ライフサイエンスコーパス: site of

1 A total of 115 tooth surface sites of 32 teeth from the 12 patients were evaluated be

2 S. cerevisiae Cdc3 guanidinium occupies the site of a 'missing' Arg side chain found in other fungal

3 escribed copper center that forms the active site of a copper-containing enzyme thiocyanate dehydroge

4 d B-form DNA duplexes, and within the active site of a DNA polymerase lambda variant.

5 At the colonization site of a foreign entity, plant cells alter their trajec

6 of a high-definition structure of the active site of a metalloprotein from a powder sample, by combin

7 lecule "anchor" groups to a specific binding site of a target biopolymer.

8 r its dynamic assembly or disassembly at the site of action exert a critical impact on damage bypass,

9 nsitive K(+) (K(ATP)) channels and the exact site of action of the hormone.

10 7 by scaffolding and concentrating it at its site of action while maintaining it in an "off" state un

11 To identify a central site of action, we showed that systemic exendin-4 penetr

12 diabetes; however, the mechanisms and tissue sites of action are incompletely defined.

13 e dose for synergistic targeting to multiple sites of action.

14 transport the hydrophilic molecules to their sites of action.

15 Rab-E co-localises with myosin XI at sites of active exocytosis, and at the growing tip both

16 Wetlands are common sites of active Hg methylation by anaerobic microbes; ho

17 ng RNA polymerase II (Pol II) materialize at sites of active transcription.

18 e and which do not necessarily coincide with sites of active translation.

19 n them showing moderate reflectivity) at the site of activity.

20 effects of varying the infection route, the site of adjuvant formulation administration, and standar

21 to changes in tissues other than the primary sites of alcohol absorption and metabolism.

22 hat AML1-ETO and RUNX1 co-occupy the binding sites of AML1-ETO-activated genes.

23 chemical tracer monitoring experiment at the site of an underground nuclear test that occurred in a t

24 es the protein to transport CQ away from its site of antimalarial action.

25 g site of lidocaine and the external binding site of aryl sulfonamides may have synergistic actions.

26 in the transport of enveloped virus from its site of assembly to the extracellular environment.IMPORT

27 The Rab33B binding site of Atg16L1 comprises 20 residues and immediately pr

28 n on local dynamics of fluorophores at their sites of attachment on LIV-BPSS and the correlations bet

29 Our findings localize the sites of attenuation when successfully ignoring a distra

30 he hair bundle of cochlear hair cells is the site of auditory mechanoelectrical transduction.

31 A major site of BA action is the terminal ileum, where enterocyt

32 nge to identify the specific targets/binding sites of BACE1.

33 cture of PAICS with CAIR bound in the active sites of both domains and SAICAR bound in one of the SAI

34 Lungs are one of the main sites of breast cancer metastasis.

35 ray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 an

36 tic seafloor is biophysically unique and the site of carbon sequestration, the benthos, faces less an

37 intercellular air spaces (IAS) to the first site of carboxylation in the mesophyll cells.

38 tions, health behaviors, medication history, site of care, and urban versus rural residence.

39 This increase was realized across all sites of care (hospital outpatient department: 36.6%, P

40 f molecules on both the termini and internal sites of Cas9, creating a platform for endowing Cas9 wit

41 ray crystallographic structure resolving the site of catalysis, a protein-bound Mn(4)CaO(x) complex,

42 Determining the site of cell cleavage is crucial for cytokinesis and inv

43 s and is involved in their reorganization to sites of cell adhesion.

44 to the face, is a rich source of Oxtr and a site of cellular co-expression with PWS gene transcripts

45 hat Endosidin20 (ES20) targets the catalytic site of CESA6 in Arabidopsis (Arabidopsis thaliana).

46 The antigenic sites of ChH1A and ChH1B strains were 10-60% distant fro

47 ations in hydrophobic residues at the active site of class D SBLs (i.e. Trp(105), Val(120), and Leu(1

48 mined that ~200 Arp2/3 complexes assemble at sites of clathrin-mediated endocytosis in human cells.

49 apocarotenoid product demonstrated that the site of cleavage is defined by interactions along the su

50 How the 12 ATPase active sites of ClpA, 6 in the D1 ring and 6 in the D2 ring, wo

51 ed serine phosphorylation that occurs at the site of communication between the nucleotide-binding and

52 eural stem cells/progenitors into the lesion site of completely transected rat spinal cord.

53 l in the "southern" sector both seemed to be sites of concern, thus making it plausible that a panel

54 The location/site of conjugation of payload-linker can have an effect

55 responses during infection and as such is a site of considerable modulation by the infecting virus.

56 Moreover, the site of contact and the point of contact around the trig

57 Consideration of the sites of control tissue and comparison of the Transwell

58 asma gondii, the apical complex is a central site of convergence for calcium-related and lipid-mediat

59 e II (Pol II) core promoter is the strategic site of convergence of the signals that lead to the init

60 can be profiled to determine potency and the site of crosslinking, and subsequently developed as repo

61 ly partially dependent on the glycan-binding site of CRT, which is generally relevant to substrate re

62 restrict any substrate access to the active site of CYP2J2.

63 lised to the endoplasmic reticulum, cellular sites of cytokinin perception and importance of spatiall

64 activating MVCs bind adjacent to the active site of Ddl from Thermus thermophilus and used a combine

65 RA1 provides a mechanism that stabilizes the sites of deposition of both cellulose and matrix polysac

66 spanning the last ~80 thousand years, at the site of Dhaba in the Middle Son River Valley of Central

67 Monocytes are rapidly recruited to sites of diabetic complications and differentiate into m

68 ntrating the immunomodulatory payload at the site of disease.

69 al and clinical features of cases, including sites of disease, diagnosis, management, and outcomes, a

70 65.2% had 1 site of distant metastasis, and 42.9% had bone-only meta

71 Bone represents one of the most common sites of distant metastases, and spinal bone metastasis

72 R-155 and enhance NF-kappaB at disease-prone sites of disturbed flow in vivo.

73 and transcriptomic analyses to characterize sites of DNA methylation that influence genital developm

74 e recruitment of the repair protein RAD51 to sites of double-strand breaks (DSBs) or the abundance of

75 are found to create the transcription start sites of downstream genes in mouse, including 117 protei

76 determinant of clinical pharmacokinetics and site of drug-drug interactions.

77 2.1- angstrom structure and the drug-binding site of E's transmembrane domain (ETM), determined using

78 ng approaches, we identify the direct target sites of E2A-PBX1 in t(1,19)-positive pre-B ALL cells an

79 ed from healthy (n = 5) and diseased (n = 5) sites of each patient.

80 n these tissues, indicating they are primary sites of EBOV infection.

81 , are enriched at the cell surface including sites of endocytosis.

82 together, our data indicate that the binding site of EphA2 on EBV gH/gL is at least in part proximal

83 Sites of equal area but different shape lead to equal oc

84 To address this, we targeted the regulatory site of ERAP1 using a high-throughput screen and discove

85 The embryonic liver is the main site of erythropoietin synthesis, after which the kidney

86 hnRNPA2B1 carries its cargo, at most, to the site of exosome assembly, but it is not itself incorpora

87 tion, ambient temperature, and institutional site of experimentation.

88 between C(2) H(2) molecules and the binding sites of FeNi-M'MOF.

89 NMR)-based studies revealed that the binding site of FHL1 in CHIKV nsP3 HVD overlaps that of another

90 e external environment and as such are major sites of foreign Ag encounter.

91 er, little is known about the nature and the site of formation and storage of this new extinction mem

92 ular medium of CADASIL brains, we mapped the site of fragmentation to the NOTCH3 N terminus at the pe

93 Sites of GA biosynthesis in the roots of 7-d-old Arabido

94 tion of the N terminus of beta-ENaC, and two sites of gamma-ENaC adjacent to the plasma membrane, sug

95 amics for both an alpha-helix and beta-sheet site of GB1, the immunoglobulin binding domain of protei

96 reference genome and aligned reads covering sites of genetic variation as numeric tensors allows us

97 to 378 glycoproteins and 604 unique protein sites of glycosylation.

98 The site of Gruta da Aroeira (Torres Novas, Portugal), with

99 Interestingly, sites of >45 degrees C were inhabited by phylogenetic re

100 competing the histone deacetylase, Clr3 from sites of heterochromatin formation.

101 ion requires microtubules and coincides with sites of high laminin concentration.

102 umulation following immunoprophylaxis at the sites of HIV exposure.

103 In this study, we have explored binding sites of host proteins, which are specific partners of n

104 eraction on the C terminus overlaps with the sites of human pathogenic mutations and toxic antibody d

105 rst, we rapidly and accurately predict major sites of hydrogen abstraction in the metabolism of drug-

106 )-Asn(149) fragment can be considered as the site of IgE recognition of Rhi o 2.

107 n in vitiligo and are hypothesized to be the site of immune attack in AA.

108 is, correlated to an anatomic failure at the site of implantation in an advanced disease.

109 ally, injection of synthetic hepcidin at the site of infection can limit or completely prevent system

110 suggesting that either the chronicity or the site of infection selects for the generation of high-avi

111 he portal of HIV-1 entry and which remains a site of infection throughout the disease.

112 frequently recur when the skin is a primary site of infection, especially in infants and children.

113 Although the oropharynx is the primary site of infection, GAS can colonize the female genital t

114 ops and remains in peripheral tissues at the site of infection, providing future host resistance upon

115 constraints on epitope display at individual sites of infection with MCMV.

116 nism by which cells counter viruses at local sites of infection, thus preventing wider spread and dis

117 tion promotes the migration of phagocytes to sites of infection.

118 crophages and neutrophils recruitment to the site of inflammation.

119 recruitment of specific monocyte subsets to sites of inflammation, and how further understanding in

120 ich is expressed on activated macrophages at sites of inflammation.

121 raffic from the circulation to extravascular sites of inflammation.

122 suggest that the renal proximal tubule is a site of injury in diabetic nephropathy (DN), and progres

123 stroke reflect both structural damage at the site of injury, and widespread network dysfunction cause

124 As cells that show prolonged recruitment to sites of injury or pathology, myeloid cells represent th

125 ly to activated microglia/macrophages at the sites of injury, and suppress the detrimental effects of

126 fide-HMGB1 that increased postreperfusion at sites of injury, paralleling increased histone acetyltra

127 Moreover, the integration sites of intact proviral sequences from elite controller

128 To explore the potential sites of interaction of PAX with the BK channel, we unde

129 metallic [2Fe](H)-subcluster assigned as the site of interconversion between protons and molecular hy

130 th either A33 or A34 for localization to the site of intracellular envelopment and incorporation into

131 a juxtanuclear region that is presumably the site of intracellular envelopment.

132 al infection of bone, one of the most common sites of invasive S. aureus infection and a unique envir

133 e elements belonging to a single atom at the site of isotopic substitution, reveals a remarkable resu

134 act proteins to show that the lysine-binding site of K2(hPg) is a major determinant of the activation

135 ecule inhibitor targeting the lysine-binding site of KIV-10 can combat the pathophysiological effects

136 nstrate that fSHAPE patterns predict binding sites of known RBPs, such as iron response elements in b

137 L1, an autophagy mediator that specifies the site of LC3 lipidation, includes a C-terminal domain for

138 ted the medial prefrontal cortex (mPFC) is a site of learning-induced plasticity and signaling of the

139 proposed model, the N-terminal actin-binding site of leiomodin can act as a "swinging gate" allowing

140 rammed disintegration of axons distal to the site of lesion.

141 f agents targeted to the pore-region binding site of lidocaine and the external binding site of aryl

142 The transcription start sites of lncRNA gene loci tend to be close to their near

143 nesis to identify K(100) and K(188) as major sites of lysine acetylation in the NAT1 protein.

144 promyelocytic leukemia protein (PML) bodies, sites of many nuclear processes including protein qualit

145 cterize the transcriptional host response at sites of MARV replication relevant to primate pathogenes

146 alcium thickness was 0.96 +/- 0.25 mm at the site of maximum calcification.

147 , our data suggested ANT1 as the most likely site of mediating increased mitochondrial proton permeab

148 Besides oxidation at certain sites of Met, His, and Tyr, conversion of histidine to a

149 bonding, Bronsted acid/base) near the active site of metal-containing catalysts is an effective way t

150 survival in circulation, and angiogenesis at sites of metastases.

151 eceptor inactive state, the putative binding site of Mg(2+) on the MOP receptor, as well as the molec

152 tions shed light on 1) the preferred binding sites of Mg(2+) on the MOP receptor, 2) details of the c

153 s the CLIP-170 remnants, which are potential sites of microtubule rescue, display a shorter lifetime

154 e have identified a highly conserved binding site of miR-124 in the 3'-untranslated region (3'UTR) of

155 e Selection) that can screen putative target sites of miRNA-target binding.

156 sity, Coupa allowed us to precisely localize sites of mitochondria-lysosome contact and reveal increa

157 er (ET) from the Fe-protein to the catalytic site of MoFe-protein and how energy from ATP hydrolysis

158 to tune the O(2) affinity at the open metal sites of MOFs for applications involving the strong and/

159 tion of which is suppressed in the catalytic site of most DNA polymerases.

160 sites for current smokers were interproximal sites of most posterior teeth.

161 ex polity in Florida, and the archaeological site of Mound Key was their capital.

162 position 8 (P8) of the proteolytic cleavage site of MuV F, because this amino acid residue shows a s

163 all Dictyostelium myosin 1s and that the BH sites of Myo1A, B, C, D, and F are in conserved position

164 ynamics of the quinone binding pocket to the site of NADH reduction.

165 ate of ligand binding to the primary binding site of neuraminidase due to the presence of glycans.

166 Ns and at the marginal zones of the VNO: the site of neurogenesis.

167 eventing efficient migration of microglia to sites of neuronal damage.

168 venules of the inflamed cremaster muscle at sites of neutrophil extravasation, as visualized by fluo

169 L-37 and HNP 1-3 when compared with diseased sites of non-smokers.

170 at the Fringe enzymes modified more O-fucose sites of NOTCH2 compared with NOTCH1.

171 d bioactive molecules of tea onto the active site of Nsp15.

172 when targeting the peptide substrate binding site of NTMT1/2.

173 occupy both substrate- and cofactor-binding sites of NTMT1, but the bisubstrate analogue with a 5-C

174 EBOV) inclusion bodies (IBs) are cytoplasmic sites of nucleocapsid formation and RNA replication, hou

175 r electronic substrate bias to influence the site of nucleophilic attack.

176 an be amplified over vast distances from the sites of nutrient addition.

177 a native directing motif, which directs the site of O-arylation at a proximal tyrosine (Tyr) residue

178 contained tingible body macrophages and were sites of ongoing cell division.

179 n-interacting protein and accumulates at the site of ookinete invasion.

180 lacking HELLS, DSBs are retargeted to other sites of open chromatin, leading to germ cell death and

181 ides a mechanism to temporally differentiate sites of organ initiation and exemplifies how spatio-tem

182 d clinical procedure with 2 induced VTs, the site of origin localization system achieved accuracy wit

183 The automated site of origin localization system consists of 3 steps:

184 hey encounter during the transition from the site of origin to a distinctly different distant organ i

185 in cortical areas closer to their respective sites of origin in the medial or caudal GE.

186 al screening, malignancy was detected at the site of original concern in 12 women at a further round

187 Saliency maps identified sites of osteophyte formation as influential to predicti

188 mentum than in normal omentum, the preferred site of ovarian cancer metastasis.

189 recipitation analyses revealed that the Y128 site of P protein is critical for its interaction with I

190 rm) are poised for immediate reactivation at sites of pathogen entry and provide optimal protection o

191 ked to volitional movements and is a primary site of pathology in movement disorders.

192 Nearer to the site of pathology, cerebrospinal fluid from patients wit

193 triatal dopamine that extend well beyond its sites of peak release, and that result in enhanced activ

194 the quinazolinones to bind to the allosteric site of penicillin-binding protein (PBP)2a, resulting in

195 Here, we identified phosphorylation sites of PER-bound TIM by mass spectrometry, given the i

196 xperience BCP after RARP and to evaluate the sites of persistent disease on PSMA PET/CT.

197 pregnenolone sulfate (PES), but the binding site of PES on the NMDAR and the molecular mechanism of

198 e canonical conserved 3' UTR miR-290-binding site of Pfn2 or overexpression of the Pfn2 open reading

199 ontrols (n = 364) were analysed across three sites of PHENOM (Psychosis Heterogeneity Evaluated via D

200 ected mutagenesis to test multiple potential sites of phosphorylation, we show that Ala substitutions

201 hin the adenosine triphosphate (ATP) binding site of PI3Kgamma.

202 on prior to the sequence entering the active site of Pol I both in vivo and in vitro.

203 P1a that promotes its stable accumulation at sites of polar growth.

204 dependent transport of secretory vesicles to sites of polarized growth.

205 d "nodes" of TP activity around the division site of predivisional cells.

206 er the transcriptional start and termination sites of primary transcripts from genomic run-on data.

207 leophilic substitution reactions on tyrosine sites of proteins.

208 ia-reperfusion injury at these sites and new sites of proximal tubule injury.

209 that reinforces oxidation-prone, bis-allylic sites of PUFAs is a novel, nonantioxidant treatment moda

210 upport a model in which the relative binding sites of Rad54 and Rdh54 help to define their functions

211 with high affinity with the effector-binding site of Ras in an active conformation.

212 were sent to referring physicians recording site of recurrence and intended (Q1 to Q2 change) and im

213 that pelvic lymph nodes were the most common site of recurrence, and 28% of patients had (11)C-cholin

214 ess the levels of relatedness at aggregation sites of reef manta rays (Mobula alfredi) in southern Mo

215 We suggest that the deep Pacific is a site of respired carbon storage associated with periods

216 The active sites of RFC are fully bound to adenosine 5'-triphosphat

217 fundamentally important biological role as a site of ribonucleoprotein particle assembly, primarily d

218 Nucleoli, the sites of ribosome biogenesis and the largest structures

219 interaction of CO(2) and O(2) at the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase.

220 TANCE Inclusion bodies (IBs) are cytoplasmic sites of RNA synthesis for a variety of negative-sense R

221 splicing QTLs and are enriched with binding sites of RNA-binding proteins, RNA structure-changing va

222 ibonucleoside monophosphates (rNMPs) in DNA, sites of rNMP incorporation remain poorly characterized.

223 oaeng and the tenth century AD at the nearby site of Sehonghong.

224 logues bind to the central substrate-binding site of SERT, stabilize the outward-open conformation, a

225 lated nuclei we determined the cross-linking sites of several factors including chromatin-modifying e

226 tion at the coordinatively unsaturated metal sites of several MOF families.

227 It is also a major site of sex steroid hormone action.

228 Skeletal muscle is a key site of shivering and non-shivering thermogenesis, but t

229 isolating viable human cells present at the site of skin wounds.

230 Diseased sites of smokers presented significantly lower levels of

231 stasis is a major determinant of the tubular site of sodium retention in nephrotic mice.

232 enitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI) and generate neuronal

233 ation prior to incorporation into the active site of spliceosomes.

234 We show that the binding site of SrmB is unperturbed by SrmB deletion, but the pe

235 The morphogen SpmX defines the site of stalk PG synthesis, but SpmX is a PG hydrolase.

236 nnectivity and excitability changes from the site of stimulation, such that after active treatment, t

237 f photoreceptor membrane proteins from their site of synthesis in the inner segment (IS) to the outer

238 s is the inefficient removal of HFA from the site of synthesis on phosphatidylcholine (PC).

239 t and is believed to chaperone Q(6) from its site of synthesis to the respiratory complexes.

240 ultiple tissues, with the endodermis a major site of synthesis.

241 oral cortical irregularity at the attachment sites of tendons was a frequent incidental finding on kn

242 The most common site of termination was at the mesial of the second mola

243 pproaches, we have characterized the binding site of the cellular FHL1 protein in CHIKV HVD and defin

244 nsport the suspended cells toward a hot-spot site of the chip, for rapid concentrating and patterning

245 ree of tetramer stabilization depends on the site of the covalent tether and the nature of the protei

246 han 10-fold depending on temperature and the site of the engineered methionine.

247 3.9 angstrom resolution revealed the active site of the enzyme.

248 Binding to the decoding site of the eukaryotic ribosomes appears to result in ot

249 at indole docks perfectly to the ATP binding site of the GyrB subunit.

250 tions were located near the receptor binding site of the HA protein, as they are in the HA protein of

251 The conjugation site of the linker-drug on the antibody was found to aff

252 y to dioxygen units in the open coordination site of the Mn center.

253 In the Niger site of the MORDOR trial, we enrolled 30 villages in a c

254 person, each obtained from the mesio-lingual site of the most posterior tooth in each quadrant, were

255 The active site of the nitrogenase MoFe protein corresponds to a [M

256 Docking was used to explore the active site of the out conformation.

257 e or the other, such as the carboxy-terminal site of the peptide and specific co-deposited proteins.

258 hich aspartate residues in the metal-binding site of the polymerase domain were replaced by alanine i

259 protease interaction surface, and the active site of the protease domain.

260 It is unknown from which anatomical site of the respiratory tract influenza A virus transmis

261 to occupy the peptidyl transferase center P-site of the ribosome.

262 the presence of ATP and GMP at the canonical sites of the Bateman domains, the latter in a so far unk

263 cation, immunity and infectivity in specific sites of the body.

264 The study was performed at 12 sites of the clinical and scientific network of German m

265 cific individual glycans on the modification sites of the ectodomain and subunit proteins.

266 that budding yeast Ty3/Gypsy co-opts binding sites of the essential meiotic transcription factor Ndt8

267 ity, recognize five conformational antigenic sites of the genotype 1 HEV p239 antigen, and cross-reac

268 Specifically, the Fe sites of the mixed-valent moiety do not have identical M

269 s of the same make and model at all clinical sites of the OHTS.

270 e and appetitive learning in distinct neural sites of the olfactory circuit.

271 act in a one-to-one fashion with the binding sites of the other polymer.

272 an integer multiple of the number of binding sites of the other.

273 when these pairs are present in the A- and P-sites of the ribosome independent of other factors known

274 e-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris).

275 rstanding of the distinctive Bronsted acidic sites of these materials.

276 receptor color signals and suggest that the site of this compensation is in early visual cortex.

277 (i.e. ischemia) recruits neutrophils to the site of tissue damage and thereby results in a positive

278 t remains unclear how GM-CSF is regulated at sites of tissue inflammation.

279 We compared binding sites of TRAMP components with multiple nuclear RNA bind

280 assembly as Pol II moves away from the start site of transcription and transitions into elongation.

281 at promoter sequence changes upstream of the site of transcription initiation similarly affect both t

282 As to help maintain heterochromatin at their sites of transcription; however, as not all heterochroma

283 analysis, we evaluated the potential binding sites of TTP to 3'-untranslated regions (3'-UTR) of NOX2

284 tive metabolite that binds to the colchicine site of tubulin to induce mitotic arrest through a micro

285 (7A-aminonoscapine) binds to the colchicine site of tubulin.

286 ode metastases that occur frequently provide sites of tumor cell spread, whereas tumor antigen transf

287 For GPLs containing sites of unsaturation in both acyl chains, an MS(3) meth

288 hy workflow and used to evaluate profiles of sites of unsaturation of lipids in Escherichia coli (E.

289 es, leaving even terminal alkynes (and other sites of unsaturation) untouched.

290 eparation of malonyl-CoA production from its site of utilization facilitates somatic control of germl

291 joins growing evidence from other Gravettian sites of variable treatment of individuals after death,

292 cantly influences platelet plug formation at sites of vascular injury (primary hemostasis).

293 infection via breastfeeding to identify key sites of viral persistence under antiretroviral therapy

294 ly in response to tumors, which are the only sites of viral replication, whereas tumored and nontumor

295 cance of throat and salivary glands as major sites of virus replication and transmission during early

296 g of stem-directed antibody responses to the site of vulnerability by glycan repositioning may be a s

297 The studies reveal diverse sites of vulnerability on RBP recognized by potent human

298 This work defines sites of vulnerability on SARS-CoV-2 S and demonstrates

299 e genomic analyses to identify the conserved sites of WDR5 binding to chromatin, and the conserved ge

300 iency of the method by mapping metal-binding sites of Zn(7-x)MT species using a bottom-up MS approach