ライフサイエンスコーパス: skeletal

1 Patients with MLII present with severe skeletal abnormalities, multisystemic symptoms, and earl

2 nd differentially regulates contractility in skeletal and atrial muscle.

3 vered actin-binding compounds for effects on skeletal and cardiac alpha-actins as well as on skeletal

4 ural, developmental, and regulatory roles in skeletal and cardiac muscle.

5 g protein that is predominantly expressed in skeletal and cardiac muscles and belongs to the AC group

6 improvements in several splicing defects in skeletal and cardiac muscles.

7 letal and cardiac alpha-actins as well as on skeletal and cardiac myofibrils.

8 zures, behavioral abnormalities, and various skeletal and structural anomalies.

9 y tissues and organs, including the nervous, skeletal, and immune systems.

10 o the environment, jawed vertebrates evolved skeletal appendages that drive oxygenated water unidirec

11 rated percutaneous implant system for direct skeletal attachment and bidirectional communication with

12 termine coral host age by quantifying annual skeletal banding patterns, and utilise high-throughput s

13 ntified the ric1 gene as being essential for skeletal biology.

14 expression of many genes and leads to severe skeletal, cardiovascular and neurological systems malfor

15 Despite the high glycolytic demand of skeletal cells, we discovered that S. aureus requires gl

16 an extensive pathological survey of a human skeletal collection, as well as a three-dimensional reco

17 we examined the vertebrae of two humans from skeletal collections with Langerhans Cell Histiocytosis

18 While many organisms synthesize robust skeletal composites consisting of spatially discrete org

19 severe nonimmunological features, including skeletal, connective tissue, and vascular abnormalities,

20 ed ADAMTSL2 secretion is not responsible for skeletal defects in PTRPLS patients.

21 fl);Dmp1-Cre) and Mekk2(-/-) each displaying skeletal defects, Nf1(fl/fl);Mekk2(-/-);Dmp1-Cre mice sh

22 d be an effective countermeasure against the skeletal deficits observed in astronauts during spacefli

23 ral biology perspective, and of its roles in skeletal development and diseases, could unlock new aven

24 -deficient mice that survive to an age where skeletal development can be studied.

25 logical processes such as blood coagulation, skeletal development, viral infection, cell-cell fusion,

26 s in decreased proliferation and altered jaw skeletal differentiation and cleft palate.

27 Indeed, several skeletal diseases, such as bone fracture, osteonecrosis,

28 products with rich oxygenation patterns and skeletal diversity in 10 steps or less from ent-steviol.

29 g and deformation, which could result in the skeletal dysplasia characteristic of HGPS.

30 filaments in situ, being embedded inside the skeletal elements.

31 nts, including the time to first symptomatic skeletal event and the time to first use of cytotoxic ch

32 ime to pain progression, time to symptomatic skeletal events, and EQ-5D-5L utility index, clinicians

33 after denervation but is required throughout skeletal growth to prevent contractures long term.

34 alcium absorption from the gut and promoting skeletal health, as well as many other important physiol

35 (Si) is beneficial for bone homeostasis and skeletal health.

36 We analysed the skeletal intracrystalline amino acids of massive, tropic

37 Moreover, a skeletal isomer of exotine A that likely originates from

38 While Notch has been studied in axial skeletal joints, little is known about the role of Notch

39 m the neural crest-derived sox9a(+)/sox10(+) skeletal lineage.

40 as collected from mice subjected to 5-minute skeletal loading and human individuals before and after

41 iversity and plasticity of SSCs that mediate skeletal maintenance and repair.

42 y for the staging and response assessment of skeletal metastases over standard imaging methods, being

43 e sacrum had to be counteracted with further skeletal modifications, e.g. a ventrally curved mid to a

44 bit tumour-associated osteolysis and prevent skeletal morbidity as well as use of appropriate local t

45 njamini-Hochberg correction, actin, alpha 1, skeletal muscle (ACTA1) was found to be significantly in

46 affected child revealed complete absence of skeletal muscle (i.e., segmental amyoplasia).

47 ssing insulin receptors (IR) specifically in skeletal muscle (IRMOE).

48 f low SMN in one relevant peripheral organ - skeletal muscle - by selectively depleting the protein i

49 A transgenic mouse model with elevated skeletal muscle 2-deoxy-ATP (dATP) was used to study how

50 etes mellitus (DM2) and DPN.PurposeTo assess skeletal muscle abnormalities in participants with DM2 w

51 d skeletal muscle NAD+ metabolites, affected skeletal muscle acetylcarnitine metabolism, and induced

52 pyrene)iodoacetamide was first used to label skeletal muscle actin in 1981, the pyrene-labeled actin

53 Bcl2 mediates exercise-induced autophagy and skeletal muscle adaptions to training during high-fat di

54 ide and methyl nicotinamide-were elevated in skeletal muscle after NR compared with placebo.

55 ion based on their physical location between skeletal muscle and bone, tendon is a surprisingly genet

56 GPRC6A's unique regulation of beta-cell, skeletal muscle and hepatic function may represent a new

57 and unsaturated long-chain FAs (LCFAs) into skeletal muscle and knockdown (Kd) of a subset of RabGAP

58 nervous, cardiovascular and immune systems, skeletal muscle and metabolic regulation as well as agei

59 athies (IIM) involve chronic inflammation of skeletal muscle and subsequent muscle degeneration due t

60 both biochemical and biomechanical roles in skeletal muscle and that mitochondrial dynamics can be m

61 - 4.4 years) and aged (83 +/- 4 years) human skeletal muscle and that of young/aged heterogenous musc

62 total force-producing capacity of exercising skeletal muscle are altered during OCC.

63 total force-producing capacity of exercising skeletal muscle are significantly altered during blood f

64 o data on the usefulness of these markers in skeletal muscle are very limited and inconsistent.

65 Skeletal muscle area z scores were significantly predict

66 odel are consistent with a Zip14 function in skeletal muscle at steady state that supports myogenesis

67 The miRNome profiles of skeletal muscle biopsies acquired from four different MD

68 is the first study to use cells derived from skeletal muscle biopsies in CFS patients and healthy con

69 mparison between NDD-CKD and HC populations, skeletal muscle biopsies were collected from the vastus

70 es the dystrophic phenotype of DMD-afflicted skeletal muscle by dysregulating muscle stem cells invol

71 he liver and lactate derived from exercising skeletal muscle can also become important energy substra

72 papers coalesced anatomical observations of skeletal muscle capillary numbers with O(2) diffusion th

73 ls via incorporation of target sequences for skeletal muscle cell-specific miR-206.

74 unctional validation in human adipocytes and skeletal muscle cells (SKMCs) confirmed the relevance of

75 erm SKE, displayed diminished replication in skeletal muscle cells in a mouse model of CHIKV disease.

76 ess the contribution of CHIKV replication in skeletal muscle cells to pathogenesis, we engineered a C

77 recapitulated by simulating lipotoxicity in skeletal muscle cells treated with saturated FA, palmita

78 investigated the gene expression patterns of skeletal muscle cells using RNA-seq of subtype-pooled si

79 ults showed that DGAT1 was dominant in human skeletal muscle cells utilizing fatty acids (FAs) derive

80 metabolism and its underlying mechanisms in skeletal muscle cells, and evaluated whether the observe

81 llular oxygen consumption, and glycolysis in skeletal muscle cells.

82 d small-molecule compounds that modulate the skeletal muscle channel isoform (RyR1) interaction with

83 ey role of the metabolic-sensing function of skeletal muscle clock in partitioning nutrient flux betw

84 sured the effect of 7 days' HFHC diet on (1) skeletal muscle concentration of lipid metabolites, and

85 Neural input into this bioprinted skeletal muscle construct shows the improvement of myofi

86 A bioengineered skeletal muscle construct that mimics structural and fun

87 suggest that the 3D bioprinted human neural-skeletal muscle constructs can be rapidly integrated wit

88 We previously showed that bioprinted human skeletal muscle constructs were able to form multi-layer

89 The study of skeletal muscle continues to support the accurate diagno

90 iggered Ca(2+) release and its influences on skeletal muscle contractility are widely used as experim

91 Skeletal muscle contraction in these mice, however, was

92 al cellular functions, including cardiac and skeletal muscle contraction.

93 f the cytotoxic protein levels and increased skeletal muscle cross-sectional area and contractility p

94 of skeletal muscle mass, and to evaluate the skeletal muscle density (SMD).

95 ifferentiated myocytes is a critical step in skeletal muscle development and repair.

96 PE caused robust vasoconstriction in resting skeletal muscle during control vasodilator infusions (De

97 EV biology and what is currently known about skeletal muscle EVs and their potential role in the resp

98 himeras protected them from both cardiac and skeletal muscle fiber damage.

99 Furthermore, repletion of vitamin D improved skeletal muscle fiber size and in vivo muscle function,

100 Transport distances in skeletal muscle fibers are mitigated by these cells havi

101 In skeletal muscle fibers, mitochondria are densely packed

102 ivation in intact loose-patch clamped murine skeletal muscle fibres subject to a double pulse procedu

103 evelopment of cachexia, as well as liver and skeletal muscle fibrosis, is dependent on intact signali

104 perfusion (IR) injury results in devastating skeletal muscle fibrosis.

105 m pathways and molecular networks of Nrf2 in skeletal muscle following Nrf2 or Keap1 deletion.

106 with reported kinetics from bulk studies of skeletal muscle for the relaxed and SRX subpopulations,

107 he effects of augmented nitric oxide (NO) on skeletal muscle force production and oxygen consumption

108 illion deletions (~ 470,000 unique spans) in skeletal muscle from 22 individuals with and 19 individu

109 We compared metabolic parameters of skeletal muscle from global Zip14 knockout (KO) and wild

110 ng small RNA sequencing of brain, heart, and skeletal muscle from individuals in late hibernation and

111 activation and stimulation of AMP kinase in skeletal muscle from smPit1(-/-); smPit2(-/-) mice consi

112 in adipose tissue, which, in turn, supports skeletal muscle function.

113 rf2 or Keap1 separately impaired or improved skeletal muscle function.

114 The effect of such treatments on juvenile skeletal muscle growth has yet to be investigated.

115 However, only the KI/KO mice have clear skeletal muscle histologic changes in MFM.

116 cin pathway were similar in control and IUGR skeletal muscle homogenate.

117 hermia (MH) is characterized by induction of skeletal muscle hyperthermia in response to a dysregulat

118 n of thermogenic genes in adipose tissue and skeletal muscle in CKD mice.

119 very of drug-loaded liposomes to an inflamed skeletal muscle in mice.

120 tudies and suggest an active contribution of skeletal muscle in NMJ dysfunction.

121 hat has been shown to be produced acutely by skeletal muscle in response to exercise, yet chronically

122 animal models also indicates involvement of skeletal muscle including loss of fast-twitch type 2 fib

123 During exercise, blood flow to working skeletal muscle increases in parallel with contractile a

124 , CT derived body composition as measured by skeletal muscle index (SMI) and skeletal muscle radioden

125 third lumbar vertebra (L3), to estimate the skeletal muscle index (SMI), a surrogate of skeletal mus

126 Despite the low skeletal muscle index and significant muscle fiber atrop

127 Using a model of skeletal muscle injury and repair, herein we identified

128 Regenerative response to skeletal muscle injury in Speg-KO mice was compared with

129 an energy-matched control on whole-body and skeletal muscle insulin and anabolic sensitivity.

130 These included miRNAs with functions in skeletal muscle insulin metabolism (miR-106b and miR-20b

131 iR-20b-5p) and miRNAs with functions in both skeletal muscle insulin metabolism and cell cycle regula

132 of lipid metabolites known to contribute to skeletal muscle insulin resistance.

133 oplets (LDs) does not directly contribute to skeletal muscle insulin resistance.

134 nd improved whole-body glucose clearance and skeletal muscle insulin sensitivity along with enhanced

135 Skeletal muscle insulin sensitivity was determined using

136 accumulation of lipid metabolites to protect skeletal muscle insulin signalling following 7 days' HFH

137 lation of lipid metabolites known to disrupt skeletal muscle insulin signalling in sedentary and obes

138 Although skeletal muscle is a key peripheral tissue, it remains u

139 Skeletal muscle is a key site of shivering and non-shive

140 ral and functional characteristics of native skeletal muscle is a promising therapeutic option to tre

141 Maintenance of skeletal muscle is beneficial in obesity and Type 2 diab

142 ue that the normally low MHC I expression in skeletal muscle is host protective by allowing for patho

143 ese results suggest that the loss of ARNT in skeletal muscle is partially responsible for diminished

144 Accumulation of lipid in skeletal muscle is thought to be related to the developm

145 r, these results suggest a critical role for skeletal muscle lamin A/C to prevent cellular senescence

146 demonstrate that RabGAP-mediated control of skeletal muscle lipid metabolism converges with glucose

147 we calculated body fat percentage (%BF) and skeletal muscle mass index (SMI).

148 light the autonomous role the VDR has within skeletal muscle mass regulation.

149 skeletal muscle index (SMI), a surrogate of skeletal muscle mass, and to evaluate the skeletal muscl

150 cytoskeleton and the extracellular matrix in skeletal muscle may contribute to reduced amino acid met

151 cytoskeleton and the extracellular matrix in skeletal muscle may contribute to reduced amino acid met

152 Future studies on the effects of NR on human skeletal muscle may include both sexes and potentially p

153 y strong and systemically dominant effect of skeletal muscle MHC expression on maintaining T cell fun

154 Inducible enhancement of skeletal muscle MHC I in mice during the first 20 d of T

155 h convective arterial oxygen delivery to the skeletal muscle microvasculature and subsequent diffusiv

156 and respiratory systems to supply oxygen to skeletal muscle mitochondria for energy production neede

157 ong the O(2) transport pathway from lungs to skeletal muscle mitochondria.

158 We identified 11 human skeletal muscle mononuclear cell types, including two fi

159 variants can be increased in human and mouse skeletal muscle myoblast cell lines using a single-guide

160 function of regulating enhancer activity in skeletal muscle myoblasts cells, further confirming the

161 mRNA transcript variants in human and mouse skeletal muscle myoblasts promoted myotube differentiati

162 s been accepted that the force produced by a skeletal muscle myofibril depends on its cross-sectional

163 Targeting skeletal muscle myosin by MPH-220 enabled muscle relaxat

164 ture of an insect myosin: the D melanogaster skeletal muscle myosin II embryonic isoform (EMB).

165 overweight or obese men and women increased skeletal muscle NAD+ metabolites, affected skeletal musc

166 h we demonstrated that selective deletion of skeletal muscle Nrf2 or Keap1 separately impaired or imp

167 mitochondria-enriched proteome of heart and skeletal muscle of aged mutator mice.

168 tectable in the primary olfactory system and skeletal muscle of Carns1-deficient mice.

169 ng intensity and improvements in VO(2max) In skeletal muscle of CON but not PCOS, training increased

170 mmatory cytokines was increased in liver and skeletal muscle of CysC KO mice.

171 The skeletal muscle of fruit flies communicates with other o

172 abundant peptides in the nervous system and skeletal muscle of many vertebrates.

173 he most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced infla

174 performed single-nucleus transcriptomics of skeletal muscle of mice with dystrophin exon 51 deletion

175 of the lower esophageal sphincter (LES) and skeletal muscle of the crural diaphragm (esophagus hiatu

176 -resistant glycogen in as little as 30 mg of skeletal muscle or a single hippocampus from Lafora dise

177 ction force, microvascular O(2) delivery and skeletal muscle oxidative metabolism.

178 f acute nitrite infusion on muscle force and skeletal muscle oxidative metabolism.

179 l and histological progression of the D2.mdx skeletal muscle pathology was evaluated to determine the

180 The conversion of proliferating skeletal muscle precursors (myoblasts) to terminally-dif

181 ults showed that PLV-LMCs do not derive from skeletal muscle progenitors.

182 Aging appears to attenuate the response of skeletal muscle protein synthesis (MPS) to anabolic stim

183 s of beta(2) -adrenoceptor activation on the skeletal muscle proteostasis and contractility propertie

184 measured by skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD), the systemic inflamm

185 easured biomechanical changes that accompany skeletal muscle regeneration and determined the implicat

186 miR-206 is required for skeletal muscle regeneration in vivo.

187 findings contribute to the understanding of skeletal muscle regeneration through the identification

188 e linked to the inflammatory response during skeletal muscle regeneration, suppressed Fbxl2 mRNA expr

189 patiotemporal control of self-renewal during skeletal muscle repair.

190 anics in contracting intact fibres from frog skeletal muscle reveal an I-band spring with an undamped

191 yrromethene-labeled ATP molecules in relaxed skeletal muscle sarcomeres from rat soleus.

192 High levels of skeletal muscle sensory feedback related to peripheral f

193 We observe a cell population with a skeletal muscle signature in etv2-deficient embryos.

194 ain/spinal cord and assemble them with human skeletal muscle spheroids to generate 3D cortico-motor a

195 SLN has also been implicated in skeletal muscle thermogenesis.

196 ndrial dysfunction and structural changes in skeletal muscle tissue remains to be discovered.

197 single-cell RNA sequencing to profile human skeletal muscle tissues from embryonic, fetal, and postn

198 The ability of contracting skeletal muscle to attenuate sympathetic vasoconstrictio

199 89 (0.18, 3.60); P = 0.03; eta2p = 0.29] and skeletal muscle uptake of glucose [between-group differe

200 ous quantification of perfusion and T(2)* in skeletal muscle using the developed technique.

201 Skeletal muscle wasting is also common in COPD, but less

202 g for sarcopenia, a debilitating age-related skeletal muscle wasting syndrome.

203 The mice demonstrated skeletal muscle weakness but did not experience early mo

204 ecapitulates hypertrophic cardiomyopathy and skeletal muscle weakness of human IOPD, indicating its u

205 stprandial glycogen storage in the liver and skeletal muscle were not altered.

206 beclin 1, is required for AMPK activation in skeletal muscle(3).

207 pical glibenclamide superfused onto hindlimb skeletal muscle) resolved a decreased blood flow and int

208 Sarcopenia is characterized by low skeletal muscle, a complex trait with high heritability.

209 se and lipid metabolism in the liver, heart, skeletal muscle, and adipose tissue.

210 es suppress sarcolemmal resealing in healthy skeletal muscle, and depletion of TRIM72 antibodies from

211 mitochondrial coupling efficiency in murine skeletal muscle, and expression of UCP3, AAC1, or AAC2,

212 d mice alters aging phenotypes in the brain, skeletal muscle, and heart.

213 xpression of which was recently confirmed in skeletal muscle, and its down-regulation is linked to re

214 abolic organs, including the adipose tissue, skeletal muscle, and liver by 9 weeks post-infection.

215 as a negative regulator of glucose uptake by skeletal muscle, and of pancreatic beta-cell phenotype i

216 iral-mediated gene transfer to liver, heart, skeletal muscle, and the central nervous system, its use

217 cretome that targets distant adipose depots, skeletal muscle, and the nervous system.

218 High-quality PCr mapping of human skeletal muscle, as well as the information of exchange

219 lization of the GLUT4 glucose transporter in skeletal muscle, but are not deficient in autophagy.

220 uced expression of the ryanodine receptor in skeletal muscle, but its observed content is even lower.

221 , an essential NAD(+) biosynthetic enzyme in skeletal muscle, decreased by 14% with NR.

222 ues (ectopic fat deposition in liver, heart, skeletal muscle, etc).

223 th muscle of resistance arterioles supplying skeletal muscle, heart and adipose tissue.

224 s across four murine muscular organs: heart, skeletal muscle, intestine and bladder.

225 utaneous WAT and can be greater than that in skeletal muscle, underscoring the potential of BMAT to i

226 Here we use skin epithelium and skeletal muscle-among the most highly-stressed tissues i

227 l-based transcriptome analyses revealed that skeletal muscle-resident macrophages are distinctive fro

228 Myosin heavy chain-embryonic (MyHC-emb) is a skeletal muscle-specific contractile protein expressed d

229 in part mediated by the release of myokines, skeletal muscle-specific cytokines, in response to exerc

230 Employing skeletal muscle-specific transgenic mouse models with un

231 Skeletal muscle-targeted Lrrc8a KO mice have smaller myo

232 sies of affected tissues, such as kidney and skeletal muscle.

233 d ventricles that are distinct from those of skeletal muscle.

234 glucose transporter 4 translocation in mouse skeletal muscle.

235 ize, and the limits of adaptability in adult skeletal muscle.

236 d uptake and protein synthesis in IUGR fetal skeletal muscle.

237 peripheral nervous system, liver, kidney and skeletal muscle.

238 ochondrial density and ETS proteins in fetal skeletal muscle.

239 1, in exercise-induced activation of AMPK in skeletal muscle.

240 2) , especially within fast-twitch oxidative skeletal muscle.

241 me, as a hallmark of aged tissues, including skeletal muscle.

242 mes play distinct roles in TAG metabolism in skeletal muscle.

243 ional role of DOCK3 in normal and dystrophic skeletal muscle.

244 ing inflammatory stimulation by TNF-alpha in skeletal muscle.

245 ne signaling and mitochondrial physiology in skeletal muscle.

246 ate and nitrite on mitochondrial function in skeletal muscle.

247 not affect NAD metabolite concentrations in skeletal muscle.

248 re preferentially associated with obesity in skeletal muscle.

249 ntly increased ATP and NAD(+) levels in mice skeletal muscle.

250 drial respiration, content and morphology in skeletal muscle.

251 peripheral dysfunction, particularly within skeletal muscle.

252 arterioles in the heart, adipose tissue and skeletal muscle.

253 oint of connection between motor neurons and skeletal muscle.

254 anes isolated from control and IUGR hindlimb skeletal muscle.

255 nce for reduced pH-buffering capacity in the skeletal muscle.

256 x7 expression marks stem cells in developing skeletal muscles and adult satellite cells during homeos

257 SPEG-deficient skeletal muscles contained fewer myogenic cells, which o

258 model consisting of motor neurons coupled to skeletal muscles interacting via the neuromuscular junct

259 Secondary mitochondrial damage in skeletal muscles is a common feature of different neurom

260 such as VEGFA and CDH5 which were blunted in skeletal muscles of 28 week old mice were found to be up

261 t analysis, at three months post excision in skeletal muscles or by 6 months post gene excision in he

262 Knocking out Nox4 in skeletal muscles or pharmacological blockade of Nox4 act

263 Altogether, our data demonstrate that skeletal muscles utilize miR-133b to mitigate the delete

264 e provide evidence that loss of lamin A/C in skeletal muscles, but not osteoblast (OB)-lineage cells,

265 To assess miR-133b function in DMD-affected skeletal muscles, we genetically ablated miR-133b in the

266 xcitation-contraction coupling in vertebrate skeletal muscles.

267 fl2 mRNA levels in various tissues including skeletal muscles.

268 es, but expression was considerably lower in skeletal muscles.

269 res of sophisticated biological devices like skeletal muscles.

270 /post-synaptic NMJ function, and maintaining skeletal muscular function and structure.

271 R-1a-2 are induced during differentiation of skeletal myoblasts and promote myogenesis in vitro.

272 FAS impairment blocks the differentiation of skeletal myoblasts in vitro.

273 to reporter mice specific for progenitors of skeletal myocytes (Pax7(+) and MyoD(+)) and VSMCs (Prrx1

274 er is paramount in evaluation of cardiac and skeletal myocytes.

275 The developmental trajectory of human skeletal myogenesis and the transition between progenito

276 e; BHC) was previously discovered to inhibit skeletal myosin II.

277 ptimal muscle relaxation; however, targeting skeletal myosin is particularly challenging because of i

278 Further, skeletal myosin provides membrane-like support for activ

279 hydrogenation (ECH) in aqueous solution over skeletal nickel cathodes to probe the various paths of r

280 ate including the tissue-skeleton interface, skeletal organic matrix, and biomineralization pathways.

281 G, and the deleterious effects on growth and skeletal phenotypes underscore the need for caution in h

282 mmunication (GJIC) influences Cx43-dependent skeletal phenotypes, including segment length.

283 l activity does not influence Cx43-dependent skeletal phenotypes.

284 the Smp/beta-catenin pathway in the lateral skeletal precursor cells, and does not influence the Sem

285 uences changes in gene expression in lateral skeletal precursor cells.

286 ndrogenic over osteogenic differentiation of skeletal progenitor cells.

287 of osteogenic differentiation, expressed in skeletal progenitor stem cells and bone-forming osteobla

288 ss by the end of lactation, followed by full skeletal recovery in NN dams, partial recovery in LN and

289 Analyses of skeletal-related events were also done in the intention-

290 are an ancient cell, appearing in fossilized skeletal remains of early fish and dinosaurs.

291 The construction of diverse sp(3) -rich skeletal ring systems is of importance to drug discovery

292 Previously, YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation an

293 postnatal and adult stages exclusively in a skeletal stem cell population.

294 Here we investigate the ability of resident skeletal stem-cell (SSC) populations to regenerate carti

295 d acidification stress significantly reduced skeletal stiffness, and warming weakened it, potentially

296 o irreversible tissue withdrawal, and weaken skeletal strength and stiffness of A. vastus.

297 6 downregulated, 10 upregulated) involved in skeletal system development and morphogenesis and patter

298 Endochondral bone is the main internal skeletal tissue of nearly all osteichthyans-the group co

299 SEM imagery, skeletal trace elements and boron isotopes (delta(11)B)

300 , 15.2 mo) was reduced to 7.3 mo in cases of skeletal uptake that was 26 %ID or higher, as compared w