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1 the Grc3 kinase activity exclusively toward single-stranded RNA.
2 RNA and how this differs from its action on single-stranded RNA.
3 r by preventing the association of Dbp2 with single-stranded RNA.
4 are monomers that induce tight compaction of single-stranded RNA.
5 uble-stranded DNA, type III complexes target single-stranded RNA.
6 alone (apo) and in complex with a nonameric single-stranded RNA.
7 bits growth by sequence-specific cleavage of single-stranded RNA.
8 ding preferences of NPH-II for duplex versus single-stranded RNA.
9 equential packaging of its three segments of single-stranded RNA.
10 he respective RNA structures, and amounts of single-stranded RNA.
11 ith a wide range of sequences and lengths of single-stranded RNA.
12 entially involved TLR7 and TLR8, which sense single-stranded RNA.
13 ng others responsible for the recognition of single-stranded RNA.
14 esis is potently inhibited by the binding of single-stranded RNA.
15 kinase is not activated by and does not bind single-stranded RNA.
16 ressed the basic physical properties of long single-stranded RNAs.
17 disposes of or processes viral and cellular single-stranded RNAs.
18 a segmented genome of eight negative-sense, single-stranded RNAs.
19 gher affinity to SL3 RNA than to double- and single-stranded RNAs.
20 ucture remained unaffected by titration with single-stranded RNAs.
21 e RNase L, causing it to dimerize and cleave single-stranded RNAs.
22 the 5'-phosphate and 3'-hydroxyl termini of single-stranded RNAs.
24 xygen species, NOX2 oxidase, is activated by single stranded RNA and DNA viruses in endocytic compart
25 ows direct visualization of the encapsidated single-stranded RNA and coat protein (CP) N-terminal reg
28 rified human PRC2 recognizes G > C,U >> A in single-stranded RNA and has a high affinity for folded g
29 ct sensitivity to pyrimidine-rich regions of single-stranded RNA and is able to process tRNA precurso
30 dered to be linked to the affinity of S1 for single-stranded RNA and its corresponding destabilizatio
31 association was dependent on the presence of single-stranded RNA and mediated by an N-terminal region
32 exit channel, extruding topologically linked single-stranded RNA and preventing the formation of paus
33 ts showed that both SUD-C and SUD-MC bind to single-stranded RNA and recognize purine bases more stro
34 aded from the periphery, TLR7 detected viral single-stranded RNA and triggered immune responses that
35 and mutational analyses show how it threads single-stranded RNA, and structural features suggest how
36 itor the in vitro co-assembly of CCMV CP and single-stranded RNA as a function of the strength of CP-
37 ed and characterized two R-plasmid-dependent single-stranded RNA bacteriophages (RPD ssRNA phages), C
40 P L binding were blocked by preannealing the single-stranded RNA bait with miR-122, indicating that t
43 tion motif, domains are the largest class of single-stranded RNA binding domains in the human proteom
48 equence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumi
50 his gene modifier screen identified EndoU, a single-stranded RNA-binding protein of ancient origin, a
52 binding miRNAs function as agonists of these single-stranded RNA-binding TLRs, leading to NF-kappaB s
56 Top3beta is capable of converting two such single-stranded RNA circles into a double-stranded RNA c
57 olism, we designed an assay by annealing two single-stranded RNA circles with complementary sequences
59 structures of apo-D1D2 and post-unwound D1D2:single-stranded RNA complex, and the structure of a D2:d
63 Pase, one of the major enzymes with 3' to 5' single-stranded RNA degradation and processing activitie
65 tably improved module for building models of single-stranded RNA, double-helical DNA, Pauling triplex
66 the HIV-1 genome, which is in the form of a single-stranded RNA enclosed inside a capsid shell, must
70 sslinks to specific regions characterized by single-stranded RNA flanked by structured elements and t
71 West Nile virus (WNV), a mosquito-borne, single-stranded RNA flavivirus, causes significant human
72 S1 promotes RNA unwinding by binding to the single-stranded RNA formed transiently during the therma
73 eceptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adap
74 NA copying to proceed, while also protecting single-stranded RNA from Mg(2+)-catalyzed degradation.
75 nsation and found that ectopic expression of single-stranded RNAs from 1.688(X) repeats enhanced the
77 s C, platelets replicated the positive sense single-stranded RNA genome of DENV by up to approximatel
78 virus particles containing a negative-sense, single-stranded RNA genome packaged within a helical nuc
80 idae family of nonsegmented, negative-sense, single-stranded RNA genome viruses, is a leading cause o
85 ining feature of these viruses is that their single-stranded RNA genomes are of opposite polarity to
86 Leviviruses are bacteriophages with small single-stranded RNA genomes consisting of 3-4 genes, one
88 uses replicate by reverse transcribing their single-stranded RNA genomes into double-stranded DNA usi
93 ase, P4, uses chemical energy to translocate single-stranded RNA genomic precursors into the procapsi
96 ch is valid with a culturable positive-sense single-stranded RNA human virus, coxsackievirus B5, by a
97 iviral immune responses by recognizing viral single-stranded RNA in endosomes, but the biosynthetic p
98 ce upon binding with double-stranded DNA and single-stranded RNA in live cells, thereby enabling real
100 rchange in the average probabilities to form single-stranded RNA in the optimal PPT and branch site l
101 al infections and cleaves cellular and viral single-stranded RNAs, including rRNAs in ribosomes.
103 the transcription of the relatively flexible single-stranded RNA into a more rigid filamentous struct
105 l functional effects from a seemingly simple single-stranded RNA junction and suggest that junction s
107 se testes, most piRNAs are derived from long single-stranded RNAs lacking annotated open reading fram
108 with or without a 5'-triphosphate (ppp), by single-stranded RNA marked by a 5'-ppp and by polyuridin
109 of stroke-inducible tRF-22-WE8SPOX52 using a single-stranded RNA mimic induced down-regulation of imm
110 e KWKK ((+)NH(3)-Lys-Trp-Lys-Lys-NH(2)) to a single-stranded RNA model, polyuridylate (polyU), by cha
113 As (miRNAs) are small (20-23 nt), non-coding single stranded RNA molecules that act as post-transcrip
114 ng a group of more than 1500 short noncoding single-strand RNA molecules of approximately 22 nucleoti
115 s due to RNase T2's preferential cleavage of single-stranded RNA molecules between purine and uridine
118 (CCMV) is capable of packaging both purified single-stranded RNA molecules of normal composition (com
119 inflammatory condition, is a class of short single-stranded RNA molecules termed microRNAs (miRNAs).
120 MicroRNAs (miRNAs) are naturally occurring single-stranded RNA molecules that post-transcriptionall
121 MicroRNAs (miRNAs) are a class of short single-stranded RNA molecules that posttranscriptionally
122 (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene express
124 amer, whose interaction depended mainly on a single-stranded RNA motif, but not that of the GFP aptam
125 glia of live zebrafish brains, we found that single-stranded RNA of bacterial origin acts as a PAMP a
126 e junction between the stem and the flanking single-stranded RNA of the pri-miRNA hairpin by DGCR8 fo
127 se H activity that act in concert to convert single-stranded RNA of the viral genome to double-strand
129 We also present modelling of pyrimidine-rich single-stranded RNA onto the highly conserved surface of
131 st resiquimod (R848; a synthetic analogue of single-stranded RNA) or saline by nasal spray to healthy
132 8 may be activated by their native ligands, single-stranded RNA, or by small molecules of the imidaz
133 viruses distantly related to members of the single-stranded RNA picorna-like virus superfamily were
134 A bacteriophage Phi6, and the positive-sense single-stranded RNA poliovirus (PV) and human rhinovirus
137 isms that are different from the established single-stranded RNA recognition mode of PPR motifs.
138 ependent RNA endonuclease activity targeting single-stranded RNA regions and demonstrate the function
139 ome, we accurately and simultaneously mapped single-stranded RNA regions in multiple ncRNAs with know
140 ur NMR spectroscopic investigations on short single-stranded RNA revealed a strong preference for C2'
141 ssential host factor for many positive-sense single-stranded RNA (+RNA) viruses including human patho
144 A virus (IAV) genomes are composed of eight single-stranded RNA segments that are coated by viral nu
145 6) and identified two conserved, putatively single-stranded RNA segments, upstream of S1 (nt 2 and 3
149 KH0, KH1, and KH2 domains bind weakly to the single-stranded RNA sequences suggesting that they may h
150 tures known for their modular recognition of single-stranded RNA sequences with each motif in a tande
151 s of Mss116p in complex with ATP analogs and single-stranded RNA show that the helicase core induces
152 protein that nonspecifically recognizes the single strand RNA (ssRNA) of viral or nonviral origin.
153 TP and subsequent cA(n)-mediated cleavage of single-strand RNA (ssRNA) by the trans-acting Csm6 RNase
154 et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to
155 serve that ATM silencing results in enhanced single-strand RNA (ssRNA) replication of RSVand Sendai v
158 ific and selective recognition of dsRNA over single-stranded RNA (ssRNA) and dsDNA regions at near-ph
159 report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three
160 Higher ratios of HCV double-stranded to single-stranded RNA (ssRNA) correlated positively with I
161 show that topological structures containing single-stranded RNA (ssRNA) free of strong base pairing
163 Viruses in the Tombusviridae family have single-stranded RNA (ssRNA) genomes with T=3 icosahedral
164 ata from a competition assay between SLA and single-stranded RNA (ssRNA) indicate that SLA competes w
165 ndicates that small phages, particularly the single-stranded RNA (ssRNA) leviviruses, have a previous
166 All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide protein
167 A ligase to capture various short 20-24 base single-stranded RNA (ssRNA) oligonucleotides from a targ
168 The recent discovery of the positive-sense single-stranded RNA (ssRNA) Orsay virus (OV) as a natura
169 ose genome is packaged sequentially as three single-stranded RNA (ssRNA) segments into an icosahedral
170 ) binds with 20nM dissociation constant to a single-stranded RNA (ssRNA) sequence adjacent to the bra
171 d protein structures are the active sites of single-stranded RNA (ssRNA) synthesis; (v) at late times
172 e show that Cas9 binds with high affinity to single-stranded RNA (ssRNA) targets matching the Cas9-as
173 ed rotavirus double-layer particles, nascent single-stranded RNA (ssRNA) transcripts (termed in vitro
174 ontal gene transfer may have occurred from a single-stranded RNA (ssRNA) virus (hypovirus) to a dsRNA
175 mes and primarily correspond to unclassified single-stranded RNA (ssRNA) viruses and viruses belongin
176 or Cas13 could be an effective antiviral for single-stranded RNA (ssRNA) viruses because it programma
177 ly for adenoviruses, which resembles that of single-stranded RNA (ssRNA) viruses but differs from the
180 h pump their genome into a preformed capsid, single-stranded RNA (ssRNA) viruses, such as bacteriopha
182 en the rates of double-stranded DNA (dsDNA), single-stranded RNA (ssRNA), and ssDNA/reverse-transcrib
183 recognizes guanosine- and uridine-rich viral single-stranded RNA (ssRNA), including influenza virus s
184 zyme Argonaute 2 (hAgo2) and Cryptosporidium single-stranded RNA (ssRNA), we induced specific slicing
185 x measures either ~22 nt from the upper stem-single-stranded RNA (ssRNA, terminal loop) junction or ~
186 ruses, especially those with positive-sense, single-stranded RNA (+ssRNA) genomes, are abundant in tr
187 important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection, especially
190 CCHF) virus is a tick-borne, negative-sense, single-stranded RNA [ssRNA(-)] nairovirus that produces
191 sent in all three pathogenic positive-sense, single-stranded RNA [(+)ssRNA] virus families which carr
193 ncoming viral genome, whereas negative-sense single-stranded RNA [(-)ssRNA] viruses carry at infectio
194 cinating features of these highly structured single stranded RNAs (ssRNAs) with emphasis on their pre
196 Here we demonstrate that wild-type FUS binds single-stranded RNA stoichiometrically in a length-depen
197 i YbeY exhibits endoribonuclease activity on single-stranded RNA substrate but not on the double-stra
198 w that Rho unidirectionally translocates the single-stranded RNA substrate via a population shift of
201 minus resemble those seen in the presence of single-stranded RNA suggesting similarities in binding.
202 signaling induced by NOD2 over-expression or single stranded RNA, suggesting specificity for the MDP-
203 lex RNA regardless of the orientation of the single-stranded RNA tail, it preferred a 5' to 3' polari
204 e CRISPR RNA and can be programmed to cleave single-stranded RNA targets carrying complementary proto
205 es the ability of VP1 to replicate synthetic single-stranded RNA templates containing the 3' untransl
212 NAs (miRNAs) are 19 to 25nt non-coding small single-stranded RNAs that negatively regulate gene expre
214 unusually long, high-affinity interface with single-stranded RNA, that this interface provides a func
216 capsidation and reverse transcription from a single-stranded RNA to a double-stranded DNA through the
217 MthRnl) catalyzes intramolecular ligation of single-stranded RNA to form a closed circular RNA via co
219 ed by the complementary association of three single-stranded RNA units, was optimized for improved ge
220 with 10-bp RNA-RNA duplexes and was aided by single-stranded RNA upstream of the duplex but was signi
221 he strength of attraction between CP and the single-stranded RNA viral genome is controlled by ionic
229 is E virus (HEV) is a 7.2-kb positive-sense, single-stranded RNA virus containing three partially ove
232 arainfluenza virus (PIV) is a negative-sense single-stranded RNA virus in the Paramyxoviridae family.
233 proach that accurately tracks positive-sense single-stranded RNA virus inactivation without relying o
234 xin (EMR) family have been shown to modulate single-stranded RNA virus infection through regulating s
235 netics and mechanisms of inactivation of the single-stranded RNA virus MS2 under temperature, pH and
236 ect experimental evidence that assembly of a single-stranded RNA virus occurs via a packaging signal-
237 amyxovirus type 1 (APMV-1), a negative-sense single-stranded RNA virus of the genus Avulavirus, famil
238 ry syncytial virus (RSV) is a negative-sense single-stranded RNA virus responsible for lower respirat
239 ry syncytial virus (RSV) is a negative-sense single-stranded RNA virus responsible for lower respirat
241 Human respiratory syncytial virus (RSV) is a single-stranded RNA virus that causes acute, and occasio
244 d the RNA content of a purified nonenveloped single-stranded RNA virus, flock house virus (FHV).
248 or the replication of various positive-sense single stranded RNA viruses, which hijack this cellular
250 ) susceptibility compared with other enteric single-stranded RNA viruses (e.g., Echovirus 12, feline
252 n is a common strategy among positive-sense, single-stranded RNA viruses for bypassing the host cell
254 he members of this family of positive-sense, single-stranded RNA viruses have limited coding capacity
256 potentially profound implications for other single-stranded RNA viruses known to have RNA PSs, inclu
257 that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negati
260 eny, experimental evidence on positive sense single-stranded RNA viruses suggests that the CP also re
261 y of enveloped, negative-sense, nonsegmented single-stranded RNA viruses that account for a significa
262 s (HAstVs) are nonenveloped, positive-sense, single-stranded RNA viruses that are a leading cause of
265 stroviruses are nonenveloped, positive-sense single-stranded RNA viruses that cause gastrointestinal
267 link between platelets and their response to single-stranded RNA viruses that involves activation of
268 s) comprise a large genus of positive-sense, single-stranded RNA viruses whose members cause a number
271 a large family of enveloped, negative-sense, single-stranded RNA viruses with significant economic an
273 We found that during sickness behavior, single-stranded RNA viruses, double-stranded RNA ligands
275 ite the threat to human health posed by some single-stranded RNA viruses, little is understood about
276 Alphavirus consists of a group of enveloped, single-stranded RNA viruses, many of which are transmitt
277 ation of selected nonenveloped and enveloped single-stranded RNA viruses, retroviruses, bacteriophage
278 ic arthropod-borne viruses (arboviruses) are single-stranded RNA viruses, the most common of which in
279 ve roles of viral genomes in the assembly of single-stranded RNA viruses, we have developed a new ana
288 omically important plant and animal positive single-stranded RNA viruses.IMPORTANCE Uncapped viral RN
289 small, spherical, enveloped, positive-sense, single-stranded, RNA viruses responsible for considerabl
291 structural homology, wild-type MAB21L2 bound single-stranded RNA, whereas this activity was lost in a
293 roaches for estimating hydrodynamic radii of single-stranded RNAs, which use generic RNA structure pr
295 c SAMHD1 was found to bind preferentially to single-stranded RNA, while the tetrameric form required
298 Circular RNAs (circRNAs) are a class of single-stranded RNAs with a contiguous structure that ha
299 It displays unusual specificity in vitro for single-stranded RNAs with at least one adenosine at the
300 is triggered by either single strand DNA or single strand RNA, yet the apparent affinity for a DNA a