ライフサイエンスコーパス: single

1 -controlled study, we investigated whether a single 10 mg dose of the GABA(B) agonist baclofen impair

2 Intravenous iron was administered as a single 1000 mg dose of ferric carboxymaltose in 100 mL n

3 ransfer from silicon to anthracene through a single 15 ns Dexter energy transfer step with a nearly 5

4 disease: Gastric lesions were multiple: 38%, single: 62%, submucosal: 13%, or ulcerated: 13%.

5 We present our experience with this single-academic-center prospective study evaluating the

6 -1 mutants due to deficient RNA editing at a single adenosine in their 3'-UTR.

7 A proof-of-concept therapy study with a single administration of (212)Pb-L2 demonstrated dose-de

8 Single-agent EV was generally well tolerated and provide

9 Single-agent immune modulators have thus far proven clin

10 Compared to single-agent sunitinib treatment, tumors in sunitinib-tr

11 des evidence that acalabrutinib is active as single-agent therapy with a manageable safety profile in

12 However, EPO or Tfr2 single-allele deletion alone, respectively, exacerbated

13 anning (DMS) datasets probing the effects of single amino acid variation on enzyme activity and stead

14 applications by quantifying a broad range of single analytes such as small molecules, proteins, nanop

15 With variations among single and binary cultures, fermented-AP counteracted th

16 uman cancer cell lines (HCT116 and CAL27) to single and combination treatments of radiation (0-20 Gy)

17 d the circuits' response to modifications in single and multiple intrinsic conductances in the indivi

18 lution), freezing and frozen storage (FS) on single and total polyphenols (free and conjugated) conte

19 in CTRP1 levels were discovered between the single- and triple-vascular-vessel lesion groups.

20 rates of 2-4 t CO(2) /ha, 1-5 years after a single application of basaltic rock dust, including via

21 amplified, longer-lasting effectiveness over single-approach interventions.

22 In this single-arm, open-label, phase 2 basket trial, we recruit

23 In this open-label, single-arm, phase 3 trial, participants were recruited f

24 This open-label, single-arm, prospective cohort trial is the first phase

25 e; cleaves ssDNA, dsDNA and RNA targets in a single assay; and operates at elevated temperatures, pro

26 identification and characterization using a single atlas segmentation performs well compared to manu

27 st-guest strategy to fabricate various metal single-atom catalysts on nitrogen-doped carbon (M(1)/CN,

28 n graphene is one of the most representative single-atom catalysts, and it has a high activity and se

29 Herein, single-atom catalytic electrodes design for advanced bat

30 Replacement of the single biotin by the biotin-Si-NPs boosted on average a

31 nal Institutes of Health-funded, randomized, single-blinded trial conducted in 12 centers in the Unit

32 e crucial role of the initial reversible C-C single bond formation for the synthesis of crystalline 2

33 ical stack-of-spirals 3D UTE sequence during single breath holds (echo time [TE], 0.05 msec) and with

34 ie PLB inhibition of SERCA, and binding of a single Ca(2+) ion is sufficient to shift the protein pop

35 y, by juxtacellularly recording and labeling single CA2/CA3 neurons in freely-moving mice, we explore

36 First, we define the single-carrier and multicarrier mechanisms for axis-depe

37 probes; recruit larger sample sizes; and use single case experimental designs for better pragmatic an

38 The incorporation of the single cell biosensor and transient gene knockdown into

39 A key missing aspect is that real single cell data usually has non-uniform uncertainty in

40 clude that the sizes of the non-backtracking single cell domains are most close to the sizes of compa

41 tion between active and inactive bacteria at single cell level is urgently needed in many fields incl

42 d (iii) The affected tissue is a homogeneous single cell monolayer, facilitating accurate transcripto

43 onding FBN1+ FAP cell type was also found in single cell RNA-seq analysis in mouse.

44 intained, making possible the correlation of single cell transcriptomes with cell location, morpholog

45 Here, we present a single-cell aggregation and integration (scAI) method to

46 ng datasets that hold the key for label-free single-cell analysis and, consequently, for differentiat

47 Thus, spatially resolved, single-cell analysis can characterize intratumour phenot

48 Here, using a modified method of single-cell analysis for somatic L1 insertions, we studi

49 Spatially resolved, single-cell analysis identified the phenotypes of tumour

50 rm FLOW-MAP analysis side by side with other single-cell analysis methods, to illustrate when it is a

51 Using single-cell and bulk TCR sequencing and structural affin

52 How best to project data across single-cell atlases is an open problem.

53 have combined two-photon Ca(2+) imaging and single-cell electrophysiology in awake behaving mice fol

54 nable such temporal analysis from multimodal single-cell experiments, we introduce an extension of th

55 ated analysis of chromatin accessibility and single-cell expression data shows that regulatory elemen

56 a soluble TFR cell effector molecule through single-cell gene expression profiling.

57 Given a single-cell image from one of the stages, ImageAEOT gene

58 p after sleep deprivation at the network and single-cell level.

59 ultrasensitive analysis of bacteria at their single-cell levels within a 3 h procedure.

60 Single-cell lysate in each microwell is "electrophoretic

61 Here, single-cell multi-omics analysis demonstrates a shared m

62 Single-cell mutation and phospho-protein analyses reveal

63 The development of single-cell RNA sequencing (scRNA-seq) has allowed high-

64 Using single-cell RNA sequencing coupled with high-resolution

65 ent of CF lung disease.Methods: We performed single-cell RNA sequencing of sputum cells from nine sub

66 Microarray analysis and single-cell RNA sequencing revealed that a number of cyt

67 Single-cell RNA sequencing uncovered three epicardial su

68 Here, we report for the first time in-depth single-cell RNA sequencing, combined with spatial transc

69 Using allele-specific single-cell RNA sequencing, we here estimate the two noi

70 Here, we integrated recently published single-cell RNA-sequencing (scRNA-seq) data from 727 per

71 We analyzed previously generated single-cell RNA-sequencing (scRNA-seq) data of gastric c

72 f the etiology of blinding diseases, we used single-cell RNA-sequencing (scRNA-seq) to analyze the tr

73 Mechanistically, single-cell RNA-sequencing analyses of a mesenchymal nic

74 xpression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues fr

75 ic gene expression from different tissues in single-cell RNA-sequencing data.

76 er, it remains difficult to isolate and then single-cell sequence such populations because of compoun

77 Single-cell sequencing (SCS) has impacted many areas of

78 Recent high-dimensional single-cell technologies such as mass cytometry are enab

79 Single-cell transcriptome analysis of Hh-deficient mesod

80 CIRCM), and TRM pools by lineage-tracing and single-cell transcriptome analysis.

81 y immune dysfunction, we performed the first single-cell transcriptome characterization of CF sputum.

82 Here we report a single-cell transcriptomic analysis of hematovascular de

83 Single-cell transcriptomics and immunostaining of both W

84 Generating single-cell, multiparametric, longitudinal atlases and i

85 reported technique can be used to study the single-cell-level dynamics of EET not only on electrode

86 let microfluidic system: droplets containing single cells are immobilized in a two-dimensional (2D) a

87 To generate scMNase-seq libraries, single cells are isolated by FACS sorting, lysed and dig

88 Mapping transposase-accessible chromatin in single cells by sequencing defined the transcription fac

89 Biophysical studies on single cells have linked cell mechanics to physiology, f

90 on of the chromatin compartmental domains in single cells Hi-C matrices.

91 The mechanical phenotyping of single cells therefore offers many potential diagnostic

92 Despite the noisy nature of single cells, multicellular organisms robustly generate

93 ntified the phenotypes of tumour and stromal single cells, their organization and their heterogeneity

94 Based on recent experimental results for single cells, we derive a minimal length scale for the p

95 ion 36 (CD36), in a spatiotemporal manner in single cells.

96 he expression of hundreds of chosen genes in single cells.

97 A single-center case series (January 2014-December 2018) c

98 A 5-year retrospective single-center study in all adult patients with SD admitt

99 In this retrospective, single-center study, T1 mapping data were collected from

100 outpatients were recruited for this 12-week, single-center, parallel-group, double-blind RCT and rand

101 This single-center, phase 2, randomized, double-blind, placeb

102 ccesses, 24 failures) were identified from a single-centre cohort of patients admitted with refractor

103 In this single-centre, double-blind, parallel-group, randomised

104 n equivalence between the driving forces for single-chain collapse in dilute solutions and the drivin

105 In the present work, enhanced single-chain magnet (SCM) behavior is observed for a Mo(

106 Here, using single-channel electrical recording in planar lipid bila

107 s in the largest German cohort observed by a single clinical site.

108 static prostate cancer seems to arise from a single clone in the primary tumour but can exhibit subcl

109 ntacts of 1 protofilament, consistent with a single cofilin having filament-severing activity.

110 xpression changes were examined in 16HBE14o- single colonies with DSP knockout.

111 Switching from single column to multiple parallel columns with differen

112 ow that both unbound linker histones adopt a single compact conformation.

113 The resulting single-component Co(-I) complex is proposed as the direc

114 to investigate bulk mosaicity within as-cast single crystal CMSX-4 and CMSX-10 Ni-base superalloys.

115 PTE and electron microscopy measurements of single-crystal and bicrystal gold microscale devices.

116 We demonstrate the growth of single-crystal layers of hexagonal boron nitride (BN) an

117 We achieve this stress by bending single-crystal silicon microbeams using an in situ therm

118 to TiO(2) surfaces (either nanostructured or single-crystal TiO(2)(110)) was found to be highly depen

119 In addition, single-crystal X-ray analysis was used to elucidate the

120 spectroscopically and, in many cases, using single-crystal X-ray crystallography.

121 ced helicene 1(2-) has been characterized by single-crystal X-ray diffraction as a solvent-separated

122 f (1)H and (13)C NMR spectrometry as well as single-crystal X-ray diffraction.

123 moreflectance measurements were performed on single crystals and thin films, and theoretical predicti

124 The trap densities in single crystals varied by five orders of magnitude, with

125 ven in high-quality, electrically insulating single crystals, leading to anomalous transport properti

126 n in precision defect engineering, down to a single defect, towards achieving the smallest memristor

127 and mesoporous SNPs 466.0 +/- 86.0 nm) upon single dose intravenous administration to female and mal

128 In vivo, this can be accomplished with a single dose of p53 inhibitor at the commencement of BRAF

129 ollowed 1 month later by saline placebo or a single dose of PCV13 followed 1 month later by 23-valent

130 s of age were randomized to receive either a single dose of PCV20 followed 1 month later by saline pl

131 ected in 32 (91%) of 35 participants after a single dose when measured in MNA(80) and in 35 (100%) pa

132 sing of terpenes and terpenoids exhibiting a single double bond as the only functional group, such as

133 and allows for the simultaneous sizing of a single droplet using its Mie scattering pattern.

134 Single-drug oral selinexor induced durable responses and

135 Methods: Phantom measurements with single-, dual- and triple-isotope combinations of (99m)T

136 nching with g((2))(0) = 0.39 +/- 0.05 in the single-electron limit (g((2))(0) = 0.63 +/- 0.03 in the

137 The final patient was a single encounter whose clinical and imaging findings sho

138 wo-level system operates with no more than a single energy quantum.

139 COM and inv(3)/t(3;3) can be classified as a single entity of 3q26-rearranged AMLs.

140 esponse as a relatively simple function of a single environmental cues (e.g. a linear function of one

141 was used in the LC-MS/MS methods, each in a single enzymatic step.

142 A single episode of febrile UTI is often caused by a virul

143 P does not result from an interaction with a single essential target but rather from the multilevel c

144 the fluorescence recovery produced a simple single-exponential decay in the spatial Fourier domain,

145 salt-assisted liquid-liquid extraction in a single extraction method for a wide range of DBPs, produ

146 from Order Thysanoptera were restricted to a single family, the Thripidae, resulting in a biased view

147 nal and anatomical analyses suggested that a single FC gradually recruits neighboring pericycle cells

148 All single feature-based LightGBM models were then integrate

149 ni (also known as cysts or spheroids) with a single, fluid-filled central lumen when grown in 3D matr

150 We estimated that a single follow-up examination at the end of the first yea

151 trichilemmal cysts is one of the most common single gene familial diseases in humans.

152 We find that a single gene, Hairy (H), which is needed to repress trich

153 ceptor neuron axons exclusively connect to a single glomerulus without any axonal branching.

154 l heterodyne imaging (IR-PHI) to interrogate single, high aspect ratio Au nanowires (NWs).

155 We compare our methods to mean imputation, single imputation, and a penalized EM algorithm incorpor

156 RNA oligonucleotides with a single incorporated zebularine also did not disrupt edit

157 The problem of single individual haplotyping (SIH) was first formalised

158 is (TB) is the leading cause of death from a single infectious agent, requiring at least 6 months of

159 s, participants with ASD were administered a single infusion of autologous umbilical cord blood and,

160 xenograft model of acute myeloid leukemia, a single injection of 10 million Jurkat cells delivered Di

161 ts obtained in the present study show that a single intramuscular immunization of domestic pigs with

162 After a single intravenous injection of human CD34+ cells, NSG-S

163 tions sampled during this time derive from a single introduction in late January or early February 20

164 ands, implying that Dy(3+) can be tuned as a single ionic white light emitter by a simple modificatio

165 he shoulder was: (1) not abducted (single-to-single-joint), (2) abducted (multi-to-multi-joint), and

166 (3) abducted and then not abducted (multi-to-single-joint).

167 emporal analysis of these maps documents the single largest loss in dense seagrass extent globally (1

168 ated by the OFDR system for 11 cycles with a single laser scan.

169 es of freedom that differs not only from the single-layer materials, but from the 3D perovskites as w

170 Single-layer mGCL thickness is comparable to the traditi

171 enzene-to-phenyl hydride landscape suggest a single linear sequence for this transformation involving

172 ID, CIT expands the types of manipulation in single live cells to address cell biology questions othe

173 given gene via dual fluorescent reporters in single, live cells of the yeast Saccharomyces cerevisiae

174 rta, based on maximum values at systole at a single location, denoted max, and a 'peak mean' value av

175 Single long covered stents or overlapping covered stents

176 single) lung recipients, and those with fewer than four

177 e targets and the largest (of right or left) single-Maddox rod values were similar to double-Maddox v

178 represents possible future rewards not as a single mean, but instead as a probability distribution,

179 ncy reported so far for catalysts based on a single metal ion mechanism.

180 mode from an N(2) S(2) (4-) cavity holding a single metal, to a binucleating H(2) ema(2-) with bridgi

181 nsitive detection of synthesis products from single microbial cells remains the bottleneck for determ

182 have been confined to pumping water across a single microcapillary or microfluidic channels.

183 deliver both kinds of radiation, but mostly single modalities have been explored for applications.

184 thod can be adopted by fitting all bins to a single model.

185 eloped a force-activatable emitter reporting single-molecular tension events and the associated cellu

186 The conductance through a single molecule can be measured by contacting the molecu

187 Single molecule imaging of p44/p62 complexes without XPD

188 silico methods were further employed to add single molecule level details on the potential interacti

189 Our real time single molecule measurements of full length p53 tetramer

190 a nucleotide resolution transcriptome-wide, single molecule SM-PAT-seq method.

191 s a critical step towards the untethering of single molecule spectroscopy.

192 Using single-molecule analyses, we examined the mechanism by w

193 ategy can be used to create highly nonlinear single-molecule circuits.

194 equipment, paving the way to cost-effective single-molecule DNA sequencing, capable of handling wide

195 ver three helical periods (100-130 bp) using single-molecule fluorescence resonance energy transfer (

196 es to organic and inorganic substrates using single-molecule force spectroscopy (SMFS).

197 Using biochemical and single-molecule Forster resonance energy transfer (smFRE

198 Here, we combine single-molecule FRET experiments and molecular dynamics

199 (2020) use an innovative single-molecule imaging approach in yeast cells to measu

200 Here, we use live-cell single-molecule imaging in human cells to determine rate

201 Using single-molecule imaging, we demonstrate that both conden

202 e designed to render large three-dimensional single-molecule localization microscopy datasets.

203 roves quality and conditions for regular and single-molecule localization microscopy on live-cell sam

204 nchorage, we demonstrate the applications in single-molecule manipulation studies of the temperature

205 In this paper, we utilize SMOLM, single-molecule orientation localization microscopy, to

206 distort the fluorescent signal emitted from single-molecule probes, which rapidly degrades resolutio

207 nce gene enrichment sequencing (RenSeq) with single-molecule real-time sequencing of PacBio for 18 ac

208 Single-molecule spectroscopy allows us to quantify the e

209 sion can achieve such compaction, but recent single-molecule studies (Golfier et al., 2020) observed

210 Some single-molecule studies have, however, suggested that th

211 Single-molecule super-resolution microscopy has develope

212 which we identify here by three-dimensional single-molecule superresolution imaging.

213 pid-protein, and lipid-dye interactions with single-molecule, nanoscale resolution.

214 and properties of materials at the level of single molecules or small interacting complexes of molec

215 Secretory immunoglobulin A (SIgA) is the single most abundant acquired immune component secreted

216 Colorectal anastomotic leakage (CAL) is the single most important denominator of postoperative outco

217 In comparison to a single mouse bed, the cost and time associated with each

218 ons of driver genes were concatenated into a single mRNA construct to vaccinate patients with metasta

219 Eggs from larp6b single mutant females showed minor chorion defects, but

220 , mtACP2 (At1g65290), and mtACP3 (At5g47630) single mutants showed no discernible morphological growt

221 s were more defective than those from larp6a single mutants.

222 r dauer formation than seen in either of the single mutants.

223 Tn-antigen (Tn), a single N-acetylgalactosamine (GalNAc) monosaccharide att

224 In CA1, both synaptic input to single neurons and population activity strongly tracked

225 A single nickel atom embedded in graphene is one of the mo

226 lutamate to outside-out patches containing a single NMDAR, we find that agonist-bound receptors trans

227 t the effectiveness of therapies targeting a single node of the oncogenic signaling network.

228 gh sequencing coverage to detect significant single nucleotide polymorphism (SNP)-trait associations,

229 lter protein binding, it has been shown that single nucleotide polymorphisms can affect RNA secondary

230 A secondary structure, and here we show that single nucleotide polymorphisms can affect RNA-protein i

231 ele-specific PCR targeting outbreak-specific single nucleotide polymorphisms was applied to 290 isola

232 lysis of Yp pagP gene sequences identified a single-nucleotide polymorphism that results in a prematu

233 ined' diagnosis of FMD were genotyped for 18 single-nucleotide polymorphisms (SNPs) from 14 candidate

234 (WGS) technology allow for the detection of single-nucleotide polymorphisms (SNPs) in the pathogen g

235 i-BLESS labels DSBs with single-nucleotide resolution, allows detection of ultrar

236 d pinpointing CodY-binding sites at close to single-nucleotide resolution.

237 ptome-wide quantitative mapping of ac(4)C at single-nucleotide resolution.

238 FGFR2 amplification (n = 20), FGFR2 or FGFR3 single-nucleotide variants (n = 19), or FGFR1 or FGFR3 f

239 However, the causal nature of single-nucleotide variants and small insertions and dele

240 e's scientific impact cannot be reduced to a single number.

241 Importantly, we found that single optogenetically evoked SW (SW(opto)) in the peri-

242 overage, and the optimisation was based on a single outcome measure, therefore this study should be u

243 riability in cell state by either shifting a single parameter or generating "populations" of model pa

244 lasma mass spectrometry (ICP-MS) operated in single particle (SP) mode.

245 red due to the lack of real-space imaging at single particle resolution.

246 h interpretability and allows us to solve 3D single particle structures of clustered protocadherin, a

247 Here, we use a machine-vision-based single-particle analysis (SPA) method to successfully de

248 and directly image structural changes using single-particle cryo-electron microscopy.

249 e target membrane enhances the efficiency of single-particle IAV lipid mixing, whereas the rate of li

250 oupled plasma mass spectrometry (ICP-MS) and single-particle ICP-MS.

251 -in the field, and indicate that in-solution single-particle tracking and ABEL trap are more reliable

252 eptionally high water flux (and throughput), single-pass water recovery and heat utilization efficien

253 so been noted that frequently a tumor from a single patient harbors more than one resistance mechanis

254 transcriptional repression of Wapl through a single Pax5-binding site by recruiting the polycomb repr

255 d up to 19-fold compared to direct ESI-MS of single-phase droplets (aqueous plugs segmented by carrie

256 .g., as robust sources of indistinguishable, single photons that can be integrated into photonic stru

257 luding a test item assessing repetition of a single phrase.

258 We recently developed high-speed single-point edge-excitation sub-diffraction (SPEED) mic

259 Compared to single probing measurements, COM seems (1) more accurate

260 itamin B(12) and fat soluble vitamin D(3) in single product.

261 d with diseases by direct optimization using single purified enzymes.

262 ques to prepare a trapped molecular ion in a single quantum state, drive terahertz rotational transit

263 For each image, a single radiologist dictated a standard phrase describing

264 To achieve single RBC trapping, we employ two parallel sidewall 3D

265 For RVI and TTPVI, the best single-reader performance had sensitivity and specificit

266 achieve bit error rates as low as 0.11% for single reads, without library purification.

267 2/Fls3 proteins, we found no evidence that a single receptor domain is responsible for the Fls3-susta

268 duces the entire hyperspectral data set to a single reconstructed color similarity map, in which the

269 problem by sorting for droplets containing a single red blood cell with 85% purity.

270 quivocally that Katanin phosphorylation at a single residue is necessary and sufficient to target Kat

271 influence pH gating properties, as well as a single residue, aspartate 348, that determines both cati

272 different B cell subpopulations present in a single sample.

273 led K562 human cell line protein digests via single-shot nanoLC-MS/MS analysis on a Q Exactive HF sys

274 rphous region of well-defined length along a single silicon nanowire.

275 h N-oxide ligands can significantly activate single-site Ru-based catalysts.

276 ging fungal pathogen Candida auris contain a single SOD5-like SOD rather than a pair, and in both fun

277 mic expressions, which might be dormant in a single-source analysis.

278 this in turn led to preferred integration of single spacers over two transposon ends.

279 to access aliphatic sulfonamides, applying a single-step hydrosulfamoylation using inexpensive olefin

280 We present a single-step, versatile strategy for the selective modifi

281 e for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA).

282 contributions from reverse-transcribing and single-stranded (ss) DNA viruses.

283 ASOs are small synthetic single-stranded chains of nucleic acids that target spec

284 eation rate of ScDmc1 results from its lower single-stranded DNA (ssDNA) affinity, compared to that o

285 dimeric protein that potentially binds with single-stranded DNA (ssDNA) in a manner similar to human

286 network mapping' to test the hypothesis that single-subject atrophy maps in patients with a clinical

287 vels of mature RNA species or editing in the single T. cruzi mitochondrion are linked to differentiat

288 effectively preserve cognitive function than single-target therapies.

289 between January 2011 and December 2015 at a single tertiary care center were identified.

290 ntal and theoretical analyses are focused on single tetracenothiophene molecules and demonstrate that

291 sCD163, MCP-1, and IL-6 levels changed at a single time point.

292 or are typically developed and validated for single time-point assessment, in highly controlled setti

293 Single-time-point dose factors for tumor were determined

294 ues when the shoulder was: (1) not abducted (single-to-single-joint), (2) abducted (multi-to-multi-jo

295 o dental exams at least 12 months apart at a single University-affiliated Dental Center.

296 y portend impaired functional reserve of the single-ventricle circulation.

297 investigate interactions with glycans at the single-virion level directly on living mammalian cells,

298 luated pre-HD stratification models based on single visit resting-state functional MRI (rs-fMRI) data

299 nd molybdenum disulfide (MoS(2)) crystals on single-walled carbon nanotubes (SWCNTs).

300 we collect high spatial resolution video of single zebrafish larvae swimming in a naturalistic envir