ライフサイエンスコーパス: site-specific

1 ent sites but most contaminant mixtures were site-specific.

2 nsport potential of PFASs is probably highly site-specific.

3 ox C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity d

4 molecules containing reductively stabilized, site-specific 5fC-polypeptide lesions and employed a qua

5 When we compared age-specific and site-specific 95th percentiles for RR and 5th percentile

6 es: CoREST, NuRD, Sin3B, MiDAC and SMRT with site-specific acetylated nucleosome substrates.

7 Mechanistically, we show that p300-mediated site-specific acetylation increases, whereas HDAC3-media

8 <80 ms) from PFC and PAR reflect stimulation site specific activity that is largely insensitive to ch

9 after ~80 ms, suggesting early peaks reflect site-specific activity, whereas late peaks reflect activ

10 s and exhibit tissue-resident signatures and site-specific adaptations.

11 zed to evaluate the biotransformation of any site-specific ADC independent of antibody type and site

12 e critical quality attributes of these novel site-specific ADC products.

13 adly distributed positions in VcINDY using a site-specific alkylation strategy.

14 uromodulin is an individual case, these same site-specific analyses provide a way forward for develop

15 sites carrying complex N-glycans based on a site-specific analysis and a glycomic workflow of the pe

16 phosphate galactose (UDP-Gal) for global and site-specific analysis of protein O-GlcNAcylation.

17 form Fc-glycans present on IgG mAbs into two site-specific anchor points for the conjugation of any a

18 bregional and local scales, the effects were site specific and included subsets of temperature, eleva

19 g ortho-carbonylphenylboronic acids, to form site-specific and functional bioconjugates with tunable

20 The modification is also site-specific and is found mainly in two separate DNA se

21 Limitations include site-specific and longitudinal variations in clinical pr

22 we report chemical modifications that allow site-specific and multiple-site conjugation of a wide as

23 can modulate social embodied processing in a site-specific and task-specific manner.

24 -casting technique to achieve heterogeneous, site-specific, and programmed bending actuations.

25 lication of ReACT for efficient, stable, and site-specific antibody and protein bioconjugation to nat

26 vances in chemical and enzymatic methods for site-specific antibody modification that result in the g

27 ternally-applied stimuli can offer improved, site-specific antitumor effects, and can improve the eff

28 Site-specific arrest of RNA polymerases (RNAPs) is funda

29 available cyclic alcohols for the remote and site-specific arylation of ketones via the combination o

30 xample, we describe here the extent to which site-specific attachment to a chemically well-defined ma

31 proactive learning algorithms to correct for site-specific biases and increase robustness as algorith

32 This study examines how site-specific binding to three identified neurosteroid-b

33 with sTCO reagents, making them the fastest site-specific bioorthogonal labels in eukaryotic systems

34 d with enhanced peroxidase-like activity and site-specific biorecognition properties using avidin-fun

35 bility of the Cas9 endonuclease to introduce site-specific breaks in double-stranded DNA.

36 amined serum retinol and risk of overall and site-specific cancer in the Alpha-Tocopherol, Beta-Carot

37 eline serum retinol quintile and overall and site-specific cancer risk in 10,789 cases.

38 p between alcohol consumption and overall or site-specific cancer risk.

39 For site-specific cancer, only high ACR showed a significant

40 on between alcohol consumption and any other site-specific cancer.

41 rall cancer, overall nonprostate cancer, and site-specific cancer.

42 nally estimated genetic associations with 19 site-specific cancers among 367,643 individuals of Europ

43 tic variants with the risk of overall and 22 site-specific cancers for 367,703 individuals in the UK

44 nd melanoma but not associated with 16 other site-specific cancers or overall cancer.

45 For site-specific cancers, use of opium was associated with

46 tween smoking and alcohol consumption and 19 site-specific cancers.

47 arly for analyses of alcohol consumption and site-specific cancers.

48 us (T2DM) with risk of overall cancer and 22 site-specific cancers.

49 bioorthogonal probes that can be utilized in site-specific carbonylation labeling to enhance new diag

50 d compartments is presented toward efficient site-specific cargo delivery, with a back-end zinc (Zn)

51 e c.677C > T polymorphism is associated with site-specific changes in DNA methylation in humans.

52 Finally, we show protein site-specific changes in regard to the common urinary gl

53 In addition to site-specific characteristics and management, a careful

54 Site-specific characteristics influencing community resi

55 ects of plant-available soil water and other site-specific characteristics might improve the predicti

56 to be context-dependent and more related to site-specific characteristics than local or regional cli

57 S. regions from 2012-2017, in the context of site-specific characteristics.

58 aconate-alkyne (ITalk), for quantitative and site-specific chemoproteomic profiling of itaconation in

59 CD imaging performance of our instrument for site-specific chirality mapping of biological tissue sam

60 es in identifying mechanisms governing their site-specific chromatin targeting and function.

61 m 151 sites across the circumarctic area and site-specific climate data.

62 Mass spectrometry provided site-specific compositions of densely distributed high-m

63 Under the modeled site-specific conditions, waterborne U uptake accounted

64 selectivity, we applied our protocol for the site-specific conjugation of two proteins with unique cy

65 dual-modality linker (DML) that facilitates site-specific conjugation to a cysteine residue-bearing

66 natural uniquely reactive lysine residue for site-specific conjugation to beta-lactam linker-function

67 ted above the putative ion channel pore, for site-specific conjugation with a photoswitchable pore bl

68 tion and bacterial transglutaminase-mediated site-specific conjugation.

69 Our results show that site-specific covalent ligation can be used to assemble

70 d pulled from the top of the E helix using a site-specific, covalent attachment.

71 rat nucleus accumbens, and that knockout or site-specific CRISPR/Cas9 gene knockdown of Gadd45b bloc

72 We use site-specific cross-linking to engineer ClpA hexamers wi

73 rfactant performance must be evaluated using site-specific crude oil at reservoir conditions.

74 like that induced by a template carrying two site-specific cyclobutane pyrimidine dimers.

75 Inclusion of site-specific data during sparsified training led to hig

76 aTS and clinical training data, inclusion of site-specific data or sparsified training was of no cons

77 omplete and incomplete data with and without site-specific data.

78 mance of a smaller model based on public and site-specific data.Supplemental material is available fo

79 Through global and site-specific demethylation, they regulate cell fate dec

80 mpers our understanding of the mechanisms of site-specific dephosphorylation and of its tumor suppres

81 Loss of p63, but not p53, caused site-specific depletion of enhancer-associated chromatin

82 DNA polymerases offers a potential basis for site-specific detection of DNA adducts, but the availabi

83 etween locations and appear mainly driven by site-specific differences in organic carbon sources.

84 We find country and body site-specific differences in the prevalence of antimicro

85 cally visualizes the substantial periodontal site-specific differences.

86 ning in the body is delicately controlled by site-specific directional cues such as chemokines.

87 op a platform to detect easily quantifiable, site-specific, disease-associated glycan alterations for

88 tress in vitro and in vivo and regulates the site-specific distribution of atherosclerotic lesions.

89 the R351A change shows only a mild defect in site-specific DNA binding.

90 sidue previously predicted to participate in site-specific DNA binding.

91 In analyzing site-specific DNA cleavage by the mammalian RAG1-RAG2 re

92 Even individual genome site-specific DNA double-strand cuts induced by CRISPR/C

93 FOXA1 are downregulated by allelic loss and site-specific DNA hypermethylation, respectively.

94 nference testing, we identify examples where site-specific DNA methylation in turn mediates gene expr

95 nctional studies, we created light-inducible site-specific DNA recombinases based on Cre, Dre and Flp

96 ParA also has a site-specific DNA-binding activity to the par operator (

97 explain the association between smoking and site-specific DNAm.

98 Developing targeting strategies to enable site-specific drug delivery holds promise in reducing of

99 We induced a site-specific DSB with HO endonuclease at the MAT locus

100 onse to both global DSBs generated by IR and site-specific DSBs in rDNA.

101 the dHis-based labelling approach to measure site-specific dynamics using room temperature lineshape

102 m compared to never-smokers; (2) patterns of site-specific effects by age among current and never-smo

103 zation techniques were used to ascertain (1) site-specific effects of cigarette smoking on the period

104 ies on natural gas-fired power plants, using site-specific emissions and regionally defined cost para

105 ick-seq is demonstrated with genomic maps of site-specific endonuclease strand-breaks in purified DNA

106 r pathways and associated factors, inducible site-specific endonucleases have proven to be fundamenta

107 ecific mutants, we demonstrate that MHB is a site-specific environmentally sensitive probe that can p

108 es on the effect of either systemic or brain site-specific epigenetic manipulations on the reinstatem

109 NMT3A and DNMT3B provides an explanation for site-specific epigenomic alterations seen in ICF syndrom

110 Site-specific experimental and docking studies were perf

111 e amplitude of temperature change was small, site-specific factors had a greater influence on the chi

112 al indicator, and the potential influence of site-specific factors on estimating RBT values.

113 ompost as ADC be considered, especially when site-specific factors such as feedstock contamination or

114 o which these weather impacts are related to site-specific factors such as landscape position and soi

115 ramidal neurons were altered in a layer- and site-specific fashion.

116 d to construct a Cys-lite variant needed for site-specific fluorescence labeling.

117 General and efficient tools for site-specific fluorescent or bioorthogonal labeling of R

118 s study, a targeting mtDNA ultrasensitive AP site-specific fluorescent rotor (BTBM-CN(2)) was designe

119 Here, we discovered site-specific fragmentation of NOTCH3 protein in patholo

120 dulin sensitivity for calcium and reveal Tyr site-specific gain or loss of functions for calmodulin-i

121 erial challenge, revealing the importance of site-specific gene expression for robust host-microbial

122 now been approved for clinical use, and the site-specific genome modification of HSPCs using gene ed

123 recise regulation of gene expression through site-specific, genome-wide binding.

124 We performed cryo-election microscopy and site-specific glycan analysis of one of the leading subu

125 The human plasma site-specific glycan map described herein has utility in

126 analyzed by mass spectrometry to reveal the site-specific glycan modifications.

127 The adaptations allow for highly precise site-specific glycan monitoring with minimum sample prep

128 ptides, while the quantitative comparison of site-specific glycans was achieved utilizing TMT reporte

129 r, due to analytical barriers, comprehensive site-specific glycoprofiling is difficult to perform.

130 protease GluC is widely established for the site-specific glycosylation analysis of rhEPO.

131 idation at specific sites in parallel to the site-specific glycosylation analysis of rhEPO.

132 ternatives for FcgammaRIIIb, we assessed its site-specific glycosylation in a single LC-MS/MS run and

133 in LC-MS/MS methodologies, the profiling of site-specific glycosylation is one of the major analytic

134 cuss glycoproteomic analysis that yields the site-specific glycosylation of membrane proteins.

135 initive identification of single to multiple site-specific glycosylation on the same peptide backbone

136 hydrate density-dependent affinity trend and site-specific glycosylation requirements for high affini

137 Cox proportional hazards models estimated site-specific hazard ratios (HRs) with 95% CIs of DKA co

138 Site-specific homo-Forster resonance energy transfer eff

139 ore the importance of revisiting the role of site-specific hyperphosphorylation in regulating tau fun

140 Pso2 translesion nuclease activity through a site-specific ICL in vitro We noted that stimulation of

141 n during reverse transcription, allowing for site-specific identification of the modification.

142 The key element is a site-specific in vivo biotinylated nanobody of broad cro

143 that enable genetic encoding of SF(5)Phe for site-specific incorporation into proteins in high yields

144 yl tRNA synthetase (aaRS)/tRNA(CUA) pair for site-specific incorporation of 3-nitro-tyrosine could no

145 Here we report the site-specific incorporation of 4-trimethylsilyl phenylal

146 stablished a sequence-independent method for site-specific incorporation of chemical lesions into dsD

147 transcription, and/or translation enable the site-specific incorporation of novel components into DNA

148 We then demonstrate site-specific incorporation of these non-canonical, back

149 72 in recombinant human apoA-I and confirmed site-specific incorporation utilizing MS.

150 vity provided with LC-MS, yielded additional site-specific information not afforded by the convention

151 utilize the dHis-Cu(II) NTA label to obtain site-specific information on dynamics for both an alpha-

152 iC31 integrase protein to mediate efficient, site-specific integration into the genome of human cells

153 Site-specific integration of HTVC019Pvirus pelagiphages

154 Existing technologies for site-specific integration of kilobase-sized DNA sequence

155 the skt gene cluster using the Streptomyces site-specific integration vector pSET152.

156 nome packaging, and during the latent phase, site-specific integration.

157 me map revealed 796 significant (FDR < 0.05) site-specific inter-protein and intra-protein glycan ass

158 lateral membrane and T-tubules, depending on site-specific interacting proteins.

159 some possible clues and basis for tailoring site-specific intervention strategies.

160 methodological limitations have hampered the site-specific investigation of the conformational prefer

161 ucible and useful analytical method to study site-specific isomeric glycosylation.

162 Here, we apply site-specific isotopic labeling to obtain high-resolutio

163 We estimate site-specific kinetic rate constants for the restoration

164 ed by random modification of lysines or more site-specific labeling of cysteines, each with attendant

165 that can be harnessed for post-synthetic and site-specific labeling of nucleic acids has increased si

166 Site-specific labeling of proteins is often a prerequisi

167 residue is among the most facile methods for site-specific labeling of proteins.

168 stics, high-affinity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism

169 Using (19)F NMR and site-specific labelling, we investigate the response of

170 e standardized S-LCI framework resulted in a site-specific LCA that aids decision-makers on choosing

171 In summary, site-specific loading of drug to albumin at 1:1 ratio al

172 ing m(6)A methylation by METTL3 depletion or site-specific m(6)A demethylation of selected carRNAs el

173 METTL14 methyltransferase complex can direct site-specific m(6)A incorporation in distinct cellular c

174 Here, we characterize site-specific m6A modifications in the non-palindromic s

175 esistance (MDR) glioma cells while providing site-specific magnetic targeting.

176 Understanding genomic functions requires site-specific manipulation of loci via efficient protein

177 rtantly, ABHD17a deacylates BK channels in a site-specific manner because it has no effect on the S-a

178 ns in genomes, including plant genomes, in a site-specific manner has been greatly advanced through a

179 during normoglycemia elicits these CRRs in a site-specific manner.

180 s allow for facile genomic modification in a site-specific manner.

181 iseases of the upper respiratory mucosa in a site-specific manner.

182 Thus, constructing a site-specific map of the human glycome for biomarker res

183 titive displacement assay in the presence of site-specific markers such as warfarin and ibuprofen.

184 Here, using a site-specific mass spectrometric approach, we reveal the

185 scopy (cryo-EM), computational modeling, and site-specific mass spectrometry (MS) to probe glycan shi

186 ts in sewer overflows and the need to assess site-specific measures.

187 le and robust device can be achieved via the site-specific mesa architecture, by enabling generation

188 t the FGFR4-induced signature also predicted site-specific metastasis for lung, liver, and brain, but

189 ecific conjugation resulting in mixtures, or site-specific methods that require multiple steps, intro

190 ependent and halfmer C/D RNAs can also guide site-specific methylation.

191 , similar to other mucosal sites, harbours a site-specific microbiome, which has an essential role in

192 ics-informed glycoproteomics to characterize site-specific microheterogeneity of glycosylation for a

193 Site-specific microinfusion of the PAC1R antagonist PACA

194 Thus, we provided the first site-specific microRNA profile of skin and oral mucosal

195 We demonstrate that site-specific modification of immunogens with short pept

196 Site-specific modification of proteins with functional m

197 n of the methylation sites, the abundance of site-specific modifications shows variability across spe

198 More importantly, the site-specific monolithic formation of mesa pillar-struct

199 s (EXoO) that enables large-scale mapping of site-specific mucin-type O-GalNAcylation sites.

200 -AAV6-based genome editing tool platform for site-specific mutagenesis and integration of up to more

201 cations at multiple sites, including Trp(72) Site-specific mutagenesis studies have suggested, but ha

202 Site-specific mutagenesis suggests that this is due to a

203 As proof-of-principle, we used site-specific mutagenesis to examine the role of NEMO in

204 We used site-specific mutagenesis to reduce the subsite specific

205 Through the use of site-specific mutants, we demonstrate that MHB is a site

206 We generated site-specific mutations in Arabidopsis At2OGO by CRISPR/

207 We found that site-specific mutations in plasmid DNA can be generated

208 The introduction of site-specific mutations predicted to alter the temperatu

209 the humanized antibody was de-immunized and site-specific mutations were introduced to restore origi

210 change our understanding of the progressive, site-specific nature of CLN1 disease pathogenesis, and h

211 lecular heterogeneity is consistent with the site-specific NBD polarization results, which suggest th

212 mics and neurite growth impairments, whereas site-specific neddylation of cofilin at K112 regulates n

213 a stable maturation complex that introduces site-specific nicks into the duplex and a dynamic motor

214 , thereby providing a molecular basis of the site-specific nMPO glycosylation.

215 Common components of MGEs, such as site-specific nucleases, are 'guns for hire' that can al

216 A) is potentially an attractive strategy for site-specific, nucleotide independent Cu2+-labelling in

217 of glycoproteins with information regarding site-specific O-GalNAc glycan can be identified and quan

218 tein interactions, and identification of the site-specific O-GalNAc glycoproteome is a crucial step t

219 Precise and automated analysis of site-specific O-glycosylation on single proteins is cruc

220 We then visualized site-specific oxidation kinetics within the three-dimens

221 ly, these findings unequivocally reveal that site-specific oxidative modification of apoA-I via 5-OHT

222 chieving elimination varied spatially due to site-specific parameter constraining; however, this spat

223 The lack of KM constitutes a site-specific phenomenon independent of the keratinized

224 copy and computational modeling implied that site-specific phosphorylation at Ser61 plays key roles i

225 We identified a pattern of tau staging where site-specific phosphorylation changes occur at different

226 ates this life-beginning event by catalyzing site-specific phosphorylation of protamine, thereby trig

227 the S2 domain of cardiac myosin to show that site-specific phosphorylation of this region of cMyBP-C

228 ILAC, to quantitatively assess the impact of site-specific phosphorylation on the turnover of thousan

229 is amyloid-forming segment were modulated by site-specific phosphorylation.

230 ays, crystallography of individual subunits, site-specific photocrosslinking, and cryo-EM reconstruct

231 Projected site-specific population growth rates initially indicate

232 sites comprised of either Al or Ga reveal a site-specific preference for stabilizing Lewis acids, wh

233 l P < 0.001) were observed for tumors in the site-specific pretransplant locations, suggesting tumor

234 In this study, we conducted a site-specific probing of hydration water motions and sid

235 We inspected site-specific processes by a comprehensive suspect scree

236 tively, our results highlight how global and site-specific programs are deployed for the assembly of

237 In the studied soils, several site-specific properties were correlated with community

238 peptide ligation is a powerful approach for site-specific protein bioconjugation, synthesis and semi

239 Site-specific protein cleavage is essential for many pro

240 been shown for various applications such as site-specific protein labelling and in vivo cancer imagi

241 ts a significant addition to the toolbox for site-specific protein modifications.

242 We report the preparation of site-specific protein-protein conjugates that arise from

243 h targeted mass spectrometry for multiplexed site-specific PTM quantitation of monoclonal antibodies

244 While site-specific PTMs act very locally on the protein, spec

245 ied at the transcriptomic level, methods for site-specific quantification of absolute m(6)A modificat

246 Finally, this workflow was applied for the site-specific quantitative comparison of the glycoforms

247 ce of, or a potential mechanism maintaining, site-specific re-encounters.

248 s in the NEA demonstrated inter/multi-annual site-specific re-encounters.

249 lean functionalization of drugs by unlocking site-specific reactivities under generally mild reaction

250 The site-specific reactivity of vessels to CO(2) is reflecte

251 HK022 coliphage site-specific recombinase Integrase (Int) can catalyze i

252 The site-specific recombinase Tn3 resolvase initiates DNA st

253 ces phage C31 integrase (Int)-a large serine site-specific recombinase-is autonomous for phage integr

254 ase Integrase (Int) can catalyze integrative site-specific recombination and recombinase-mediated cas

255 were constructed and examined by integrative site-specific recombination and RMCE assays in human cel

256 al application of the split intein-regulated site-specific recombination system in building reversibl

257 This review focuses on conservative site-specific recombination that generates reversible DN

258 In Cre site-specific recombination, the synaptic intermediate i

259 uption of wobble base pairing of SsrA due to site-specific recombination, thus disrupting the trans-t

260 ised from and integrated into the genome via site-specific recombination, whereas pandemic Aux3 recom

261 alized immune response, and is mediated by a site-specific recruitment process of memory T cells.

262 t affect global H3K9me3 levels but induced a site-specific reduction of repressive H3K9me3 marks at p

263 omarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (includin

264 Substitution site-specific replacement and network analysis revealed

265 Site-specific replacement of active-site amino acids rev

266 ed photoactive antibody fragments by genetic site-specific replacement of single tyrosine residues wi

267 tumor-adjacent tissues, indicating plausible site-specific repressive roles of HDAC1 and Sp1 in GM2-s

268 ative profiling of IgA1 HR O-glycoforms with site-specific resolution will enable identification of p

269 The Varkud satellite ribozyme catalyses site-specific RNA cleavage and ligation, and serves as a

270 ractions to demonstrate the capabilities for site-specific self-assembly to create higher ordered arc

271 lit-pulse stimulation revealed an additional site-specific sensitization that has not previously been

272 Root trait results were site-specific showing great variations between the mid a

273 terature-guided causal inference tools, >300 site-specific signaling relations were mapped from phosp

274 lative flexibility and dynamic coupling at a site-specific, single-amino-acid level, we provide evide

275 lective interaction of GPA-3 with NPR-17 and site-specific SKN-1 binding to the promoter of nlp-24 to

276 realized soil net N(min) were contingent on site-specific soil and climatic properties.

277 This site-specific spectroscopic approach opens the door to u

278 Similar site-specific stability has been previously reported for

279 onsistent ("always" or "sometimes") exposure site-specific STI screening during PrEP care.

280 In this study, a site-specific stress-diffusive manipulation is demonstra

281 pectroscopy is a powerful tool for obtaining site-specific structural and dynamical information on ID

282 with an ARFI discharge diagnosis (across 25 site-specific study seasons), only 1030 (6%) of the preg

283 3) -Na-Co(III) (acac)(3) ] (3) via isovalent site-specific substitution at either of the cobalt posit

284 By introducing site-specific substitutions within the C-terminal recept

285 g reconstituted mononucleosomes containing a site-specific synthetic abasic site (tetrahydrofuran, TH

286 sed to generate clickable sgRNA of choice by site-specific tailoring of multiple azide-modified nucle

287 targeting moieties, controlled release, and site-specific targeting.

288 This site-specific thermogenic remodeling of canine tissue by

289 d its diagnostic performance was compared to site-specific thresholds.

290 extensively studied, systematic analysis of site-specific TIM phosphorylation is lacking.

291 This approach revealed noncanonical target sites specific to each miRNA, miRNA-specific differences

292 roteins, phosphoproteins and phosphorylation sites specific to each tissue source, to identify key si

293 management opportunities, and accounting for site-specific trade-offs.

294 osed of two functional modules: a variant of site-specific tyrosine recombinase Flp, which can have e

295 ected seismic hazards in the presence of the site-specific uncertainty such as hidden/undetected faul

296 B and MreB, photo-cross-linking studies with site-specific unnatural amino acids, and species-specifi

297 couples stoichiometry and kinetics to obtain site-specific water, air, and soil emissions.

298 We modeled monthly activity of sCoVs using site-specific weather data.

299 This reaction is site specific, which overcomes prior limitations associa

300 compositions of the bacterial biofilms were site specific, with the greatest differences between ins