コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
2 is initiated with end resection, leading to single-stranded 3' ends, which require microhomology ups
4 e CTL weakens the driving forces for forming single-stranded active polymers and suppresses lateral a
6 inefficiently) transferred to the 3' ends of single-stranded and (fully) double-stranded acceptor RNA
7 nant CinB has nuclease activity against both single-stranded and double-stranded DNA but not RNA unde
8 zymes were active on modified mC residues in single-stranded and double-stranded DNA in vitro, while
9 s mostly on the DNA structure containing the single-stranded and duplex DNA junction with the allowed
10 the 2CNqA fluorophore has a quantum yield in single-stranded and duplex DNA ranging from 10% to 44% a
14 scale, we investigate binding of the E. coli single stranded binding protein to two DNA oligos both i
15 at PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in t
16 DNA bound snugly between two dimers in which single-stranded casposon end binding resembles that of s
20 ection of two gRNAs, Cas9 protein and a long-single-stranded-circular DNA donor vector (lsscDNA, 6.7
22 r RNAs (circRNAs) are a distinct category of single-stranded, covalently closed RNAs formed by backsp
23 eplication-associated protein (Rep) encoding single-stranded (CRESS) DNA viruses detected in the faec
25 deno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulat
27 ine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced durin
28 becomes activated and degrades a fluorescent single stranded DNA (ssDNA) reporter present in the assa
29 hanistic understanding of Sgs1 activities on single stranded DNA (ssDNA), which is a central intermed
30 ial signal was generated by hybridization of single stranded DNA targets to immobilized recognition p
31 ) and Minute Virus of Mice (MVM), both T = 1 single stranded DNA viruses, and Bromo Mosaic Virus (BMV
32 molecular Fe(II)(4)L(4) tetrahedron binds to single stranded DNA, mismatched DNA base pairs, and thre
35 eation rate of ScDmc1 results from its lower single-stranded DNA (ssDNA) affinity, compared to that o
37 by hyperphosphorylation of RPA, a sensor of single-stranded DNA (ssDNA) and DNA replication stress.
39 he AID/APOBEC enzymes deaminate cytosines in single-stranded DNA (ssDNA) and play key roles in innate
40 replication by excising oxidized bases from single-stranded DNA (ssDNA) and unhooking interstrand cr
41 ere, three different methods that can detect single-stranded DNA (ssDNA) are utilized to identify the
42 loading of Redbeta directly onto the initial single-stranded DNA (ssDNA) at a 3'-overhang, and second
43 The XPA protein functions together with the single-stranded DNA (ssDNA) binding protein RPA as the c
44 d-specific excision that begins at a distant single-stranded DNA (ssDNA) break and proceeds back past
45 hemically, human RAD51 polymerises faster on single-stranded DNA (ssDNA) compared to double-stranded
47 atalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides
48 iency virus type 1 (HIV-1) infectivity, is a single-stranded DNA (ssDNA) deoxycytidine deaminase with
49 f a DSB, controlling the formation of the 3' single-stranded DNA (ssDNA) filament needed for recombin
51 dimeric protein that potentially binds with single-stranded DNA (ssDNA) in a manner similar to human
52 n is a highly dynamic process that generates single-stranded DNA (ssDNA) in the genome as 'transcript
54 induces the generation of large stretches of single-stranded DNA (ssDNA) intermediates that are rapid
55 mportant DNA metabolic events by stabilizing single-stranded DNA (ssDNA) intermediates, activating th
56 coupled with a gold substrate can resolve a single-stranded DNA (ssDNA) molecule with a spatial reso
59 nds of linear chromosomes and terminate in a single-stranded DNA (ssDNA) overhang recognized by POT1-
61 In the marine environment, only a few lytic single-stranded DNA (ssDNA) phages have been isolated an
62 in models containing up to 1-kb inserts when single-stranded DNA (ssDNA) repair templates are supplie
64 ceeds via binding of RPA, RAD51, and DMC1 to single-stranded DNA (ssDNA) substrates created after for
66 tly, we find no evidence for BLM activity on single-stranded DNA (ssDNA) that is bound by replication
67 helicase activity, ScPif1 is also known as a single-stranded DNA (ssDNA) translocase, while how ScPif
72 t of DNA-RNA hybridization and the displaced single-stranded DNA (ssDNA), have been identified in bac
73 ) for the label-free electrical detection of single-stranded DNA (ssDNA), in-solution- and on-chip-hy
74 ins engineered for large-scale production of single-stranded DNA (ssDNA), we probed the substrate spe
75 py structure of human CST bound to telomeric single-stranded DNA (ssDNA), which assembles as a decame
78 is a bifunctional enzyme that contains both single-stranded DNA (ssDNA)-specific nuclease and motor
82 le-stranded DNA-binding proteins (SSBs) bind single-stranded DNA and help to recruit heterologous pro
84 e Pif1, which tracks in a 5'-3' direction on single-stranded DNA and plays a role in genome maintenan
85 f iminosulfur oxydifluorides to amine-tagged single-stranded DNA and to BSA protein demonstrate the p
86 BV DNA polymerase inhibitor, at the stage of single-stranded DNA and was followed by removal of PFA t
90 can covalently cross-link to abasic sites in single-stranded DNA at stalled replication forks to prev
93 with the in vivo occupancy of mitochondrial single-stranded DNA binding protein reported previously
94 ivity, which is alleviated by binding of the single-stranded DNA binding protein, RPA, to the exclude
95 ic target sites and report that simultaneous single-stranded DNA break formation at donor and accepto
96 measure the kinetics of translocation along single-stranded DNA by the helicase Hel308 from Thermoco
98 slocates sequentially hand-over-hand along a single-stranded DNA coil, akin to the way AAA+ ATPases (
99 oligonucleotide-based FISH probes with long, single-stranded DNA concatemers that aggregate a multitu
100 J and RAP80 exposed to MMC are attributed to single-stranded DNA created by Mre11 and CtIP nucleases.
101 erfacial potential changes were measured for single-stranded DNA detection with an unprecedented zept
102 ki2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by the
103 nthesis downstream of the lesion, creating a single-stranded DNA gap that is repaired primarily in an
106 vely charged DNA binding protein J guide the single-stranded DNA genome into the icosahedral capsid.
107 tructures of Pf4 with and without its linear single-stranded DNA genome, and studied Pf4 assembly int
108 are structurally simple viruses with linear single-stranded DNA genomes and nonenveloped icosahedral
109 geminiviruses (plant viruses with circular, single-stranded DNA genomes) are the major group of emer
111 which long distance binding (25 angstrom) of single-stranded DNA in an allosteric site primes the act
112 nded sites and also at AT-rich regions where single-stranded DNA is exposed during origin opening.
113 sversion substitutions; results suggest that single-stranded DNA is formed during the genesis of the
115 In this regard, aptamers, as artificial single-stranded DNA or RNA oligonucleotides with catalyt
117 nvolves introducing multiple, short pairs of single-stranded DNA overhangs to components of the struc
118 nthesized oligonucleotides or amplicon-based single-stranded DNA probes and validated the technique o
119 relies on the immobilization on a surface of single-stranded DNA probes that bind complementary targe
120 or annealing activities limit the amount of single-stranded DNA product that Pif1 can generate, lead
121 d complex thereafter nonspecifically cleaves single-stranded DNA reporter probes labeled with a fluor
123 esection of broken ends to generate long, 3' single-stranded DNA tails, annealing of complementary se
124 res formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic i
127 OBEC3A, an enzyme that converts cytosines in single-stranded DNA to uracil, and mutations in a variet
129 s endocytose Pf, and internalization of this single-stranded DNA virus results in phage RNA productio
131 19) uncover a previously undefined family of single-stranded DNA viruses, Redondoviridae, in human or
133 nt R-loops (RNA-DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genom
136 ES acts at replication forks, binds PCNA and single-stranded DNA, and generates a DNA-protein crossli
137 NA) could be used as a magnified analogue of single-stranded DNA, and that two meta-DNAs that contain
138 es comprising a DNA:RNA hybrid and displaced single-stranded DNA, are important drivers of damage ari
139 We propose that the presence of persistent single-stranded DNA, as a consequence of transcription-r
140 They exhibit 5' exonuclease activity on single-stranded DNA, hydrolyzing it at the acidic pH ass
141 an entry site for Exo1 in vitro to generate single-stranded DNA, which would be susceptible to both
142 A Polymerase Cofactor), preferentially binds single-stranded DNA, yet contains a structural fold dist
143 ted to a handful of microorganisms for which single-stranded DNA-annealing proteins (SSAPs) that prom
145 CST (CTC1-STN1-TEN1) proteins, which form a single-stranded DNA-binding complex, localize at stalled
146 on between Escherichia coli RNase HI and the single-stranded DNA-binding protein (SSB) in this proces
148 of core subunits of LMO2 and LDB1 as well as single-stranded DNA-binding protein (SSBP) cofactors and
149 The Chip/LIM-domain binding protein (LDB)-single-stranded DNA-binding protein (SSDP) (ChiLS) compl
150 1) transcription factor and the co-regulator single-stranded DNA-binding protein 3 (SSBP3) regulates
151 overcome by the DNA-binding activity of the single-stranded DNA-binding protein RPA, efficient DNA r
153 107Q amino acid changes in the mitochondrial single-stranded DNA-binding protein, a crucial protein i
155 o three hexanucleotide repeats resulted in a single-stranded DNA-like mechanical behavior under all c
156 eavage can be rapidly digested by a 3' to 5' single-stranded DNA-specific exonuclease, indicating Cas
165 However, because of saturation and because a single-stranded donor DNA replaces the original allele,
168 obases predominantly occurs when DNA becomes single-stranded during replication and transcription.
169 2 activity is required for rendering complex single-stranded, exogenous RNA molecules detectable for
171 In this report, we examined the roles of single-stranded exposed guanosines at NC binding sites i
172 P.BeF(3) (-) even when nucleosomes contained single-stranded gaps that disrupted most DNA contacts wi
173 eq) to generate a high-resolution profile of single-stranded genomic RNA inside viral particles.
174 res show how CHMP1B first polymerizes into a single-stranded helical filament, shaping membranes into
177 architecture of DNA logic circuits based on single-stranded logic gates using strand-displacing DNA
179 ally, and much to our surprise, we also find single-stranded loops of minimal G4s within individual L
180 y to an RNAG-quadruplex structure that lacks single-stranded loops, double-stranded stems, or junctio
185 abditis elegans protein related to the human single-stranded nucleic acid-binding protein Pur-alpha,
187 sly described cytidine deaminases operate on single-stranded nucleic acids(3), their use in base edit
188 generation of simple knock-in alleles using single-stranded oligodeoxynucleotide (ssODN) repair temp
190 and deletion events, maintains or increases single-stranded oligodeoxynucleotides mediated precise g
192 is biosensor is based on immobilizing 20-mer single stranded oligonucleotide (probe) on the Au nanopa
193 e precisely incorporate exogenously supplied single-stranded oligonucleotide donor (ssODN) at the DNA
194 e demonstrate the dual sgRNA approach with a single-stranded oligonucleotide donor is highly specific
195 the cell cycle, are present predominantly as single-stranded oligonucleotides and are suitable substr
196 jection of 2 single guide RNAs (sgRNA) and 2 single-stranded oligonucleotides as donors (referred her
197 in three K-12 E coli strains using multiple single-stranded oligonucleotides containing homological
198 e generated in Escherichia coli using mutant single-stranded oligonucleotides to target PCR-derived l
199 f these studies have been performed in short single-stranded oligonucleotides, far from the intracell
200 ic acid (PNA) scaffolds for the detection of single-stranded oligonucleotides, in particular microRNA
202 rchitecture comprised of a T7 promoter and a single-stranded overhang domain (ss-dsDNA), can unlock d
203 s via T-junctions formed by hybridization of single-stranded overhangs on the linkers with the loops.
204 nces of all lengths and types (5' and 3') of single-stranded overhangs, if present, on each DNA fragm
206 uding dengue virus and Zika virus, contain a single-stranded positive sense RNA genome that encodes v
207 ous bronchitis virus (IBV) possesses a long, single-stranded, positive-sense RNA genome (~27 kb) and
210 s a specialized machinery that converts long single-stranded precursors into small RNAs of ~25-nucleo
212 and in human A549 cells, appending a 3'-end single-stranded pyrimidine (3'-ssPy) can strongly enhanc
214 subunits bind sequence-nonspecifically to a single-stranded region and, on breathing of the inhibito
216 l tisB standby site consists of the expected single-stranded region, but surprisingly, also a 5'-end
219 olving Watson-Crick base pairing between the single-stranded regions of a bulged helix and a hairpin
220 rly from the 5'-terminal monophosphate along single-stranded regions of RNA and that its progress is
223 ific and selective recognition of dsRNA over single-stranded RNA (ssRNA) and dsDNA regions at near-ph
224 report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three
225 Viruses in the Tombusviridae family have single-stranded RNA (ssRNA) genomes with T=3 icosahedral
227 ncoming viral genome, whereas negative-sense single-stranded RNA [(-)ssRNA] viruses carry at infectio
228 aded from the periphery, TLR7 detected viral single-stranded RNA and triggered immune responses that
231 structures of apo-D1D2 and post-unwound D1D2:single-stranded RNA complex, and the structure of a D2:d
232 sslinks to specific regions characterized by single-stranded RNA flanked by structured elements and t
233 eceptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adap
235 Leviviruses are bacteriophages with small single-stranded RNA genomes consisting of 3-4 genes, one
238 ch is valid with a culturable positive-sense single-stranded RNA human virus, coxsackievirus B5, by a
239 ce upon binding with double-stranded DNA and single-stranded RNA in live cells, thereby enabling real
240 of stroke-inducible tRF-22-WE8SPOX52 using a single-stranded RNA mimic induced down-regulation of imm
241 glia of live zebrafish brains, we found that single-stranded RNA of bacterial origin acts as a PAMP a
242 A bacteriophage Phi6, and the positive-sense single-stranded RNA poliovirus (PV) and human rhinovirus
243 isms that are different from the established single-stranded RNA recognition mode of PPR motifs.
245 KH0, KH1, and KH2 domains bind weakly to the single-stranded RNA sequences suggesting that they may h
246 tures known for their modular recognition of single-stranded RNA sequences with each motif in a tande
247 Here we demonstrate that wild-type FUS binds single-stranded RNA stoichiometrically in a length-depen
248 i YbeY exhibits endoribonuclease activity on single-stranded RNA substrate but not on the double-stra
249 is E virus (HEV) is a 7.2-kb positive-sense, single-stranded RNA virus containing three partially ove
252 proach that accurately tracks positive-sense single-stranded RNA virus inactivation without relying o
255 ) susceptibility compared with other enteric single-stranded RNA viruses (e.g., Echovirus 12, feline
257 s) comprise a large genus of positive-sense, single-stranded RNA viruses whose members cause a number
260 ite the threat to human health posed by some single-stranded RNA viruses, little is understood about
261 ic arthropod-borne viruses (arboviruses) are single-stranded RNA viruses, the most common of which in
262 omically important plant and animal positive single-stranded RNA viruses.IMPORTANCE Uncapped viral RN
265 st resiquimod (R848; a synthetic analogue of single-stranded RNA) or saline by nasal spray to healthy
268 se testes, most piRNAs are derived from long single-stranded RNAs lacking annotated open reading fram
270 Circular RNAs (circRNAs) are a class of single-stranded RNAs with a contiguous structure that ha
276 The decay pathway is independent of specific single-stranded sequences, as regulation is maintained i
277 ins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary str
281 in of clusters are lesions in long tracts of single-stranded (ss) DNA damaged by apolipoprotein B mRN
284 We found that the addition of mitochondrial single-stranded (ss) DNA-binding protein both influences
289 ZIKV 3'UTRs occur predominantly in unpaired, single-stranded structural context, thus corroborating e
290 fers DNA or RNA substrates with TTGT or UUGU single-stranded tails and that the KH domain is critical
293 e, the complementarity of the invader to the single-stranded toehold provides the free energy bias of
294 RNA, we use antisense oligos to hybridize to single-stranded transcripts exposed on the surface of hu
295 leoprotein complex reveals that the terminal single-stranded transposon DNA adopts unusual A-form and
296 chestrated by the Z ring, which is formed by single-stranded treadmilling protofilaments of FtsZ.