ライフサイエンスコーパス: single-positive

1 ation of dysfunctional CD3(high)CD8(+)CD4(-) single-positive 8 (SP8) thymocytes with low expression o

2 earrangements of CD3(-)CD4(+)CD8(-) immature single-positive and CD3(+)CD4(+)CD8(+) double-positive c

3 eta-selection checkpoint to the CD8 immature single-positive and CD4+ CD8+ double-positive stages.

4 T cell populations (CD4 single positive, CD8 single positive, and CD4(dim)CD8(bright)) were found in

5 e-TCR/TCR signaling during the DN4, immature single-positive, and double-positive stages of developme

6 N, minimal surgeon experience, presence of a single positive axillary LN, and use of immunohistochemi

7 sIgE to Ves v 5 and/or Ves v 1, and 78.3% of single-positive bee venom-allergic patients had sIgE to

8 tropenic patients were less likely to have a single positive blood culture than were nonneutropenic p

9 Among single-positive CA30 thymocytes, few reached maturity an

10 eficient mice was already observed in CD4(+) single-positive CD25(+) GITR(+) Foxp3(-) thymic Treg cel

11 10 and results in the accumulation of mature single-positive CD3(high)heat-stable Ag(low) thymocytes.

12 eration of natural Tregs (nTregs) within the single positive CD4 thymocyte compartment, accounting fo

13 -positive thymocytes, for differentiation of single-positive CD4 and CD8 T cells, and for the prolife

14 tes that are capable of differentiating into single-positive CD4 and CD8 T cells.

15 rom DN3 through to DN4, double-positive, and single-positive CD4 and CD8.

16 d in beta selection and is indispensable for single-positive CD4 thymocyte development.

17 esulting in decreases in double-positive and single-positive CD4 thymocytes.

18 - or staphylococcal enterotoxin B-stimulated single-positive CD4(+) and CD8(+) T cells.

19 1017-DRAK2 Tg mice displayed a reduction of single-positive CD4(+) and CD8(+) thymocytes in context

20 ed a significant reduction in the numbers of single-positive CD4(+) and CD8(+) thymocytes.

21 ble-positive (DP) CD4(+)CD8(+) thymocytes to single-positive CD4(+) or CD8(+) T cells is regulated by

22 As single-positive CD4(+) thymocytes (CD4(+)(SPT)) exit the

23 ulations demonstrated a reduced expansion of single-positive CD4(-) CD8(+) thymocytes in JSY3DeltaORF

24 tes correlates with the generation of mature single-positive CD4(-)CD8(+) thymocytes that have low ex

25 The lymphomas were single positive (CD4+CD8-, CD4-CD8+), double positive (C

26 producing cells in the thymus are mature CD4 single-positive (CD4SP) thymocytes and that continuous I

27 Together, these studies indicate that single positive CD8(+) T cells entering the CNS during H

28 D8 T cells were positively selected into the single-positive CD8 population.

29 The selection is already established in single-positive CD8 thymocytes.

30 educed numbers of both TCRbeta(low) immature single-positive CD8(+) cells and double-positive T cells

31 entiation into mature CD3(+)TCR-alphabeta(+) single-positive CD8(+) or CD4(+) cells is limited.

32 All three T cell populations (CD4 single positive, CD8 single positive, and CD4(dim)CD8(br

33 ell receptor beta genes of human CD4 and CD8 single positive cells developing in HU and SW thymus gra

34 r Notch1IC matured normally into CD4 and CD8 single positive cells in vivo.

35 motes positive selection of both CD4 and CD8 single positive cells without playing a major role in ne

36 ewer total CD3 cells and reduced CD4 and CD8 single positive cells.

37 ymocytes but inhibits the development of CD4-single positive cells: effects also observed in E2A-defi

38 led to reduced numbers of CD4(+) and CD8(+) single-positive cells and reduced thymic cellularity due

39 tive stage, with few mature CD4(+) or CD8(+) single-positive cells being produced.

40 cells increasing over time, while INF-gamma single-positive cells declined with time.

41 nge, a higher frequency of CD4(+)CD8(+) than single-positive cells displayed a T helper 1/T cytotoxic

42 Ex vivo, more double-positive than single-positive cells exhibited a differentiated phenoty

43 m immature CD11b(+)Ly6G(+) cells to CD11b(+) single-positive cells in marrow and tissues and partiall

44 their thymic precursors, because CD4(+)8(-) single-positive cells in the neonatal thymus also showed

45 ositive selection of n3.L2 PKCtheta(-/-) CD4 single-positive cells resulted from "weaker" signaling t

46 SRYMYC-single-positive cells were first observed in the gonad a

47 or alphabeta transgene, normal levels of CD4 single-positive cells were produced.

48 mice contains an expanded population of CD8 single-positive cells with the characteristic phenotype

49 D8(+) double-positive, and CD4(+) and CD8(+) single-positive cells) only induced p-STAT5.

50 of IFN-beta) resulted in YFP(+) and eGFP(+) single-positive cells, whereas among messenger of IFN-be

51 ositively selected on both CD4(+) and CD8(+) single-positive cells.

52 unable to rescue development of CD4 and CD8 single-positive cells.

53 proved they had divided more frequently than single-positive cells.

54 nly for a few hours before turning into SOX9-single-positive cells.

55 effect being particularly evident among CD8 single-positive cells.

56 sion of double-negative CD4 and CD8 immature single-positive cells.

57 The acpcPNA probe contains a single positive charge from the lysine at C-terminus and

58 t metal (TC-Me(2+)) complex that bears a net single positive charge, Na+, and K+.

59 ibility is altered by the presence of even a single positive charge.

60 A single positive clone, designated HIPM (HrpN-interacting

61 ty was nearly exclusively restricted to 2DS1 single positive clones lacking inhibitory KIR.

62 Furthermore, CD4+ or CD8+ single positive CnAbeta-/- thymocytes also underwent acc

63 . coli transcriptional activator that uses a single positive control surface to make specific protein

64 ytes are more primed for death than those in single positive counterparts.

65 However, many patients with a single positive cTn test result do not have AMI.

66 MAC pulmonary disease to 75 subjects with a single positive culture without disease.

67 Single positive cultures after completion of therapy occ

68 s use multiple interlinked loops rather than single positive feedback loops.

69 rease the hysteretic region, compared to its single-positive feedback counterpart.

70 n neuropeptides, and these screens yielded a single positive hit: prosaptide, which promoted the endo

71 BAT was double positive/double negative/single positive in 6/2/14 patients.

72 We detected five single positive isolates (positive culture followed by a

73 ls are normally extinguished by the immature single positive (ISP) stage of thymocyte development.

74 a significant impairment at the CD8 immature single-positive (ISP) stage and the CD4/CD8 double-posit

75 R gamma)0/0 thymi, which accumulate immature single-positive (ISP) thymocytes that precede the DP sta

76 k sac and neuroectoderm; 2) at E10.5, CX3CR1 single-positive microglial cells were visualized penetra

77 : subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demog

78 2DS1 single positive NK clones with anti-HLA-C2 reactivity we

79 er congenic HSCT, we found that Ly49G2(high) single-positive NK cells repopulated, displayed an activ

80 in the rapid expansion of these Ly49G2(high) single-positive NK cells.

81 on-small cell lung cancer target tumors over single-positive, non-target NCI-H358-HER2 CRISPR knock o

82 of antigen double-positive cancer cells over single-positive normal tissue is believed to enhance the

83 ors and repressors and resolving them into a single positive or a negative signal that is transmitted

84 mice, thymocyte deletion now occurred at the single positive or medullary stage.

85 sets, whereas SLAMF1 single positive, SLAMF6 single positive, or SLAMF1SLAMF6 double negative cells w

86 All wasp-allergic single-positive patients had sIgE to Ves v 5 and/or Ves

87 racteristics of more severe dysfunction than single-positive (PD-1(+) or CTLA-4(+)) TIL, including an

88 ated diverse TCR expression, a primarily CD4 single-positive phenotype, and lack of CD1d reactivity.

89 D8 avidity during the double-positive to CD8 single-positive progression.

90 ase is gemcitabine plus cisplatin based on a single positive randomized trial.

91 sensitivity and specificity obtained using a single positive result as significant were 80% and 77.8%

92 rformed 164 times at a cost of $21,789 for a single positive result effecting modification of patient

93 heterogeneity index for 2 consecutive vs one single positive results, 0% vs 72.6%, respectively).

94 agnostic odds ratio for 2 consecutive vs one single positive results, 111.8 [95% confidence interval

95 A single positive sample can be detected in pools of up to

96 Single positive samples can be detected when pooling eit

97 ) and CD24(+)CD73(+) subsets, whereas SLAMF1 single positive, SLAMF6 single positive, or SLAMF1SLAMF6

98 benefit for adjuvant HDI in patients with a single positive SLN was found.

99 , PAXIP1 was essential for release of mature single positive (SP) alphabeta T cells from the thymus t

100 ions in postselection maturation by studying single positive (SP) CD4 thymocytes from K14/A(beta)(b)

101 o undergo positive selection to CD4+ or CD8+ single positive (SP) cells in vivo or activation-induced

102 ient inducers of thymocyte maturation to CD4 single positive (SP) functional cells.

103 ined in the cortex, maturing to form ectopic single positive (SP) thymocyte clusters in Plxnd1-defici

104 kappaB) signaling is considered critical for single positive (SP) thymocyte development because loss

105 le of CD8alpha-associated Lck in driving CD8 single positive (SP) thymocyte development.

106 C transgenic lines display a decrease in CD4 single positive (SP) thymocytes and a corresponding incr

107 In contrast, CD4 single positive (SP) thymocytes migrated directionally t

108 ble positive (DP) thymocytes, but not mature single positive (SP) thymocytes or splenic T cells.

109 n to be delayed compared with that of CD4(+) single positive (SP) thymocytes, with tTregs being detec

110 o myriad death stimuli than CD4(+) or CD8(+) single positive (SP) thymocytes.

111 nsition block, and an accumulation of mature single positive (SP) thymocytes.

112 ated marker genes (Nur77 and CD5high) in CD4 single positive (SP) thymocytes.

113 greater numbers of double positive (DP), CD4 single positive (SP), and CD8SP thymocytes in TgA mice w

114 We demonstrated that single-positive (SP) CD4 thymocytes, with the characteri

115 )CD62L(low)) and proliferation compared with single-positive (SP) CD4(+) and CD8(+) T cells.

116 ead, these mice harbored a reduced number of single-positive (SP) CD8(+) thymocytes without any defec

117 y responses of CD4(+)CD8(-) and CD4(-)CD8(+) single-positive (SP) cells and increased percentage of C

118 one excludes the other in mature CD4 or CD8 single-positive (SP) cells.

119 ive selection; reducing the ratio of CD4/CD8 single-positive (SP) cells; and reducing cell surface CD

120 The capacities of single-positive (sp) KIR2DL1, KIR2DL2, KIR2DL3, and KIR3

121 d silenced in cells committing to the CD4(+) single-positive (SP) lineage, remaining active in the CD

122 e selection and lineage differentiation into single-positive (SP) mature cells.

123 double-positive (DP) to the CD4(+) or CD8(+) single-positive (SP) stage of alphabeta T cell developme

124 ive (DP) thymocytes to the mature CD4 or CD8 single-positive (SP) stage requires proper T cell recept

125 The number of double-positive (DP) and single-positive (SP) T cells are decreased in Notch1(12f

126 Differentiation of CD8 single-positive (SP) T cells is predicated by the abilit

127 or to the CD45RA(+) mature CD4(+) and CD8(+) single-positive (SP) T cells.

128 SRF.V194E effectively restores ERK-dependent single-positive (SP) thymocyte development.

129 nsition from the double-positive (DP) to the single-positive (SP) thymocyte stage and predisposes DP

130 Nonetheless, we find that CD8 single-positive (SP) thymocytes and peripheral CD8(+) T

131 eptor (TCR)-associated signaling pathways of single-positive (SP) thymocytes are attenuated to respon

132 urther implies that the number of mature CD8 single-positive (SP) thymocytes greatly underestimates C

133 CD4(+)CD8(-) and CD4(-)CD8(+) single-positive (SP) thymocytes in DKO mice resemble mat

134 D4+CD8+ double-positive thymocytes into CD8+ single-positive (SP) thymocytes is regulated by TCR and

135 were unperturbed, maturation of CD4 and CD8 single-positive (SP) thymocytes was blocked in mice lack

136 lar, DN-IkTg induced the accumulation of CD4 single-positive (SP) thymocytes with a developmentally t

137 nactivation of CBP in the thymus yielded CD8 single-positive (SP) thymocytes with an effector-, memor

138 te number of total, double-positive, and CD4 single-positive (SP) thymocytes, as well as a defect in

139 ty leads to a reduction in numbers of CD8(+) single-positive (SP) thymocytes, suggesting a selective

140 vel of surface TCR than do mature T cells or single-positive (SP) thymocytes.

141 thymocytes but inactive in CD4(+) or CD8(+) single-positive (SP) thymocytes.

142 kinetics, first appearing by day 4 among CD4 single-positive (SP) thymocytes.

143 development, in turn, requires signals from single-positive (SP) thymocytes.

144 The double-positive (DP) to single-positive (SP) transition during T cell developmen

145 with shorter CDR3 at the double-positive to single-positive (SP) transition.

146 cells transition to the mature CD4+ or CD8+ (single-positive (SP)) stage.

147 e previously reported that CD163(+)CD206(-) (single-positive [SP]) interstitial macrophages of the lu

148 e CD4(+)CD8(-) and CD4(-)CD8(+) (CD4 and CD8 single-positive [SP]) thymocytes and T cells.

149 Itk-deficient mice, mature CD4(-)CD8(+) (CD8 single-positive [SP]) thymocytes express high levels of

150 The third was CD4 single positive, specific for an HLA-DR7-restricted HY e

151 prevent their development into committed CD4 single positives (SPs), nor their continued maturation t

152 the thymic cortex, compared with 25% at the single positive stage in the medulla.

153 rly during the transition from the DP to the single positive stage.

154 -MHC complexes direct differentiation to the single-positive stage (positive selection), whereas high

155 d for the NK cell maturation beyond the CD27 single-positive stage and is indispensable for the maint

156 tes and their commitment to the CD4(+)CD8(-) single-positive stage are impaired in Themis(-/-) mice,

157 e negative (DN) stage 2 through the immature single-positive stage of thymocyte development, before t

158 ed from the double-positive thymocyte to the single-positive stage, and within single-positive thymoc

159 accelerates development to the CD8 immature single-positive stage, but retards subsequent differenti

160 Consistent with defective progression to the single-positive stage, CD4-Cre/ShcFFF mice also had sign

161 , a substantial fraction survived to the CD4 single-positive stage.

162 uring transition from the double-positive to single-positive stage.

163 P) stage and from the DP stage to the mature single-positive stage.

164 8(+) double-positive stage to the CD4 or CD8 single-positive stage.

165 ble-positive thymocytes to the CD4+ or CD8+ (single-positive) stage, and only a minor subset of CD8+

166 arrow progressed through double-positive and single-positive stages only when IL-7 concentrations wer

167 1Delta/Delta adult thymus to the double- and single-positive stages, but in the apparent absence of d

168 e 3 (CD25(+)CD44(-)) and CD8-immature CD8(+) single-positive stages.

169 er of the CrPV-like virus family, contains a single positive-stranded RNA genome that encodes two non

170 showed a reduction in both CD4(+) and CD8(+) single-positive subsets, and double-positive thymocytes

171 cells (R = -0.62; p </= 0.001), but not CD8 single positive T cells (R = -0.24; p </= 0.27), negativ

172 KLF2 is expressed exclusively in CD4 and CD8 single positive T cells and promotes a nonproliferative,

173 In contrast, viable Id1 transgenic CD4 single positive T cells exhibit costimulation-independen

174 ated the role of CD4(dim)CD8(bright) and CD8 single positive T cells in HIV-infected brain using NOD/

175 B to promote the survival and development of single positive T cells in the thymus.

176 Injection of highly purified CD8 single positive T cells into mouse brain induced CD4(dim

177 vely induce changes in CD69(int) CD62L(high) single positive T cells, resulting in down-modulation of

178 cific function of CnAbeta in the survival of single positive T cells.

179 ocytes in circulation, an increase in mature single-positive T cells in the thymus, and a selective r

180 t increased frequencies of CD4(+) and CD8(+) single-positive T cells in the thymus.

181 icient mice had normal levels of CD4 and CD8-single-positive T cells in thymus and spleen.

182 sible for the block in development of mature single-positive T cells is not well characterized.

183 er IL-7R alpha, and a decrease in CD4(-)8(+) single-positive T cells that can be mitigated by transge

184 echanisms that regulate the tuning of CD4(+) single-positive T cells to MHC class II encountered in t

185 d appears to play a role in the migration of single-positive T cells to the periphery.

186 e, a conditional knockout of SHP-1 in mature single-positive T cells was developed to analyze cell-in

187 uced similar antibody levels in vitro, CXCR5-single-positive T cells were superior in inducing B cell

188 rected ESCs differentiated to CD4 + or CD8 + single-positive T cells, confirming correction of the ce

189 CXCR4-single-positive T cells, present in B cell-mediated auto

190 /-) iG6 mice were derived from CD8 immature, single-positive T cells, whereas Atm(-/-) lymphomas were

191 te of thymic generation or emigration of CD8 single-positive T cells.

192 ncrease in the number of double-negative and single-positive T cells.

193 as cells mature from CD4+CD8+ thymocytes to single-positive T cells.

194 s essential during pulmonary development and single-positive T-cell development and is indispensable

195 ed but rare in the CD8+ CD4 HSA(hi) immature single-positive T-cell subset.

196 Single positive test results had modest sensitivity and

197 ress TOX show expanded CD8+ and reduced CD4+ single positive thymocyte subpopulations.

198 Early thymocyte development was normal, but single-positive thymocyte and peripheral T cell numbers

199 (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development without increased

200 ression of RasGRP1 selectively increases CD8 single-positive thymocyte numbers and enhances their res

201 nslocation of TMEM131L may regulate immature single-positive thymocyte proliferation arrest by acting

202 interacting protein 2 is not involved in CD8 single-positive thymocyte selection or ERK signaling.

203 FLIP conditional knockout mice occurs at the single-positive thymocyte stage and may be caused by enh

204 defective for N-ras have low numbers of CD8 single positive thymocytes and decreased thymocyte proli

205 ted the proliferation and survival of CD4(+) single positive thymocytes and peripheral T cells in vit

206 ent phenotype, yet nevertheless give rise to single positive thymocytes and yield mature class I MHC-

207 ion, tal-1 stimulates differentiation of CD8-single positive thymocytes but inhibits the development

208 of mature T cells, given its absence in CD8 single positive thymocytes derived from MHC II(-/-) mice

209 Double and single positive thymocytes from reconstituted mice were

210 Surprisingly, Pak2 deficiency in CD4 single positive thymocytes prevented functional maturati

211 to the variegated expression of CD8-negative single positive thymocytes seen upon deletion of several

212 lularity, impaired transition from double to single positive thymocytes, and decreased numbers of mat

213 election promotes not only the production of single positive thymocytes, but also the survival of sel

214 itically depends upon the presence of mature single positive thymocytes.

215 tions and spectratyping of human CD4 and CD8 single positive thymocytes.

216 an intrinsic property of the T cells nor of single positive thymocytes.

217 ecific cognate interaction with CD4+ or CD8+ single-positive thymocytes (SP).

218 of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotyp

219 However, the numbers of double-positive and single-positive thymocytes after CD3gamma(C82S/C85S) tra

220 lf-tolerance by eliminating autoreactive CD4 single-positive thymocytes and by supporting regulatory

221 ration initiates after positive selection in single-positive thymocytes and continues in the peripher

222 50% reduction in the generation of n3.L2 CD4 single-positive thymocytes and n3.L2 CD4 mature T cells.

223 Single-positive thymocytes and naive T cells also had co

224 strongly dependent on the presence of mature single-positive thymocytes and on the interactions of th

225 In contrast, CD4 single-positive thymocytes and peripheral T cells develo

226 nd negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and i

227 substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells.

228 tes, resulting in complete absence of CD4(+) single-positive thymocytes and severe reduction of CD3(+

229 We also show that both non-Treg CD4 single-positive thymocytes and Tregs are efficiently del

230 h which TCR-associated signaling pathways of single-positive thymocytes are attenuated to respond app

231 ired for the survival of double-negative and single-positive thymocytes as well as naive and activate

232 of Ikaros is specific to double-positive and single-positive thymocytes because derepression of Notch

233 PCR and Western blot as well as in CD4+CD8- single-positive thymocytes by real-time quantitative PCR

234 D8 double-positive thymocytes and mature CD4 single-positive thymocytes compared with controls.

235 els were much greater in IL-4-expressing CD4 single-positive thymocytes compared with unactivated cel

236 the number of CD4(+)CD8(-) and CD4(-)CD8(+) single-positive thymocytes correlating with increased DA

237 a >80% reduction in generation of n3.L2 CD4 single-positive thymocytes derived from PKCtheta(-/-) mi

238 Deletion of TAK1 prevented the maturation of single-positive thymocytes displaying CD4 or CD8, leadin

239 via the TCR and failed to differentiate into single-positive thymocytes efficiently.

240 n and ERK activation block maturation of CD8 single-positive thymocytes even when added after 24 h.

241 We show here that single-positive thymocytes express IL-4, but attenuate G

242 sitive thymocytes and a very small number of single-positive thymocytes expressing TCRs.

243 These single-positive thymocytes failed to upregulate Bcl-2, l

244 By contrast, TGF-beta1(-/-) CD4+ single-positive thymocytes from 11-day-old mice exhibite

245 The IL-4 mRNA level is high in CD4 single-positive thymocytes if they are selected on thymo

246 ote the positive selection/maturation of CD8 single-positive thymocytes in a thymocyte-intrinsic mann

247 n causes apoptosis of CD4 and CD8 double- or single-positive thymocytes in HY- or AND-TCR transgenic

248 thymocytes fail to efficiently generate CD8+ single-positive thymocytes in mixed bone marrow chimeric

249 th dramatic reduction of double-positive and single-positive thymocytes in the tid1(-/-) thymus.

250 feration, whereas adaptive CD4(+) and CD8(+) single-positive thymocytes including thymic Tregs cycled

251 The altered response of mature CD4 single-positive thymocytes is characterized by the inhib

252 wly generated conventional CD69(+)Qa2(-) CD4 single-positive thymocytes mature to the late CD69(-)Qa2

253 8 thymocyte generation such that CD4 and CD8 single-positive thymocytes mature with the same kinetics

254 Rather, post-selection single-positive thymocytes must undergo T cell maturatio

255 s, but an increase in the percentage of CD8+ single-positive thymocytes seen in CBP mutant mice was n

256 Single-positive thymocytes that successfully complete po

257 P L also blocked the migration and egress of single-positive thymocytes to peripheral lymphoid organs

258 eased positive selection of both CD4 and CD8 single-positive thymocytes was also seen in nontransgeni

259 (int) thymocytes as well as CD4(+) or CD8(+) single-positive thymocytes was lower.

260 Positive selection of CD8 single-positive thymocytes was restored in RORgammat-KO

261 In addition, CD4 single-positive thymocytes were detected in MHC class I-

262 thymocytes, whereas double-positive and CD8 single-positive thymocytes were only partially affected.

263 Whereas naive single-positive thymocytes were reduced >500-fold in the

264 As expected, CD4 and CD8 single-positive thymocytes were responsive to IL-7.

265 sion of double-negative thymic precursors to single-positive thymocytes with increased IL-7Ralpha exp

266 lopment in turn requires signals from mature single-positive thymocytes, a bidirectional relationship

267 We analyzed rearranged BV19 genes from CD8 single-positive thymocytes, a surrogate for the naive re

268 geranyltransferase Pggt1b is up-regulated in single-positive thymocytes, and loss of Pggt1b leads to

269 ion of superantigen-specific, self-reactive, single-positive thymocytes, and we show that CD40 expres

270 yte to the single-positive stage, and within single-positive thymocytes, complement binding gradually

271 s lowered the numbers of double-positive and single-positive thymocytes, concomitant with reduced pos

272 itive selection and is sustained in immature single-positive thymocytes, despite the strong decrease

273 on of CD8 T-cells with a predominance of CD8 single-positive thymocytes, in spite of thymic insulin e

274 transgenic mice had a 4-fold increase in CD8 single-positive thymocytes, most of which had atypically

275 their further differentiation to double- and single-positive thymocytes, whereas B cells in the marro

276 e mice resulted in efficient ablation of CD4 single-positive thymocytes, whereas double-positive and

277 ignaling needed to initiate proliferation of single-positive thymocytes, with this effect being parti

278 sitive selection of conventional CD4 and CD8 single-positive thymocytes.

279 ival time of both immature and mature CD4(+) single-positive thymocytes.

280 mocytes and severe reduction of CD3(+)CD8(+) single-positive thymocytes.

281 ompletely abolished the generation of CD8(+) single-positive thymocytes.

282 ses apoptosis, and reduces the number of CD4 single-positive thymocytes.

283 le-positive thymocytes and CD8(+) and CD4(+) single-positive thymocytes.

284 pairs positive selection of both CD4 and CD8 single-positive thymocytes.

285 tate was already established in neonatal CD4 single-positive thymocytes.

286 mocyte development and reexpressed in mature single-positive thymocytes.

287 a, associated with an accumulation of mature single-positive thymocytes.

288 -positive transition, and was upregulated in single-positive thymocytes.

289 the efficient production of both CD4 and CD8 single-positive thymocytes.

290 t without increased CD4+CD8+ double- or CD8+ single-positive thymocytes.

291 omparable to that observed in the absence of single-positive thymocytes.

292 t through epigenetic modifications of CD4(+) single-positive thymocytes.

293 sitive selection and final maturation of CD8 single-positive thymocytes.

294 turation of CD4- or CD8alphabeta-expressing 'single-positive' thymocytes from CD4(+)CD8alphabeta(+) '

295 Approximately 10% of patients with a single positive TMA result at the end of treatment still

296 ith negative PCR results during treatment, a single positive TMA test did not exclude SVR, although p

297 ions during therapy should not be based on a single positive TMA test result.

298 A single positive training set, however, may be biased and

299 er block from CD4 and CD8 double-positive to single-positive transition compared with PLCgamma1 singl

300 partially blocked at the double-positive to single-positive transition.

301 ith no sIgE to rSSMA of the other species in single-positive venom-allergic patients and only one con