ライフサイエンスコーパス: skin pigmentation

1 of exposure, latitude, season, and degree of skin pigmentation.

2 oupled receptor involved in inflammation and skin pigmentation.

3 tor system participates in the regulation of skin pigmentation.

4 tor cells, and the treatment of disorders of skin pigmentation.

5 hort-term PPARgamma antagonization, restored skin pigmentation.

6 ht spectrum, was recently reported to induce skin pigmentation.

7 s of phenotypic differences in hair type and skin pigmentation.

8 finger, as it is the primary determinant of skin pigmentation.

9 ption factor (MITF)-independent mechanism of skin pigmentation.

10 to learn about the evolutionary genetics of skin pigmentation.

11 l validation of adaptive variants related to skin pigmentation.

12 eratinocytes is tightly regulated to warrant skin pigmentation.

13 ; however, there was no evidence of abnormal skin pigmentation.

14 imeter performance difficulties arising from skin pigmentation.

15 ntify a natural acidic formulation to reduce skin pigmentation.

16 opulations to discover new genes influencing skin pigmentation.

17 tion of this analog still led to significant skin pigmentation.

18 HERC2 that are significantly associated with skin pigmentation.

19 n regenerate mature melanocytes for hair and skin pigmentation.

20 as a melanocyte reservoir for both hair and skin pigmentation.

21 l processes including vision, olfaction, and skin pigmentation.

22 mbining different viable mutations affecting skin pigmentation.

23 p53-mediated upregulation of Kitl influences skin pigmentation.

24 nt has pleiotropic effects on eye, hair, and skin pigmentation.

25 attractive and distinct avenue of modulating skin pigmentation.

26 skin represents the key phenotypic event in skin pigmentation.

27 dvanced breast cancer among women with light skin pigmentation.

28 olymorphism associated strongly with lighter skin pigmentation (0.22 [0.21-0.23] s.d.; P = 2.8 x 10(-

29 ammals to respond to UVR by increasing their skin pigmentation, a protective process driven by melani

30 Season, latitude, time of day, skin pigmentation, aging, sunscreen use, and glass all i

31 g cells leads to the development of familial skin pigmentation alterations, reminiscent of those in p

32 None had abnormalities of skin pigmentation, although other skin conditions were r

33 ta confirm the association of rs1426654 with skin pigmentation among South Asians, consistent with pr

34 the MC1R, a melanocyte receptor involved in skin pigmentation and animal coat coloration.

35 RMT1) and clinically characterized by patchy skin pigmentation and atrophy.

36 that MC1R350 acts as a negative regulator of skin pigmentation and demonstrate for the first time tha

37 xtracardiac myxomas in the setting of spotty skin pigmentation and endocrinopathy.

38 the effects of serine protease inhibitors on skin pigmentation and found that the protease-activated

39 ed transcription factor expression can alter skin pigmentation and further confirm the central role o

40 hus strongly implicated in the regulation of skin pigmentation and inflammation.

41 inherited syndrome associated with abnormal skin pigmentation and multiple neoplasias, including PPN

42 w failure disorder characterized by abnormal skin pigmentation and nail dystrophy.

43 ined in modern cohorts with detailed data on skin pigmentation and other covariates.

44 a crucial process underlying maintenance of skin pigmentation and photoprotection against UV damage.

45 This disparity contributes to differences in skin pigmentation and photoprotection, but the control o

46 rm-specific expression is closely related to skin pigmentation and photoprotection.

47 Skin pigmentation and receipt of vasopressors were not a

48 Resulting mice exhibit abnormalities in skin pigmentation and reproductive tissue architecture,

49 es reflecting cutaneous vitamin D synthesis (skin pigmentation and season) were also strongly associa

50 e determinants of vitamin D status including skin pigmentation and season.

51 The risk attributes of skin pigmentation and some dietary factors in cancer can

52 i et al. explore a direct connection between skin pigmentation and susceptibility to angiogenic disea

53 l overlap in the genetic factors influencing skin pigmentation and tanning response.

54 Skin pigmentation and the development of photoadaptation

55 n identified that are involved in regulating skin pigmentation and these act during development, surv

56 report that PDK1 contributes functionally to skin pigmentation and to the development of melanomas ha

57 intensity, (4) BCVA, (5) VEP asymmetry, (6) skin pigmentation, and (7) hair pigmentation (of head ha

58 SH), and beta-endorphin in the regulation of skin pigmentation, and a role has been put forward for a

59 such as vitamin D supplementation, degree of skin pigmentation, and amount and intensity of sun expos

60 d by the triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia; Hoyeraal-Hreida

61 e individual, growth abnormalities, abnormal skin pigmentation, and/or thumb/radius malformations.

62 Among the 24 patients, skin pigmentation appeared after a median HCQ treatment

63 all of the genetic variation associated with skin pigmentation as opposed to just a small number of l

64 e quantify the impact of hair properties and skin pigmentation, as well as head size, sex and age, on

65 al leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow

66 e (DDD) is an autosomal-dominant disorder of skin pigmentation associated with mutations in keratin 5

67 skin by improving facial lines, wrinkles and skin pigmentation associated with photo-ageing.

68 l selection in ancient West Eurasians on 170 skin pigmentation-associated variants ascertained in the

69 Strongest association with skin pigmentation at 19p13 was observed for an Y182H mis

70 ctivated receptor 2 (PAR-2) is important for skin pigmentation because activation of keratinocyte PAR

71 delineate a regulatory role of IFN-gamma in skin pigmentation biology.

72 confounders [baseline 25(OH)D concentration, skin pigmentation, body mass index, compliance, etc], sp

73 nship between self-reported hearing loss and skin pigmentation by using hair color, skin tanning abil

74 populations, we show how the architecture of skin pigmentation can vary across humans subject to diff

75 e neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine

76 g to extreme sensitivity to sunlight-induced skin pigmentation changes and increased skin cancer risk

77 tivation did not engage the key regulator of skin pigmentation, cyclic AMP, showing a major differenc

78 s, epidermal melanocytes are responsible for skin pigmentation, defence against ultraviolet radiation

79 and dyschromatosis symmetrica hereditaria, a skin pigmentation disorder.

80 As safe and effective treatment options for skin pigmentation disorders are limited, these specific

81 w the potential for developing therapies for skin pigmentation disorders by manipulating McSCs.

82 and rs2470102) play an important role in the skin pigmentation diversity of South Asians.

83 hich is vital for facilitating MeSC mediated skin pigmentation during postnatal development.

84 Variation in human skin pigmentation evolved in response to the selective p

85 For example, novel roles in skin pigmentation for loci near MFSD12 and DDB1 have rec

86 ated the association of two previously known skin pigmentation genes, SLC24A5 (minimum p = 2.62 x 10(

87 ividual carries ancestral alleles in several skin pigmentation genes, suggesting that the light skin

88 Here, we summarize recent progress in skin pigmentation genetics in Africans and discuss the i

89 Our meta-analysis of skin pigmentation GWAS in recently admixed populations p

90 Our understanding of the genetics of skin pigmentation has been largely skewed towards popula

91 ritable human trait, and global variation in skin pigmentation has been shaped by natural selection,

92 Therapeutic methods to modulate skin pigmentation has important implications for skin ca

93 heir individual molecular relationships with skin pigmentation have not been clearly resolved.

94 lar mechanisms associated with alteration of skin pigmentation have remained elusive.

95 l role of the IFN-gamma signaling network in skin pigmentation homeostasis, which could have implicat

96 te the genetic factors influencing intrinsic skin pigmentation in a population of South Asian descent

97 a large fraction of the natural variation of skin pigmentation in a South Asian population.

98 so far to characterize the genetic basis of skin pigmentation in admixed populations (N = 2,104).

99 heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a k

100 Recent genome-wide genetic studies of skin pigmentation in African populations have advanced o

101 screen 1,157 candidate variants influencing skin pigmentation in Africans and identified 165 single-

102 ) in MFSD12, a gene recently associated with skin pigmentation in Africans.

103 We present a GWAS of skin pigmentation in an admixed sample from Cuba (N = 76

104 We also demonstrate that light skin pigmentation in Europeans was already present at hi

105 des the SLC24A5 allele associated with light skin pigmentation in Europeans, may represent gene flow

106 Skin pigmentation in humans and coat color in fleece-pro

107 Despite the wide range of skin pigmentation in humans, little is known about its g

108 follicle (HF) melanocyte SC (MeSC) mediated skin pigmentation in juvenile life.

109 als who have ocular features of albinism and skin pigmentation in keeping with their familial backgro

110 ows that the response to selection for light skin pigmentation in West Eurasia was driven by a relati

111 These include one novel locus for skin pigmentation (in 10q26) and three novel loci for ey

112 Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both i

113 ly breastfed infants who have high levels of skin pigmentation, inadequate vitamin D supplementation,

114 rences in genetic factors, sun exposure, and skin pigmentation, iron deficiency may affect vitamin D

115 Skin pigmentation is a classic example of a polygenic tr

116 Skin pigmentation is a complex trait that varies largely

117 Rather, baseline skin pigmentation is a complex, polygenic trait in the K

118 To test whether clofazimine-induced skin pigmentation is due to CLDI formation, we synthesiz

119 We demonstrate that skin pigmentation is highly heritable, but known pigment

120 ese results suggest that clofazimine-induced skin pigmentation is not due to clofazimine precipitatio

121 s involves loss of hair pigmentation whereas skin pigmentation is not reduced, and a predisposition t

122 Skin pigmentation is paused after sun exposure; however,

123 Human skin pigmentation is the product of two clines produced

124 that clofazimine bioaccumulation results in skin pigmentation, its most common side effect.

125 e syndrome that is characterized by abnormal skin pigmentation, leukoplakia and nail dystrophy.

126 his, we identify canonical and non-canonical skin pigmentation loci, including near SLC24A5, TYRP1, S

127 Skin pigmentation measurements were taken on the upper u

128 keratinocytes and/or fibroblasts that affect skin pigmentation might be regulated differently by UV,

129 t neoplasia syndrome characterized by spotty skin pigmentation, myxomatosis, endocrine tumors, and sc

130 mucocutaneous features that include abnormal skin pigmentation, nail dystrophy, and oral leucoplakia.

131 bone marrow failure and a triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia.

132 from 21 to 58 years) with light-to-moderate skin pigmentation, none of whom had current or prior ski

133 t cancer among women with light constitutive skin pigmentation (odds ratio = 0.53, 95% confidence int

134 Skin pigmentation of the arms, ankles, and abdomen had s

135 This review examines the impact of skin pigmentation on disease presentation, clinical diag

136 the ongoing concerns regarding the impact of skin pigmentation on healthcare devices.

137 nresolved limitation of PPG is the effect of skin pigmentation on the signal and its impact on PPG ba

138 ng a reflectometer, we measured constitutive skin pigmentation on the upper underarm (a sun-protected

139 tamin D level appeared similar regardless of skin pigmentation or season.

140 and in adults of all ages who have increased skin pigmentation or who always wear sun protection or l

141 al plasticity, exogenous TH treatment alters skin pigmentation patterns in adult zebrafish after 5 da

142 tem in India has a profound influence on the skin pigmentation patterns of the subcontinent.

143 y assembling a global survey of quantitative skin pigmentation phenotypes, we demonstrate that pigmen

144 nes (including OCA2 and BNC2) that influence skin pigmentation phenotypes.

145 toreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and

146 presentation and disease burden can vary by skin pigmentation, race and ethnicity, and socioeconomic

147 Skin pigmentation ranged from 20 to 80 melanin units, av

148 hromosomal breakage as well as pancytopenia, skin pigmentation, renal hypoplasia, cardiac defects, mi

149 dominant disorder characterized by abnormal skin pigmentation, retinal detachment, anodontia, alopec

150 Genes that encode functions related to skin pigmentation (SCL4A5) and cutaneous glands (EDAR) a

151 n in patients with Carney complex was spotty skin pigmentation, similar to that observed in Peutz-Jeg

152 susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface disease,

153 n, we examined polymorphisms associated with skin pigmentation (SLC24A5) and with the ability to tast

154 ism and the related ultraviolet response and skin pigmentation standing out as a shared pathway, perh

155 of several physiological functions including skin pigmentation, steroidogenesis, obesity, energy home

156 ortin pathway is an important participant in skin pigmentation, steroidogenesis, obesity, energy home

157 ene, a critical component of the facultative skin pigmentation system, has a highly complex and ineff

158 A5, SNX13, TYRP1, and UVRAG) associated with skin pigmentation, three of which already have been repo

159 protease-activated receptor 2 is involved in skin pigmentation through increased phagocytosis of mela

160 and physiological data, including age, sex, skin pigmentation, tissue thickness, and mean arterial p

161 put to the circuit controlling adaptation of skin pigmentation to background, changes the number of n

162 traits ranging from lactase persistence, to skin pigmentation, to hypoxic response, to arsenic toler

163 h facial SL but not with other skin aging or skin pigmentation traits.

164 dardized erythema responses across different skin pigmentation types and shows strong internal consis

165 rtin 1 receptor polymorphisms correlate with skin pigmentation, UV sensitivity, and skin cancer risk.

166 Here, we investigate skin pigmentation variation in a cohort of 1,167 individ

167 15 genes have been directly associated with skin pigmentation variation in humans, leading to its ch

168 els of genetic and phenotypic diversity, and skin pigmentation varies widely across Africa.

169 associations because the trait under study (skin pigmentation) varies with admixture proportions.

170 ur understanding of the mechanism underlying skin pigmentation via a paracrine EV-mediated communicat

171 ic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 recep

172 ormone are well documented to regulate human skin pigmentation via action at the melanocortin-1 recep

173 Skin pigmentation was measured by a color meter (chromom

174 complex anthropometric and metabolic traits, skin pigmentation was the only one with significant evid

175 ces and infer possible mechanisms underlying skin pigmentation, we performed a large-scale transcript

176 , arthropathies, arrhythmias, impotence, and skin pigmentation were no more prevalent among the 152 i

177 In our cohort of white women, surrogates for skin pigmentation were not associated with risk of heari

178 haracteristics, receipt of vasopressors, and skin pigmentation were recorded at the time of a clinica

179 In study 1, 74 men and women with diverse skin pigmentation were recruited.

180 se to melanoma as a result of alterations in skin pigmentation (which affords less protection against

181 Skin pigmentation, which is regulated by the melanocorti

182 melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human geneti

183 tic determinants of the natural variation of skin pigmentation within a human population.

184 anin-producing enzymes, resulting in delayed skin pigmentation within days [7].

185 mma-MSH-NH2 is ideal for inducing short-term skin pigmentation without sun for melanoma prevention.