecules.

108 sed lung angiogenesis and prevented alveolar simplification in neonatal mice exposed to hyperoxia.Con

109 morphological consequences of this adaptive simplification in the Pachydactylus radiation of geckos,

110 The methodological advance and thermodynamic simplification in the paper have implications in control

111 This results in a significant simplification in the system hardware, requiring only a

112 as lost in A. thaliana, contributing to leaf simplification in this species.

113 erpretation of the results is limited by the simplifications in country structure, vaccination policy

114 Despite some modeling simplifications in one of the examples, the obtained res

115 supports the validity of the assumptions and simplifications in our model.

116 nblastine, have not been easily subjected to simplifications in their structures by synthetic means o

117 that both spine loss and dendritic branching simplification induced by Abeta exposure were mimicked b

118 ing of how different components of landscape simplification influence insecticide use over space and

119 One of the simplifications introduced in the control of such moveme

120 The simplification involved eliminating the need for additio

121 Implicit in this simplification is a crucial assumption that has never be

122 ysical geography predominates, a significant simplification is achieved, implicitly accounting for th

123 This simplification is attainable without loss of the accurac

124 Fgfr4 (Fgfr3;4) global mutant mice, alveolar simplification is first observed at the onset of alveolo

125 Simplification is important for routine clinical practic

126 We find that topology simplification is not significantly dependent on circle

127 Simplification is obtained by mathematically breaking a

128 Such simplification is often at odds with field observations

129 The key to this simplification is the realization that the step of activ

130 A typical simplification is to reduce the number of equations by m

131 any additional NMR experiments for spectral simplification, is easy to perform and has the potential

132 e ask whether, and to what extent, landscape simplification, measured as the percentage of arable lan

133 de that poses more challenges to traditional simplification methods based on collision activated diss

134 We also speculate whether topology simplification might simply be an evolutionary relic, wi

135 pulmonary angiogenesis resulting in alveolar simplification mimicking BPD in neonatal mice, but the u

136 ht implementation of the graph traversal and simplification modules that achieves comparable assembly

137 Consequently, approximations and simplifications must often be used which increase the ri

138 the mounting interest in promoting ease and simplification ("navigability"); in increasing effective

139 resources, and psychological variables is a simplification neglecting various intervening variables.

140 udies for the more general SLE outcome are a simplification of a complex multivariate genetic associa

141 Unfortunately, even with the simplification of a constant drug efficacy, we show that

142 We present a technique to construct a simplification of a feature network which can be used fo

143 restrained differentiation, resulting in the simplification of a pseudostratified epithelium into a c

144 ts in the construction of a highly effective simplification of a weighted heterogeneous network.

145 ific overexpression of EMAPII in mice caused simplification of alveolar structures, apoptosis, and ma

146 Simplification of alveolar-capillary structure is highly

147 this review, we call for standardization and simplification of assay methods and stress the importanc

148 h-latitude endemics, point to climate-driven simplification of assemblage structures and progressive

149 sible solutions stated in this document: (a) simplification of authorization for diagnostic allergens

150 c disturbances in bringing about large-scale simplification of avian communities.

151 ecision-making, resulting in a possible over-simplification of behavioral types.

152 As part of a program aimed at structural simplification of bioactive natural products utilizing m

153 llow sustained virological suppression after simplification of cART to dolutegravir monotherapy.

154 More significantly, simplification of catalytic mechanisms through the incor

155 icrocephaly, severe intellectual disability, simplification of cerebral gyration, corpus callosum hyp

156 hese results are of great importance for the simplification of cloud water chemistry models.

157 iency virus (HIV) include once-daily dosing, simplification of co-treatment for tuberculosis, preserv

158 Significantly, IVA allows unprecedented simplification of complex cloning procedures: five simul

159 Simplification of complex fluorescent decays by phasor d

160 The continuing simplification of design along with continued reduction

161 es, providing a new means for retrosynthetic simplification of differentiated diol and polyol targets

162 Consequently, simplification of diverse ecosystems will likely have gr

163 Aiming at a simplification of dosimetry, we analyzed the accuracy of

164 Simplification of electrochemically mediated atom transf

165 phylogeny reconstruction are a considerable simplification of epidemic process, as they assume that

166 The simplification of fabrication processes that can define

167 treme low pH, suggesting that there may be a simplification of food webs with ocean acidification.

168 Reductions in bivalve size and simplification of gastropod trophic structure further im

169 orizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that p

170 ative application of this principle leads to simplification of imine libraries containing up to 16 me

171 ion causes pleiotropic defects, most notably simplification of inflorescences into single flowers, re

172 zation of reaction parameters, the scope and simplification of its implementation through in situ ena

173 essential crossings, in turn catalyzing the simplification of knots and links by TopoII enzymes even

174 obligate endoparasitic lifestyle led to the simplification of many orthologous gene families involve

175 ristics for enhanced sensing performance and simplification of microsystems.

176 l updates, the changes made largely provided simplification of more complex staging details.

177 en species (ROS), autophagy dysfunction, and simplification of neurites.

178 Thus, it is not surprising that secondary simplification of novel locomotory traits has occurred s

179 rivers due to low model resolutions and the simplification of NP chemistry and sediment transport.

180 By stepwise simplification of our models, we found that the gamma-me

181 ween muscle activity is not solely driven by simplification of overt task performance.

182 the current model of homologous groups; (d) simplification of pharmacovigilance reporting; (e) reduc

183 ole, secondary axis and endomesoderm support simplification of planulae and polyps in Hydrozoa, inclu

184 st is driving a trend in miniaturization and simplification of procedures.

185 mass mapping approaches involves structural simplification of proteins with the use of a protease fo

186 lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations lead

187 rived to provide theoretical support for the simplification of reaction kinetics and the approximatio

188 A simplification of routes to known preclinical drug candi

189 easurements, (iii) short analysis time, (iv) simplification of sample preparation and (v) effective s

190 ential amplitudes, reduced endplate size and simplification of secondary synaptic folds, which were c

191 ftware for combined synthesis, inference and simplification of signal transduction networks.

192 We show that soil biodiversity loss and simplification of soil community composition impair mult

193 protonated counterparts, allows significant simplification of spectra, and facilitates NOE assignmen

194 in grammatical and speech sound errors and a simplification of spoken syntax relative to age-matched

195 dely applicable and will lead to substantial simplification of strategies for synthesis of polyketide

196 cs and microwave concepts and allowing for a simplification of structure design and analysis; in prac

197 exing of distributed Coulter sensors enables simplification of such integration by offloading the har

198 scope (including several applications to the simplification of synthetic problems and to parallel syn

199 e common proposal, this covariation reflects simplification of task performance by the nervous system

200 bits multiple unambiguous losses or bouts of simplification of the adhesive system.

201 Simplification of the algorithm by removing age did not

202 as we show here, all composite numbers admit simplification of the algorithm to a circuit equivalent

203 cium indicators in terms of reagent cost and simplification of the assay process.

204 This paper proposes a least-squares simplification of the binomial likelihood model motivate

205 ury is the loss of unique ultrastructure and simplification of the cell shape, called foot process ef

206 observations that it also leads to strategic simplification of the ecological food web, and generates

207 configuration is an essential player in the simplification of the entanglement of chromatin fibers.

208 There is a need for standardization and simplification of the existing methods for molecular det

209 duction and diversity through 2 years caused simplification of the food web and deep reductions in co

210 , the latter description is widely used as a simplification of the former.

211 beling strategy achieves spectral editing by simplification of the HalphaCalpha and aliphatic side ch

212 ene structure and gene content that parallel simplification of the Hydra life cycle.

213 The attraction with DIY kits is the simplification of the intervening steps going from basic

214 This protocol represents a considerable simplification of the isolation procedure and is particu

215 In the second case, by a simplification of the mechanisms for inter and intra-spe

216 novel mobile health applications as well as simplification of the medication dosing regimen.

217 d predictable patterns, were associated with simplification of the metabolic capacity of the microbio

218 The model is a simplification of the natural history of prostate cancer

219 Further simplification of the new ESPGHAN guidelines might be ma

220 The model presented in this paper is a simplification of the organized chaos that constitutes t

221 SF3B1 in splicing and also demonstrate that simplification of the PB scaffold is feasible.

222 The model represents a simplification of the previously described coalescent wi

223 However, simplification of the procedures for analyzing samples w

224 ractive metallurgy offers both a substantial simplification of the process and a significant reductio

225 al for small size and greater reliability by simplification of the pumping mechanism.

226 d depth of information that can be gained by simplification of the sample prior to the MS analysis th

227 proposed microbiosensor as probe tip allows simplification of the set-up used for the evaluation of

228 together, these findings provide a powerful simplification of the social network, where cores repres

229 Moreover, we introduce a complimentary simplification of the tQSSA rate law that is valid in st

230 isting memory technology, size reduction and simplification of the used material systems are essentia

231 ression at E14.5, which is associated with a simplification of the vascular tree at E18.5.

232 and Naor, and our proof is an adaptation and simplification of their argument.

233 verely glaucomatous optic nerves also showed simplification of their processes.

234 Simplification of this latter result provides a momentum

235 involved C-H bonds allows for a significant simplification of this parametric scheme, requiring only

236 Models are simplifications of complex systems, and often simulate s

237 eal-world contexts often relies on strategic simplifications of decision problems.

238 lectron microscopy, TEM) can only provide 2D simplifications of size and shape with a spatial resolut

239 This observation allowed further simplifications of the scaffold to generate new lead com

240 Previous simplifications of the tQSSA rate law are valid in a par

241 This simplification often leads to inaccurate motif counts (o

242 study indicates that the effects of food web simplification on the performance of A. opacum are compl

243 Signal decreases, presumably alveolar simplification, only appeared in the most severe BPD cas

244 ine, and tenofovir might be a useful regimen simplification option for virologically supressed adults

245 of life, thus expanding the offer of 2-drug simplification options among virologically suppressed in

246 Our previous study showed that, despite simplifications, our discrete molecular dynamics approac

247 Rational design and substantial structural simplification permitted the expedient chemical synthesi

248 for the hypothesized link between landscape simplification, pest pressure, and insecticide use.

249 eral models of this non-equilibrium topology simplification phenomenon have been proposed.

250 draw speculative parallels with the alveolar simplification phenotype of bronchopulmonary dysplasia i

251 at the United Nations Office in Geneva and a simplification process of the hypersensitivity/allergic

252 The success of this MS/MS simplification process stems from extensive secondary fr

253 es show distinct advantages based on process simplification, product quality and environmental footpr

254 Similarly, landscape simplification reduced the phylogenetic congruence among

255 Our empirical data show that landscape simplification reduces pathogen prevalence in bee commun

256 means were apparently buffered by landscape simplification (reduction in habitat heterogeneity withi

257 ism underlying this non-equilibrium topology simplification remains speculative.

258 Common policy simplifications result in a 49-100% loss in biodiversity

259 A pervasive concern is that such landscape simplification results in an increase in insect pest pre

260 del postulates that non-equilibrium topology simplification scales with the bend angle imposed on the

261 nd indirect environmental costs of landscape simplification should be considered in design of land us

262 The implications of such simplifications should be understood.

263 ce reported with DTG/3TC, supporting it as a simplification strategy for virologically suppressed peo

264 Our results suggest that future simplification studies should use a stratification accor

265 iew concludes by showing how seemingly small simplifications, such as assuming thermal equilibrium ac

266 n of 3D atomic similarities introducing some simplifications that allow us to extend its applicabilit

267 were calculated while avoiding commonly made simplifications that do not apply to large pathogen popu

268 This motivated 3 ingenious simplifications that underpinned a century of developmen

269 investigate the role of bending in topology simplification, the DNA bend angles of four enzymes of d

270 A new parameter more appropriate for the simplification, the EC20, has been proposed to express t

271 Despite this simplification, the product multiplicity and novelty ove

272 However, for reasons of simplification, this CO2-SLCF linkage was often disregar

273 how that mammals are sensitive to structural simplification through disturbance, emphasizing the impo

274 Besides providing a considerable technical simplification through the dual-locked solitons and enha

275 ticipants enrolled and 2 discontinued before simplification to atazanavir-ritonavir alone.

276 101 patients randomized, 68 were assigned to simplification to dolutegravir monotherapy and 33 to con

277 n a systematic manner, (2) applying sentence simplification to improve the coverage of extraction pat

278 etroviral therapy might benefit from regimen simplification to reduce pill burden and dosing frequenc

279 To accomplish this, several simplifications to a log-normal Langmuir (LNL) isotherm

280 andwidth-efficiency, but require fundamental simplifications to become economically viable for access

281 e data on key model parameters and necessary simplifications to model structure and outcomes.

282 Political simplification undermines traditional structures of auth

283 rade forests in the future (phase IV, global simplification) unless new "development without destruct

284 how environmental change can cause ecosystem simplification via environmentally mediated changes in c

285 ss the seven-state region in 2007, landscape simplification was associated with insecticide applicati

286 county in cropland--my metric for landscape simplification--was positively correlated with insectici

287 A discussion of the simplifications we used in the context of the results in

288 To determine the robustness of this simplification, we compared two small helix-turn-helix t

289 With this simplification, we found that elimination of the lysine

290 However, several simplifications were followed by proof-of-principle demo

291 inetic parameters, a series of kinetic model simplifications were made, resulting in fewer kinetic pa

292 Nevertheless, a number of simplifications were still made and future work should e

293 Type II topoisomerases exhibit topology simplification, whereby products of their reactions are

294 Therefore, simplification with better predictability of overall sur

295 thus, genetic depletion resulted in alveolar simplification with reduced adaptive angiogenesis.

296 we correlated alveolar-capillary structural simplification with reduced functional gas exchange as m

297 velopment has benefited from patient-centred simplification with several effective regimens now avail

298 to severe airspace enlargement and alveolar simplification, with concurrent thinning in the outer la

299 alike, nonfasting lipid profiles represent a simplification without negative implications for prognos

300 This remarkable simplification yields the single sorbate-specific parame