ライフサイエンスコーパス: site of action

1 ects on cell movement required a cytoplasmic site of action.

2 n and mechanical allodynia via only a spinal site of action.

3 ects on root meristem size, depending on its site of action.

4 aired-pulse stimuli indicated a postsynaptic site of action.

5 r RyR2 inhibition, both having a cytoplasmic site of action.

6 ith enhanced delivery of these agents to the site of action.

7 multiple copies of regulatory proteins to a site of action.

8 or concentrating toxic chemotherapies at the site of action.

9 ec61alpha, thus revealing cotransin's likely site of action.

10 of the local exposure to unbound drug at the site of action.

11 fect by prolonging its residence time at the site of action.

12 order to enhance therapeutic efficacy at the site of action.

13 y release drugs that may then diffuse to the site of action.

14 ontrol system and route to their physiologic site of action.

15 eously absorbed across the gut wall to their site of action.

16 particles can be targeted to their requisite site of action.

17 or 2 (BDM14471) revealed that it reaches its site of action.

18 g an effective release of doxorubicin at the site of action.

19 rticomuscular coherence partly via a central site of action.

20 h the cell envelope to reach their cytotoxic site of action.

21 reduced drug bioavailability at the desired site of action.

22 abilized at 3'-DNA ends corresponding to its site of action.

23 plitude and kinetics indicates a presynaptic site of action.

24 ential for telomerase to be recruited to its site of action.

25 e of tetrodotoxin, suggesting a postsynaptic site of action.

26 ial translation as a previously unrecognized site of action.

27 th the carrier protein and duplex DNA at the site of action.

28 to target a dominant negative protein to its site of action.

29 ng therapeutics that target the specific CNS site of action.

30 indicates that norBNI did not persist at the site of action.

31 intravenously), which indicates a peripheral site of action.

32 d pulse ratio, consistent with a presynaptic site of action.

33 converted back to curcumin on demand at the site of action.

34 ed antihyperalgesia indicating a supraspinal site of action.

35 agonist binding domain, suggesting a unique site of action.

36 other pains, and a predominantly peripheral site of action.

37 nkage to the drug's clinical endpoint and/or site of action.

38 itination state, suggesting a post-endocytic site of action.

39 transport the hydrophilic molecules to their sites of action.

40 f partner proteins, recruiting them to their sites of action.

41 eable molecules to reach their intracellular sites of action.

42 highly conserved catalytic subunits to their sites of action.

43 distinction required for excluding redundant sites of action.

44 mensional chromosome contacts to move to its sites of action.

45 ecruit proteins to or away from their normal sites of action.

46 lp to recruit heterologous proteins to their sites of action.

47 tential to introduce mutations at off-target sites of action.

48 ther by allosteric effects or via additional sites of action.

49 eostasis involve both central and peripheral sites of action.

50 pathways recruit ESCRT-III proteins to their sites of action.

51 nti-dyspnea drug development with peripheral sites of action.

52 y target ER or AR; others have still unknown sites of action.

53 options to treat or modulate pain at various sites of action.

54 ies that neutrophils use to find their local sites of action.

55 us, vagus and brainstem regions as potential sites of action.

56 e dose for synergistic targeting to multiple sites of action.

57 d therefore offer both multiple and variable sites of action.

58 lower toxicity by concentrating drugs at the site-of-action, a method embodied by the seven current F

59 sary for the spreading of the complex to its sites of action along the X chromosome.

60 hosphate, at the putative vaginal and rectal site of action and its relationship to concentrations at

61 gnals during invasion, we have used genetic, site of action and live-cell imaging studies to examine

62 by inhalation are delivered directly to the site of action and may improve the therapeutic index req

63 he concentration of administered drug at the site of action and provides information concerning the e

64 In this study, we investigated the site of action and sleep-promoting mechanisms of glycine

65 t enrich a therapeutic agent at a particular site of action and those that link a therapeutic target

66 However, the brain site of action and underlying cellular mechanisms remain

67 herbicides of different chemical groups and sites of action and can extend to new herbicide(s).

68 noparticles can preferentially accumulate at sites of action and hold great promise to improve the th

69 l hypersensitivity via peripheral and spinal sites of action and mechanical allodynia via only a spin

70 However, their sites of action and their hierarchical relationships are

71 shield, target the F protein directly at its site of action, and expand the potential utility of inhi

72 n normal human male subjects the importance, site of action, and receptor-mediated processes involved

73 al to prevent the toxins from reaching their site of action, and thus avoid the ensuing diarrhoea.

74 through the sharing of signalling pathways, sites of action, and evolutionary history.

75 concentrations and targeted delivery to the site of action appear possible, and most importantly, re

76 As the main CGRP-mAb site of action appears to be situated outside the brain,

77 the auditory and vestibular systems and its site of action are not well understood.

78 cytokines, or radiolabels to their intended site of action are required for these applications.

79 n channel, but the underlying mechanisms and site of action are unknown.

80 It is currently unknown where the potential sites of action are in the neonate for these robust leve

81 diabetes; however, the mechanisms and tissue sites of action are incompletely defined.

82 in colon cancer, but their relevant cellular sites of action are obscure.

83 that coordinate their expression at neuronal sites of action are poorly characterized.

84 They are transported to their site of action as blood-borne endocrine hormones but can

85 These results establish latonduines novel site of action as well as its proteostatic mechanism of

86 CXCL10 is unable to localize to its presumed site of action at the bacterial cell membrane, suggestin

87 degrade BST-2 and/or direct it away from its site of action at the cell surface.

88 iary space of the eye adjacent to the drug's site of action at the ciliary body.

89 ich TET1 protein may be targeted to specific sites of action at enhancers by direct interaction with

90 ionships between their site-of-synthesis and site-of-action ("autonomy" versus "non-autonomy") remain

91 to deliver an adequate dose to intracellular sites of action because they cannot traverse other biolo

92 st of many ligand-gated ion channels, with a site of action believed to be within the ion-conducting

93 functions have been ascribed to postsynaptic sites of action, but there is now an appreciation that p

94 holerae genomes, identifying an antibiotic's site of action by identifying sequence differences betwe

95 This study aimed to identify the site of action by which extracellular protons regulate t

96 e that these complexes are directed to their sites of action by long non-protein-coding RNAs (lncRNAs

97 Further, we propose these two sites of action comprise the likely mechanism underlying

98 nce for the cooperative contributions of two sites of action (decidua and ovary) toward preterm birth

99 /reoxygenation) demonstrated a mitochondrial site of action (decreased MitoSOX fluorescence), where t

100 channel opening, which is consistent with a site of action distal to the ATP-binding pocket.

101 t2 activity supports axon survival through a site of action distinct from Nmnat2 transport vesicles a

102 and the raphe nuclei, a postulated brainstem site of action during migraine, suggesting that dihydroe

103 c rescues, determining DAF-6/patched-related site of action during sensory-organ development.

104 sDNA and recruits multiple proteins to their sites of action during genomic maintenance.

105 ion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.

106 r its dynamic assembly or disassembly at the site of action exert a critical impact on damage bypass,

107 tility in transcriptional reporter analysis, site-of-action experiments and exogenous transgene expre

108 he barriers and challenges on the way to the site of action following various dosing modes.

109 Our work explains the site of action for a series of P2X7R antagonists and est

110 5-HT) signals in the nervous system and is a site of action for a variety of psychoactive drugs inclu

111 ling as a previously unrecognized pathogenic site of action for Abeta.

112 is shown by multiple studies to be a likely site of action for allosteric modulators, one of which i

113 levels within the synaptic cleft and are the site of action for amphetamine (AMPH) and cocaine.

114 m of fast axonal transport of Nmnat2 and its site of action for axon maintenance.

115 Such a dual site of action for beta-arrestins helps explain the plei

116 he dopamine transporter (DAT) is the primary site of action for cocaine, and the dopamine system is k

117 nd bipolar disorders, and DAT is a prominent site of action for drugs such as amphetamines and cocain

118 al play, and identify the BLA as a prominent site of action for endocannabinoids to modulate the rewa

119 Escape mutations were used to map the site of action for FIP.

120 These new findings define the lysosome as a site of action for FLCN and indicate a critical role for

121 er, these data establish the lPBN as a novel site of action for GLP-1R-mediated control of food intak

122 suggest that the spinal cord is an important site of action for H(3) antagonism and the effect can be

123 in which the plasma membrane is an important site of action for Mats tumor suppressor to control tiss

124 Furthermore, this could be a site of action for mGlu2 PAMs to modulate cognitive proc

125 surface of the subunit interface at a likely site of action for modulatory proteins.

126 primary pathogenic mechanism and subcellular site of action for mutant Htt are still unclear.

127 n the rodent spinal dorsal horn, a principal site of action for opiate analgesia.

128 ons, indicating that the VTA is an important site of action for orexin's role in reward processing.

129 racellular cysteine-rich domain (CRD) as the site of action for oxysterols on Smo, involving residues

130 cholinergic interneurons (CINs) as a primary site of action for p11 in the NAC.

131 These results suggest a novel site of action for potentiation of NMDA receptors by sma

132 s efficacy in cancer therapy, mechanisms and site of action for progesterone remain unknown.

133 he dopamine transporter (DAT) is the primary site of action for psychostimulant drugs such as cocaine

134 e expression of diffuse anxiety and is a key site of action for the anxiogenic neuromodulator, cortic

135 has previously been found to be an important site of action for the dysphoric effects of dynorphin-ka

136 Studies seeking a dominant site of action for the hormone leptin have focused on le

137 sulin resistance, pointing to a hypothalamic site of action for the metabolic dysregulation of atypic

138 within the RVM offer an additional potential site of action for the modulation of visceral pain by tr

139 y reveals that inhibition of PHOX is a novel site of action for the mu-opioid receptor-independent ef

140 We have also determined the site of action for the P2X7R-selective antagonists ZINC5

141 that the bacterial membrane was the primary site of action for these agents.

142 en C9orf72 and SMCR8 and support a lysosomal site of action for this protein complex.

143 ransferase (CT) domain of this enzyme is the site of action for three different classes of herbicides

144 thermore, these studies demonstrate that the site of action for TRPV1 blockade elicited hyperthermia

145 targeted the mesolimbic dopamine system, the site of action for virtually all abused substances.

146 se models, we identify mitochondria as a key site of action for Wld(S) neuroprotective function.

147 action on muscle promotes atrophy, nonmuscle sites of action for inflammatory mediators are less well

148 nicotinic acetylcholine receptors as common sites of action for nicotine and alcohol.

149 inted interactions with multiple established sites of action for other known drugs of abuse including

150 These findings disclose new sites of action for statins against Abeta-induced neuron

151 s in NAD synthesis and suggest that critical sites of action for supplemental NAD precursors reside o

152 tion and identify these domains as potential sites of action for the targeted development of KAR-spec

153 he RPCs, it appears that these cells are the sites of action for this entire enzymatic pathway in Dro

154 one secretagogue receptors (GHS-R), the only sites of action for this gastric hormone identified to d

155 to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resis

156 food intake and body weight, but few central sites of action have been identified for its effect on e

157 erapies, as delivering siRNA directly to its site of action helps to ensure that a sufficient dose re

158 acilitate access of alphaTAT1 to its luminal site of action if microtubules undergo lateral opening b

159 nervous system, in part attributable to its site of action in blocking the function of monoamine reu

160 ovides for high concentrations at the target site of action in patients with pulmonary infections.

161 ansport short interfering RNA (siRNA) to the site of action in the cells of target tissues.

162 first definitive evidence that the PFC is a site of action in the cognition-enhancing and presumably

163 e therapeutic concentration of a drug at the site of action in the eye.

164 t that targets their delivery to the primary site of action in the liver.

165 nic acid (AA) was conducted to determine the site of action in the PGD2 synthetic pathway.

166 l nucleus of the amygdala (CeA) as potential sites of action in mediating the side effects of cisplat

167 efficient access of these molecules to their sites of action in the cytosol or nucleus.

168 tions with plant cells, to accumulate at its sites of action in the host nucleus.

169 of data regarding its temporal dynamics and sites of action in the living human brain.

170 m from the photoreceptor, but their relative sites of action in the transduction pathway are unknown.

171 lerance, but their functional mechanisms and sites of action in vivo are poorly defined.

172 spite the widespread use of these drugs, the sites of action involved in their cognition-enhancing an

173 ric oxide (NO) dependent, although the exact site of action is controversial.

174 However, a peripheral site of action is indicated by the ability of intravenou

175 The site of action is located at the extracellular vestibule

176 e receptor (RyR2); however, an extracellular site of action is suggested because of the hydrophilic n

177 plasma supports the notion that the primary site of action is the gut itself.

178 form interacting SNARE proteins reach their sites of action is virtually unknown.

179 hetic input to the heart, suggesting a novel site of action leading to Kv1.1-associated cardiac brady

180 ribution of the compounds at the therapeutic site of action (liver) relative to the periphery.

181 We developed and evaluated a site-of-action mechanistic PK model using nonlinear mixe

182 food intake and reward, was identified as a site-of-action mediating the anorectic effects of amylin

183 To elucidate the sites of action mediating this effect, we initially foun

184 tes synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs.

185 and suggest the vasculature as the potential site of action of Adamts16 to lower BP.

186 lation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represent

187 imple protocol is described for locating the site of action of an antioxidant (AO) in a micro-heterog

188 In addition, it is the site of action of antidepressants (which block the trans

189 A major site of action of apolipoprotein mimetic peptides was fo

190 Understanding the mechanism and site of action of BigDyn on ASICs could thus enable the

191 hromatin immunoprecipitation to identify the site of action of CPIC.

192 The critical site of action of DRs is completely dependent on the nat

193 ify Adelta meningeal nociceptors as a likely site of action of fremanezumab in the prevention of head

194 To elucidate the site of action of GSK3beta in regulating DA- or lithium-

195 sphorylation in living cells and hence a key site of action of inhibitors targeting mTOR phosphorylat

196 tors (with S961) in the arcuate nucleus, the site of action of insulin, did not decrease LSNA in preg

197 The site of action of JA in the context of reproductive deve

198 e glycine site or which occurs distal to the site of action of kynurenic acid.

199 action with the 5-HT(2A) receptor, a primary site of action of lysergic acid diethylamine (LSD), appe

200 e to multiple receptor subtypes that are the site of action of many clinically important drugs.

201 and has been used extensively to examine the site of action of many gastrointestinal (GI) neuropeptid

202 Voltage-gated potassium channels are the site of action of many therapeutic drugs.

203 s are known to modulate nociception, but the site of action of MC4R signaling on nociception remains

204 ough the activation of opioid receptors, the site of action of morphine and related analogues, there

205 effects of NO on M-channels and identified a site of action of NO to be the redox modulatory site at

206 an distal convoluted tubule (DCT) and is the site of action of one of the most effective classes of a

207 Mu-opioid receptors (MORs) are the primary site of action of opioid drugs, both licit and illicit.

208 y intracellular GTP have been invoked as the site of action of peripheral inflammatory mediators that

209 after ICV injection of PK2, the hypothalamic site of action of PK2, and interaction between PK2 and o

210 onin 2A (5-HT2A) receptor densities (the key site of action of psychedelic drugs [4]).

211 results unveil what we believe to be a novel site of action of resistin on GP and inflammation and su

212 m for the gating of the Kv7.3 PM and for the site of action of RTG as a Kv7.2/Kv7.3 K(+) current acti

213 lity of expanding plant tissue, which is the site of action of thaxtomin.

214 Sensitisation is independent of the site of action of the agonist, because covalent and non-

215 nsitive K(+) (K(ATP)) channels and the exact site of action of the hormone.

216 , hypothalamic LepRb(NOS1) neurons are a key site of action of the leptin-mediated control of systemi

217 he high-affinity, slow washout, and external site of action of the MalH-lectin conjugates support the

218 RMG is the central site of action of the neuropeptide receptor gene npr-1,

219 on loss when deficient, the precise cellular site of action of the SMN protein in SMA remains unclear

220 However, the proximal tubular site of action of the sodium-glucose cotransporter-2 inh

221 Therefore, to functionally identify the site of action of the vesicle-associated membrane protei

222 metabolism and repress growth; however, the site of action of these diverse effects remains unclear.

223 In an attempt to map the site of action of these inhibitors, we generated mutant

224 Our work suggests that the principal site of action of TNF to cause this change in gastric fu

225 The N-heptad repeat (N-HR) of gp41 is the site of action of two classes of inhibitors.

226 Here we present findings on the site of action of YbcL and demonstrate a novel mode of s

227 meric approach, we were able to localize the site-of-action of NS8593 to the K(Ca)2 pore.

228 We incorporated sites of action of four drugs (palbociclib, gemcitabine,

229 tations induced by chronic opioid treatment, sites of action of MOR modulation of specific brain circ

230 ic sensory neurons that are also the primary sites of action of nerve growth factor, a powerful modul

231 The specific functions and sites of action of p24 proteins are still unknown.

232 al-specific manner and investigate the major sites of action of phytochromes during seedling developm

233 Binding studies further supported distinct sites of action of small molecules relative to that of c

234 These findings reveal the respective sites of action of systemically administered MJN110 and

235 being able to order, for the first time, the sites of action of the various reaction components: GR <

236 into host plant cells, yet the functions and sites of action of these effectors in promoting pathogen

237 to reverse this effect, suggesting that the sites of action of these pesticides are COX enzymes.

238 that has been made in defining new cellular sites of action of this receptor, the mechanisms through

239 oach and to measure target engagement at the site of action, offering the potential for dose selectio

240 m different chemical families to share their site of action on a channel accessory subunit.

241 alization of the vitamin D receptor (VDR) at sites of action on a genome-scale using ChIP sequence an

242 of additional proteins and enzymes to their sites of action on DNA.

243 dgE, can acetylate Hbsu, and their potential sites of action on HBsu were identified.

244 Depending upon their nervous system site of action, opioid receptor agonists alter food cons

245 TDF protein has no identified site of action or receptor, and its mechanism of action

246 Mash1, and Hes5 either by controlling their site of action or their activity.

247 s to their subcellular destinations, such as sites of action or degradation.

248 in pruritogen-induced scratching may involve sites of action other than the primary afferent terminal

249 Although the NEG site of action overlaps with that of tetracycline (TET),

250 in invertebrates.SIGNIFICANCE STATEMENT The site of action potential (AP) initiation in invertebrate

251 of this characteristic region and thus, the site of action potential generation are of particular im

252 dium and potassium channels that defines the site of action potential generation.

253 s, in conjunction with a distal shift in the site of action potential initiation and increased preval

254 y specialized neuronal subregion that is the site of action potential initiation and the boundary bet

255 The axon initial segment (AIS) serves as the site of action potential initiation in most neurons, but

256 The axon initial segment (AIS) is the site of action potential initiation in neurons.

257 The site of action potential initiation in sensory neurons r

258 that T-type Ca(2+) channels localized to the site of action potential initiation in the axon initial

259 re highly excitable and are likely to be the site of action potential initiation in these neurons.

260 Ns) at their axon initial segment (AIS), the site of action potential initiation, allowing them to ex

261 The AIS is not only the site of action potential initiation, but it also has a u

262 egion near the start of the axon that is the site of action potential initiation.

263 ial segments (AISs) and nodes of Ranvier are sites of action potential generation and propagation, re

264 y of axon initial segments (AISs), which are sites of action potential generation located in proximal

265 l segment (AIS) and nodes of Ranvier are the sites of action potential initiation and regeneration in

266 se between the transductive membrane and the site of action-potential generation.

267 be delivered to the pilosebaceous unit, the site of action, preferentially by the follicular route.

268 NMD, but for which the precise function and site of action remain unclear.

269 se anorexigenic effects, their mechanism and sites of action remain poorly understood.

270 y of oligonucleotides to their intracellular sites of action remains a major issue.

271 eled Lipoplex and the amount of siRNA at its site of action RISC (RNA-induced silencing complex) were

272 nsmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains

273 ng of multiplication (pre/post-zygotic), and site of action (soma vs. germen).

274 (payload) for targeted delivery to specific sites of action such as cancer cells.

275 m channels, it has a very different mode and site of action than other anticonvulsant compounds.

276 one (GnRH) neurons, suggesting an additional site of action that has not been studied at the cellular

277 e, of mEPSC events, confirming a presynaptic site of action that is independent of glutamatergic netw

278 These concentrations, evaluated at the site of action, the brain, have been correlated with ora

279 with reduced effects of cocaine at its main site of action, the dopamine transporter (DAT).

280 cient to deliver neuroactive levels to their site of action: the bee brain.

281 Pemetrexed has more than one site of action; the primary site is thymidylate synthase

282 ion of tissue distribution and access to the site of action; the second, engagement of the target; an

283 array of genome maintenance enzymes to their sites of action through direct protein interactions.

284 We address the neural sites of action through which ghrelin regulates the hypo

285 tor for rest:activity rhythms and mapped its site of action to hugin-expressing neurons in the subeso

286 assessed the tissue source of FGF21 and its site of action to regulate core body temperature in resp

287 partner proteins and recruits them to their sites of action using its four intrinsically disordered

288 d T cell function, as well as the anatomical site of action, varies extensively with the pathogen.

289 we considered that choosing a physiological site of action was a priority and focused on the locus c

290 A peripheral site of action was also suggested by studies on the extr

291 vo electrophysiology, evidence for a central site of action was provided by dose-dependent reductions

292 To identify a central site of action, we showed that systemic exendin-4 penetr

293 ponents to achieve a desired response at the site of action, which imparts nanogels the ability to pa

294 atural product demonstrated an extracellular site of action, which requires the extracellular domain

295 7 by scaffolding and concentrating it at its site of action while maintaining it in an "off" state un

296 crobial agents, having only a single mode or site of action, will not alleviate the situation because

297 eral parabrachial nucleus, thus indicating a site of action within the cutaneous cooling neural pathw

298 in the tumor and delivering the drug to its site of action within the tumor tissue.

299 e, GNA is also capable of delivering Hv1a to sites of action within the insect central nervous system

300 holipids--are proposed to have intracellular sites of action, yet a conduit for these choline phospho