ライフサイエンスコーパス: skin disorder

1 skin syndrome (PSS), an autosomal recessive skin disorder.

2 ncies and in psoriasis, a hyperproliferative skin disorder.

3 isoform 1), causes Hailey-Hailey disease, a skin disorder.

4 s for this inherited, currently intractable, skin disorder.

5 a paradigm for treating a localized dominant skin disorder.

6 opic dermatitis (AD), a chronic inflammatory skin disorder.

7 rstanding of the pathobiology of this common skin disorder.

8 D) is a highly pruritic chronic inflammatory skin disorder.

9 Atopic dermatitis (AD) is a common skin disorder.

10 the mechanisms of skin aging and age-related skin disorders.

11 offer a potential tool for the treatment of skin disorders.

12 r loss, wound healing and other degenerative skin disorders.

13 therapeutic strategies against aging-related skin disorders.

14 eveloping treatments for hair loss and other skin disorders.

15 ial asthma, inflammatory bowel diseases, and skin disorders.

16 inflammation, and dominant negative genetic skin disorders.

17 understanding, particularly for inflammatory skin disorders.

18 sk of congenital malformations, alopecia, or skin disorders.

19 egrity may underlie or contribute to various skin disorders.

20 ytokine that has pathogenic roles in various skin disorders.

21 ess observed in PC and related keratin-based skin disorders.

22 s common to wound repair and many neoplastic skin disorders.

23 of a novel therapeutic approach for treating skin disorders.

24 icta, a close relative implicated in similar skin disorders.

25 sis and lamellar ichthyosis, two devastating skin disorders.

26 ectors, may be effective agents for treating skin disorders.

27 for wounds, hair loss and other degenerative skin disorders.

28 el targets for the treatment of inflammatory skin disorders.

29 n may positively affect the course of common skin disorders.

30 icine in the development of formulations for skin disorders.

31 erapeutic benefit in some human inflammatory skin disorders.

32 ired for the development of Th1 inflammatory skin disorders.

33 novel therapy against constantly increasing skin disorders.

34 s to the pathogenesis of psoriasis and other skin disorders.

35 r a variety of cutaneous neoplasms and other skin disorders.

36 es various pathologies including cancers and skin disorders.

37 reatment of psoriasis and other inflammatory skin disorders.

38 regimens for the management of inflammatory skin disorders.

39 dermal gene expression in hyperproliferative skin disorders.

40 al approach to the treatment of inflammatory skin disorders.

41 treatment of skin cancer and possibly other skin disorders.

42 se compounds as pharmaceutics for cancer and skin disorders.

43 rovided valuable insights into human genetic skin disorders.

44 unexplained gastrointestinal, neurologic, or skin disorders.

45 y activity in a number of chronic autoimmune skin disorders.

46 utic implications for the treatment of other skin disorders.

47 es for the topical treatment of inflammatory skin disorders.

48 is and other hyperproliferative inflammatory skin disorders.

49 on by TREX1 may contribute to photosensitive skin disorders.

50 gy metabolism have been reported in multiple skin disorders.

51 idermal differentiation characterize various skin disorders.

52 to predict novel treatments for a number of skin disorders.

53 d its deficiency causes immunodeficiency and skin disorders.

54 en exploring NRF2 as a therapeutic target in skin disorders.

55 , a validated quality of life instrument for skin disorders.

56 involvement of EMILINs in fibrillin-related skin disorders.

57 a role in inflammation, pain sensation, and skin disorders.

58 nsdermal drug carriers to treat a variety of skin disorders.

59 ytokine tightly associated with inflammatory skin disorders.

60 reating neutrophilia-associated inflammatory skin disorders.

61 f homeostasis, skin injury, and inflammatory skin disorders.

62 spiratory (15%), gastrointestinal (12%), and skin disorders (10%); polyneuropathy was infrequent (1%)

63 rash (88.6%), dry skin (34.3%), asthenia and skin disorders (31.4%), mucositis/stomatitis (25.7%), fe

64 The most frequent adverse events were skin disorders (35 patients [63%] in the lenalidomide gr

65 is is a highly pruritic chronic inflammatory skin disorder affecting 10-20% of children worldwide.

66 y skin diseases, such as psoriasis, a common skin disorder affecting approximately 2% of the US popul

67 Acne vulgaris is the most common skin disorder affecting millions of people worldwide and

68 Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreate

69 23; 95% CI, 1.45-3.46; P < .001) and bullous skin disorders (AHR, 4.88; 95% CI, 2.47-9.66; P < .001)

70 Acne vulgaris is a common skin disorder among children and young adults that carri

71 c dermatitis is the most common inflammatory skin disorder and characterized by abnormalities in both

72 epidermis, results in a characteristic scaly skin disorder and excessive epidermal water loss.

73 , plakophilin 1 has been linked to a genetic skin disorder and shown to play important roles in desmo

74 member with a putative role in inflammatory skin disorders and a complex biology.

75 Data on S. aureus-associated skin disorders and atopy in PIDs were limited.

76 nce of Staphylococcus (S.) aureus-associated skin disorders and atopy was reviewed, as these are the

77 ly, retinoids are effective in treating many skin disorders and cancers.

78 idermal adhesion is a hallmark of blistering skin disorders and chronic wounds, implicating integrins

79 pproach to understanding the pathogenesis of skin disorders and for developing therapeutic strategies

80 oding connexin 26 (Cx26) have been linked to skin disorders and genetic deafness.

81 s important roles in preventing inflammatory skin disorders and improving wound healing.

82 s the diagnosis and treatment of sun-related skin disorders and recommendations for reducing photodam

83 The most common indications were skin disorders and respiratory tract infections.

84 in the Cx26-encoding GJB2 gene lead to many skin disorders and sensorineural hearing loss.

85 We analyze genetic skin disorders and suggest a manually designed set of el

86 rovide a systematically obtained overview of skin disorders and their prevalence in PIDs.

87 in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions.

88 ession of ErbB ligands in hyperproliferative skin disorders and wound healing.

89 ct dermatitis (ACD), a pruritic inflammatory skin disorder, and both mast cell number and PAMP1-20 co

90 seases, metabolic syndrome, renal disorders, skin disorders, and cancer.

91 aracterized as mild and included infections, skin disorders, and dizziness.

92 ople were for trauma, respiratory disorders, skin disorders, and infectious diseases (excluding the a

93 iated with barrier impairment and consequent skin disorders, and it is therefore important to monitor

94 trophy, myopathy, neuropathy, progeria, bone/skin disorders, and overlap syndromes.

95 Examples include hemophilia A, many skin disorders, and several cancers such as retinoblasto

96 Pustular skin disorders are a category of difficult-to-treat and

97 Skin disorders are also common clinical features in PIDs

98 Many skin disorders are associated with increased numbers of

99 Skin disorders are common in the general population, and

100 In conclusion, skin disorders are prominent features in PIDs.

101 que-type psoriasis is a chronic inflammatory skin disorder associated with chemoattractants driving n

102 s autosomal recessively inherited blistering skin disorder associated with fragility at the dermal-ep

103 ic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous presentation

104 s commonly used to treat psoriasis, a common skin disorder associated with rapid proliferation of cel

105 Psoriasis is an immune-mediated skin disorder associated with severe systemic comorbidit

106 a chronic, inflammatory, intensely pruritic skin disorder associated with significant patient burden

107 nts could be beneficial for the treatment of skin disorders associated with hyperproliferation and/or

108 However, the LTR/IFD can also be seen in skin disorders associated with systemic illnesses (lupus

109 onic spontaneous urticaria (CSU) is a common skin disorder, but its clinical course reported so far i

110 Psoriasis is a common chronic skin disorder, but the mechanisms involved in the resolu

111 common immune-mediated chronic inflammatory skin disorder, but the mechanisms of pathogenesis are st

112 observed in patients with various inherited skin disorders, but not in connexin-related disease.

113 Despite clear exacerbation of several skin disorders by stress, the effect of psychologic or e

114 Acantholytic skin disorders, by definition, compromise intercellular

115 ly available microarray data from a range of skin disorders can elucidate disease pathways, generate

116 phic epidermolysis bullosa is a rare genetic skin disorder caused by COL7A1 sequence variations that

117 Darier disease (DD) is a rare genetic skin disorder caused by heterozygous variants in the ATP

118 of harlequin ichthyosis (HI), a devastating skin disorder caused by loss-of-function mutations in th

119 olysis bullosa (RDEB) is a complex inherited skin disorder caused by loss-of-function mutations in th

120 olysis bullosa simplex (EBS) is an inherited skin disorder caused by mutations in keratins K5 (kerati

121 is bullosa (RDEB) is an inherited blistering skin disorder caused by mutations in the COL7A1 gene-enc

122 However, the severity and type of the skin disorders caused by Cx26 mutations are heterogeneou

123 cause of ichthyosis vulgaris (IV), a common skin disorder characterised by dry skin, palmar hyperlin

124 Atopic dermatitis is a common inflammatory skin disorder characterised by recurrent eczematous lesi

125 pic dermatitis (AD) is a common inflammatory skin disorder characterized by a heterogeneous and fluct

126 -Hailey disease (HHD), an autosomal dominant skin disorder characterized by abnormal keratinocyte adh

127 underlie harlequin ichthyosis, a devastating skin disorder characterized by abnormal lamellar bodies

128 ARCI) is a heterogeneous group of hereditary skin disorder characterized by an aberrant cornification

129 ton syndrome is a severe autosomal recessive skin disorder characterized by congenital erythroderma,

130 ic dermatitis (AD) is a chronic inflammatory skin disorder characterized by defective skin barrier an

131 amellar ichthyosis is a congenital recessive skin disorder characterized by generalized scaling and h

132 Psoriasis is a common skin disorder characterized by hyperproliferation and ab

133 Psoriasis is a skin disorder characterized by hyperproliferation of epi

134 disease is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between

135 Darier disease (DD) is an autosomal-dominant skin disorder characterized by loss of adhesion between

136 se (DD) is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between

137 Vitiligo is a common chronic skin disorder characterized by loss of epidermal melanoc

138 erythema (KWE) is a rare autosomal-dominant skin disorder characterized by recurrent episodes of pal

139 us urticaria (CSU) is a common, debilitating skin disorder characterized by recurring episodes of rai

140 iley-Hailey disease is an autosomal dominant skin disorder characterized by suprabasal cell separatio

141 Vitiligo, a skin disorder characterized by the spontaneous destructi

142 dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization wi

143 rier's disease (DD) is an autosomal dominant skin disorder characterized clinically by multiple kerat

144 , or acne inversa, is a chronic inflammatory skin disorder characterized clinically with acne-like le

145 ease (DD) is an inherited autosomal-dominant skin disorder characterized histologically by loss of ad

146 congenita (PC) is a rare autosomal dominant skin disorder characterized predominantly by nail dystro

147 ing could comprise a novel approach to treat skin disorders characterized by abnormalities in differe

148 ormalities in Ctip2 could therefore underlie skin disorders characterized by an aberrant epidermal pe

149 refers to a heterogeneous group of inherited skin disorders characterized by blister formation within

150 stular psoriasis indicates a group of severe skin disorders characterized by eruptions of neutrophil-

151 g was specific and was not observed in other skin disorders characterized by erythema and abnormal co

152 atin genes can cause a number of inheritable skin disorders characterized by intraepidermal blisterin

153 LIMK1 is lost in psoriatic lesions and other skin disorders characterized by lack of cell compaction

154 disease is an autosomal dominantly inherited skin disorder, characterized by loss of adhesion between

155 ies in adults and children, across different skin disorders, correlating blood and skin phenotypes an

156 ce offers therapeutic potential for treating skin disorders, delivery hurdles have hampered clinical

157 d that is associated with deafness but has a skin disorder distinct from the KID syndrome mutations.

158 The blistering skin disorder epidermolysis bullosa simplex (EBS) result

159 should be considered in the pathogenesis of skin disorders exacerbated by stress.

160 nockout mice harboring mutations relevant to skin disorders, few organotypic mouse skin models are av

161 Psoriasis is a common inflammatory skin disorder for which multiple genetic susceptibility

162 original articles using the MID concept for skin disorders from inception to December 29, 2021.

163 r non-syndromic (W44S, R75W) or with various skin disorders (G59A, D66H, R75W).

164 nvestigate the molecular basis of 3 pustular skin disorders: generalized pustular psoriasis (GPP), pa

165 Transcriptomic changes in 3 pustular skin disorders, GPP, PPP, and AGEP, converged on neutrop

166 id, and parathyroid function; weight change; skin disorders; hair disorders; and teratogenicity.

167 ery of new genetic determinants of inherited skin disorders has been instrumental to the understandin

168 The discovery of genetic causes of inherited skin disorders has been pivotal to the understanding of

169 Genetic investigation of inherited skin disorders has informed the understanding of skin se

170 st, integrative biological analysis of human skin disorders has revealed unexpected functions for ele

171 igation of genetic determinants of Mendelian skin disorders has substantially advanced understanding

172 Rosacea, a common facial skin disorder, has a poorly understood pathogenesis in w

173 dentified as the cause of the common genetic skin disorder ichthyosis vulgaris (IV), the most prevale

174 utations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant ri

175 cular basis of the filaggrin-deficient human skin disorder ichthyosis vulgaris.

176 Atopic dermatitis (AD) is a common chronic skin disorder in children.

177 nce their absence gives rise to a blistering skin disorder in neonatal epidermis, and hemorrhaging wi

178 Netherton disease is a rare recessive skin disorder in which atopy is a universal accompanimen

179 Hidradenitis suppurativa (HS) is a common skin disorder in which excessive inflammation is believe

180 hyosis vulgaris (IV) is an inherited scaling skin disorder in which expression of profilaggrin is red

181 of desmo-plakin and also the first inherited skin disorder in which haploinsufficiency of a structura

182 Chronic skin disorders in children frequently are visible and ca

183 to epidermal barrier dysfunction in allergic skin disorders in mice and humans.

184 Skin disorders in OTRs of color (OTRoC) have rarely been

185 l human studies that address the presence of skin disorders in PIDs were selected.

186 ) is a heterogeneous group of rare inherited skin disorders in which defects in cell adhesion compone

187 such events are particularly evident in some skin disorders in which normal clones develop on a backg

188 at may result in the development of fibrotic skin disorders in which reduced fibrinolysis is a featur

189 ing the molecular mechanisms of inflammatory skin disorders in which TGFbeta1 is overexpressed.

190 skin mycobiome and is associated with common skin disorders including atopic eczema (AE)/dermatitis.

191 involved in the pathogenesis of a number of skin disorders including photosensitivity diseases and s

192 nt of several ayurvedic preparations against skin disorders including psoriasis and herpes, though no

193 of LXR as a potential therapeutic target for skin disorders including skin aging, psoriasis, and atop

194 potential for the treatment of Th2-mediated skin disorders, including atopic dermatitis.

195 For some genetic skin disorders, including neurofibromatosis, tuberous sc

196 Although many skin disorders, including psoriasis and atopic dermatiti

197 isease Area Index (PDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), and Pemphigus Vul

198 ex (R = 0.42) and Autoimmune Bullous Disease Skin Disorder Intensity Score (R = 0.48).

199 recently described ABSIS (autoimmune bullous skin disorder intensity score) instrument.

200 ase Area Index (PDAI) and Autoimmune Bullous Skin Disorder Intensity-Score (ABSIS) scores have been p

201 al, CTIP1-regulated avenues for treatment of skin disorders involving EBP defects.

202 sequences for the expression of inflammatory skin disorders involving Th17 cells.

203 Psoriasis, a common skin disorder, is widely regarded to be multifactorial i

204 group of autosomal dominant human blistering skin disorders it was discovered that defects in the ker

205 lantar keratoderma, a rare dominant-negative skin disorder, its functional significance is poorly und

206 neated in the autosomal recessive blistering skin disorder, junctional epidermolysis bullosa, particu

207 d individuals with a severe autoinflammatory skin disorder known as pustular psoriasis.

208 Ichthyoses are a group of rare skin disorders lacking effective treatments.

209 s produce syndromic deafness associated with skin disorders, like the Keratitis-Ichthyosis-Deafness s

210 s and is a potential target for treatment of skin disorders linked to abnormal sebaceous gland functi

211 In every pediatric practice, skin disorders make up a large percentage of outpatient

212 phenotype provides a model for inflammatory skin disorders, may have general relevance to polygenic

213 e most effective treatments for inflammatory skin disorders might concomitantly suppress the immune r

214 lammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carci

215 che (n = 87 [52.4%]), anemia (n = 83 [50%]), skin disorders (n = 81 [48.8%]), back pain (n = 54 [32.5

216 Allergic reactions and other skin disorders occurred significantly more after MM trea

217 nant condition characterized by the furrowed skin disorder of cutis gyrata, acanthosis nigricans, cra

218 Keratosis pilaris (KP) is a common skin disorder of follicular prominence and erythema that

219 asis (OMIM 177900) is a chronic inflammatory skin disorder of unknown pathogenesis affecting approxim

220 Single gene recessive genetic skin disorders offer attractive prototypes for the devel

221 c epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers.

222 V3 result in the development of a congenital skin disorder, Olmsted syndrome.

223 ir loss, or alopecia, may occur as a primary skin disorder or because of an underlying health problem

224 f patients, most often because of cytopenia, skin disorders, or gastrointestinal reactions.

225 mutation responsible for the rare monogenic skin disorder pachyonychia congenita (PC), we demonstrat

226 ed in a phase 1b clinical trial for the rare skin disorder, pachyonychia congenita (PC).

227 ong chain fatty acid uptake may underlie the skin disorder phenotype of null mice.

228 Among children with chronic skin disorders, predominantly acne, atopic dermatitis, a

229 The chronic and highly prevalent skin disorder psoriasis vulgaris is characterized by a h

230 e responses, as observed in the common human skin disorders psoriasis and atopic dermatitis.

231 human p34, which is mutated in the inherited skin disorder punctate palmoplantar keratoderma type I.

232 atin genes as the cause of several inherited skin disorders raised the possibility that molecular-bas

233 rited human diseases, such as the blistering skin disorder recessive dystrophic epidermolysis bullosa

234 Current therapeutic strategies for genetic skin disorders rely on the complex process of grafting g

235 of stem cells in the pathogenesis of mosaic skin disorders remains unclear.

236 l reflux disease and blistering/desquamating skin disorder respectively in female duplication carrier

237 Inflammatory skin disorders result in significant epidermal changes,

238 suggested that a number of different LTR/IFD skin disorders share a common inflammatory signaling pat

239 rmatitis (nACD) remains a major occupational skin disorder, significantly impacting the quality of li

240 from a kindred with the dominantly inherited skin disorder, striate palmoplantar keratoderma.

241 ance of this finding in mediating androgenic skin disorders such as acne, hirsutism, or androgenetic

242 Common inflammatory skin disorders such as atopic dermatitis and psoriasis e

243 n of TLR2 was not seen in other inflammatory skin disorders such as atopic dermatitis or psoriasis.

244 ay be therapeutic in a range of inflammatory skin disorders such as psoriasis and AD.

245 In humans, inflammatory skin disorders such as psoriasis are associated with acc

246 can be highly beneficial in the treatment of skin disorders such as psoriasis.

247 may be a mechanism for hyperproliferation in skin disorders such as psoriasis.

248 and its function in modulating the course of skin disorders, such as AD, might result in novel therap

249 It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, pso

250 Certain skin disorders, such as contact dermatitis and chronic u

251 and cause syndromic deafness associated with skin disorders, such as keratitis-ichthyosis-deafness sy

252 at typically occur in human Th1 inflammatory skin disorders, such as psoriasis.

253 tis (AD) is a chronic relapsing inflammatory skin disorder that affects approximately 15% of children

254 Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the pop

255 s in mice and to Darier disease in humans, a skin disorder that also involves keratinocytes.

256 sive macular hypomelanosis (PMH) is a common skin disorder that causes hypopigmentation in a variety

257 genic systemic fibrosis (NSF) is a fibrosing skin disorder that develops in patients with kidney fail

258 e affected transgenic mice manifested with a skin disorder that fulfilled the clinical diagnostic cri

259 rpetiformis (DH) is an autoimmune blistering skin disorder that is associated with gluten sensitivity

260 rpetiformis (DH) is an autoimmune blistering skin disorder that is associated with intestinal gluten

261 lantar keratoderma) is an autosomal dominant skin disorder that is associated with the early onset of

262 splasia verruciformis (EV) is a rare genetic skin disorder that is characterized by the development o

263 Psoriasis is an inflammatory skin disorder that is inherited as a complex trait.

264 Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trai

265 D) is a highly prevalent, itchy inflammatory skin disorder that is thought to arise from a combinatio

266 ic dermatitis (AD) is a chronic inflammatory skin disorder that lacks ideal long-term treatment optio

267 ontaneous urticaria (CSU) is an inflammatory skin disorder that manifests with itchy wheals, angioede

268 Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin.

269 Vitiligo is an autoimmune skin disorder that reacts against melanocytes.

270 s in several different benign and neoplastic skin disorders that are characterized by a prominent ang

271 ine model of hyperproliferative inflammatory skin disorders that is induced by transfer of minor hist

272 Although psoriasis is a hyperproliferative skin disorder, the possible role of amino acid transport

273 overy about the mutations underlying genetic skin disorders, there have been few therapeutic advances

274 orm the clinical management and treatment of skin disorders through diagnostic tests to stratify pati

275 Association of congenital skin disorders to mutations in different connexins has u

276 d genes and increase the categories of human skin disorders to which parallels could be drawn.

277 Mg(2+) deficiency causes skin disorders under certain pathological conditions suc

278 CD1d in normal skin, psoriasis, and related skin disorders, using a panel of CD1d-specific mAbs.

279 e pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression.

280 This skin disorder was diminished when memory T cells were co

281 An overview of associated PIDs per skin disorder was generated.

282 analysis of normal skin as well as specific skin disorders was carried out.

283 A broad spectrum of skin disorders was reported in 30 PIDs, mostly in single

284 al pain, Crohn's disease-related anemia, and skin disorders was similar in both groups.

285 Vitiligo, an autoimmune skin disorder, was evaluated in 49 metastatic melanoma p

286 Through clustering of PIDs per skin disorder, we provide a support tool to use in clini

287 rom normal human skin and hyperproliferative skin disorders were examined by immunohistochemistry and

288 Rosacea is a common chronic inflammatory skin disorder where upregulation of matrix metalloprotei

289 Atopic dermatitis (AD) is a common chronic skin disorder, which may persist into adulthood; however

290 gs in normal human skin and in parakeratotic skin disorders, which exhibit nuclear staining of granul

291 0 group, and 11/25 in the placebo group) and skin disorders, which were seen in 50/120 patients (26/6

292 r keratosis (NPPK) is an autosomal recessive skin disorder with a high, unmet medical need that is ca

293 ermatitis is a complex, chronic inflammatory skin disorder with a profound symptom burden, and substa

294 Psoriasis is an inflammatory skin disorder with aberrant regulation of keratinocytes

295 r type 6 (PTPN6) in a mouse that developed a skin disorder with clinical and histopathological featur

296 f Siemens (IBS) is a rare autosomal dominant skin disorder with clinical features similar to epidermo

297 Bullous pemphigoid is a blistering skin disorder with increased mortality.

298 Psoriasis is a chronic skin disorder with multifactorial aetiology.

299 Two common inflammatory skin disorders with impaired barrier, atopic dermatitis

300 in regeneration and the treatment of various skin disorders, yet research were rarely investigated ab