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1 ion in multiple biomes across the world (131 sites).

2 r-related gene expression at the integration site.

3 in specific targeting/delivery to the tumor site.

4 iver structures from the river mouth to each site.

5 inferred to occur at the coral calcification site.

6 etry peak corresponding to PCET at this acid site.

7 German cohort observed by a single clinical site.

8 ide monophosphate product from the catalytic site.

9 atase with a trapped substrate in its active site.

10 f dynamics that are localized to the binding site.

11 ation from the allosteric site to the active site.

12 uired for optimal interaction at the binding site.

13 er reservoir of unmeasured ROC at the former site.

14 ere heavier at fledging than at the suburban site.

15 than expected by independent action at each site.

16 tein CopC share a similar mononuclear copper site.

17 , even for different rain events at the same site.

18 S substrate and selects a favorable cleavage site.

19 s at a position far from the antigen binding site.

20 exosomes, finding on average 5.9 glycans per site.

21 local protein environment for the functional site.

22 ubiquitin chain attached to the UBE2K active site.

23 A-binding domain, distal to the zinc-binding site.

24 A) cosubstrate is bound at the MmOGOR active site.

25 ive to thiocyanate ions near neutral surface sites.

26 opeptides with a total of 399 phosphorylated sites.

27 gh-fidelity comparisons across biogeographic sites.

28 ctarepeat and nonoctarepeat (non-OR) binding sites.

29 a from all sites but often not at individual sites.

30 ion between protein interactions at distinct sites.

31 mmunosurveillance through diverse peripheral sites.

32 existence in hostile polymicrobial infection sites.

33 own CFSs and identification of novel fragile sites.

34 nesis, metastasis, and invasion to secondary sites.

35 e protein depending on the preferred binding sites.

36 ator species, such as bumble bees, at warmer sites.

37 posed to be mediated by their lysine-binding sites.

38 lies that parameter values have to vary with sites.

39 porting radiologists for all three datasets (site 1 FFDM: linearly weighted Cohen kappa [kappa(w)] =

40 appa [kappa(w)] = 0.75 [95% CI: 0.74, 0.76]; site 1 SM: kappa(w) = 0.71 [95% CI: 0.64, 0.78]; site 2

41 1 SM: kappa(w) = 0.71 [95% CI: 0.64, 0.78]; site 2 SM: kappa(w) = 0.72 [95% CI: 0.70, 0.75]).

42 rface to hIL-23R and found that the combined site 3 substitutions of W156A and L160E, which become bu

43 ks and increases beta-catenin occupancy at a site 4 kb upstream to Lef1.

44 Transfer of the 5' splice site (5'SS) from U1 to U6 snRNA triggers unwinding of U6

45 uantified using Sanger sequencing of the CpG sites 74-98 within the MGMT promotor region.

46 8 experimentally validated internal mRNA m7G sites, a sequence-based high-accuracy predictor, the fir

47 DNMDP, and substitutions in the PDE3A active site abolish compound binding.

48 adly and for understanding how copper active sites achieve activation of strong C-H bonds.

49 ic mole fraction of CO(2), measured from six sites across China during 2009 to 2016.

50 nd women collected at geographically diverse sites across the United States.

51 s a model, we show that low-affinity binding sites act as a competitive reservoir in vivo from which

52 n the selection of the precursor mRNA branch-site adenosine, the nucleophile for the first step of sp

53 gnificant variation in rates across hospital sites (adjusted median rate, 11.4%; IQR, 8.9-14.5).

54 Site-specific replacement of active-site amino acids revealed the presence of a water-coordi

55 hat depend on direct competition for binding sites among protective RNA-binding proteins and decay fa

56 its pro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and bo

57 and their effects on the ubiquinone-binding site and a connected cavity in ND1.

58 is important for determining if a transplant site and capsules with certain passive diffusion charact

59 The mitochondrial contact site and cristae organizing system (MICOS) is a multisub

60 r and acceptor substrates bind in the active site and how ethambutol inhibits arabinosyltransferases

61 DN+L formed a vaccine depot at the injection site and induced a remarkable increase of functional imm

62 n of mycotoxins can be carried out at remote sites and by minimally trained personnel, while quantifi

63 mparing alpha and beta gene occupancy at PPP sites and gene bodies suggests that Pol II is released m

64 for further investigation of glycan-binding sites and glycan structures.

65 ler Au NPs as numerous cavitation nucleation sites and Mn(2+) for chemodynamic therapy (CDT), resulti

66 cyanate anions at positively charged surface sites and negatively charged surface sites and those par

67 l coincidence with biodiversity conservation sites and priorities.

68 latory SVs, particularly those altering CTCF sites and provides a simple approach for functionally an

69 he identification of novel ubiquitin and UBL sites and the characterization of the writers, erasers,

70 surface sites and negatively charged surface sites and those participating in contact ion pairing ado

71 brine, we sampled reef fishes at two outlet sites and two close reference sites, as well as four ref

72 e urinary microbiome is distinct from nearby sites and unrelated to stool microbiome with more Actino

73 One clade has replaced others at several sites, and rates of DFT1 coinfection are high.

74 epressive complex occupancy and CTCF binding sites are associated with cancer-specific gene dysregula

75 le-stranded DNA until both dif recombination sites are placed at mid cell for subsequent dimer resolu

76 information about PrEP, and that health-care sites are prepared to provide quality care for transgend

77 rabinosyltransferases by binding to the same site as both substrates in EmbB and EmbC.

78 ished and p53 binds initially to cognate DNA sites as a dimer.

79 d by two Rh-O bonds at framework tetrahedral sites, as shown by infrared and extended X-ray absorptio

80 at two outlet sites and two close reference sites, as well as four reference sites that were located

81 of the data allowed pinpointing CodY-binding sites at close to single-nucleotide resolution.

82 egy to introduce artificial tryptic cleavage sites at Cys29 and Cys33 in rhEPO.

83 ntify ZMAT3-regulated RNAs and their binding sites at nucleotide resolution in intact colorectal canc

84 a symmetric dimer with two (p)ppGpp binding sites at the dimer interface.

85 housing the Zn(2+) substrate; an interfacial site between TMD and C-terminal domain (CTD) that modula

86 Syt1-membrane interaction and fully map the site-binding energetics of Syt1 both in the absence and

87 The structure reveals a composite binding site bridging over three domains of one capsid protein (

88 ansport activity of HsZnT8; and two adjacent sites buried in the cytosolic domain and chelated by con

89 chromosomal DNA, containing the same binding site but with a different reporter.

90 vely correlated when combining data from all sites but often not at individual sites.

91 revealed maize and mixed-food refuse at both sites, but this study documents actual food consumption,

92 ession of Wapl through a single Pax5-binding site by recruiting the polycomb repressive complex 2 to

93 nition of highly degenerate mammalian splice sites by the core spliceosomal machinery is regulated by

94 vage frequently involves unmasking of target sites by translating ribosomes.

95 poat(O)](-) is the inclusion of an auxiliary site capable of binding a Lewis acid (LA(II)); we used t

96 ut") varied by various individual, trial, or site characteristics.

97 on opposite sides of the murine Esco2 active site cleft, are critical for catalysis.

98 effect on end-of-life care expenditures than site COC did, which indicated significant care coordinat

99 t the low reduction potentials of the active site cofactors are optimized for fast elimination of the

100 o differences in the structure of the active site compared with other zinc-dependent nucleotide deami

101 responding to the sensorimotor stroke lesion site compared with spontaneous recovery and control cond

102 te their impact on the incidence of surgical site complications.

103 nt protein interaction sites, in addition to sites corresponding to heme-CPR domain interactions at t

104 e to phenylalanine substitution at a binding site could be detected.

105 Three S-palmitoylation sites (Cys(1169), Cys(1170), and Cys(1978)) were identif

106 Fragile site damage is thought to arise from the aberrant repair

107 allinity, micro-/mesoporosity, Bronsted acid site density and distribution (in micro- vs. mesopores),

108 ody, antibody specific-activity, and antigen-site density most impacted median survival.

109 phorylation at an evolutionarily more recent site diminishes p38 binding and made the phosphoswitch d

110 hese 2 intermediates and iterative rounds of site-directed mutagenesis allowed us to identify 4 of 41

111 Kinetic, molecular docking, and site-directed mutagenesis analyses confirmed these compo

112 Site-directed mutagenesis of both cofilin and actin reve

113 evan-type fructooligosaccharide and utilized site-directed mutagenesis to identify residues involved

114 Using site-directed mutagenesis, surface plasmon resonance, an

115 epair in E coli supports efficient multiplex site-directed mutagenesis.

116 These determinants were resolved further by site-directed mutagenesis.

117 analyses confirmed these compounds as active site-directed reversible inhibitors of mPTPB.

118 Site-directed spin labeling (SDSL) ESR is a valuable too

119 complex that differ based on whether target site DNA is annealed or dynamic.

120 x1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absen

121 t Gag-RNA interactions occur at multiple RNA sites during genome packaging; furthermore, there are fu

122 scattering revealed that confined nickel(II) sites enabled chemoselective and reversible binding to a

123 The gradient to the regional background site exceeded 1 order of magnitude.

124 These solvent-exposed sites featured an axial ZFS of 0.21 cm(-1) when hydrated

125 Although the liver is the primary site for clinical islet transplantation, it poses severa

126 To date, a binding site for P on L had not been described.

127 carboxylic acid groups provide an anchoring site for the stable immobilisation of an NADH-dependent

128 Modeling studies unveil the specific binding sites for acetylene capture as well as the interconnecte

129 infection without the need to evolve binding sites for antisilencing proteins at each foreign gene.

130 y allows distinction of two separate binding sites for BODIPY-cyclopamine on the SMO transmembrane co

131 n a membrane environment, revealing putative sites for conformational switching.

132 ith the selection of suitable reintroduction sites for Southern Ground-hornbills.

133 r assay (MPRA) libraries composed of binding sites for SOX2, POU5F1 (OCT4), KLF4, and ESRRB.

134 We identify binding sites for substrate K(+) and Cl(-) ions, demonstrate the

135 Resistance mapping revealed a druggable site formed by the G protein fusion loops that has not p

136 proteins and 55,000 phosphorylation sites (p-sites) from 125 CCLs.

137 additional recombination occurring at distal sites harboring virulence-associated genes.

138 vates the channel; a secondary anionic lipid site has been identified, which augments the activation

139 er of subscribers to a commonly used testing site has grown to more than 10 million.

140 a proper actin-binding interface and active site have formed before producing a power stroke.

141 density and an amplifying effect that urban sites have on each other.

142 f the Ealpha and its downstream CTCF binding site (here named EACBE) in dynamic chromatin regulation

143 We also assessed between-site heterogeneity.

144 g of the conjugates at the polymerase active site, however, in different modes in the presence of Mg(

145 in a set of 55 high-confidence gRNA cleavage sites identified by both methods.

146 the allosteric ligands and receptor binding sites important for these allosteric activities.

147 The absence of the polybasic cleavage site in SARS-CoV-2 did not affect virus replication in V

148 till agriculture over a 29-year period at a site in the upper Midwest, US.

149 We found that the cleavage site in this 1192-amino-acid-long fragment is located be

150 hin each subunit: a highly conserved primary site in transmembrane domain (TMD) housing the Zn(2+) su

151 nd, placebo-controlled study was done at 118 sites in 13 countries across Asia, Europe, and North Ame

152 tic use across inpatient and ambulatory care sites in an integrated healthcare system to prioritize a

153 ip1 complex in vitro, and both hFip1 binding sites in CPSF30 can support polyadenylation.

154 , double-blind, randomised trial done at 121 sites in Europe, South America, and Singapore.

155 There were four trial sites in hospitals in Ghana (Agogo, Tepa, Nkawie, Dunkwa

156 The iron atoms substitute molybdenum sites in MoS(2) crystals, as confirmed by transmission e

157 luxes from the FLUXNET Network for 34 forest sites in North America, the seasonal pattern of sensitiv

158 es resulted in only 13 similar metal binding sites in other proteins, indicative of the rareness of t

159 eotic confirmed previously reported O-GlcNAc sites in TAB1 (S395 and S396) and uncovered new sites wi

160 rences in surface reactivity of different Au sites in the DFT model.

161 vapor and particle samples collected at six sites in the Laurentian Great Lakes basin every 12 days

162 he pervasiveness of spurious and deleted cut sites in the raw data, which are called Rmaps, make asse

163 )), but were notably lower under sorghum for sites in the southwestern study region (13.6 +/- 3.0 vs

164 participants were recruited from 24 academic sites in the USA and Israel.

165 re, there are functionally redundant binding sites in viral RNA.

166 The active sites in Y-DeAlBEA are 70 times more active than the Y s

167 and are 7 times more active than the active sites in Zn-DeAlBEA.

168 We identified important protein interaction sites, in addition to sites corresponding to heme-CPR do

169 nied by conformational changes in the active site, including the translation of an alpha-helix by 1 a

170 m the Gd atom being trapped at two different sites inside the C(82) cage.

171 ch a selective multivalent metal ion binding site into target macromolecules for structural and bioph

172 igger loop, a flexible element of the active site involved in nucleotide addition, can stimulate tran

173 ound p53 mutants reveal a cryptic allosteric site involving three arsenic-coordinating cysteines with

174 The product-bound active site is almost identical to that of the substrate-bound

175 s, finding that for G1 and G2, the insertion site is recognized through defined mechanisms, at least

176 Y sites supported on silica, for which the Y site is similar to that in Y-SiO(2) but which lacks adja

177 een the LC3-interacting region (LIR) docking site (LDS) in ATG8s and LIR motifs in various interactio

178 mediate specific binding by the SHP2 active site, leading to blockade of RasGAP binding and optimal

179 ocation of the centrosome toward the contact site leads to reorganization of microtubules and associa

180 taining the flavivirus internal NS3 cleavage site linker reported the highest fluorescence activation

181 sing TR ChIP-seq peaks or imputed TR binding sites, Lisa probes the chromatin models using in silico

182 Use of alternative transcription start sites located within the Arabidopsis (Arabidopsis thalia

183 equences C-terminal to the dephosphorylation site make intimate contacts with the composite Phactr1/P

184 by the MatP protein, which binds to specific sites (matS) within ter, and interacts with other protei

185 To determine whether this glycosylation site may be the binding region for EphA2, we compared th

186 Among those 759 CpG sites, methylation of 42 is associated with expression o

187 and interactions that allow and limit active-site motions.

188 ive characterization of spontaneous polarity site movement as a search process and use a mechanistic

189 how various processes might affect polarity site movement.

190 ba province was mainly due to a P106S target-site mutation in the 5-enolpyruvylshikimate 3-phosphate

191 On the other hand, CpGs at sites not bound by transcription factors during the glob

192 with exothermic energetics, binding to these sites occurs endothermically due to concomitant unwindin

193 7 by scaffolding and concentrating it at its site of action while maintaining it in an "off" state un

194 intercellular air spaces (IAS) to the first site of carboxylation in the mesophyll cells.

195 ray crystallographic structure resolving the site of catalysis, a protein-bound Mn(4)CaO(x) complex,

196 can be profiled to determine potency and the site of crosslinking, and subsequently developed as repo

197 hnRNPA2B1 carries its cargo, at most, to the site of exosome assembly, but it is not itself incorpora

198 )-Asn(149) fragment can be considered as the site of IgE recognition of Rhi o 2.

199 n in vitiligo and are hypothesized to be the site of immune attack in AA.

200 when targeting the peptide substrate binding site of NTMT1/2.

201 d "nodes" of TP activity around the division site of predivisional cells.

202 We suggest that the deep Pacific is a site of respired carbon storage associated with periods

203 isolating viable human cells present at the site of skin wounds.

204 nnectivity and excitability changes from the site of stimulation, such that after active treatment, t

205 han 10-fold depending on temperature and the site of the engineered methionine.

206 transport the hydrophilic molecules to their sites of action.

207 n on local dynamics of fluorophores at their sites of attachment on LIV-BPSS and the correlations bet

208 s and is involved in their reorganization to sites of cell adhesion.

209 ed from healthy (n = 5) and diseased (n = 5) sites of each patient.

210 Sites of equal area but different shape lead to equal oc

211 Sites of GA biosynthesis in the roots of 7-d-old Arabido

212 promyelocytic leukemia protein (PML) bodies, sites of many nuclear processes including protein qualit

213 sity, Coupa allowed us to precisely localize sites of mitochondria-lysosome contact and reveal increa

214 to tune the O(2) affinity at the open metal sites of MOFs for applications involving the strong and/

215 L-37 and HNP 1-3 when compared with diseased sites of non-smokers.

216 P1a that promotes its stable accumulation at sites of polar growth.

217 leophilic substitution reactions on tyrosine sites of proteins.

218 The active sites of RFC are fully bound to adenosine 5'-triphosphat

219 Diseased sites of smokers presented significantly lower levels of

220 enitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI) and generate neuronal

221 We compared binding sites of TRAMP components with multiple nuclear RNA bind

222 cantly influences platelet plug formation at sites of vascular injury (primary hemostasis).

223 Interestingly, elimination of the O-fucose site on EGF12 allowed LFNG to inhibit JAG1-NOTCH2 activa

224 evel characterization identified the docking site on PrP(C) that underlies the stereoselective bindin

225 , but surprisingly also to relocalization to sites on autosomes.

226 By selectively patterning nucleation sites on monolayer or bilayer s-TMDs, we precisely contr

227 these displaced Rohingya settled in informal sites on previously forested land, in areas without basi

228 ctions of the latter with oppositely charged sites on the cationic surfactant headgroups and deproton

229 rfactant headgroups and deprotonated silanol sites on the pore walls.

230 Cu particles or atomically dispersed Cu-O-Zr sites only catalyze the reverse water-gas shift reaction

231 eiosis, whereas phosphorylation at the other sites only inhibits Katanin ATPase activity stimulated b

232 context, either deletion of the CTCF binding site or depletion of RAD21 cohesin complex protein can r

233 the enzyme, such as a nucleotide hydrolysis site or multiple intermediate conformations.

234 Disruption of the NAD(+)-binding site or the ARM-TIR interaction caused constitutive acti

235 is way often contain multiple ligand binding sites or modification sites, which can operate to create

236 which is initiated between homologs at >200 sites originating from meiotic double-strand breaks (DSB

237 using free gingival grafts (FGG) at implant sites over a 3-month follow-up period.

238 is in comparison with peri-implant mucositis sites (P = 0.011, P = 0.020, respectively).

239 r 10,000 proteins and 55,000 phosphorylation sites (p-sites) from 125 CCLs.

240 B can be correlated to the change of binding site polarity and that a tyrosine to phenylalanine subst

241 This spectral site polymorphism is expected to confer expanded "UV-blu

242 cytoplasm, the peptide occupies its binding site prior to the transition from initiation to the elon

243 aller oligonucleotides the number of binding sites remained unchanged with pressure rise while an inc

244 tes while the proportion in non-intervention sites remained unchanged.

245 plication stress, however successful fragile site repair cannot be calculated using existing techniqu

246 ger substrate is accommodated and how active site residues have changed to recognize N-citrylornithin

247 h target-site resistance (TSR) and nontarget-site resistance (NTSR) mechanisms have evolved to most h

248 Both target-site resistance (TSR) and nontarget-site resistance (NTS

249 temperature, CFTR-targeting drugs and second-site revertant mutation R1070W.

250 de ligands can significantly activate single-site Ru-based catalysts.

251 gy using regional aerial dieback surveys and site-scale field surveys.

252 where detailed hydraulic stimulation and on-site seismicity monitoring data provide an unprecedented

253 ilized by surface adsorbed iodide enable the site-selective oxidative etching of Au(0), which leads t

254 Here, we discovered site-specific fragmentation of NOTCH3 protein in patholo

255 stics, high-affinity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism

256 ecific conjugation resulting in mixtures, or site-specific methods that require multiple steps, intro

257 Site-specific replacement of active-site amino acids rev

258 terature-guided causal inference tools, >300 site-specific signaling relations were mapped from phosp

259 of graphene nanoribbons (GNRs) that contain site-specifically substituted backbone heteroatoms is on

260 ily and comparing the conservation of active site structure and specificity among a sampling of plant

261 2A.Z, thereby focusing the pathway on select sites such as transcriptionally active genes.

262 -DeAlBEA are 70 times more active than the Y sites supported on silica, for which the Y site is simil

263 in considering that only weak clay fraction sites take part in the adsorption.

264 e reference sites, as well as four reference sites that were located from 2-8 km from the outlet.

265 ies richness at the spatial scale of a study site, the losses of small-ranged species reduce biome-sc

266 producing Ocr have partially methylated BREX sites, their viability is unaffected.

267 se synovial joints include immune privileged sites, these findings are significant for future investi

268 hese QTL in each environment and across both sites, three main QTL hotspots were found in chromosomal

269 msR4Ms') designed to mimic the CXCR4-binding site to MIF, selectively bind MIF with nanomolar affinit

270 t for signal propagation from the allosteric site to the active site.

271 ng tumor cell dissemination from the primary site to the skeleton remain largely unknown.

272 g, which allows for spurious and deleted cut sites to be accounted for.

273 in (13)C over the transect from the control site towards the seep, suggesting that CO(2) exerts a st

274 On-site translation is supported by the localization of a t

275 x protein can recover distal polyadenylation site usage.

276 The plane site vacancies are reoccupied during post-annealing trea

277 ely delineated by active transcription start sites, validate that these boundaries are sufficient for

278 ere given intraperitoneally and implantation sites visualized.

279 defined as the number of stable AF reentrant sites, was concordant between noninvasive and invasive m

280 Offspring from the rural site were heavier at fledging than at the suburban site.

281 failures, and pain/discomfort at the implant site were significantly associated with both outcomes (i

282 ere for two different miRNAs or when the two sites were bound to miRNAs loaded into two different AGO

283 ooperative binding was retained when the two sites were for two different miRNAs or when the two site

284 In total, 212 patients in 35 sites were treated; mean (SD) baseline PASI score was 20

285 However, ADM-adjacent untreated sites which had presented with recession at baseline but

286 Unlike the other high-affinity sites, which bind NC with exothermic energetics, binding

287 ultiple ligand binding sites or modification sites, which can operate to create an ultrasensitive dos

288 connectivity of dozens of tightly spaced M1 sites, which was the linchpin for uncovering organizatio

289 PSC and 66% by CDC light trap in the sprayed sites while the proportion in non-intervention sites rem

290 activity and availability of surface iridium sites, whilst significantly inhibiting the surface catio

291 dergo endoscopy with endoscopic treatment of sites with active bleeding or high-risk stigmata for reb

292 e also identified two distal quinone-binding sites with bound quinones.

293 nthesis because it features several reaction sites with nucleophilic or electrophilic properties.

294 leaf litter manipulation experiment at three sites with paired paper birch (Betula neoalaskana) and b

295 tal indicators (missing teeth, percentage of sites with pocket probing depth >=6 mm, and mean pocket

296 ells, closely spaced microRNA (miRNA) target sites within a messenger RNA (mRNA) can act cooperativel

297 es in TAB1 (S395 and S396) and uncovered new sites within both proteins.

298 a dimeric structure with four Zn(2+) binding sites within each subunit: a highly conserved primary si

299 enomic alterations to be written into target sites without requiring double-strand breaks or donor te

300 x ratios at population levels across nesting sites worldwide, a crucial step in assessing the impact

301 Fourteen site years of data were used from two different trials,