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4 tured region of DNA corresponds to the break site for a large (3,895 bp) deletion observed in mitocho
5 this may represent an as-yet-unknown binding site for a partner protein required for tumorigenesis.IM
6 ok 10-20 s on average to predict the binding site for a protein complex whereas the state-of-the-art
7 PPC indicates that it is an appropriate BMI site for a very wide range of neuroprosthetic applicatio
8 tory of liver disease were recruited at four sites for a research MRI and blood draw between February
11 proach, we show that the orthosteric binding sites for acetylcholine and nicotine in the two major br
12 Modeling studies unveil the specific binding sites for acetylene capture as well as the interconnecte
14 e single crystal and (ii) to modify the step sites for adsorption of reactants by selective depositio
18 infection without the need to evolve binding sites for antisilencing proteins at each foreign gene.
21 a, identify the acidic pocket as the binding site for BigDyn, and thus highlight this cavity as an im
22 DNA structures with a GC/GA-5' intercalation site for binding by the GC-selective intercalator actino
26 y allows distinction of two separate binding sites for BODIPY-cyclopamine on the SMO transmembrane co
27 tant isolates involved AmpC, a known binding site for both ceftolozane and ceftazidime, and DNA polym
29 e present study, we mapped a polyadenylation site for both mouse and human MOR-1Bs that defines the 3
30 apF (Ct) utilizes a shared substrate-binding site for both racemase and epimerase activities, only on
31 structures have uncovered unforeseen binding sites for both cooling agonists and membrane lipid phosp
32 set of unique de novo DNA methylation target sites for both DNMT3 enzymes during mammalian developmen
35 onstrate that precise mutation of hth 3' UTR sites for BX-C miRNAs or deletion of its neural 3' UTR e
36 rol as a concept for the design of catalytic sites for C-H bond activation, thereby enabling nondirec
37 (PPR) proteins specifically recognize target sites for C-to-U RNA editing in the transcriptomes of pl
39 IV/AIDS Program Services Reports (RSRs) from sites for calendar years (CYs) 2014-2016, corresponding
41 red, and the defect alone acted as catalytic sites for carbon dioxide activation and hydrogen dissoci
42 ludes ubiquitous polymorphisms within target sites for Cas9-based gene drive (CGD) and that these "dr
47 R) to be swept rapidly for potential binding sites for cholesterol at the bilayer interfaces on the t
50 e isolated In(delta+) -N(4) atomic interface sites for CO(2) electroreduction to formate with high ef
51 ially at island edges, deactivating the edge sites for CO(2) formation, even while the reaction proce
52 hanced adsorption of CO(2), increased active sites for CO(2) reduction and improved charge carriers s
54 core/silica shell microparticles to create a site for competitive binding of the antibodies (Abs).
62 ionic nano-construct of Avidin (mAv) with 28 sites for covalent drug conjugation can rapidly penetrat
64 100) and Asp(171) were preferential affinity sites for Cu(II) and that Cys(163) is an active site for
67 heme is readily transferred to the catalytic site for degradation to facilitate turnover but can also
69 ands identify an additional membrane binding site for diazepam and suggest an allosteric mechanism fo
70 Here we show that interspersing coordination sites for different metal ions within an artificial mole
71 th sensitive nanospace and selective binding sites for discriminating the subtle structural differenc
74 tion with LegK7 but also served as a docking site for downstream substrates such as the transcription
76 However, while individual ribosomal binding sites for each functional half of everninomicin P are to
78 enables us to identify the activity of step sites for electrocatalytic reactions, as demonstrated fo
83 e nicked NEIL2 product can serve as an entry site for Exo1 in vitro to generate single-stranded DNA,
84 uxiliary cluster may serve as a coordination site for exogenously derived sulfur destined for attachm
85 (TBs) in Ni-based superalloys are vulnerable sites for failure in demanding environments, and a curre
91 rom E50C to P54C as the other thiol function site, for forming longitudinal disulfide bond chains.
94 s, including the digestive tract, could be a site for future coronavirus emergence events in humans.
96 The upper respiratory tract is the primary site for GAS colonization, infection, and transmission,
98 SS5 has a conserved putative surface binding site for glucans and also interacts with MYOSIN-RESEMBLI
99 y glycoproteins have defined the interaction sites for glycoprotein complexes and receptors, and have
100 and a competitive loss of available binding sites for glyphosate-functionalized poly(ethylene glycol
103 ding template strand alignment in the active site for high-affinity binding of the initiating nucleot
104 l subsets in the rectal mucosa (RM), a major site for HIV acquisition and replication, in adults is n
105 cl1 can remain bound to a specific chromatin site for hours or days and thereby help to stabilize gen
106 and heat shock elements (HSEs), the binding sites for HSF1 - between Antarctic fishes and the basal
109 erature and insight into the possible active sites for hydrogen reactions on layered dichalcogenides
110 target positions in the nitroTyr aaRS active site for improved substrate binding, and then constructe
114 unnel in DENV RdRp offers interesting target sites for inhibition.IMPORTANCE Dengue virus (DENV), an
115 Hsp90-TPR domain interface is an alternative site for inhibitors, which could result in effects disti
117 with ancillary ligands, freeing coordination sites for internal alkene coordination polymerization.
119 omic 40S subunit models showed that a likely site for labile RNA binding is a cluster of positively c
122 The bone marrow constitutes the primary site for life-long blood production and skeletal regener
123 sites identifies key residues in the active site for ligand interactions, including those in the "ar
124 of MXene and sufficient accessible attacking sites for ligands are responsible for the evolution of 2
126 e state, and some of them function as active sites for lithium sulfide growth at the full discharge s
129 d demonstrated to possess sufficient binding sites for LPS adsorption and removal with ~100% protein
130 hologic abnormalities of the CLS, and access site for lymphatic interventions (ie, clinically useful
132 A-RNA interactions, which can conceal target sites for many minutes in the absence of translation.
133 ucleus of the amygdala (CeA) as an important site for mediating the somatic symptoms of withdrawal an
135 The truncation leads to a loss of target sites for microRNAs known to repress translation of LDLR
136 (MACF1), a scaffolding protein with binding sites for microtubules (MT) and actin, is concentrated a
137 LIN D1 and c-MYC mRNAs revealed that binding sites for miR33b, miR96, and miR503 are critical for tra
138 overexpress oncogenic (proviral integration site for Moloney murine leukemia virus (PIM) 1, 2, and 3
139 of the oncogenic kinase proviral integration site for Moloney-murine leukemia 1 (PIM1) in CD127+ T-AL
140 ifs in the transmembrane domain as potential sites for monomers docking and identified three cysteine
147 gastric adenocarcinoma in specific anatomic sites for non-Hispanic White (NHW), non-Hispanic Black,
148 , the atomic-scale regulation of such active sites for NRR catalysis remains challenging because of t
150 ol extrinsic morphological factors of FeN(4) sites for optimal porosity, electrochemically active sur
151 The gut-draining lymph nodes (gLNs) are key sites for orchestrating adaptive immunity to luminal per
152 thin PBS1 can be altered to contain cleavage sites for other proteases, enabling RPS5 activation by t
155 ructure suggested the existence of 2 docking sites for PC1 within the N terminus of Kv4.3, supporting
157 channels presenting a high-affinity binding site for PF-05089771 and suggesting that combinations of
158 (cryo-EM) structures reveal that the binding sites for PF 06882961 and GLP-1 substantially overlap, w
159 pecific lipids and forming essential binding sites for phosphoinositides and cholesterol that are fun
161 thylation signals around transcription start site for predicting gene expression, and increased predi
162 sing the polyclonal antisera overlap binding sites for previously reported monoclonal antibodies, sug
164 s steric fit and H-bonding within the active site for proper alignment with MutY catalytic residues.
166 tal heart defects, and the PV is usually the site for prosthetic replacement following a Ross operati
167 Nup153), which is known to provide a docking site for protein-cargo complexes at the nuclear pore com
168 CD5 tyrosine 429, which serves as a docking site for proteins with adaptor functions (c-Cbl, CIN85,
170 both RBDs suggests that the receptor-binding site for QX is located at a different location on the sp
171 change of the ELMO1 subunit, exposes binding sites for RAC1 on DOCK2(DHR2), and RHOG and BAI GPCRs on
172 Cepsilon was proposed to the primary binding site for Rap1A, we first confirmed using purified protei
174 ribed into RNA, as they serve as the binding sites for RBPs that control post-transcriptional process
176 elta1-147), suggesting an allosteric binding site for recifin A on the regulatory domain of TDP1.
177 alpha4 helix of its 4HB domain as a crucial site for recruitment of adaptor proteins that mediate me
178 patch on the nucleosome disk may be a common site for recruitment to chromatin, the pervasiveness of
179 mitochondria and suggest that they serve as sites for regulating the supply of nascent pro-survival
180 uate nucleus of the hypothalamus, as a major site for regulation of food intake, sends only very indi
182 sult in presence or absence of miRNA binding sites for regulatory miRNAs with consequences on posttra
189 eworks allows design of well-defined binding sites for selective molecular adsorption, which has a pr
190 ered arrays could be used to provide surface sites for selective redox reactions, or for storing info
191 thod, here we comprehensively define binding sites for Semliki Forest virus (SFV) Cp on the gRNA.
192 organs in the lamina terminalis are critical sites for sensing both types of thirst-inducing stimulus
193 potentially creates a novel phosphorylation site for Ser/Thr kinases and because Nav1.7 had been sho
194 -acid region of VP1 that is also the binding site for several previously identified monoclonal antibo
195 del was used to determine overlap of binding sites for several inhibitory and potentiating steroids.
196 distributed octopus nervous system is a key site for signal processing and highlight how molecular a
198 The trans-Golgi network (TGN) is a major site for sorting of cargo to either the vacuole or apopl
201 sed method that accurately annotates binding sites for specific TFs automatically with no requirement
202 nges, we first consider alternative anatomic sites for specimen collection, then discuss self-collect
205 st three classes of distinct, nonoverlapping sites for steroids, one each for the inhibitory steroids
206 Visceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also serves as
211 gion of the hypothalamus (AVPO; an important site for Tb control), oxygen consumption analysis, cardi
212 esters, (2) these OH groups act as catalytic sites for TBA dehydration to isobutylene, and (3) TBA al
213 single nucleotide variants in active binding sites for TEAD4 (P = 6 x 10-11) and its binding partner
214 e encompasses and better defines the binding site for TFIID and is surprisingly invariant over a wide
215 tudies have identified a new surface binding site for the 3' vRNA and cRNA promoters on FluPol, refer
217 t (helix 1) constitutes the main interaction site for the adaptors Spindly (SPDL1), bicaudal D homolo
218 racts of the female flowers, are the primary site for the biosynthesis and storage of resins rich in
219 of mammalian Cx36 harbors a phosphorylation site for the Ca(2+)/calmodulin-dependent kinase II at se
220 onal changes that create a potential binding site for the CaM binding domain of a target protein, whi
222 e of the sodium channel as a viable receptor site for the design of selective ligands targeting Na(V)
223 d thus highlight this cavity as an important site for the development of ASIC-targeting therapeutics.
224 he basic pyridyl functional group provides a site for the formation of a fixed charge, enabling detec
225 ) calculations predisposes the copper active site for the formation of a stable Cu-O(2) intermediate.
226 pigment epithelium (RPE) cells, the primary site for the fusion of optic fissure margins, FAT1 is lo
227 h specialized functions, and is a privileged site for the generation of both peripherally induced reg
228 s in the formation of a catalytic bimetallic site for the hydrolytic cleavage of the RNA model substr
231 which DNA containing one copy of the binding site for the neural-inducing factor Ascl1 is injected di
233 Together, our data identify a likely binding site for the NMDAR-positive allosteric modulator PES and
234 hermore, the connector domain as an acceptor site for the P protein represents a new understanding of
241 y, SNP rs17651213 created a putative binding site for the splicing factor RBFOX2 and was associated w
242 carboxylic acid groups provide an anchoring site for the stable immobilisation of an NADH-dependent
243 these promoters are enriched for the binding site for the TALE-class homeodomain transcription factor
244 e the coronoid process provides an insertion site for the temporalis attachment, we examined the init
247 nal analysis of single-cell data and binding sites for the CD4(+)-lineage transcription factor Thpok,
248 entify accurate transcription factor binding sites for the core regulatory complexes in the two diffe
251 a trend for more leakage at thinner palatal sites for the FGGT group (P = 0.09), and a statistically
253 The human ANO1 promoter contains binding sites for the glioma-associated oncogene (Gli) proteins.
256 eneous Fenton's reaction and provided active sites for the heterogeneous Fenton process, whereas nano
257 cts have been intensively explored as active sites for the hydrogen evolution reaction (HER) to split
260 ss involves the use of alternative 3' splice sites for the internal intron, the resulting alternative
262 8% (9%), 15% (1%), and 1% (0%) of coral reef sites for the low, moderate, and high emission scenarios
264 ter coverage, leaving more unoccupied active sites for the N(2) reduction (especially for the potenti
266 eport a new concept of utilizing dual active sites for the ORR and demonstrate its effectiveness by s
267 utions possess more active iridium catalytic sites for the oxygen evolution reaction (OER) than IrO(2
268 kocytes and increasing the range of drainage sites for the peritoneal expansion of lymphoid malignanc
269 ethylesterified pectin presents more binding sites for the protein-pectin interaction than to pectin
270 at chemical synapses are highly specialized sites for the regulated release of neurotransmitters.
271 icellular vertices are emerging as important sites for the regulation of epithelial integrity and fun
272 The structures reveal two novel recognition sites for the small-molecule modulators corroborated by
273 rtant insights into the functions of IVCs as sites for the synthesis of EV-associated proteins target
274 tracellular vesicle clusters (IVCs)-serve as sites for the synthesis of proteins targeted for secreti
280 Crystal structures revealed a common binding site for these monoclonal antibodies (mAbs) on FZD, bloc
282 denocarcinoma incidence in specific anatomic sites for this age group has impeded prevention and earl
283 irected mutagenesis showed that the relevant sites for this regulation are residues S561 and S1987.
285 several high-affinity non-functional binding sites for transcription factors (TFs) creating a hidden
286 ediated by DNA sequences that harbor binding sites for transcription factors, which can up- or down-r
287 on) and lack methylation at specific binding sites for transcription factors; 83% of samples of this
290 The other cluster is adjacent to the binding site for two COPII components, SEC31 homolog A COPII coa
292 t protein G3BP and the P4 residue of the 1/2 site for viral RNA replication of Old World alphaviruses
294 catalysts, including NiO, that offer active sites for water dissociation have been extensively inves
295 '-dicarboxylate) with phosphonate or pyridyl sites for water oxidation, gives surfaces with a 5:1 chr
296 nse elements, and we also discovered binding sites for XBP1, a transcription factor of endoplasmic re