ライフサイエンスコーパス: skin

1 from a secondary infectious challenge in the skin.

2 et in some epithelial barriers such as mouse skin.

3 of cpdm mice and mediated cell death in the skin.

4 ows for higher S. aureus colonization in SLE skin.

5 ture is detected in the periphery and in the skin.

6 ly in imiquimod-treated psoriasis-like mouse skin.

7 ention for the treatment of xerotic pruritic skin.

8 healthy Swedish children with fair and dark skin.

9 t only partially recapitulate human diseased skin.

10 ons of minocycline and tazarotene within the skin.

11 or for the effect of the cool ocean surface skin.

12 ime-consuming purification of LCs from human skin.

13 distortion and signal attenuation under the skin.

14 bonyls to induce iCGRP release from isolated skin.

15 ytes in a syngeneic mouse T-cell lymphoma in skin.

16 ing and functional characterization of qFIRM SKIN 1 (qFIS1), a major quantitative trait locus that pa

17 -controlled trial enrolling females with dry skin, 2% IDL lotion applied over 2 weeks significantly i

18 rees N, respectively) in both fair- and dark-skinned 5- to 7-y-old children.

19 en products demonstrated a certain degree of skin absorption of UV filters using IVPT, and a formulat

20 The incidence of dental and skin adverse events of special interest was higher with

21 active ingredients for the protection of the skin against UVR.

22 of the cellular and molecular intricacies of skin aging provide a foundation for future approaches de

23 uld be new therapeutic strategies to promote skin allograft longevity and, hence, the survival of pat

24 class I can enhance tolerance to subsequent skin allografts through indirectly expanded nTreg leadin

25 health effects of forces that are "above the skin." Although causal inference should be a key goal fo

26 We performed scRNA-seq on skin and blood from a patient with refractory DiHS/DRESS

27 Skin and blood samples were obtained from 61 patients wi

28 G2D are upregulated in vitiligo perilesional skin and especially in patients with active disease.

29 ermis to reach the epidermis, colonising the skin and eventually homing within the hair follicles.

30 ers and structures of ex vivo nude mouse ear skin and extracted pharmacokinetic parameters through co

31 derlying cause of natural variation in fruit skin and flesh color in octoploid strawberry.

32 (gallotannin, ellagitannin, quebracho, grape-skin and grape-seed) in comparison with ascorbic acid (A

33 rkers to simulate contamination of uncovered skin and hair of health care workers wearing personal pr

34 ronan are constitutively expressed in normal skin and increase post-wounding but are completely absen

35 y disorder, which affects the intertriginous skin and is associated with numerous systemic comorbidit

36 The psoriatic skin and joint phenotypes are reversed by normalization

37 Staphylococcus aureus adhesion to the host's skin and mucosae enables asymptomatic colonization and t

38 del samples (i.e., chicken thigh muscle with skin and murine renal biopsy including medulla (M) and c

39 lay the same specificity as that detected in skin and provocation testing, and to explore T-cell acti

40 y tract infection (UTI), and acute bacterial skin and skin structure infection (ABSSSI) do not addres

41 linically for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcu

42 es, and 24.4 to 32.9 per 100 000 persons for skin and soft tissue infections.

43 rature review was conducted for estimates of skin and soft-tissue infection and endocarditis disease

44 100 000 persons who inject drugs (PWID) with skin and soft-tissue infections annually in the United S

45 86.0 billion [95% CI, $76.3-$95.9 billion]), skin and subcutaneous diseases ($85.0 billion [95% CI, $

46 ed mutations in habitually sun-exposed human skin and subsequent development of actinic keratoses (AK

47 oside was the predominant compound in almond skin and whole kernel but it was not found in deskinned

48 rat cornea), organs (Xenopus gills and mouse skin) and appendages (Xenopus tail), and provide recomme

49 Tissues adjacent to melanoma lesions (skin) and distant organs (intestine) in tert mutants exh

50 calamus (quill), which is inserted into the skin, and a more distal rachis.

51 ells that encountered cognate antigen in the skin, and bystander Trm cells that did not, both display

52 vivors, adherence to COG breast, colorectal, skin, and cardiac surveillance was 12.6% (95% CI, 10.0%

53 e human body, including the oral cavity, the skin, and the gastrointestinal tract.

54 argeted therapies can repigment vitiliginous skin, and well-powered clinical trials are underway.

55 Electronic skins are essential for real-time health monitoring and

56 gs, immune system, gastro-intestinal system, skin as well as nervous system.

57 tributes to autoreactive CD4 T cell-mediated skin autoinflammation.

58 Frogs were swabbed for pathogen load and skin bacterial diversity and stimulated to release store

59 Atopic dermatitis (AD) is characterized by a skin barrier defect aggravated by mechanical injury infl

60 The skin barrier of subjects with PA without AD (AD(-)PA(+))

61 e effects of air pollutant exposure on human skin be investigated.

62 ies were collected (lesional and nonlesional skin) between baseline and 12 weeks.

63 show that TRPV3 and PAR2 were upregulated in skin biopsies from patients and mice with atopic dermati

64 gether with cultured Schwann cells (SCs) and skin biopsies from patients with type 2 diabetes (T2DM),

65 heral nerves, which were further verified in skin biopsies of patients with T2DM.

66 PXE diagnosis was confirmed by a positive skin biopsy and/or genetic testing.

67 Skin biopsy specimens and blood samples were collected o

68 Mucosal and skin bleeding scores, number of previous treatments, age

69 n of genes encoding proteins associated with skin blood supply and wound healing were altered.

70 Improving management of skin breakdown and early recognition of skin infection c

71 can act similarly to S aureus and damage the skin by expression of a cysteine protease.

72 Our findings suggest that human skin can be successfully cultured for pharmacodynamic us

73 our results demonstrate that nearly complete skin can self-assemble in vitro and be used to reconstit

74 gus that colonizes human mucosal tissues and skin, can become pathogenic, clinically manifesting most

75 carcinoma (cuSCC) is the second most common skin cancer and commonly arises in chronically UV-expose

76 calculated bidirectionally for any SPC after skin cancer and for skin cancer as SPC.

77 ability of solar ultraviolet (UV) to induce skin cancer and photoaging is well recognized.

78 onally for any SPC after skin cancer and for skin cancer as SPC.

79 d colony formation and cell proliferation of skin cancer cells.

80 ements in the accuracy of image-based AI for skin cancer diagnosis to address the effects of varied r

81 carcinoma (MCC) is a rare, highly aggressive skin cancer for which immune modulation by immune checkp

82 or are also sufficient to delay prostate and skin cancer initiation of Pten-deficient mice.

83 Herein, we established and characterized a skin cancer model, in which Mus musculus papillomavirus

84 as a dosimeter of exposure and predictor of skin cancer risk has been proposed by multiple groups.

85 Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (c

86 s, with major complications of infection and skin cancer.

87 carcinoma (MCC), an extremely lethal form of skin cancer.

88 , and KMT2C, which are frequently mutated in skin cancers, indicating their potential role as foundin

89 t development of actinic keratoses (AKs) and skin cancers.

90 -O-tetradecanoylphorbol-13-acetate two-stage skin carcinogenesis mouse model.

91 eady been demonstrated, ranging from on-site skin care testing, to food safety to the most frequent i

92 We revealed hierarchical changes in skin cell biology, including activation of an immune res

93 ncluding better transcriptomic resolution of skin cells, combined with proteomic information from int

94 , endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystem dise

95 soluble solids (SS), flesh firmness (FF) and skin color (SC).

96 Moreover, melanocytes from healthy skin commonly contained pathogenic mutations, although t

97 o was associated with CD4+ cells in AD human skin compared with those in healthy controls.

98 Phenotypes were scored for severity of skin condition, specific hair shaft defects, atopy, and

99 Skin conditions affect 1.9 billion people.

100 o assist general practitioners in diagnosing skin conditions.

101 f pavlovian threat conditioning by assessing skin conductance response (SCR) and declarative memory o

102 ng, pathological anxiety involves heightened skin conductance response to potential but not immediate

103 In contrast to skin conductance responses or pupil dilation, modulation

104 surements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp E

105 trategy to incorporate T cells into human 3D skin constructs (HSCs), which enabled us to closely moni

106 re significantly more likely to have skin-to-skin contact after birth, to have it for a longer time,

107 Human skin contains a population of memory T cells that suppor

108 9/24 [79%]) and avoidance of antibiotics for skin contaminants (30/85 [35%]).

109 ron terminals, cells that dwell close to the skin contribute significantly to itch.

110 hitecture, component release profiles in the skin could be independently tuned to allow release of ad

111 sily penetrate the battery casing due to the skin depth.

112 e treatment on the aortic ultrastructure and skin dermis of MFS mice through immunohistochemical eval

113 as well as fully monolithically integrated e-skin devices.

114 of innate lymphocyte biology with a focus on skin disease and the roles of commensal and pathogen res

115 Fogo selvagem (FS) is a blistering skin disease caused by pathogenic IgG4 autoantibodies to

116 Psoriasis is a frequent, inflammatory skin disease characterized by keratinocyte hyperprolifer

117 Although IL-22 deficiency did not affect skin disease development, IL-22 deficiency aggravated th

118 equired for autoreactive CD4 T cell-mediated skin disease pathogenesis and that the NLRP3-dependent i

119 Psoriasis is an inflammatory skin disease that is associated with multiple comorbidit

120 /CYP1A1 axis may play a role in inflammatory skin disease.

121 ntly contributed to the development of overt skin disease.

122 the leading cause of the global burden from skin disease.

123 Drug screening studies for inflammatory skin diseases are currently performed using model system

124 sights into the pathogenesis of inflammatory skin diseases that have thus far evaded understanding by

125 riasis, dermatitis, infection, and malignant skin diseases.

126 of harlequin ichthyosis (HI), a devastating skin disorder caused by loss-of-function mutations in th

127 l ascites, pleural or pericardial effusions, skin edema, cystic hygroma, increased nuchal translucenc

128 ral such features, such as the non-Hermitian skin effect, are only present in spatially extended syst

129 ly, electrical stimulation based on drawn-on-skin electronics demonstrates accelerated healing of ski

130 However, the research of making on-skin electronics with passive-cooling capabilities, whic

131 odegradable, self-healing, or breathable, on-skin electronics.

132 a, and immune homeostasis but also enhancing skin epithelial differentiation.

133 Here we use skin epithelium and skeletal muscle-among the most highl

134 Js in human lung as well as human and murine skin epithelium, enabling epicutaneous vaccine delivery.

135 ped fever and self-limiting vesiculopustular skin eruptions.

136 ion via optogeneics and chemogenetics in the skin evokes itch- but not pain-related scratching or wip

137 Here we describe an ex vivo cultured human skin explant model in which we have characterized pathol

138 ulture and prevented epidermal disruption in skin explants.

139 intradermal injections into primary, human, skin explants.

140 eved across different stimuli and regions of skin (face and hand).

141 D and 662 DEGs in nonlesional AD, vs healthy skin (fold-change >=2, FDR <0.05), with 100% sample reco

142 The pig's rostrum has three major skin-folds.

143 melanocytes from intermittently sun-exposed skin (for example, the back).

144 er, melanocytes from chronically sun-exposed skin (for example, the face) had a lower mutation burden

145 in punch biopsies of IBH lesions and healthy skin from IBH-affected and healthy horses.

146 roved PAR1 antagonist, on explanted lesional skin from patients with psoriasis.

147 nstruction using a temporary split-thickness skin graft.

148 Adoptively transferred TEa cells in skin-graft recipients were not exhausted.

149 CD28 accelerated the rejection of allogeneic skin grafts in young RAG2(-/-) recipient mice.

150 modulation led to permanent acceptance of F1 skin grafts.

151 nor (bm1 or F1) and third-party B10.BR (H-2) skin grafts.

152 We observed acute skin GVHD in the presence of 100% host T cells.

153 By E15.5, wild-type skin had undergone angiogenesis and formed a hierarchica

154 joint hypermobility, hypotonia, hyperelastic skin, hearing loss and aortic rupture.

155 9Q) mouse model of OS abundantly express the skin homing receptors cutaneous lymphocyte associated an

156 applied over 2 weeks significantly improved skin hydration and decreased transepidermal water loss (

157 demonstrate mechanisms by which IDL improves skin hydration and epidermal barrier function, supportin

158 tions in gene and chromatin structure within skin immunocytes could provide key insights into the pat

159 eceptor subtypes homotypically tile glabrous skin in a manner that is offset with respect to one anot

160 ubsets of gammadelta T-cells detected in the skin in steady-state, psoriasis, dermatitis, infection,

161 ssemble in vitro and be used to reconstitute skin in vivo.

162 ement of the muscle boundary relative to the skin) in response to impact forces elicited by walking a

163 e of CD8(+) T cells in psoriatic and healthy skin, including 2 nonexhausted Tc17 cell subsets associa

164 d in the upper outer quadrant with overlying skin induration.

165 t of skin breakdown and early recognition of skin infection could prevent iGAS infections in these pa

166 To this end, mouse skin infection models allow researchers to examine host

167 response against Staphylococcus aureus (SA) skin infection substantially improved systemic host defe

168 verse events such as hypo/hyperpigmentation, skin infection, or recurrence were reported.

169 esions than the wild type (WT) during murine skin infection.

170 disseminated systemic diseases, particularly skin infections and arthritis in severely immunocompromi

171 oorly understood whether localized S. aureus skin infections persistently alter the resident Mphi sub

172 immune response, and susceptibility to viral skin infections that are normally restrained by a T(H)1

173 our data indicate that omalizumab can induce skin inflammation and anaphylaxis by engaging FcgammaRs,

174 henotype was associated with chronic sterile skin inflammation and could be partially rescued by dexa

175 ts with murine models of allergic airway and skin inflammation and offer an overview of studies focus

176 l numbers strongly increase during psoriatic skin inflammation and were recently shown to limit psori

177 ting Treg function may be useful in treating skin inflammation in DOCK8 deficiency.

178 determine the immunologic rules that govern skin inflammation in early life.

179 useful immunosuppressive strategy to control skin inflammation mediated by the IL-23/IL-1beta/IL-17 a

180 reactions and imiquimod-triggered psoriatic skin inflammation, indicating that E-cadherin on LC does

181 Aldara (5% imiquimod)-induced psoriasis-like skin inflammation.

182 n and were recently shown to limit psoriatic skin inflammation.

183 how loss of TSG-6 affects wound closure and skin inflammation.

184 ensable for the development of AD-associated skin inflammation.

185 cytes induces ZBP1-dependent necroptosis and skin inflammation.

186 e fluoride) membrane, referred to as a "meta-skin" insulator, which is able to confine acoustic waves

187 Patients with skin involvement and itch showed the highest levels of I

188 Adult human skin is an appropriate model for these viruses because m

189 ine, we show that the upper epidermis of the skin is exclusively innervated by GRP fibers, whose acti

190 Skin is the largest barrier organ and an important inter

191 edge that pollutants can interact with human skin, it is now of even greater importance that the effe

192 organization and dynamics of keratin IFs in skin keratinocytes.

193 phenotypes are reversed by normalization of skin KLK6 levels and attenuated following genetic elimin

194 acy of primary care physicians to categorize skin lesion morphology in the same test bank of images w

195 e, 786 free-ranging snakes were examined for skin lesions consistent with ophidiomycosis and swabbed

196 ool to assist physicians in the diagnosis of skin lesions while still requiring the user to criticall

197 piRNAs examined are downregulated in leprosy skin lesions.

198 To combat this, the amplitude of skin lightening agents are commercially available, most

199 m can sense the changes in areas near to the skin-like sensors by measuring the capacitances between

200 ight ventricular cardiomyopathy (ARVC), with skin manifestations, has been associated with mutations

201 er it represents the main opiate receptor of skin mast cells remains unknown.

202 a release of proinflammatory mediators from skin mast cells.

203 with bone, lymph node, and chest wall/breast/skin metastases at baseline was observed.

204 ver, lung, lymph node, and chest wall/breast/skin metastases.

205 l, these data show how a member of the human skin microbiome can be useful as a biotherapy for acne v

206 assembly processes structuring the amphibian skin microbiome.

207 The skin microbiota interacts with the host immune response

208 of immune-mediated diseases by gut, oral and skin microbiota.

209 ocerciasis has insufficient sensitivity when skin microfilarial (mf) densities are low, such as follo

210 NFAT-luciferase transcriptional activity in skin microvessels, resulting in improved microvascular f

211 on of collagen degradation in an ex vivo pig-skin model.

212 Wounded skin models were inoculated with bacteria and left to in

213 fects during mouse embryonic development and skin morphogenesis.

214 l evidence indicated that iNPWT also reduced skin necrosis (RR 0.49, 95% CI: 0.33-0.74), seroma (RR 0

215 hat iNPWT may also prevent wound dehiscence, skin necrosis, seroma, and hematoma.

216 ential expression of STS PC1 proteins in the skin of adult patients with AD with the history of clini

217 erize the autoinflammatory phenotypes in the skin of both autoimmune polyendocrinopathy-candidiasis-e

218 ckgrounds, with longer micropore lifetime in skin of color.

219 MP-2 and MMP-9 expression was reduced in the skin of doxycycline-treated MFS mice.

220 skin organoids are equivalent to the facial skin of human fetuses in the second trimester of develop

221 are the most abundant bacteria found on the skin of patients with atopic dermatitis (AD).

222 Gd) has been detected in the brain, bone and skin of patients, months and years following GBCA admini

223 expression of IL-17 mRNA between OVA-treated skin of VAN and VAD mice.

224 Extrapulmonary (skin or bone) disease, probably resulting from hematogen

225 nd commonly arises in chronically UV-exposed skin or chronic wounds.

226 by showing little scarring or fibrosis after skin or muscle injury, but the Acomys response to spinal

227 al pathogens in the intestinal tract, on the skin or on the vaginal mucosa.

228 nagement of grade 2 acute GVHD with isolated skin or upper gastrointestinal tract manifestations; flu

229 mparison to fetal specimens suggest that the skin organoids are equivalent to the facial skin of huma

230 med STAR particles, to dramatically increase skin permeability.

231 skin pH and urges for larger studies linking skin pH and skin S aureus abundance to understand drivin

232 tial of sustained intervention regarding the skin pH and urges for larger studies linking skin pH and

233 in skin to enable multifactorial analysis of skin pharmacokinetics.

234 y, treatment with an NLRP3 inhibitor reduced skin phenotypes and decreased infiltration of CD4 T cell

235 udy period, the overall prevalence of severe skin photoaging increased from 42% at baseline to 88%.

236 Skin prick test (n = 51) and ImmunoCAP (Thermo Fisher) (

237 l visits including structured interviews and skin prick tests (SPT).

238 clinically confirmed fish allergy underwent skin prick tests to salmon and catfish.

239 s: all had negative results for aeroallergen skin prick tests.

240 In addition, since human skin proteins were also identified, this method offers t

241 Human skin provides both physical integrity and immunological

242 rimary and secondary metabolite profiling in skin + pulp/flesh and seeds were also determined.

243 ripheral blood mononuclear cells (PBMCs) and skin punch biopsies of IBH lesions and healthy skin from

244 in 5/6 pigs including diarrhoea, emesis, and skin rash.

245 l environment and Sm infection, but not with skin reactivity to extracts or sensitization to their ma

246 nescence led to the evolution of ultra-black skin (reflectance <0.5%) in 16 species of deep-sea fishe

247 insights about the unique characteristics of skin-resident innate lymphoid cells (ILCs).

248 e present study reports the piRNome of human skin, revealing that all but one of the piRNAs examined

249 urges for larger studies linking skin pH and skin S aureus abundance to understand driving factors of

250 y eliciting induction of genes that preserve skin's integrity.

251 e effects of loss of ABCA12 using HI patient skin samples and an engineered CRISPR/Cas9 ABCA12 KO cel

252 ntly improve the accuracy of the traditional skin score in patients with systemic sclerosis and may a

253 Lesional AD skin shows a NK-cell dysregulation, which despite clinic

254 Skin snip evaluation for onchocerciasis has insufficient

255 matology QOL instruments may measure general skin-specific, disease-specific, or condition-specific Q

256 nfection (UTI), and acute bacterial skin and skin structure infection (ABSSSI) do not address treatme

257 for the treatment of Gram-positive skin and skin structure infections (SSSI), Staphylococcus aureus

258 It may be caused by bacteria in deep skin structures unsusceptible to surface decontamination

259 UV-B-induced metabolic changes only in peach skin subjected to direct UV-B irradiation.

260 in lesional and nonlesional AD and psoriasis skin, suggesting their utility as a minimally invasive a

261 of cotton threads to harvest sweat from the skin surface and to transport it to the paper-based sens

262 phylum and Corynebacteriaceae family in MCT skin surface when compared to the healthy contralateral.

263 We found that this passive extraction of the skin surface yields abundant metabolites.

264 Skin symptoms included papular eruptions (100%), sclerod

265 measurement of glucose and lactate, pH, and skin temperature.

266 sehold member with TB or a recent tuberculin skin test (TST) conversion were included in this study.

267 drug dose, latency periods, test results of skin test and cellular assays, and tolerated drugs in su

268 generated from seven patients with positive skin test to either AX or Clav.

269 Of 1406 skin test-positive contacts, TB developed in 49 (9.8%) o

270 Hypersensitivity reaction rate after allergy skin testing (17%; 95% CI: 7%, 29%; zero of 21 studies)

271 s and 39% had access to inpatient penicillin skin testing, indicating that the majority of US hospita

272 Skin tests (STs) and single-blind placebo-controlled dru

273 roblast, and immune cells of Ovol1-deficient skin that reflect an altered course of epidermal differe

274 lipid matrix in the outer layer of mammalian skin, the stratum corneum, has been previously investiga

275 igher wavelengths ranging from 450-500 nm in skin to 500-600 nm in both brain and liver).

276 cells, cell junctions, and cell types within skin to enable multifactorial analysis of skin pharmacok

277 Here we show that exposure of the skin to the experimental contact allergen DNFB results i

278 group were significantly more likely to have skin-to-skin contact after birth, to have it for a longe

279 recorded the highest concentrations in berry skins total anthocyanins, flavanols, flavonols, antioxid

280 ce the Tactile Resistive Annularly Cracked E-Skin (TRACE) sensor to address the inherent trade-off be

281 Skin transcriptome studies in atopic dermatitis (AD) sho

282 The authors demonstrated that, following skin transplantation, the donor mast cell-mediated senes

283 Varicella zoster virus (VZV) is a skin-tropic virus that infects epidermal keratinocytes a

284 ial role as founding mutations in UV-induced skin tumorigenesis.

285 iculin (FLCN) and is characterized by benign skin tumours, lung and kidney cysts and renal cell carci

286 Comparisons between extreme skin types II and VI showed melanin inhibition factors o

287 Skin undergoes constant self-renewal, and its functional

288 The affected skin was often colonized by a variety of fungal, bacteri

289 re, immunohistology of healthy and psoriatic skin was performed.

290 isolated from late-stage wounds into healthy skin was sufficient to induce itching in a manner depend

291 econd in situ squamous cell carcinoma of the skin were found after Kaposi sarcoma (685.68) and Merkel

292 y donor-derived T cells, most T cells in the skin were host derived.

293 he proposition that afferent signalling from skin wetness enhances the desire to engage in cool-seeki

294 e and alarmin production, and seeding of the skin with antigen-presenting cells capable of instructin

295 subtle changes in blood perfusion below the skin with at least two times better sensitivity, three t

296 he graphene film endow the robust protective skin with high stretchability.

297 nd high amounts of interleukin 31 (IL-31) in skin wound tissue during the peak of itch responses.

298 following an established splinted excisional skin wounding model.

299 ng viable human cells present at the site of skin wounds.

300 ctronics demonstrates accelerated healing of skin wounds.