ライフサイエンスコーパス: skin disease

1 /CYP1A1 axis may play a role in inflammatory skin disease.

2 contributes to the development and course of skin disease.

3 Atopic eczema is a common inflammatory skin disease.

4 oplantar keratoderma type 1 (PPKP1), a human skin disease.

5 , complex, and highly heritable inflammatory skin disease.

6 r the prevention or treatment of this common skin disease.

7 orrelate negatively with the severity of SSc skin disease.

8 a (HS) is a chronic, relapsing, inflammatory skin disease.

9 judice in our society directed at those with skin disease.

10 ay a critical role in the early stage of SSc skin disease.

11 logical process in this complex inflammatory skin disease.

12 s suppurativa (HS) is a chronic inflammatory skin disease.

13 mutations found in patients with phenotypic skin disease.

14 interest in the contribution of microbes to skin disease.

15 ment of methylation patterns in inflammatory skin disease.

16 cal manifestations and pathology of allergic skin disease.

17 ntly contributed to the development of overt skin disease.

18 may change their occupation because of their skin disease.

19 o is of critical importance in understanding skin disease.

20 ecific gene expression and its disruption in skin disease.

21 is suppurativa (HS) is a common inflammatory skin disease.

22 ), with low cardiovascular risk and moderate skin disease.

23 he future understanding of this debilitating skin disease.

24 iasis, a hyperproliferative and inflammatory skin disease.

25 dermatitis (AD) is the most common pediatric skin disease.

26 s underlying its pathogenic role in fibrotic skin disease.

27 or management strategies to control tropical skin disease.

28 ful application of non-viral gene therapy in skin disease.

29 and smartphone apps diagnosing and treating skin disease.

30 mple, scalable prodrug platform for treating skin disease.

31 a common inflammatory and hyperproliferative skin disease.

32 erlying phospholipase-dependent inflammatory skin disease.

33 the leading cause of the global burden from skin disease.

34 als" can cause disorder, damage, and promote skin disease.

35 onents of the case definition for freshwater skin disease.

36 ostasis, microbial defense, and inflammatory skin disease.

37 this most common yet enigmatic inflammatory skin disease.

38 atitis (AD) is a common chronic inflammatory skin disease.

39 pic dermatitis (AD) is a severe inflammatory skin disease.

40 on of previously ascribed pDC involvement in skin disease.

41 to define mechanisms contributing to atopic skin disease.

42 mplicated in breast cancer and Hailey-Hailey skin disease.

43 riasis, dermatitis, infection, and malignant skin diseases.

44 ew research area in clinical trials to treat skin diseases.

45 l Institute of Arthritis Musculoskeletal and Skin Diseases.

46 and the IL-36 subfamily are associated with skin diseases.

47 mavirus 6 and 7 have been linked to specific skin diseases.

48 rders, autoimmune disorders and inflammatory skin diseases.

49 ologic feature of various human inflammatory skin diseases.

50 ional link between epigenetic regulation and skin diseases.

51 discordant cytokine signatures of these two skin diseases.

52 n mechanism by which S. aureus may influence skin diseases.

53 apparently to repel ectoparasites and treat skin diseases.

54 shows therapeutic potential for inflammatory skin diseases.

55 tes of global morbidity and mortality due to skin diseases.

56 arch, including the study of immune-mediated skin diseases.

57 es show tantalizing promise for treatment of skin diseases.

58 en exploited therapeutically in inflammatory skin diseases.

59 mates of morbidity and mortality metrics for skin diseases.

60 utations in K1/K10 are associated with human skin diseases.

61 o a broad range of allergic and inflammatory skin diseases.

62 ial target for the treatment of inflammatory skin diseases.

63 potential therapeutic target in inflammatory skin diseases.

64 pment of therapeutics to target inflammatory skin diseases.

65 either deafness or deafness associated with skin diseases.

66 on of which might promote the development of skin diseases.

67 contributes to the pathogenesis of fibrotic skin diseases.

68 utation databases in patients with heritable skin diseases.

69 can be targeted toward inflammation-related skin diseases.

70 ghlight an emerging role for Cx43 in genetic skin diseases.

71 phigoid are autoantibody-mediated blistering skin diseases.

72 atological services to patients with chronic skin diseases.

73 JunB, in addition to molecular signatures of skin diseases.

74 stitute of Arthritis and Musculoskeletal and Skin Diseases.

75 pathophysiology and severity of inflammatory skin diseases.

76 ution of inflammation in neutrophil-mediated skin diseases.

77 e therapeutic potential against inflammatory skin diseases.

78 rier that is often disrupted in inflammatory skin diseases.

79 pical delivery of siRNA for treating genetic skin diseases.

80 anese patients with pruritus associated with skin diseases.

81 the skin, promoting or exacerbating various skin diseases.

82 wide range of highly prevalent inflammatory skin diseases.

83 tiates it from other inflammatory/autoimmune skin diseases.

84 6% for viral skin diseases, 0.15% for fungal skin diseases, 0.07% for scabies, 0.06% for malignant sk

85 riasis, 0.19% for urticaria, 0.16% for viral skin diseases, 0.15% for fungal skin diseases, 0.07% for

86 n: (1) oral mucosal disease and erythematous skin disease, (2) salivary gland dysfunction and lacrima

87 The growing diversity of heritable skin diseases, a practical challenge to clinicians and d

88 n proposed to contribute to the common human skin disease acne vulgaris.

89 Integration may advance the control of skin disease across a range of domains, including mappin

90 Skin disease activity was determined using the Cutaneous

91 VII collagen autoantibodies, which mirrored skin disease activity, support a potential role in their

92 sk factors of the 2 most common inflammatory skin diseases, AD and PSO.

93 Inflammatory skin disease affected 24.5%, and was most common in blac

94 Psoriasis is a chronic inflammatory skin disease affecting 2-3% of the world population and

95 Psoriasis is a chronic inflammatory skin disease affecting 2.5-6 million patients in the Uni

96 pic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of a

97 Atopic dermatitis (AD) is a common skin disease affecting up to 20% of the global populatio

98 one of the most common chronic inflammatory skin diseases, affecting 3% of the world's population, a

99 n of IL-23 or IL-17A improves psoriasis-like skin disease and also improves cardiovascular disease in

100 se severe morbidities such as elephantiasis, skin disease and blindness, presenting a major public he

101 have a shorter elapsed time between onset of skin disease and BP diagnosis and that patients with pre

102 esults identify a major additional burden of skin disease and have important clinical implications.

103 Dermatitis (AD) is a T cell-mediated chronic skin disease and is associated with altered skin barrier

104 ophan metabolism enzyme KYNU in inflammatory skin disease and its potential contribution to general h

105 ify MPO as a genetic determinant of pustular skin disease and neutrophil abundance.

106 The pathogenic link between skin disease and systemic exacerbations in SLE remains e

107 ovide a biological measure for the extent of skin disease and that could be combined into a longitudi

108 of innate lymphocyte biology with a focus on skin disease and the roles of commensal and pathogen res

109 phocytic infiltrates in chronic inflammatory skin diseases and cutaneous malignancies including melan

110 ther connexins in keratinocytes will lead to skin diseases and hearing loss, whereas mutants having r

111 plicated in the pathogenesis of inflammatory skin diseases and in limiting human papillomavirus repli

112 K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratifi

113 be targeted therapeutically in inflammatory skin diseases and lymphoma.

114 tial fibroblast states in inflammatory human skin diseases and relate these states to perivascular ly

115 -blooded animals and have been implicated in skin diseases and systemic disorders, including Crohn's

116 The high prevalence of skin diseases and their visible symptoms result in major

117 emerging as an important clinical target for skin disease, and bermekimab may represent a new therape

118 these approaches have been extended towards skin disease, and their future directions.

119 stitute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging.

120 empathetic about the emotional difficulty of skin disease; and cognizant of cost.

121 Drug screening studies for inflammatory skin diseases are currently performed using model system

122 medical sector and clinical trials to treat skin diseases are underway.

123 and a CCR2 inhibitor reduced the severity of skin disease as well as dermal cellularity.

124 Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response.

125 Atopic Dermatitis is an inflammatory skin disease associated with broad defects in skin barri

126 Psoriasis, a chronic inflammatory skin disease associated with increased susceptibility to

127 Psoriasis is an inflammatory skin disease associated with itch, which is a troublesom

128 ion of cis-UCA may be a potential target for skin diseases associated with IgE-mediated mast cell deg

129 lem in children with the common inflammatory skin disease atopic dermatitis (AD).

130 une activation in patients with inflammatory skin diseases (atopic dermatitis [AD] and alopecia areat

131 Although AD and PSO are both inflammatory skin diseases, both show a distinct genetic profile.

132 erans, is the central virulent factor in the skin disease Buruli ulcer.

133 irectional network that can reinforce atopic skin disease but can also be ameliorated by targeted the

134 (AD) is the most common chronic inflammatory skin disease, but its complex pathogenesis is only insuf

135 ith descriptions of obtaining photographs of skin disease, but universal imaging standards have not b

136 e potential to reveal functional triggers of skin diseases, but issues of cost, robustness and sampli

137 ys a key role in the pathogenesis of several skin diseases, but its role in cellulitis remains unknow

138 o demonstrate how pathogenic mutations cause skin disease by altering filament assembly, we additiona

139 patients, six had 90% or more improvement in skin disease by modified Severity Weighted Assessment To

140 epidermolysis bullosa (RDEB), a rare genetic skin disease, carry mutations in the COL7A1 gene that co

141 Psoriasis vulgaris is an inflammatory skin disease caused by hyperactivated T cells regulated

142 epidermolysis bullosa (DEB) is a blistering skin disease caused by mutations in the gene COL7A1 enco

143 Fogo selvagem (FS) is a blistering skin disease caused by pathogenic IgG4 autoantibodies to

144 chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and envi

145 (AD) is a paradigmatic chronic inflammatory skin disease characterized by a complex pathophysiology

146 Psoriasis is a common inflammatory skin disease characterized by aberrant inflammation and

147 ic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barr

148 Generalized pustular psoriasis is a severe skin disease characterized by epidermal hyperplasia, neu

149 matitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening.

150 titis (AD) is a common, chronic inflammatory skin disease characterized by impaired barrier function,

151 Atopic dermatitis is a chronic inflammatory skin disease characterized by infiltration of eosinophil

152 Atopic dermatitis (AD) is an inflammatory skin disease characterized by infiltration of skin homin

153 Psoriasis is a frequent, inflammatory skin disease characterized by keratinocyte hyperprolifer

154 Rosacea is a chronic skin disease characterized by photosensitivity, abnormal

155 Atopic dermatitis is a chronic inflammatory skin disease characterized by pruritic skin lesions.

156 Chronic urticaria (CU) is a frequent skin disease characterized by relapsing appearance of pr

157 aneous urticaria (CSU) is a mast cell-driven skin disease characterized by the recurrence of transien

158 Psoriasis is a chronic inflammatory skin disease characterized mainly by epidermal hyperplas

159 (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and s

160 Skin disease data were extracted from more than 4000 sou

161 natures may distinguish between inflammatory skin diseases despite similar epidermal barrier disrupti

162 Although IL-22 deficiency did not affect skin disease development, IL-22 deficiency aggravated th

163 however, raise concerns about the quality of skin disease diagnosis and treatment provided by many DT

164 Clinical skin disease dramatically and rapidly decreased (P < 0.0

165 We aimed to ascertain the burden of skin disease encountered in OTRoC by prospectively colle

166 more than half of cases of the pre-malignant skin disease epidermodysplasia verruciformis (EV).

167 Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases o

168 e autosomal disease, characterized by severe skin disease, hair shaft defects, atopic diathesis, and

169 e used to test whether genetic risk for this skin disease has a causal effect on BMI.

170 of psychological disorders to the burden of skin disease has been poorly explored, and this is a lar

171 tment of skin conditions (alopecia, allergic skin diseases, hyperpigmentation, psoriasis, skin cancer

172 nding of this still underinvestigated severe skin disease in a European and largely white study popul

173 ons following the emergence of an ulcerative skin disease in August 2017, when estimated disease prev

174 matitis (AD) is the most common inflammatory skin disease in children, with 30% of all those diagnose

175 The severe, progressive skin disease in EKVP subjects with GJA1 mutations is dis

176 skin inflammation, we used imiquimod-induced skin disease in rodents and showed that rats with geneti

177 keratosis is the most frequent premalignant skin disease in the white population.

178 Psoriasis is an inflammatory, IL-17-driven skin disease in which autoantigen-induced CD8(+) T cells

179 derstand the pathophysiology of inflammatory skin diseases in a human-relevant and patient-specific c

180 stitute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, MD, on March 22-23, 2018.

181 involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is assoc

182 lement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, an

183 Many patients with limited skin disease, including genital psoriasis and psoriatic

184 potential novel treatments for inflammatory skin diseases, including atopic dermatitis (AD).

185 rget for the treatment of CD8 T cell-related skin diseases, including CHS and GVHD.

186 ype that is the hallmark of a broad range of skin diseases, including ichthyosis, atopic dermatitis,

187 ferentiation genes that are altered in human skin diseases, including keratins 1 and 10, filaggrin, a

188 idermal development may lead to a variety of skin diseases, including melanoma.

189 le coexpression module activated in multiple skin diseases, including psoriasis.

190 nd its role in development and treatments of skin diseases, including wound healing.

191 n cell-type associated eQTLs colocalize with skin diseases, indicating that variants which influence

192 These mice displayed slower onset skin disease initially, but then worsened over time, sug

193 e theme of the meeting was "Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disea

194 stinct therapeutic approach for inflammatory skin diseases involving dysregulated IL-36 signaling, su

195 signaling changes may underlie or exacerbate skin disease is limited.

196 Currently, diagnosis of skin diseases is based primarily on the visual pattern r

197 t ulcerative dermatitis known as "freshwater skin disease" is an emerging clinical and pathological p

198 s (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte di

199 h acne is the most common human inflammatory skin disease, its pathogenic mechanisms remain incomplet

200 mmatory responses, dietary manipulation, and skin diseases lacking biomarkers and therapeutic targets

201 stone deacetylase (HDAC) inhibitors to treat skin diseases led us to investigate HDAC's role in the r

202 ibroblasts, we demonstrate that in the human skin disease lichen simplex chronicus, WNT5a and KRT9 ar

203 VB irradiation (290-320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and

204 t could potentially be used as a therapy for skin diseases like psoriasis, where AQP3 is abnormally e

205 trophic epidermolysis bullosa is a heritable skin disease manifesting with sub-lamina densa blisterin

206 Vitiligo is an autoimmune skin disease mediated by autoreactive CD8(+) T cells tha

207 Final validation into a skin disease model showed that impaired autophagy contri

208 Buruli ulcer (BU) is a necrotizing skin disease most prevalent among West African children.

209 stitute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, Damon Runyon C

210 va (HS) is a chronic, recurrent inflammatory skin disease of the apocrine sweat glands.

211 Psoriasis is a chronic inflammatory skin disease of unknown etiology.

212 Rosacea is a common chronic inflammatory skin disease of unknown etiology.

213 nhibitory ligands as an approach to treating skin diseases of inflammatory etiology.

214 stitute of Arthritis and Musculoskeletal and Skin Diseases of the NIH.

215 on of cutaneous plasma cells in inflammatory skin diseases or cutaneous plasma cell malignancies.

216 Tissue samples of patients with eosinophilic skin diseases or eosinophilic esophagitis were used for

217 has not been explored in patients with these skin diseases or in general human immunology.

218 lated to the acquisition or use of images of skin disease (or related conditions).

219 nges in diffuse cutaneous systemic sclerosis skin disease over time.

220 mmasome as an important initiating signal in skin disease pathogenesis and provide novel insights abo

221 equired for autoreactive CD4 T cell-mediated skin disease pathogenesis and that the NLRP3-dependent i

222 The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies a

223 Patients with the blistering skin disease pemphigus vulgaris (PV), which is caused by

224 y aspects of the major autoimmune blistering skin diseases, pemphigus and bullous pemphigoid.

225 al differentiation is a main feature of many skin diseases, pharmacological agents targeting AHR sign

226 Skin disease preceded development of PsA, including enth

227 topic dermatitis (AD) is a chronic relapsing skin disease prevalent in 1% to 3% of adults in Western

228 t risk for the development of the autoimmune skin disease psoriasis.

229 is strongly associated with the inflammatory skin disease psoriasis.

230 in the light dependent treatment of certain skin diseases (PUVA therapy).

231 d to develop predictive models that identify skin diseases, ranging from melanoma to psoriasis, based

232 to better understand some of the most common skin diseases, ranging from psoriasis to alopecia areata

233 ify new therapeutic targets for inflammatory skin diseases related to epidermal barrier defects.

234 nd which immune pathways are associated with skin disease remained open questions.

235 scovery of pathogenic mutations in inherited skin diseases represents one of the major landmarks of l

236 anced MRI in pregnancy, connective tissue or skin disease resembling nephrogenic systemic fibrosis (N

237 d of the Brigham and Women's Hospital, Human Skin Disease Resource Center, Harvard Medical School (Bo

238 me (KS) is an autosomal recessive blistering skin disease resulting from pathogenic mutations in FERM

239 onths post-ECP were compared with changes in skin disease scores or global organ involvement, or the

240 nvestigate the association between change in skin disease severity and change in vascular inflammatio

241 Improvement in psoriasis skin disease severity was associated with improvement in

242 n those who had higher than 75% reduction in skin disease severity.

243 In psoriasis, an IL-17-mediated inflammatory skin disease, skin lesions resolve with therapy, but oft

244 r (BDNF) play a role in chronic inflammatory skin diseases such as atopic dermatitis (AD).

245 nd to be upregulated in chronic inflammatory skin diseases such as atopic dermatitis and psoriasis.

246 ulation can trigger and promote inflammatory skin diseases such as atopic dermatitis and psoriasis.

247 lts suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a d

248 Skin diseases such as lupus, cancer, psoriasis, and hype

249 ht to predispose individuals to inflammatory skin diseases such as psoriasis through the development

250 ate the role of this pathway in inflammatory skin diseases such as psoriasis.

251 he pathogenesis of chronic, autoinflammatory skin diseases such as psoriasis.

252 or suppression of IL-33-induced inflammation skin diseases such as psoriasis.

253 wever, in patients with chronic inflammatory skin disease, such as psoriasis and atopic dermatitis (A

254 Allergic skin diseases, such as atopic dermatitis, are clinically

255 can lead to the development of inflammatory skin diseases, such as psoriasis, a common skin disorder

256 to the pathogenesis of chronic inflammatory skin diseases, such as psoriasis.

257 Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population,

258 Psoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide.

259 Psoriasis is a chronic inflammatory skin disease that develops under the influence of the IL

260 Psoriasis is a common inflammatory skin disease that has been reported to be associated wit

261 Psoriasis is a chronic inflammatory skin disease that is associated with increased vascular

262 Psoriasis is an inflammatory skin disease that is associated with multiple comorbidit

263 itis is a chronic T cell-driven inflammatory skin disease that is caused by repeated exposure to cont

264 ) is a highly prevalent chronic inflammatory skin disease that is known to be, at least in part, gene

265 Psoriasis is a frequent inflammatory skin disease that is mainly mediated by IL-23, IL-1beta,

266 enhanced xanthomatosis in apoe(-/-) mice, a skin disease that is not associated with diet-induced at

267 opic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a c

268 e (Ptpn6(spin) mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in h

269 atitis (AD) is a common chronic inflammatory skin disease that results in significant morbidity.

270 and mechanistic underpinning of inflammatory skin diseases that have been revealed in recent years.

271 sights into the pathogenesis of inflammatory skin diseases that have thus far evaded understanding by

272 the C-82-treated skin of biomarkers of local skin disease, THBS1 and COMP.

273 stitute of Arthritis and Musculoskeletal and Skin Diseases; the National Institute of Allergy and Inf

274 s regulating the development of inflammatory skin diseases, this review aimed to discern the overlap

275 ptional landscape of five human inflammatory skin diseases, thus providing a resource for the further

276 G mutations also influence pregnancy-related skin disease; thus, women with FLG mutations had an incr

277 For the rare skin disease trichodysplasia spinulosa, we show that man

278 c dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving I

279 s among the most common chronic inflammatory skin diseases, usually occurring early in life, and ofte

280 Individual skin diseases varied in size from 0.38% of total burden

281 all other genus serotypes A, SAT2 and Lumpy skin disease virus (LSDV), as well as, the inactivated s

282 both AD and CD, and 10 HC with no history of skin disease was analysed using high-throughput proteomi

283 Clinical skin disease was assessed using the modified Rodnan skin

284 icacy and safety of robed-siRNA for treating skin disease was confirmed by its ability to limit break

285 Excluding mortality, skin diseases were the fourth leading cause of disabilit

286 Psoriasis is a chronic inflammatory skin disease with a clear genetic contribution, characte

287 dermatitis (AD) is a prevalent inflammatory skin disease with a complex pathogenesis involving immun

288 tis (AD) is a complex, chronic, inflammatory skin disease with a diverse clinical presentation.

289 Hidradenitis suppurativa is a chronic skin disease with a significant genetic component and pr

290 Psoriasis is an immune-mediated inflammatory skin disease with a strong genetic background in which a

291 ris is a common T cell-mediated inflammatory skin disease with a suspected autoimmune pathogenesis.

292 ppurativa is a painful, chronic inflammatory skin disease with few options for effective treatment.

293 Acne is a multifactorial inflammatory skin disease with high prevalence.

294 Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalence, is closely asso

295 ular rosacea (PPR) is a chronic inflammatory skin disease with limited treatment options.

296 Prurigo nodularis is a chronic pruritic skin disease with multiple nodular skin lesions.

297 ic dermatitis (AD) is a chronic inflammatory skin disease with periods of flares and remission.

298 Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration a

299 To measure the burden of skin diseases worldwide.

300 to the upper dermis in several inflammatory skin diseases, yet in systemic sclerosis, it can occur i