ライフサイエンスコーパス: skeletal muscle myosin

1 tem that produces active recombinant type II skeletal muscle myosin.

2 than 100-fold greater than that measured for skeletal muscle myosin.

3 f glycation on the structure and function of skeletal muscle myosin.

4 n II, the cytoplasmic analogue of smooth and skeletal muscle myosin.

5 in the fulcrum region of the molecule as the skeletal muscle myosin.

6 motility are generally correlated for human skeletal muscle myosins.

7 double-headed and single-headed smooth- and skeletal-muscle myosins.

8 he in vitro motility assay using fast rabbit skeletal muscle myosin (28-29 degrees C).

9 rstood, our study aimed to determine whether skeletal muscle myosin and its metabolic efficiency unde

10 the biochemical and biophysical function of skeletal muscle myosin and the normal ultrastructural an

11 Further studies identified skeletal muscle myosin as a specific target of ubiquitin

12 Sequencing of the slow-twitch skeletal muscle myosin binding protein C1 (MYBPC1), loca

13 Skeletal muscle myosin-binding protein C (MyBP-C) is a m

14 Targeting skeletal muscle myosin by MPH-220 enabled muscle relaxat

15 To test the hypothesis that skeletal muscle myosins can directly influence blood coa

16 using the crystal structures of the chicken skeletal muscle myosin catalytic domain and essential li

17 nity is fairly insensitive to Mg(2+) in fast skeletal muscle myosin, CMIIB, and DdMII.

18 is and the atomic structure of MPH-220-bound skeletal muscle myosin confirmed the mechanism of specif

19 active thiol region has been well studied in skeletal muscle myosin, crystal structures of truncated

20 C residues 816-835 in the neck region of the skeletal muscle myosin directly bind factor Xa and, with

21 , selective, orally active inhibitor of fast skeletal muscle myosin, EDG-5506.

22 s (MyHCs) (IIa, IId, and embryonic) and that skeletal muscle myosin enzymatic activity is required fo

23 , to identify a potential binding site(s) on skeletal muscle myosin for factor Xa, 19 peptides (25-40

24 olve in vitro motility of actin propelled by skeletal muscle myosin for L = 0.2-3 mum.

25 e weak actin-binding loop (ABL) from chicken skeletal muscle myosin for that of gizzard smooth muscle

26 Thus, glycation of skeletal muscle myosin has a significant effect on both

27 the heavy meromyosin subfragment (HMM) of a skeletal muscle myosin has been investigated by in vitro

28 Skeletal muscle myosin has potent procoagulant activity

29 Skeletal muscle myosins have two ELC isoforms, A1 and A2

30 c smooth muscle heavy meromyosins containing skeletal muscle myosin heavy chain (HC) sequences were u

31 The evolutionarily conserved order of the skeletal muscle myosin heavy chain (MHC) genes and their

32 rco(endo)plasmic reticulum Ca2+ ATPase), and skeletal muscle myosin heavy chain are present in both d

33 missense mutations in the beta-cardiac/slow skeletal muscle myosin heavy chain rod.

34 nhibited with high selectivity compared with skeletal muscle myosin (IC50 = 9 nM and 11,300 nM, respe

35 ture of an insect myosin: the D melanogaster skeletal muscle myosin II embryonic isoform (EMB).

36 in IIA (MYH-9) but exhibit little binding to skeletal muscle myosin II.

37 with ADP release that is not seen with fast skeletal muscle myosin II.

38 ying the single-headed subfragment-1 of fast skeletal muscle myosin II.

39 I is weakly bound to the actin filament like skeletal muscle myosin-II and unlike the microtubule-bas

40 Incorporation into skeletal muscle myosin indicated a half-life of 54 days.

41 A) dramatically alters the motor activity of skeletal muscle myosin, inhibiting the velocity of actin

42 orm, but a functional analysis of homogenous skeletal muscle myosin isoforms has not been possible.

43 nd thick filaments of nonmuscle, smooth, and skeletal muscle myosin isoforms with varied length.

44 nalysis of all six recombinant human type II skeletal muscle myosin isoforms.

45 and a peptide from the CaM binding domain of skeletal muscle myosin light chain kinase (MLCK(579-595)

46 onse by ablating Ca(2+)/calmodulin-dependent skeletal muscle myosin light chain kinase (MLCK) gene ex

47 he interactions between calmodulin (CaM) and skeletal muscle myosin light chain kinase (MLCK), as wel

48 an enzymatically active truncation mutant of skeletal muscle myosin light chain kinase (MLCK).

49 an enzymatically active truncation mutant of skeletal muscle myosin light chain kinase (MLCK).

50 Skeletal muscle myosin light chain kinase (skMLCK) activ

51 from calmodulin (CaM) complexes with rabbit skeletal muscle myosin light chain kinase (skMLCK), rat

52 ylation by Ca(2+)/calmodulin (CaM)-dependent skeletal muscle myosin light chain kinase (skMLCK).

53 abolishes calmodulin-dependent activation of skeletal muscle myosin light chain kinase activity and r

54 F hand IV by II reduces by 60% activation of skeletal muscle myosin light chain kinase activity.

55 Skeletal muscle myosin light chain kinase and the cataly

56 the complex between (Ca(2+))4-calmodulin and skeletal muscle myosin light chain kinase or a peptide c

57 ases containing either the catalytic core of skeletal muscle myosin light chain kinase or Ca2+/calmod

58 protein substrates by the catalytic core of skeletal muscle myosin light chain kinase was altered wi

59 f CaM missing residues 2-8 (DeltaNCaM) binds skeletal muscle myosin light chain kinase with high affi

60 , which represents the CaM binding domain of skeletal muscle myosin light chain kinase, forms a compl

61 -26 of M13, the calmodulin binding region of skeletal muscle myosin light chain kinase.

62 is composed of the globular motor domain of skeletal muscle myosin (Met1-Gly773) and the C-terminal

63 We conclude that ELC of skeletal muscle myosin modulates strong-to-weak structur

64 To better understand how skeletal muscle myosin molecules move actin filaments, w

65 facilitated manipulation and analysis of the skeletal muscle myosin motor domain and is also amenable

66 n when various ligands are bound to isolated skeletal muscle myosin motor domain in solution.

67 in filaments propelled in vitro by groups of skeletal muscle myosin motors exhibit distinct phases of

68 Using parameters representative of skeletal muscle myosin, nonmuscle myosin IIB, and nonmus

69 L342Q change within the motor domain of the skeletal muscle myosin protein MYH4 (MyHC IIb).

70 eba myosin II rod is different from those of skeletal muscle myosin rod and tropomyosin, for which no

71 In skeletal muscle myosin, SH1 and SH2 can be chemically cr

72 Skeletal muscle myosin (SkM) has been shown to possess p

73 nce of five class II myosins, including fast skeletal muscle myosin, smooth muscle myosin, beta-cardi

74 The ionic strength dependence of skeletal muscle myosin subfragment 1 (S1) binding to act

75 The Mg-ATPase activity of skeletal muscle myosin subfragment 1 (S1) is reversibly

76 Lys-553 of skeletal muscle myosin subfragment 1 (S1) was specifical

77 for the reactions of Cys-697 and Cys-707 of skeletal muscle myosin subfragment 1 (S1) with N,N'-p-ph

78 as shown that the binding of actin to rabbit skeletal muscle myosin subfragment-1 (a single-headed su

79 s not compete with nucleotide binding to the skeletal muscle myosin subfragment-1.

80 In skeletal muscle myosin, the reactive thiols (SH1 and SH2

81 of a monoclonal antibody (10F12.3) to tether skeletal muscle myosin to nitrocellulose-coated glass.

82 RD from chicken skeletal muscle myosin was prepared in Escherichia coli

83 Chicken skeletal muscle myosin was thermally unfolded at heat-sh

84 Using Drosophila melanogaster skeletal muscle myosin, we performed a novel in vivo mol

85 e motor working stroke is similar to that of skeletal muscle myosin, whereas its speed is about three

86 ) isoforms (A1 and A2) on the interaction of skeletal muscle myosin with actin, to relate structural

87 tics, and there are no crystal structures of skeletal muscle myosin with bound nucleotides, so anothe