ライフサイエンスコーパス: skew

1 ariants than are expected without selection (skew).

2 scosity and shear thinning with opposite MWD skew.

3 hus deduced to be the proximate cause of the skew.

4 ing of the demise dependent on the amount of skew.

5 round selection, and, more recently, progeny skew.

6 als are non-normal, zero-inflated and highly skewed.

7 r Systems of the Web of Science is extremely skewed.

8 itu (732 species), the distribution is right-skewed.

9 croL/min, with the distribution being highly skewed.

10 ctivation energy" values, is typically right-skewed.

11 lated genes, largely lacking significant Th1-skewing.

12 the KAI2/MAX2 complex in the context of root skewing.

13 in sperm function associated with sex ratio skewing.

14 is that they are present and can affect root skewing.

15 g ability and consequently lead to sex ratio skewing.

16 nitrogenous species and especially NH(3) are skewed; 10% of trucks contribute 95% of the on-road flee

17 nt RNA-seq data verified the XIST-associated skewed AE on X chromosome in SLE.

18 ons were evaluated and 46% of catchments had skewed age distributions: 6% were skewed older, and 40%

19 t upregulation of XIST accompanied with more skewed allelic expression on X chromosome is associated

20 known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have b

21 FN-gamma, OASL, and T(H)2/IL-4 receptor/IL-5 skewing, although less than seen in patients with AD (al

22 low human impacts, to predominantly negative skew amongst lakes in highly disturbed regions in east C

23 The more axial-rich donors in skew and boat conformations are thus preorganized closer

24 how that they drive lineage-specific spindle skew and cell reorientation events.

25 n regions and is demarcated by localised G/T skew and G4 patterns.

26 ormation near gene promoters with strong G/C skew and propensity to form G-quadruplex in non-template

27 anscriptional signatures were clonotypically skewed and selectively confined to the intravascular cir

28 tions were broader, yet these were rightward-skewed and similar in shape when scaled by mean synaptic

29 ation, which massively reduced T-cell subset skewing and exhaustion.

30 endently promoted proinflammatory macrophage skewing and increased dendritic cell activation in the t

31 ind strong evidence of progressive rightward skewing and tail-fattening over time.

32 er access to females, high male reproductive skew, and more male investment in mating effort than par

33 ematics show that the wing's stroke plane is skewed, and the wing supinates and pronates during its p

34 ed increased T-cell activation, naive T-cell skewing, and elevated serum CXCL9 and CXCL10 levels.

35 une signaling, complement dysregulation, Th2 skewing, and increased secretion of MCP-1.

36 Many proteins are involved in root skewing, and we investigated the link between MAX2 and t

37 date, it is only the third known example of skewed azaphilic cycloaddition of tetrazine.

38 of chronic lymphocytic leukaemia cells, can skew B cell development in mice, most likely as a result

39 in Th1/17-skewed responses in inherently Th2-skewed BALB/c mice.

40 ase, center of gravity of the fitted bimodal skewed baseline cosine curve was used for melatonin, and

41 ing of the zinc complexes adopted axial-rich skew boat conformations.

42 This skewing came at the expense of the number of lymphoid-pr

43 cally by a second T2 network derived from T2-skewed, CD11b(+)/CD103(-)/IRF4(+) classical dendritic ce

44 is study, we show that Plasmodium falciparum skewed CD16+ DC cytokine responses towards interleukin (

45 se of substance P to induce migration of Th2-skewing CD301b(+) DC to draining lymph nodes.

46 We present novel evidence that Treg-DC skewed CD4(+) naive T cell polarization toward a regulat

47 emory T cell proliferation in coculture, and skewed CD4(+) T cells to express an increased ratio of I

48 ed in these individuals, with cell death and skewed cellular composition playing significant roles.

49 whether helminthes prevent T cell priming or skew clonal recruitment and effector differentiation is

50 showing increased sensitivity to colitis and skewed composition of fecal microbiota.

51 ions, consistent with some amounts of handed skew configurations of PCG segments in a melt state pack

52 severe hyperinflammatory disease exhibit TCR skewing consistent with superantigen activation.

53 and Kruskal-Wallis testing were utilized for skewed continuous data, and Chi-square or Fisher exact t

54 Follicular skewing correlated with IgA deficiency-associated endoto

55 ion of the genome that it covers, the highly skewed coverage of exons of different genes depending on

56 with production of proinflammatory and TH17-skewing cytokines, resulting in a TH17 immune response w

57 MPK signaling cascade, leading to macrophage skewing, dampening of inflammation, and regeneration of

58 use pLoc-mAnimal was trained by an extremely skewed dataset in which some subset (subcellular locatio

59 , linking exposure to activation of allergic-skewing DCs and the initiation of an allergic immune res

60 om networks and on two dynamic networks with skewed degree distribution, of which one is additionally

61 mand or time requirement despite evidence of skewed demand distributions.

62 These in turn skew differentiation towards the tumor cell-of-origin an

63 ), a VEGF receptor antagonist, in a hydrogel skewed differentiation of MF-activated SSCs toward artic

64 ects for cohesin-deficient HSCs with myeloid-skewed differentiation.

65 Within an individual, XCI-skew differs between blood, fat and skin tissue, but is

66 I procedures were analyzed with a negatively skewed distribution and an annualized median of 3 proced

67 We find high emission variability and a skewed distribution in which the 10% highest 3 h emissio

68 er characterization of the upper tail of the skewed distribution of emission rates.

69 ies risk has become a reality to address the skewed distribution of the disease.

70 Some wells displayed a skewed distribution which resulted in a small bias in es

71 The duration of ripples shows a skewed distribution with a minority of long-duration eve

72 a more private repertoire, lower diversity, skewed distribution, and reduced usage of the V9-JP pair

73 istance, DeltaMGW exhibited a strongly right-skewed distribution, highlighting the infrequency of SNP

74 the total emissions, indicating an extremely skewed distribution.

75 atistical framework, which creates anomalous skewed distributions consistent with recent laboratory e

76 estinal peptide (VIP)-expressing INs exhibit skewed distributions towards strong network-coupling; in

77 owever, tensile testing reveals that the MWD skew does not impact the strain at break, signifying the

78 rong correlations or history-dependence, but skewed-enough distribution of visiting probabilities, th

79 bred individuals and of domestic animals can skew estimates of genome-wide heterozygosity rates.

80 We investigated whether specific patterns of skewed expression were related to the enrichment of biol

81 ety of statistical regimes, including highly skewed extreme events.

82 between the ribosome and nascent polypeptide skew folding pathways.

83 single metric representing the degree of GC skew for a genome.

84 nize in an unstressed system to a positively skewed frequency distribution of nodal degree.

85 athway is that the immunopeptidome is highly skewed from the cellular degradome, indicating high sele

86 We provide evidence that over-expressed BNA2 skews glycolytic flux from LDs towards the SA-BNA pathwa

87 y diseases, and it has been suggested that a skewed gut microbial colonization process early in life

88 that streptozotocin-induced diabetes in mice skewed hematopoiesis toward the myeloid lineage via hema

89 Skewing human antibody repertoires to target more conser

90 e in animals models of autoimmunity and Th17-skewing human cell culture in vitro.

91 The analysis of cumulative GC skew identified potential misassemblies in some referenc

92 ondary to increased production and a robust, skewed IFN response that is regulated by PITX1.

93 3), but AD tissues showed preferential T(H)2 skewing (IL-13, CCL17/TARC, and CCL18), whereas psoriasi

94 nulin was accompanied by a significantly Th1-skewed immune profile characterized by increased T-bet(+

95 infection, a highly T helper type 2 (T(H)2)-skewed immune response directed at bladder re-epithelial

96 mmunologic processes having the potential to skew immunity toward inflammatory responses.

97 osis, whereas early innate signaling and Th1-skewed immunity are important for survival.

98 ltration of antitumor effector T cells and a skewed immunogenic immune profile.

99 gnant women's blood led to an exacerbated M2-skewed immunosuppression of non-classical monocytes in c

100 enomes, we verify the value of cumulative GC skew in combination with other metrics to establish bact

101 s associations across regions, from positive skew in lakes in west China with a history of low human

102 opose an explanation for lower than expected skew in low CO regions, and validate it using computer s

103 or caspase activation eliminated the type-2 skew in mice lacking Dock8.

104 To address this, we quantify XCI-skew in multiple tissues and immune cell types in a twin

105 ods are limited by issues of sample bias and skew in search query volumes, perhaps as a result of med

106 A low skew in very low CO regions, compared with theoretical p

107 In contrast, no corresponding skew in Z genotype was detected in their (hemizygous) si

108 TCRdelta repertoire, in contrast, was highly skewed in the lungs, where it was dominated by Vdelta1 a

109 ived butenolides), caused alteration in root skewing in Arabidopsis thaliana.

110 cent studies have uncovered T helper type 17 skewing in ichthyotic skin, resembling psoriasis, and hi

111 We also observed a skewing in the balance between proinflammatory and regul

112 of urothelial hyper-diploidy and cell cycle skewing in wild-type but not Il4ra(-/-) mice.

113 was initially observed through an increased skewing in X-chromosome inactivation [1].

114 omes with targeted genotyping showed similar skews in transcriptional priming of DNMT3A-mutated human

115 shifts trace back to transcriptional priming skews in uncommitted hematopoietic stem cells.

116 XCI skew increases with age in blood, but not other tissues,

117 Although T(H)1/T(H)17 skewing increases in both patients with AD and control s

118 genomes, we introduce a new method, SkewIT (Skew Index Test), that calculates a single metric repres

119 oves a conjecture made for the Wigner-Yanase skew information as a special case.

120 ly, we constructively prove that any type of skew information cannot be superadditive, where the viol

121 The Wigner-Yanase skew information was proposed to quantify the informatio

122 nd the two-mode cavity have been analyzed by skew information, log-negativity, and Bell function quan

123 Here, we analyze this general family of the skew informations from an operational point of view by u

124 kew informations, and this general family of skew informations have also been found to be valid asymm

125 The Wigner-Yanse-Dyson skew informations have been further generalized to a cla

126 Recently, the Wigner-Yanase-Dyson skew informations have been recognized as valid resource

127 had been only known for a specific class of skew informations with numerical counterexamples.

128 eneralized to a class called metric-adjusted skew informations, and this general family of skew infor

129 ation applicable to the general class of the skew informations, which proves a conjecture made for th

130 as later extended to the Wigner-Yanase-Dyson skew informations.

131 roofs of some of the basic properties of the skew informations.

132 + subsets as a result of HIV-1 infection may skew iNKT cell functionality toward cytotoxicity.

133 GC skew is a phenomenon observed in many bacterial genomes,

134 XCI-skew is heritable in blood of females >55 years old (h(2

135 XCI-skew is increased in twins with Rheumatoid Arthritis com

136 eceptor (Fgfr) and ERK pathways reversed the skewed lineage specification of Klf5 KO blastocysts.

137 Conversely, Utx deficiency skews lipid catabolism to enhance cholesterol/steroid ho

138 equencing, we found that erythrophagocytosis skewed liver macrophages into an antiinflammatory phenot

139 ctivity levels of CA1 neurons showed a right-skewed lognormal distribution, with a small portion of h

140 Furthermore, AREG directly skewed M/M to a proinflammatory M1 phenotype and protect

141 te-macrophages in particular, accompanied by skewed M2 to M1 macrophage phenotype.

142 Finally, we demonstrate that C5orf30 skews macrophage immunometabolism, demonstrating a mecha

143 ed that iron promotes differentiation, while skewing macrophages toward a hypersecretory M2-like pola

144 (ASD) is highly familial, with a positively skewed male-to-female ratio that is purported to arise f

145 red, which suggests the existence of a right-skewed model of genetic evolution from monoclonal gammop

146 analyses revealed that NR4A3 is required to skew monocyte differentiation toward MoDCs, at the expen

147 y, CD8 T cells in B cell-deficient mice were skewed more toward effector phenotype and less toward me

148 l parameters - variable cell division rates, skewed mutational outcomes, target dropouts and differen

149 High-dimensional data of discrete and skewed nature is commonly encountered in high-throughput

150 tion and suggest that PD-1 may contribute to skewing NK cells toward enhanced ADCC during infections

151 econd-best incorrect PSMs are modeled by the skew normal family.

152 towards regions that replicate early and the skew of the latter towards regions that replicate late.

153 For carriers with extreme XCI skewing of 80:20 or more, 57% were affected severely com

154 on against antigenically variable viruses is skewing of antibody responses to variable immunodominant

155 rculating T, B, and NK cells and exhibited a skewing of CD8+ T cells toward a terminally differentiat

156 w consistent with a retinoid-induced myeloid skewing of hematopoiesis.

157 A skewing of immune responses toward Th2 in transplant pat

158 r stress conditions, including an adipocytic skewing of perivascular cells.

159 AR1 knock-out mice occurred in tandem with a skewing of reactive astrocyte signatures toward a prorep

160 une correlates of allergy protection include skewing of regulatory over effector T cells, expansion o

161 Further, HIV exposure led to skewing of T cell phenotypes predominantly to inflammato

162 Clonality and skewing of TCR repertoires were associated with interfer

163 f the hematopoietic stem cell, even a slight skewing of the fraction of cells that differentiate woul

164 in autoimmune diseases is associated with a skewing of the immunometabolic programs.

165 a desirable broad antibody response, without skewing of the response toward preferential recognition

166 bstract, phenomenological, or rely on highly skewed offspring distributions in network models.

167 As the demographics of the modern world skew older, understanding and mitigating the effects of

168 hments had skewed age distributions: 6% were skewed older, and 40% were skewed younger.

169 s via ITAM-based calcium signaling pathways, skewing osteoclast metabolism toward oxidative phosphory

170 covering from past disturbances, potentially skewing our interpretations of forest dynamics and our u

171 Using this metric, we demonstrate how GC skew patterns are conserved within certain bacterial phy

172 ECM proteins-potentiate T cell signaling and skew phenotype of both murine and human T cells.

173 nd gammadelta-T cells showed unique and Th17-skewed phenotype and gene expression profiles.

174 , showing that altering these conditions can skew phenotypes.

175 In addition, diabetes mellitus skews plaque macrophages toward an atherogenic inflammat

176 on in maternal investment contributes toward skewed pollutant concentration ratios between males and

177 Therefore, alpha-GalCer treatment skewed pre-mNK cell responses away from an APC-like phen

178 est modelers consider heavy-tailed, downward-skewed probability distributions, such as the skewed Stu

179 tors, and increases the frequency of myeloid-skewed progenitors.

180 metry, inferior-superior dioptric asymmetry, skewed radial axis, logarithm of keratoconus percentage

181 These findings suggest reduced or skewed, rather than blocked, differentiation is responsi

182 A skewed ratio (4.83) of nonsynonymous versus synonymous (

183 SCs that occur in old age, including myeloid skewing, reduced reconstitution potential, impaired self

184 onstructions through time show that positive skew reduces with temporal intensification of human impa

185 ction resulted into a pronounced immunologic skewing regarding the expansion of CD8(+) T cells in the

186 elicited by FHA and Prn, resulting in Th1/17-skewed responses in inherently Th2-skewed BALB/c mice.

187 Skewing responses toward IgG(2) and IgG(4) subclasses mi

188 listed approaches are biased and can produce skewed results under the null.

189 These accelerated paths are fueled by a skewed risk-benefit ratio and are necessary to advance t

190 ults showed some data processing methods can skew sequence-based biodiversity measurements from corre

191 owth and survival, impaired immune function, skewed sex ratios, ovarian atresia, reduced egg producti

192 enefit the driver, and not to compensate for skewed sex ratios.

193 These skewed signals in T cells may sustain accumulation of EB

194 ped based on the complex system phenomena of skewed size abundance (decreasing abundance with increas

195 he production of B cells with self-reactive, skewed specificity receptors that are peculiar to the B-

196 kewed probability distributions, such as the skewed Student [Formula: see text] used here, when makin

197 nerates concomitant changes to the proteome, skewing synthesis of newly synthesized proteins away fro

198 ost participants had T helper type 1 (T(H)1)-skewed T cell immune responses with RBD-specific CD8(+)

199 on response, profound immune exhaustion with skewed T cell receptor repertoire and broad T cell expan

200 ition in CD4(+)CD8(+) thymocytes resulted in skewed T cell repertoire, contributing to a reduction in

201 Strong, Th1-skewed T cell responses can drive protective humoral and

202 ons in humans and mice are associated with a skewed T- and B-cell gene repertoire, characterized by i

203 aive T lymphocytes in pDGS as well as a more skewed T-cell repertoire in older pDGS patients.

204 (FasL), CD69, and IL-R1 expression, and (2) skewed T-lymphoblast cells toward a Th1 subtype, (CD4(+)

205 Finally, skewing T cell metabolism toward aerobic glycolysis by d

206 operate in low CO regions, producing a lower skew than in its absence.

207 The preterm infants were also more Th2 skewed than the full-term infants.

208 ange between the daytime and night-time will skew the climatic pressures placed on them, and this cou

209 observational studies; that animal products skew the diet toward saturated fat, excess protein, chol

210 ults show that photobleaching can critically skew the estimation of oligomeric distributions, so that

211 e known caveats of this technology which can skew the gene expression estimates.

212 Here, we show that TBL1XR1 mutations skew the humoral immune response toward generating abnor

213 Enhancing the Treg compartment can skew the patient's immune system toward an anti-inflamma

214 cktail of antigenically related antigens can skew the responses and change the epitope hierarchy, we

215 functional virus-specific CD8(+) TILs could skew the results of prognostic or diagnostic TIL assays.

216 Most importantly, it skewed the cytokine profiles into antitumor one in the t

217 on after activation of a recall response and skewed the cytokine response away from a dominant type 2

218 Nicotine skewed the polarity of microglia to the M2 phenotype, th

219 ly, activation of Wnt/beta-catenin signaling skewed the profile of human and murine MVPC toward an ad

220 and altered the T cell repertoire landscape, skewing the distribution of T cells toward lower-frequen

221 s, due to enigmatic physiological influences skewing the elemental record.

222 function in vivo exacerbates shigellosis by skewing the inflammatory cytokine response, disrupting c

223 e that nicotine promotes brain metastasis by skewing the polarity of M2 microglia, which enhances met

224 increase in the response magnitudes without skewing the quality.

225 of monocytes in microbial recognition and in skewing the T cell response towards Th17.

226 of monocytes in microbial recognition and in skewing the T-cell response toward Th17.

227 The overall effect is skewing the TAMs from M2-polarized TAMs into the M1-pola

228 t independent normalization at each position skews the site probabilities.

229 d antigen presentation by renal macrophages, skewed their polarization toward the M(2) phenotype, and

230 innate and adaptive immune cell populations skewing their polarization toward a more tolerogenic ant

231 depletes betaOHB levels in Lgr5(+) ISCs and skews their differentiation toward secretory cell fates,

232 y analysis showed loss to follow-up may have skewed these estimates.

233 Here we show that myelin uptake temporarily skewed these phagocytes toward a disease-resolving pheno

234 on changes are transduced to differentiation skews through biases in CpG enrichment of the transcript

235 d from CLL patients or murine CLL models are skewed to an antigen-experienced T-cell subset, indicati

236 The distribution of scores w skewed to the left, which gradually shifted to the right

237 dependent CLL patient cohorts, failed T-cell skewing to antigen-experienced subsets, decreased costim

238 changes in function and structure, including skewing to myeloid lineages, lower reconstitution potent

239 rains stimulated the innate immune system to skew toward M1 macrophages and release inflammatory cyto

240 nd the composition of the cTfh cell pool was skewed toward a cTfh1 cell phenotype.

241 Peripheral blood NK cell phenotype was skewed toward a defective/exhausted immune profile with

242 le of CD154(+) T cells in the reactive group skewed toward a polarized T(H)2 effector phenotype, and

243 transcriptional regulatory network that was skewed toward a proinflammatory angiostatic phenotype.

244 ion-induced hypoxia, and a metabolic profile skewed toward aerobic glycolysis.

245 F total and EBV-specific CD8(+) T cells were skewed toward an effector phenotype, with exaggerated ex

246 omain-containing protein 2 signaling and are skewed toward an interleukin (IL)-17A(+) phenotype in an

247 ased toward myelopoiesis and differentiation skewed toward granulocyte-monocyte progenitors (GMP) dur

248 rotein-level distributions are substantially skewed toward high predictive quality while having long

249 The PRO scores were skewed toward higher functional vision.

250 ploy to maintain genome integrity, a process skewed toward homologous recombination through the evolu

251 The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by ma

252 rocircuit, whereby the balance is relatively skewed toward inhibition during repetitive thalamic acti

253 y balance, whereby the balance is relatively skewed toward inhibition.

254 f neonatal and maternal antibodies differed, skewed toward natural killer (NK) cell-activating antibo

255 nfected cells; 2) term pregnancy dNK are not skewed toward recognition of HLA-C, as was previously sh

256 shape and center distributions that are more skewed toward reward.

257 Class I and class II chiasmata are skewed toward the chromosome ends, but class II chiasmat

258 t-derived induced pluripotent stem cells was skewed toward the myeloid lineage.

259 ) as the extracellular trigger of macrophage skewing toward a pro-reparative phenotype.

260 olution and decreased lymphoid output with a skewing toward myeloid development, and increased memory

261 ow considerable heterogeneity of N-ERD, with skewing toward T2 response and eosinophilic inflammation

262 ntiation and exhaustion as well as increased skewing toward Th17 cells.

263 Phenotypic and transcriptional skewing toward the memory fate was observed during the C

264 nd adapt through increased proliferation and skewing toward the myeloid lineage.

265 wn that research into human genes is heavily skewed towards genes that have been widely studied for d

266 igh resolution; (iii) adaptive mutations are skewed towards genomic positions with fewer features; an

267 scarce and their spatial distribution highly skewed towards industrialized countries.

268 show that the probability distributions are skewed towards lower values (under very high greenhouse

269 The BM composition was skewed towards myelopoiesis and transcriptome analysis o

270 eover, S-cone bipolar cells (SCBCs) are also skewed towards ventral retina, with wiring patterns matc

271 The outbreak was heavily skewed towards young children younger than 5 years, with

272 l translocation and natural killer (NK) cell skewing towards an inflammatory state, with chromatin st

273 s we observe global hypomethylation but with skewing towards hypermethylation when interrogating gene

274 oxp3(+) and CD4(+)Foxp3(-) cells show strong skewing towards Tfh/Th17 phenotypes.

275 that include a decline in lymphopoiesis and skewing towards the myeloid lineage.

276 tion at these upstream sites, differentially skewing translation and protein expression.

277 We have identified 2 mechanisms that lead to skewed Treg composition in AA: first, FasL-mediated apop

278 ice sheet instability greatly amplifies and skews uncertainty in sea-level projections with worst-ca

279 For skewed underlying beta distributions, 4 of the 5 retaine

280 dominated by the IgA isotype, together with skewed use of the IGHV genes in these and other diseases

281 Skew values relate strongly to nutrient loading from agr

282 in a recent study of human populations, the skew was reduced in the lowest CO regions compared with

283 This skewing was associated with oligoclonality and restricte

284 ith specific erythroid versus myelomonocytic skews, we provide evidence in support of differential se

285 This signalling capacity is skewed when placental damage occurs and can deliver a da

286 ify a subset of RNA-DNA hybrids with high GC skew which are partially resistant to RNase H.

287 a therefore, KAI2 and MAX2 act to limit root skewing, while kai2's gravitropic and mechano-sensing re

288 omputer simulations; explanations for higher skew with higher CO rates, as in D. simulans, will be ex

289 entralized, peaked distributions (negatively skewed with positive kurtosis) reflecting a mature popul

290 The observed distribution is skewed with the top two emitters accounting for 20% of t

291 lant-herbivore interactions are consistently skewed, with a small percentage of plant genera supporti

292 Furthermore, skewed X chromosome inactivation has been found in the t

293 ically having normal intelligence and highly skewed X chromosome inactivation.

294 layed normal RLIM mRNA levels and had highly skewed X chromosome inactivation.

295 show limited IQ with developmental delay and skewed X-inactivation.

296 , but nephrotic syndrome in only one case of skewed X-inactivation.

297 to which genetics and environment influence skewed XCI is largely unexplored.

298 Skewed XCI toward inactivation of the normal RPGR allele

299 Skewed XCI toward one parental X has been observed in se

300 ibutions: 6% were skewed older, and 40% were skewed younger.