ライフサイエンスコーパス: single chain

1 fore they have been fully amplified within a single chain.

2 ed in a linear fashion, with the majority as single chains.

3 and functional characterizations of a novel single-chain (120 kDa), multi-domain biotin-dependent ca

4 , consisting of DAP12 fused to the anti-PSCA single-chain Ab fragment scFv(AM1) confers improved cyto

5 ngle-chain BAFF (BBB) and to a lesser extent single-chain ABB, but not APRIL or single-chain BAA, res

6 ing the photoluminescence (PL) from isolated single-chain aggregates and multichain mesoscopic aggreg

7 of photon antibunching contrast compared to single-chain aggregates, implying rather weak interchain

8 bit red-shifted and broadened PL compared to single-chain aggregates.

9 ssembly and survival of vesicles composed of single chain amphiphiles as model protocell membranes.

10 Vesicles formed from single-chain amphiphiles (SCAs) such as fatty acids prob

11 lipid liposomes (Sterosomes) formulated with single-chain amphiphiles and high content of sterols hav

12 d public receptors observed when compared to single-chain analyses, and a distance-based classifier t

13 e arranged in a linear fashion, primarily as single chains and, to a lesser degree, as branched chain

14 Comparing the single-chain and split ESX ATPases, we reveal difference

15 e second minireview describes application of single chain antibodies (nanobodies) for monitoring and

16 ha-syn::GFP was reduced by immunization with single chain antibodies against alpha-syn.

17 self-assembled nanorings (CSANs) displaying single chain antibodies can bind to both the CD3 epsilon

18 rapeutic applications.The therapeutic use of single-chain antibodies (VHHs) is limited by their short

19 tely 100 million secreted and membrane-bound single-chain antibodies and identify antibodies that can

20 hile chimeric antigen receptors (CARs) using single-chain antibodies as binding domains are growing i

21 f chimeric antigen receptors (CARs) based on single-chain antibodies for gene immunotherapy of cancer

22 Single-chain antibodies from camelids have served as pow

23 on has been in the area of nanobodies, small single-chain antibodies from camelids or sharks.

24 ells expressing tumor-associated antigens by single-chain antibodies fused to a receptor-binding-defi

25 otherapy for HIV-1 using novel CARs based on single-chain antibodies.

26 ing mesothelin-targeted TR3 variants using a single chain antibody (scFv) delivery format (SS-TR3), w

27 stomize the in vivo behavior of an anti-METH single chain antibody (scFv7F9Cys).

28 ant antivenom composed of a few neutralizing single chain antibody fragments (scFvs) that bind to two

29 il dimer forming polypeptides was fused to a single chain antibody specific for tumor antigen CD20.

30 nap) into specific positions of an anti-EGFR single chain antibody to generate an emission wavelength

31 ification, we constructed an anti-annexin IV single-chain antibody (scFv) and an scFv linked to Crry,

32 Conjugation to the corona of a single-chain antibody (scFv), which binds to the ligand-

33 n order to fulfill this goal, we generated a single-chain antibody (scFv47) from our parental IL13Ral

34 tilizing Herceptin and its derived humanized single-chain antibody (single-chain fragment variable, d

35 via a recombinant fusion protein combining a single-chain antibody against activated glycoprotein IIb

36 ticles of iron oxide (MPIOs) conjugated to a single-chain antibody directed against a ligand-induced

37 Here, we used a single-chain antibody fragment (scFv) derived from the a

38 Here we develop single-chain antibody fragments (nanobodies) against tub

39 arting from large phage display libraries of single-chain antibody fragments (scFvs), the three-stage

40 assemblies for a monoclonal antibody and its single-chain antibody fragments derivatives.

41 ity/specificity trade-offs, we have selected single-chain antibody fragments specific for the negativ

42 In this study, we isolated a single-chain antibody from an Indian dromedary camel (IC

43 assessed using monoclonal antibody NV23 and single-chain antibody HJT-R3-A9 to identify both virus-l

44 ncAA (CypK) at diverse sites on a displayed single-chain antibody variable fragment (ScFv), in respo

45 on status of monocytes was determined with a single-chain antibody, MAN-1, which is specific for the

46 BNAbs varying in binding sites and generated single-chain-antibody-based CARs.

47 ecreted by Group A Streptococcus (GAS), is a single-chain approximately 47-kDa protein containing thr

48 erature T( *)cr, is related to the protein's single-chain average radius of gyration <Rg>.

49 er extent single-chain ABB, but not APRIL or single-chain BAA, rescued BAFFR-dependent B cell maturat

50 Single-chain BAFF (BBB) and to a lesser extent single-ch

51 than ligands of monomers, or homomers with a single-chain binding site.

52 erent allosteric pathways than homomers with single-chain binding sites (SBSs) or monomers.

53 CAR formats, but also can be used to create single-chain bispecific CARs and TCRs.

54 A single chain camelid antibody fragment specific for the

55 This letter describes formation of single chain cationic polymer dots (Pdots) made of poly[

56 ed hydrogel that releases nanoparticles with single-chain CD98 antibodies on their surface (scCD98 fu

57 We report the design and application of single-chain cofactor-free kinases with photoswitchable

58 n equivalence between the driving forces for single-chain collapse in dilute solutions and the drivin

59 ion of F-P3EHT leads to an extended rod-like single-chain conformation and hence highly ordered inter

60 ve similarly significant impact on promoting single-chain conformational compactness and phase separa

61 very unusual and complex chain structure; a single chain contains alternating zigzag and helical sec

62 stance 2 orders of magnitude longer than the single-chain contour.

63 In particular, monellin and its single chain derivative (MNEI) are among the sweetest pr

64 mutations of amino acid residues of MNEI, a single chain derivative of the natural sweet protein mon

65 hniques including PEGylation, Fc fusion, and single-chain design.

66 rt on our efforts to engineer a (monovalent) single-chain dimeric streptavidin (scdSav) as scaffold f

67 ible, regulated, surface expression of HLA-E single-chain dimers (fused to B2M) or trimers (fused to

68 iples to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nan

69 Using the single-chain due ferri (DFsc) peptide scaffold, the diff

70 tic sublattices built of [FenSe4n+2]infinity single-chain edge-sharing octahedra, coherently embedded

71 himeric subunit protein vaccine (full-length single chain) elicits heterologous protection against si

72 electivity of a single catalyst for either a single-chain-elongation or a single-chain-termination ev

73 It is a single-chain enzyme in eukaryotes and most bacteria, and

74 The mechanochemical kinetics, single-chain extensibility, toughness and potentially op

75 ystem while also amplifying product yield in single chain-extension experiments and enabling multiple

76 ent study, we have developed a novel one-arm single chain Fab heterodimeric bispecific IgG (OAscFab-I

77 ization with one heavy chain consisting of a single chain Fab to prevent wrong pairing of light chain

78 ient and expressed as two recombinant forms (single-chain Fab in Pichia pastoris and Fab in Escherich

79 Single-chain FLARE (scFLARE) is a single polypeptide cha

80 monomeric gp120 boost, with the full-length single-chain (FLSC) protein.

81 ts for open promoter complex formation using single-chain forms of bEBP lacking the full complement o

82 resents the crystal structure of two chicken single chain fragment variable (scFv) antibodies generat

83 s work we report the patterned attachment of single chain fragment variable (scFv) antibodies to the

84 A novel single chain fragment variable (scFv) fragment was gener

85 alibu-Glo assay for the selection of optimal single chain fragment variables (scFvs) with desired aff

86 mmunological characterization of a monomeric single-chain fragment (ScFv) of human origin specific fo

87 A synthetic gene coding for a single-chain fragment (ScFv) specific for the major timo

88 Recently, a single-chain fragment antigen binding (Fab) (scFab) form

89 on of a generic anti-immunocomplex (anti-IC) single-chain fragment of antibody variable domain (scFv)

90 A single-chain fragment variable (scFv) recognizing beta2-

91 Cells that secrete a single-chain fragment variable (scFv) that binds to the

92 Methods: A human single-chain fragment variable (scFv) was generated by p

93 orable binding to FcRn was maintained when a single-chain fragment variable antibody was genetically

94 scribe, to our knowledge, the first anti-NCL single-chain fragment variable displaying antineoplastic

95 e display selections using a synthetic human single-chain fragment variable library.

96 ing to the identification of a high-affinity single-chain fragment variable region (scFv).

97 ntially combine the high display levels of a single-chain fragment variable with the high stability o

98 its derived humanized single-chain antibody (single-chain fragment variable, designated 4D5), we gene

99 play technology, we engineered a fully human single-chain fragment variable, named 4LB5.

100 pecially engineered anti-h-FABP and anti-MPO single-chain fragment variables (scFv) were immobilized

101 Anti-METH IgGs and single chain fragments (scFvs) have shown efficacy in pr

102 )-1 stimulate each other's binding, we fused single-chain fragments (scFv) of paired anti-mouse PECAM

103 fferential cell screening of a yeast-display single-chain fragments variable (scFv) library derived f

104 s conventional alphabeta heterodimers, or as single-chain fragments variable constructs linked to CD3

105 xes whereas CARs typically use an Ab-derived single-chain fragments variable that recognizes cancer-a

106 e cells, we developed a genetically encoded, single-chain FRET-based biosensor for Rac2.

107 al models of common biosensor architectures (single-chain FRET-based biosensors), which include both

108 Single-chain fusion proteins comprised of GM-CSF and neu

109 By displaying the humanized 8H9 single chain Fv (scFv) on the surface of yeast, the affi

110 single anti-beta-galactosidase intracellular single chain Fv antibody fragment, fused to inactive pro

111 its natural substrate-binding domain with a single-chain Fv (scFv) intrabody or a fibronectin type I

112 Fully-human single-chain Fv (scFv) proteins are key potential buildi

113 The C4 single-chain Fv antibody (scFv) binds to the first 17 re

114 The binding affinity of a model single-chain Fv antibody was optimized by using ALV disp

115 t versatile biosensing elements are antibody single-chain Fv fragments (scFv), antibody fragment-anti

116 response maps that track changes across each single chain-Fv fragment, thus providing valuable insigh

117 Across a set of six single chain-Fv fragments of the anti-lymphotoxin-beta r

118 bining two corresponding Tag-fused anti-EGFR single-chain Fvs (scFvs), which recognize different epit

119 To test the hypothesis that single-chain FXII expresses activity that could initiate

120 ct activation in which activity intrinsic to single-chain FXII initiates alphaFXIIa and alpha-kallikr

121 droplets that spontaneously assemble from a single-chain galactolipid and nonionic detergents.

122 t experimental evidence of an existence of a single-chain glass state in conjugated polymers.

123 umab and adalimumab) to generate recombinant single chain GloBodies, which retain the drug antibody p

124 sultant linked gp120-gp41 constructs, termed single-chain gp140 (sc-gp140), exhibited different level

125 Neutral thiourea and the single-chain guanidinium receptor did not bind phosphate

126 on scattering experiments, we argue that the single-chain Hamiltonian contains a staggered spin-excha

127 xhibited an increase in conversion of latent single-chain HGF to active two-chain HGF, coinciding wit

128 spatially close and can be linked to create single-chain homo- or hetero-ligands of defined stoichio

129 A Streptococcus pyogenes [GAS]) recruit host single-chain human plasminogen (hPg) to the cell surface

130 trinsic immunoregulatory activities of other single chain IL-12 subunits might be exploited to treat

131 Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symp

132 We determined that a single chain in the asymmetric unit forms a pseudo-hexag

133 tion not only rationalizes the inactivity of single-chain insulin (SCI) analogs (in which the A and B

134 nd stability of such an analog, a 57-residue single-chain insulin (SCI) with multiple acidic substitu

135 t high-fidelity reporting is possible when a single-chain intermolecular biosensor is used that canno

136 nucleotide coding sequences were cloned as a single chain into a lentiviral backbone and secured with

137 apasin binding to the core TM domain of TAP1 single chains is mysterious because this interaction is

138 (3), can be synthesized in the few- (2-4) to single-chain limit via nanoconfined growth within the st

139 onal antiprismatic rocking distortion in the single-chain limit.

140 In the present work, enhanced single-chain magnet (SCM) behavior is observed for a Mo(

141 b(valpn)Cu](3+) dinuclear cations produced a single-chain magnet (SCM) involving stacking interaction

142 ity measurements revealed the existence of a single-chain magnet behavior hidden below the canted ant

143 nge magnetic ordering below 5.1 K as well as single-chain magnetic behavior at lower temperatures wit

144 These compounds are single-chain magnets and exhibit wide, square magnetic h

145 ical assembly of a query (in addition to the single chain), mapping of the conservation grades onto 2

146 Self-assemblies of equimolar double and single chain mixed ionic surfactants, with increasing nu

147 umatin and, together with the Y65R mutant of single chain monellin, one of the two sweetest proteins

148 the TSE in a beta-sandwich (I27) protein and single-chain monellin as the denaturant concentration is

149 antigen binding domains (VHH) of five unique single-chain monoclonal antibodies that differ in their

150 aryotic Cu-ATPases, ATP7B is assumed to be a single-chain monomer.

151 The application of llama-derived single chain nanobodies for passive immunotherapy was co

152 We report a strategy to codeliver a single-chain nanoparticle (SCNP) catalyst and an exogeno

153 we use gating to develop a copper-containing single-chain nanoparticle (SCNP) catalyst as an artifici

154 ivation by Pd(OAc)2 is demonstrated as a new single-chain nanoparticle (SCNP) folding process, enabli

155 rein, we introduce the first approach to map single-chain nanoparticle (SCNP) folding via high-resolu

156 al single rings, complex multi-ring systems, single chain nanoparticles, tadpoles, dumbbells and hair

157 characterization of platinum(II)-crosslinked single-chain nanoparticles (Pt(II) -SCNPs) to demonstrat

158 These single-chain nanostructures also display ultra-high ther

159 o assemble individually folded proteins into single-chain nanostructures with bespoke architectures a

160 served that in the presence of chloride, the single-chain NC1-trimer self-assembles into a hexamer, f

161 These compartmentalized single-chain objects were prepared by performing success

162 ructures could be efficiently compacted into single-chain objects.

163 6)) and [(C(6)H(11)NC)(2)Au](AsF(6)) contain single chains of cations and are vapochromic, yellow [(C

164 Here we report that proteins with single chains of K48-linked ubiquitin are targeted for d

165 Single chains of poly(3-hexylthiophene) (P3HT) exhibit l

166 In addition to single chains of proteins, we have also analyzed the sha

167 2M, using the ALT-803 scaffold fused to four single chains of the tumor-targeting monoclonal antibody

168 Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase that catalyzes tryptophan de

169 uble-compaction occurred and that the formed single-chain particles contain distinct cross-linked sub

170 The single chain Pdot formation relies on a simple process w

171 n, with one primary strand equivalent to the single chain peptide ligands, while the second strand re

172 -peptide-HLA crystal structures and, using a single-chain peptide-HLA phage library, we generated pep

173 t the activation cleavage site (PK-R371A, or single-chain PK).

174 We describe single-chain polymer nanoparticles (SCNPs) possessing in

175 four nanometres thick-in which warp and weft single-chain polymer strands remain associated through p

176 sts studied are a group of copper-containing single-chain polymeric nanoparticles (Cu(I)-SCNP) that e

177 Single-chain polymeric nanoparticles (SCPNs) are intrigu

178 cule force spectroscopy (SMFS) is applied to single-chain polymeric nanoparticles (SCPNs) to acquire

179 Despite being constrained to the single-chain precursor form, PK-R371A cleaves high-molec

180 The 63-kDa single-chain precursor protein localizes to pre-lysosoma

181 We produced and characterized >20 single-chain protein cages in three shapes-tetrahedron,

182 main organization was further validated with single-chain protein constructs in which the two enzyme

183 we present an approach to rationally design single-chain protein constructs that mimic the NHR coile

184 Here, we report the synthesis of single-chain protein nanostructures with triangular and

185 S neurons, but not glia, express SorCS2 as a single-chain protein that is essential for proBDNF-induc

186 This study analysed one such single-chain protein, TstI.

187 cterize a hypothetical approximately 100 kDa single-chain protein, YonO, encoded by the SPbeta propha

188 nd gmrD genes are fused together to encode a single-chain protein.

189 These single-chain proteins bound to synthetic CHR peptides wi

190 ype ISP restriction-modification enzymes are single-chain proteins comprising an Mrr-family nuclease,

191 een classified as type 1 RIPs, consisting of single-chain proteins, and type 2 RIPs, consisting of an

192 ade significant improvements to our existing single-chain Rac1 biosensor.

193 Here, we describe the development of a single-chain rare-cleaving nuclease architecture, which

194 ns from cyclin B en bloc, proceeding until a single chain remains.

195 at integrate 16S and 23S ribosomal RNAs into single-chain ribosomal RNAs that remain uncleaved by rib

196 moral delivery of adenoviral vector encoding single-chain (sc)IL-23 (Ad.scIL-23) was able to induce s

197 der to reduce TDP-43 pathology, we generated single-chain (scFv) antibodies against the RNA recogniti

198 dation of polymers is typically limited to a single chain scission per triggering chain stretching ev

199 tificial heteropolymers the control over the single chain self-assembling properties does not reach t

200 First, RNAMake discovers highly stable single-chain solutions to the classic problem of alignin

201 Some factors, including the choice of single-chain spacer(6) and extracellular(7) and costimul

202 ves exhibit a size that is consistent with a single-chain species, the self-assembled SCTPs were foun

203 The single-chained sphingolipid sphingosine is an essential

204 Overexpression of the single-chain SPT fusion protein under the control of a t

205 s individual subunits or as a heterotrimeric single-chain SPT fusion protein.

206 assays Rpn13 retarded degradation of various single-chain substrates.

207 Ultrafine single-chain tadpole polymers (SCTPs), containing an int

208 This review covers the recent advances in single chain technology for the construction of soft nan

209 s through the full development of so-called "single chain technology".

210 e the expected, long-term valuable output of single chain technology.

211 Moreover, the single-chain technology is foundational for generating t

212 de ion-mediated protomer assembly by using a single-chain technology to produce a stable NC1 trimer c

213 st for either a single-chain-elongation or a single-chain-termination event during ruthenium-catalyze

214 ion, we constructed differently oligomerized single chain TNF ligands (scTNF) comprised of three TNF

215 ter system to measure translocation by an AB single-chain toxin in intact cells.

216 The single-chain toxins TcdA and TcdB are the main virulence

217 Furthermore, we demonstrate that all single-chain TTLLs with known glutamylase activity utili

218 Intranuclear single-chain uPA binds directly to and interferes with t

219 Here we report that wild type single-chain uPA, but not uPA variants incapable of nucl

220 We fused single-chain urokinase plasminogen activator (scuPA) to

221 G221S variants displayed moderately reduced single-chain urokinase-type plasminogen activator activa

222 The G221E variant failed to activate the single-chain urokinase-type plasminogen activator, and t

223 gs algorithm that allows for parallelizing a single chain using existing MCMC methods.

224 distinct, high affinity antibody fragments (single chain variable and antigen-binding (Fab) fragment

225 We report the molecular design of a single chain variable antibody fragment (scFv) that bind

226 in both free anti-IL-1beta Fab and anti-IL-6 single chain variable exist in multiple conformations, w

227 ls were genetically modified to display both single chain variable fragment (scFv) antibodies and gol

228 eins which involves the use of i) nano yeast single chain variable fragment (scFv) as a promising alt

229 Recombinant HSV-1 containing the ch14.18 single chain variable fragment (scFv) at the N-terminus

230 The VEGF binding domain consists of a single chain variable fragment (scFv) based on ranibizum

231 tom Pinnularia sp. and functionalized with a single chain variable fragment (scFv) derived from an an

232 We constructed a phage recombinant single chain variable fragment (scFv) library with a div

233 alpha-FLT3-A192 fusion protein composed of a single chain variable fragment antibody conjugated with

234 Phl p 1 using allergen-specific IgE-derived single-chain variable Ab fragments (IgE-ScFvs) isolated

235 riable fragment (muscFv1E4), and a humanized single-chain variable fragment (huscFv1E4) retained the

236 agment of 1E4 (Fab1E4), a recombinant murine single-chain variable fragment (muscFv1E4), and a humani

237 eptide (Asp-Tyr-Lys-Asp) were grafted onto a single-chain variable fragment (scFv) acceptor framework

238 igands of choice, such as anti-Her2 antibody single-chain variable fragment (scFv) and luteinizing ho

239 On the other hand, single-chain variable fragment (scFv) antibodies have be

240 Single-chain variable fragment (scFv) antibodies increas

241 The HJT-R3-A9 single-chain variable fragment (scFv) antibody epitope w

242 as "RTH258" and "ESBA1008") is a humanized, single-chain variable fragment (scFv) antibody with a mo

243 CAR) in which targeting was achieved using a single-chain variable fragment (scFv) derived from the 5

244 fically target NCT and expressed them in the single-chain variable fragment (scFv) format in mammalia

245 M204 and an engineered single-chain variable fragment (scFv) inhibited seeding

246 b) was constructed by inserting an anti-Her2 single-chain variable fragment (ScFv) into an anti-CD3 F

247 A single-chain variable fragment (scFv) intrabody was gene

248 electing ligands to salivary proteins from a single-chain variable fragment (scFv) PD combinatorial l

249 A nonimmune, human single-chain variable fragment (scFv) phage display libr

250 A 3H3 single-chain variable fragment (scFv) retained the bindi

251 mation, leading to a monovalent "stapler," a single-chain variable fragment (scFv) that binds at the

252 strated by evolution of an anti-Fas receptor single-chain variable fragment (scFv) that was improved

253 t anti-CAR T-cell responses against a murine single-chain variable fragment (scFv) used clinically in

254 Here, we report a human single-chain variable fragment (scFv), identified via ye

255 sensor was 0.62 ppb, and hence comparable to single-chain variable fragment (scFv)-based TNT sensors.

256 Engineered single-chain variable fragment antibodies (scFv) are muc

257 previously designed a fusion protein of TM [single-chain variable fragment antibody (scFv)/TM] targe

258 Anti-FvTox1 single-chain variable fragment antibody expressed in tra

259 maging in living cells, we have engineered a single-chain variable fragment binding the linear HA epi

260 MA(+)TACI(-) and BCMA(-)TACI(+) cells, and a single-chain variable fragment CAR targeting BCMA alone

261 with anti-CD19 CAR T-cell construct type or single-chain variable fragment clone, but was higher wit

262 Phage display was then used to identify single-chain variable fragment clones that selectively b

263 ron microscopy of a broadly neutralizing IgG single-chain variable fragment complexed with BK virus-l

264 Constructs containing a single-chain variable fragment derived from an anti-NKG2

265 ith random in-frame InDels across the entire single-chain variable fragment gene that were further re

266 of nonspecific antibodies from two synthetic single-chain variable fragment libraries expressed on th

267 tion was reported by anti-HT2 immune complex single-chain variable fragment of antibody fused with al

268 ic CAR in which a CD4 segment is linked to a single-chain variable fragment of the 17b human monoclon

269 xpress a CD19-CAR incorporating an anti-CD19 single-chain variable fragment plus TCR zeta and CD28 si

270 brary representing a highly diverse array of single-chain variable fragment sequences was first desig

271 We have used Phage Display to select scFv (single-chain variable fragment) clones from a combinator

272 etected when an anti-EGFR antibody (425 Snap single-chain variable fragment) that allows for dimeriza

273 at an immunotoxin consisting of an anti-PD-1 single-chain variable fragment, an albumin-binding domai

274 We recently demonstrated that single-chain variable fragment-based bispecific chemical

275 ed by nuclear magnetic resonance using a 7A1-single-chain variable fragment.

276 rein, we report on newly developed nanoyeast single-chain variable fragments (NYscFv) as an attractiv

277 ins, we expressed a library of intracellular single-chain variable fragments (scFvs) ("intrabodies")

278 To overcome this issue, we engineered single-chain variable fragments (scFvs) against fibrilla

279 ed for the therapeutic effect, we engineered single-chain variable fragments (scFvs) derived from HJ8

280 Our selections elicited "stapler" single-chain variable fragments (scFvs) of antibodies th

281 We here describe an approach to identify single-chain variable fragments (scFvs) specific for mut

282 We generated two single-chain variable fragments (scFvs) that recognize d

283 tives, such as antibody fragments (Fabs) and single-chain variable fragments (scFvs), are now being u

284 These binding proteins are based on antibody single-chain variable fragments and activate fluorogenic

285 to an intrabody format by converting them to single-chain variable fragments and used them to monitor

286 It consists of 2 single-chain variable fragments specific for CD19 presen

287 V3 loop, we generated 20 variants of KD-247 single-chain variable fragments with mutations in the an

288 red by antigen-independent clustering of CAR single-chain variable fragments, can induce early exhaus

289 , called F7L6, comprised of antibody-derived single-chain variable fragments, that selectively binds

290 Using single-chain variable fragments, we tested antibody resi

291 ates MG to a similar extent as FAPs based on single-chain variable fragments.

292 stone-modification fluorescent probe using a single-chain variable region (scFv) fragment of a specif

293 of recombinant immunotoxins containing mouse single-chain variable regions fused with a Pseudomonas t

294 ucture of influenza-virus hemagglutinin (HA):single-chain variable-domain fragment complexes, by stud

295 In particular, smaller, single-chain-variable antibody fragments (scFv's) are at

296 ally active mutants of scVEGF (an engineered single-chain version of pan-receptor VEGF-A with an N-te

297 e of subunit communication in a reengineered single-chain version of the homodimeric transcription fa

298 e generated a chimeric prodrug composed of a single-chain version of the variable region of an anti-a

299 lowed for the intramolecular crosslinking of single chains via the addition of [Pt(1,5-cyclooctadiene

300 However, single chains were often shared between patients and use