ライフサイエンスコーパス: single amino acid

1 cell entry were observed upon mutation of a single amino acid.

2 may differ by only minor modifications of a single amino acid.

3 ess protein stability at the resolution of a single amino acid.

4 -4-amino-4-carboxylic acid substituted for a single amino acid.

5 ion in S/N is attributable to differences of single amino acids.

6 hydrophobicity or aggregation propensity of single amino acids.

7 Resultant mutations ranged from single amino acid (aa) substitutions to frameshift mutat

8 Demonstration of the methodology uses single amino acids (AAs) and peptides of increasing size

9 trate that inward rectification depends on a single amino acid (Ala(254)) at the inner pore mouth of

10 Moreover, results demonstrate that the single amino acid alanine to valine substitution at posi

11 cal isolate of measles virus (MeV) bearing a single amino acid alteration in the viral fusion protein

12 A single amino acid and various oligopeptides are grafted

13 tion is a robust feature within proteins and single amino acids and discuss potential applications.

14 translational modifications (PTMs) affecting single amino acids and peptides.

15 sis ICP55 was responsible for the removal of single amino acids, and its action explained the -3 argi

16 glucose than on other sugars, namely when a single amino acid (arginine, glutamate, or proline) is t

17 re, the potential of end-to-end learning for single amino acids, as compared to more classical manual

18 A single amino acid (Asn to Ile) substitution in the homeo

19 However, apoE4 differs from apoE3 by only a single amino acid at position 112, which is arginine in

20 By using reverse genetics, we found that a single amino acid at position 158 of the hemagglutinin (

21 We undertook single amino acid C and N isotope analysis on two Neande

22 ApoE4 differs from its wild-type ApoE3 by a single amino acid C112R in the 299-amino-acid-long seque

23 mutations in proteins, in which exchange of single amino acids can radically alter structure and fun

24 We tested the hypothesis that a single amino acid change (Arg135Gly) in a highly conserv

25 sialic acid (SA) receptor recognition via a single amino acid change at position 226 (H3 numbering),

26 f variants in vivo and in vitro IMPORTANCE A single amino acid change at position 226 in the hemagglu

27 ar example of convergent evolution and how a single amino acid change can have a major effect on ecol

28 wn that complement polymorphisms affecting a single amino acid change cause subtle changes in individ

29 A single amino acid change converting DLD to DWD within PI

30 ock-in mouse model, we demonstrate that this single amino acid change drives a functionally relevant

31 A single amino acid change in IR75b is sufficient to recod

32 Importantly, a single amino acid change in the amyloidogenic TDP-43 pep

33 This could be explained by a single amino acid change in the filovirus receptor, NPC1

34 e evolved strain, among which we confirmed a single amino acid change in the hexose transporter HXT7

35 oreover, the full-length DDX43 protein, with single amino acid change in the KH domain, had reduced u

36 Our results demonstrate that a single amino acid change in the RRV VP4 gene influences

37 The M132V mutant harbors a single amino acid change in the VP1 capsid coding that i

38 eate a mutant of RRV (RRV(VP4-R446G)) with a single amino acid change in the VP4 protein compared to

39 The mutation is a single amino acid change of histidine into arginine at a

40 In this study, we report a single amino acid change that significantly and consiste

41 However, a single amino acid change two residues upstream of the ac

42 A single amino acid change was critical to seroreactivity

43 o bind to the challenge virus V2 HS due to a single amino acid change.

44 us dimethylallyl diphosphate [DMAPP]) with a single amino acid change.

45 rgo profound tuning at the minimal cost of a single amino acid change.

46 difference can be attributed primarily to a single amino acid change: Glu198 on the rat alpha3 subun

47 ound that similar to the ROD10/ROD14 Envs, a single-amino-acid change (T568I) in the ectodomain of th

48 ry, and passaging experiments selected for a single-amino-acid change in capsid (CA) that leads to re

49 2 antagonism to an inactive Env protein by a single-amino-acid change.

50 Single amino acid changes around Cys-739 in FL-NCX1 and

51 ts of structural heterogeneity introduced by single amino acid changes around the binding site on the

52 similar rate but differ in cell shape due to single amino acid changes in the actin homolog MreB.

53 Our analysis pinpoints two single amino acid changes in the central domain that ren

54 responsive to riboflavin were shown to have single amino acid changes in the FADS domain.

55 Single amino acid changes in the SAMHD1-degrading Vpx ma

56 tematic interrogation of mechanisms by which single amino acid changes in various regions of gp120 (i

57 nfluenza viruses and the resulting effect of single amino acid changes on the phenotype of variants i

58 ous up-down-up-down tetramers in response to single-amino-acid changes and solution conditions.

59 itulation of this motif by the addition of a single amino acid conferred targeting function on an N-t

60 Mutations of COX15 causing single amino acid conversions associated with fatal infa

61 E280del, a single amino acid deletion in the autoinhibitory helix i

62 missense mutations affecting p.Arg1809 and a single amino acid deletion p.Met922del.

63 erization of the mutations revealed that the single-amino-acid deletion affecting the TEL patch surfa

64 In total, we identified two single-amino-acid deletions and three non-synonymous var

65 Surprisingly, we find that differences in a single amino acid determine if IL-27alpha can be secrete

66 al human mitochondria encodes a 9-mer with a single amino acid difference from P9 with 89% homology t

67 ructures bound to suvorexant, we exploited a single amino acid difference in the orthosteric binding

68 reactive Th1/Th17 cells is hindered due to a single amino acid difference in the OSP(142-161) region

69 We showed that a single amino acid difference in this motif between mamma

70 ng mouse polyomavirus, we demonstrate that a single amino acid difference in VP1 known to shift viral

71 tial kinetic behaviors of NOV2 and CAO1 to a single amino acid difference near the solvent-binding si

72 subtype selectivity through recognition of a single amino acid difference on a key regulatory domain,

73 Hence, the puzzle remains: how a single-amino-acid difference between the ApoE3 and ApoE4

74 We previously reported that a single-amino-acid difference between the laboratory-adap

75 mutant monomer and vice versa revealed that single-amino acid differences between seed and monomer p

76 n, a frameshift, three nonsense mutations, a single amino acid duplication, a recurrent mutation, and

77 g LCDs parsed by the nature and magnitude of single amino acid enrichment.

78 lished the causative mutation of repp12 as a single amino acid exchange in Aminophospholipid ATPase3

79 ing mitochondrial proteins by the removal of single amino acids from mitochondrial processing peptida

80 ICP55 also removed single amino acids from mitochondrial proteins known to

81 Humans express a repertoire of single-amino acid genetic variants of SP-A that may be a

82 We examined how a single amino acid, glutamate (GLM), modulates intestinal

83 ies within the ATP binding site highlights a single amino acid (I960 -> V) responsible for the potenc

84 Our study demonstrates that a single amino acid in a histone variant can integrate sig

85 d toxin CdtB subunit after substitution of a single amino acid in ArtA, while ArtB can form a functio

86 ys, isoallelic strains that varied by only a single amino acid in CovS, and transcriptome analyses to

87 esistant to lenalidomide but that changing a single amino acid in mouse Crbn to the corresponding hum

88 ustion and improve persistence by changing a single amino acid in the costimulatory domain of CD28.

89 s show that phosphorylation of the NHE3 at a single amino acid in the distal part of the C-terminus a

90 3 and MsexD2 demonstrated that swapping of a single amino acid in the fatty acyl substrate binding tu

91 h LCMV WE v54, which differed from v2.2 by a single amino acid in the viral glycoprotein, failed to g

92 the molecular mechanisms and contribution of single amino acids in OST interaction with its substrate

93 elationships, we created a library of random single-amino-acid IN mutations that could mimic the type

94 rehensive analysis of the fitness effects of single amino acid InDels in TEM-1 beta-lactamase.

95 n revealed by demonstrating that for ABCG2 a single amino acid is essential for engaging and initiati

96 er, elongation pausing during starvation for single amino acids is highly sensitive to the kinetics o

97 mutations focus on either the entire-gene or single amino-acid level.

98 ity and dynamic coupling at a site-specific, single-amino-acid level, we provide evidence that the mi

99 site-directed mutagenesis experiments at the single-amino-acid level.

100 s further evolved, modern strains acquired a single amino-acid modification within Pla that optimizes

101 Single amino acid modifications identified a novel pepti

102 r connecting their two active domains, and a single amino acid mutant (F19Y), were used as probes to

103 y, we screened a library of all 361 possible single-amino-acid mutant forms of ST by using the T84 ce

104 We identified single amino acid mutants of alpha-COP that selectively

105 t on ampicillin resistance of ~12,500 unique single amino acid mutants of the TEM-1, TEM-17, TEM-19,

106 teins, we created a large library of random, single-amino-acid mutants in HIV-1 integrase (IN), cover

107 We discovered that a single amino acid mutation (Met-48 to Phe) in the PRMT1

108 A single amino acid mutation at position 85 (E85V) impairs

109 Our findings revealed that a single amino acid mutation at residue 218 of the HA impr

110 rus, we generated a recombinant virus with a single amino acid mutation at this site through a revers

111 A new methodology termed Single Amino Acid Mutation based change in Binding free

112 A single amino acid mutation in SPA that abrogates assembl

113 bit TrkB kinase activity as a result of this single amino acid mutation in the ATP binding domain.

114 restriction to humans can be attributed to a single amino acid mutation in the RH5 sequence.

115 one of these HAstV strains and found that a single amino acid mutation induces a structural change i

116 These observations beg the question of how a single amino acid mutation may have such wide ranging co

117 A single amino acid mutation near the active site of the C

118 basolateral targeting of TbetaRIII through a single amino acid mutation of proline 826 in the cytosol

119 Our results indicated that the effect of a single amino acid mutation on the peptides drastically i

120 and subsequent experiments confirmed that a single amino acid mutation to the core transcriptional r

121 These studies confirmed that a single amino acid mutation was sufficient to reverse the

122 Single amino-acid mutation of potential signal-transduct

123 We identify a single-amino acid mutation conferring resistance to myco

124 We characterized a Tmc1 mouse with a single-amino-acid mutation (D569N), homologous to a domi

125 AV1 and AAV8 were modified to bind HS with a single-amino-acid mutation and tested in mice.

126 Our studies reveal that single amino acid mutations at the IL-37 dimer interface

127 Here, we mapped how all possible single amino acid mutations in Env affect neutralization

128 ed the immunogenicity of peptides containing single amino acid mutations in mouse tumor models and di

129 ralization sensitivity of pseudoviruses with single amino acid mutations in various regions of gp120

130 Each of the identified single amino acid mutations result in impaired shRNA-med

131 el experimental approach to quantify how all single amino acid mutations to HIV Envelope (Env) affect

132 (TCR) mechanically samples antigens carrying single amino acid mutations.

133 the variation in integration efficiency upon single amino-acid mutations, and the orientation of tran

134 three independent lines of knockin mice with single-amino acid mutations of conserved class II MHC am

135 e report here both C and N isotope ratios on single amino acids of collagen samples for these two Nea

136 Mutation of a single amino acid on a 34-mer PEDF peptide increased min

137 ons mediated by multiple REs, suggesting how single amino acid oncogenic CARD11 mutations can perturb

138 Single amino acid point mutations in the conserved eIF2a

139 Identifying the effect of single amino acid point mutations on the thermodynamic e

140 Using single amino acid point substitutions in these proteins,

141 s that can bind selectively to proteins with single amino-acid point mutations offer the potential to

142 sulting in 636 novel peptides, including 510 single amino acid polymorphism (SAP) peptides, 2 INDEL p

143 ous systems, and this difference mapped to a single amino acid polymorphism at position 26 of the end

144 irulence protein SpvD and demonstrate that a single amino acid polymorphism can affect the overall vi

145 Previously we developed SAAPdap (Single Amino Acid Polymorphism Data Analysis Pipeline) a

146 rphism Data Analysis Pipeline) and SAAPpred (Single Amino Acid Polymorphism Predictor) that use a com

147 N-terminal beta-strand-and, in particular, a single amino acid polymorphism-underpins binding specifi

148 polymorphisms (SNPs) are often conserved as single amino acid polymorphisms in genetically variant p

149 Single amino acid polymorphisms in the SP1 region of Gag

150 n the context of DNA binding, variation at a single amino acid position promotes divergence of the At

151 illustrate the significance of mutations in single amino-acid position for particular bone tissue pa

152 To determine if this single amino acid (R) influences the pathogenicity of th

153 tative monoclonal antibodies revealed that a single amino acid replacement at residue K163 in the Sa

154 ogenic strains to test the hypothesis that a single amino acid replacement in PBP2X conferred a fitne

155 e of the MastR-T74D mutant, which contains a single amino acid replacement in the TSD motif.

156 We observed that no single amino acid replacement is capable of recreating t

157 unctional roles, we constructed full sets of single amino acid replacement mutants at E402 and R404 a

158 tion was observed in algal mutants hosting a single amino acid replacement residing in a D1 domain fa

159 ns are vulnerable towards disease-associated single amino acid replacements affecting protein stabili

160 Single amino acid replacements along the entire length o

161 Single amino acid replacements I32V, V47I, and M76L incr

162 d mortality in vivo In summary, we show that single amino acid replacements in a regulatory accessory

163 nthesis, and this inhibition was relieved by single amino acid replacements in IMP dehydrogenase.

164 Virtually all analyzed strains had single amino acid replacements in penicillin-binding pro

165 We brought to light that single amino acid replacements in the plastoquinone (PQ)

166 The phenotypic difference mapped to a single amino acid residue at position 162 in the E2 enve

167 Here, we show that a single amino acid residue in CD28 drove T cell exhaustio

168 enzymes were interconvertible by switching a single amino acid residue in their active sites.

169 We further determined that a single amino acid residue substitution in NY1682 hemaggl

170 n ovine but not in Culicoides cells due to a single amino acid residue that, most likely, leads to ra

171 Substitution of a single amino acid residue within the degenerin region of

172 iple instances of methylation can occur on a single amino acid residue, and the relative mass of the

173 Enteritidis (SEn) by a single amino-acid residue, immunization with STmOmpD con

174 a large number of exopeptidases that cleave single amino acid residues from the N-terminus of peptid

175 or entire PTS1 domains and position-specific single amino acid residues, including residues upstream

176 of a defined subset of proteins/peptides at single amino acid resolution with attomole level sensiti

177 -DNA contacts at single nucleotide and up to single amino acid resolution.

178 Here, at single amino-acid resolution, we identify the determinan

179 Enlarging the URS by a single amino acid resulted in increased translational in

180 structural difference between variants was a single amino acid resulting from a codon insertion, and

181 ime due to the reversible light-switching of single amino acid side-chains, adding a dynamic dimensio

182 ocking studies, we found that replacing this single amino acid significantly changed the PPO's substr

183 Herein, we demonstrate that replacement of a single amino acid stereocenter with a stereodynamic nitr

184 ccessful generation of global gene-knockout, single-amino-acid-substituted, as well as floxed mice th

185 t the infectivity of B virus isolates with a single amino acid substitution (D122N) in the IgV-core o

186 study demonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembr

187 Indeed, this single amino acid substitution (G-->V) at a residue inva

188 e strains carried hly mutations leading to a single amino acid substitution (G299V) or a premature st

189 from the same parental stock and differ by a single amino acid substitution (H1047R) caused by a sing

190 t disruption of the SpoIIQ LytM domain via a single amino acid substitution (H120S) impairs engulfmen

191 ression, but this activity was restored by a single amino acid substitution (K186E), which was respon

192 ingly, the S. suis NrtR naturally contains a single amino acid substitution (K92E) in the catalytic s

193 Here, we identify a single amino acid substitution (M159I) that fundamentall

194 a severely autistic male patient carrying a single amino acid substitution (R101Q) in the NLGN4 gene

195 We find that the blue trait maps to a single amino acid substitution (R644W) in an uncharacter

196 Here we show that a naturally occurring single amino acid substitution (tyrosine to cysteine) at

197 We found that a single amino acid substitution (V6A) in a motif associat

198 The results suggest that this single amino acid substitution acts as a thermal and reg

199 AATD is most often caused by a single amino acid substitution at position 342 in the ma

200 A single amino acid substitution at position 61 in the SNH

201 Thus, a single amino acid substitution can significantly alter t

202 This simple switch in mechanism by a single amino acid substitution could potentially generat

203 beta(2)m aggregation in vitro However, how a single amino acid substitution enhances the rate of aggr

204 y minor variants comprised from conservative single amino acid substitution events.

205 A single amino acid substitution evolved together with thi

206 In this paper, we generated a single amino acid substitution FMDV variant with a high-

207 ults demonstrate that a change as small as a single amino acid substitution in a FAD enzyme might res

208 The authors demonstrated that this single amino acid substitution in CD28-based mesothelin

209 The single amino acid substitution in FMDV polymerase result

210 semidominant mutation (ref4-3) that causes a single amino acid substitution in MED5b functions as a s

211 he Arabidopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROT

212 za B/Yamanashi/166/1998 viruses containing a single amino acid substitution in NA generated by revers

213 Both mutations cause a single amino acid substitution in one OPR repeat.

214 sistance, virtually all emm12 isolates had a single amino acid substitution in penicillin-binding pro

215 Such ability was restored by a single amino acid substitution in position 186 (K186E) t

216 A single amino acid substitution in that domain abolished

217 A single amino acid substitution in the binding pocket can

218 agues describe a new mouse model featuring a single amino acid substitution in the coiled-coil motif

219 tetraploid wheat accessions revealed that a single amino acid substitution in the DNA-binding domain

220 in vitro evolution also revealed that just a single amino acid substitution in the envelope can confe

221 Taken together, the study demonstrates how a single amino acid substitution in the histidine kinase r

222 be reengineered in both TRPV1 orthologs by a single amino acid substitution in the N-terminal ankyrin

223 Thus, a single amino acid substitution in the regulatory domain

224 ity of both ALA1 and ALA2 was abolished by a single amino acid substitution known to inactivate the f

225 The single amino acid substitution l-Leu47Lys results in 340

226 generated novel transgenic mice harbouring a single amino acid substitution of arginine 124 with cyst

227 A single amino acid substitution responsible for SSS (W157

228 ructose 6-P-specific enzyme was started by a single amino acid substitution resulting in negative sel

229 pic analysis of the two iNK TCR types with a single amino acid substitution revealed that the stainin

230 iosynthetic enzyme from IPMDH results from a single amino acid substitution that alters substrate spe

231 t PrP mutants were designed to contain every single amino acid substitution that distinguishes rabbit

232 ther mutant allele produces a protein with a single amino acid substitution that is stable but assemb

233 accumulation is most likely attributed to a single amino acid substitution that leads to different O

234 se inhibitor 1A (SERPINA1) gene leading to a single amino acid substitution that results in an unfold

235 Resistance to C1 was conferred by a single amino acid substitution within the compound-bindi

236 M) were calculated for nearly every possible single amino acid substitution within this fragment.

237 We found that a single amino acid substitution, F548S, in the Ebola viru

238 of site-specific mutant HAs indicate that a single amino acid substitution, Thr-30 --> Ser, influenc

239 A single amino acid substitution-based adaptive coevolutio

240 n) in which self-assembly was abolished by a single amino acid substitution.

241 We demonstrate that a single amino-acid substitution in a banana lectin, repla

242 eloped an engineered mouse model harboring a single-amino acid substitution in FAAH (S268D) that sele

243 he N-linked glycosylation site is mutated by single-amino-acid substitution are highly attenuated and

244 tagenesis, i.e. the scanning of all possible single amino acid substitutions at all sequence position

245 Novel recombinants of Hb S with single amino acid substitutions at the putative axial (r

246 olyleucine transmembrane proteins containing single amino acid substitutions can activate the platele

247 Finally, we show that antibiotics and single amino acid substitutions can be used to target sp

248 This revealed that single amino acid substitutions can silence the extended

249 f transcripts, the mechanisms by which these single amino acid substitutions change gene expression r

250 Whereas the single amino acid substitutions do not affect the functi

251 rrestin recruitment, by different effects of single amino acid substitutions in ACKR3 on arrestin in

252 We use single amino acid substitutions in DAXX that abrogate fo

253 Single amino acid substitutions in the C-terminal membra

254 e multifocal leukoencephalopathy (PML) carry single amino acid substitutions in the domain of the VP1

255 Importantly, single amino acid substitutions in the EF-hand domain of

256 l scanning approach to evaluate all possible single amino acid substitutions in the human TpoR TMD fo

257 Our studies show that single amino acid substitutions in the selectivity filte

258 Here, we identified single amino acid substitutions in Vps13 (vacuolar prote

259 We show that single amino acid substitutions near the receptor bindin

260 mapping information as a guide to introduce single amino acid substitutions of nine different residu

261 We identified nine single amino acid substitutions that could not complemen

262 substrate binding cavity predisposes them to single amino acid substitutions that enable a switch bet

263 Single amino acid substitutions to benenodin-1 generate

264 our previous study of the fitness effects of single amino acid substitutions to calculate epistasis f

265 We tested 7800 of 7828 possible single amino acid substitutions to the beta-2 adrenergic

266 Single amino acid substitutions were introduced into the

267 a) to study the molecular consequences of 16 single amino acid substitutions, classified as pathogeni

268 tion of the Galpha:RGS protein pair based on single amino acid substitutions.

269 in human populations that result in specific single amino acid substitutions.

270 tions to the hypervariable region, including single-amino acid substitutions, are sufficient to elimi

271 struct a library encoding all 9,595 possible single-amino acid substitutions.

272 ts of BamD depletion were partly reversed by single-amino-acid substitutions mapping within the beta-

273 sulting in a set of fragments differing by a single amino acid that remain spatially confined on the

274 Mutational analysis revealed that a single amino acid (Thr(24)) in the extracellular domain

275 Therapeutic administration of a single amino acid to experimentally infected mice was su

276 re, we present evidence for the ability of a single amino acid to self-assemble into a potent and sta

277 uctural information on peptides ranging from single amino acids to large peptides and peptide cluster

278 s to quantify the energetic contributions of single amino acids to the stability of the ALS related p

279 ed proteins, namely, the ones labeled with a single amino acid type, or a limited subset of types, is

280 and MFN1 largely derives from a primate-only single amino acid variance.

281 a subset that retained function, including a single amino acid variant (Y100Q).

282 nal scanning (DMS) to generate comprehensive single amino acid variant data on a major clinical MBL,

283 unrelated individuals differ by about 10,000 single amino acid variants (SAVs).

284 gle nucleotide variants, also referred to as single amino acid variants (SAVs).

285 y and comprehensively assaying the effect of single amino acid variants (SAVs; also referred to as mi

286 ma proteome analysis, we enable detection of single amino acid variants and for the first time demons

287 onsensus predictions on the pathogenicity of single amino acid variants in ROMK.

288 ROMK-dependent yeast growth assay and tested single amino acid variants selected by a series of compu

289 novel proteins, novel splice junctions, and single amino acid variants using simulations and experim

290 Here, we employed single-amino acid variants (SAAVs) to investigate ecolog

291 Comprehensive mutational scanning of p53 single-amino acid variants demonstrated that missense va

292 in Tat-transactivation has been traced to a single amino acid variation between the two proteins, wh

293 s, there is very little understanding of how single amino acid variation in amelogenins can lead to m

294 anning (DMS) datasets probing the effects of single amino acid variation on enzyme activity and stead

295 d a large-scale structural analysis of human single amino acid variations (SAVs) and demonstrated tha

296 These single-amino acid variations (SAVs) are routinely found

297 othesis that Rf4 restoration is altered by a single amino acid was tested by using clustered regularl

298 , our results point to a critical role for a single amino acid within the membrane-proximal region of

299 surface on cGAS and we show that mutation of single amino acids within this surface renders cGAS mass

300 in the previous studies, to targeting only a single amino acid without compromising the intensity of