ライフサイエンスコーパス: sleep loss

1 The hippocampus is particularly sensitive to sleep loss.

2 etes risk and inflammation, independently of sleep loss.

3 reased, indicating a homeostatic response to sleep loss.

4 in sleep timing and homeostatic responses to sleep loss.

5 nd memory deficits comparable to those after sleep loss.

6 higher level of arousal despite the similar sleep loss.

7 d differently in males and females following sleep loss.

8 cesses with regard to trait vulnerability to sleep loss.

9 rom it may require more time than from acute sleep loss.

10 multiplicative effect on performance during sleep loss.

11 , and associates with EEG differences during sleep loss.

12 siological sleepiness in response to chronic sleep loss.

13 out the cellular adaptations that occur with sleep loss.

14 eep and learning impairments associated with sleep loss.

15 campus-related cognitive deficits induced by sleep loss.

16 may be involved in regulating sensitivity to sleep loss.

17 prevented cognitive deficits associated with sleep loss.

18 orted believing that they had adapted to the sleep loss.

19 ial feature of performance impairment due to sleep loss.

20 on of psychomotor vigilance as a function of sleep loss.

21 ndicative of a homeostatic response to acute sleep loss.

22 n the brain and body of animals experiencing sleep loss.

23 generalize to conditions of chronic partial sleep loss.

24 chanisms underlying the anxiogenic impact of sleep loss.

25 dicate that the hippocampus is vulnerable to sleep loss.

26 reduced expression of heat-shock genes after sleep loss.

27 esponse variability, which is exacerbated by sleep loss.

28 es compensatory REM sleep in response to REM sleep loss.

29 KC output connections is scaled uniformly by sleep loss.

30 rmance under challenging conditions, such as sleep loss.

31 groups also experienced different effects of sleep loss.

32 f presynaptic scaling in the fly brain after sleep loss.

33 d neocortex after a brief period of sleep or sleep loss.

34 nd are more resistant to negative effects of sleep loss.

35 own about how these patterns are impacted by sleep loss.

36 d is linked to energy deficit accrued during sleep loss.

37 rlies the adaptive evolution of albinism and sleep loss.

38 l to study the evolution and consequences of sleep loss.

39 REM sleep and compensatory changes following sleep loss.

40 ls, also display mitochondrial changes after sleep loss.

41 memory associations after one night of total sleep loss.

42 57 of 151) were non-resilient after moderate sleep loss.

43 uscle Bmal1 reduced the recovery response to sleep loss.

44 might be causal for individual responses to sleep loss.

45 is associated with intermittent hypoxia and sleep loss.

46 ntain daytime sleep in the face of nighttime sleep loss.

47 to maintain normal blood sugar levels during sleep loss.

48 oday's society due to many factors including sleep loss.

49 ic dysfunction, and potential biomarkers for sleep loss.

50 occurs regardless of the approach to achieve sleep loss.

51 Sleep loss, a costly challenge of modern society, has pr

52 c adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26

53 Chronically isolated animals exhibit sleep loss accompanied by overconsumption of food, which

54 different rules may govern plasticity during sleep loss across cell types.

55 h is predicted by the subjective severity of sleep loss across participants.

56 ast, chronic sleep restriction but not acute sleep loss activates microglia, promotes their phagocyti

57 Sleep loss adversely affects certain types of cognitive

58 We found that sleep loss affected phosphorylated tau differently depen

59 To glean whether sleep loss affected song output, we also conducted impro

60 Sleep loss affects activity patterns, increases anxiety-

61 is unclear how uniformly or heterogeneously sleep loss affects the brain.

62 s and nuclear proteomics we investigated how sleep loss affects the cellular composition and molecula

63 While sleep loss altered many cytosolic ribosomal transcripts,

64 addition, experimental studies suggest that sleep loss alters cerebrospinal fluid Abeta dynamics, de

65 Therefore, we suggest that sleep loss alters emotional reactivity by lowering the t

66 Nevertheless, it remains unknown how sleep loss alters the dynamics of brain and behavioral r

67 Here, we demonstrate that sleep loss amplifies preemptive responding in the amygda

68 nts underlie the hyperexcitability caused by sleep loss and Abeta expression.

69 Both sleep loss and amyloid beta increase neural excitability

70 -promoting circuits become hyperactive after sleep loss and are associated with increased whole-brain

71 her investigations, the relationship between sleep loss and behavior has the potential to be used as

72 Chronic sleep loss and circadian misalignment enhance developmen

73 Sleep loss and circadian misalignment have long been kno

74 Sleep loss and circadian misalignment may disrupt reward

75 es) to systematically examine the effects of sleep loss and circadian misalignment using a constant r

76 n time to a visual cue is impaired following sleep loss and circadian misalignment, but it has remain

77 racts with early school start times to cause sleep loss and circadian misalignment.

78 and specific behavioural biomarker of acute sleep loss and circadian misalignment.

79 th impaired alertness and performance due to sleep loss and circadian misalignment.

80 Evidence has shown that both sleep loss and daily caffeine intake can induce changes

81 Difficulties with jet lag because of sleep loss and decreased performance are emphasised.

82 significantly impaired when performed after sleep loss and during the biological night, and thus may

83 r to promptly curtail the chronic effects of sleep loss and effectively screen for underlying, potent

84 on on which to consider interactions between sleep loss and emotional reactivity in a variety of clin

85 Recent studies, however, suggest that sleep loss and fatigue result in significant neurobehavi

86 onic social isolation and thereby results in sleep loss and increased feeding.

87 Sleep loss and insufficient sleep are risk factors for c

88 on of this circuit in young flies results in sleep loss and lasting deficits in adult courtship behav

89 academic year were associated with the most sleep loss and longest shift durations.

90 mework for a positive feedback loop, whereby sleep loss and neuronal excitation accelerate the accumu

91 emiological evidence supports a link between sleep loss and obesity.

92 ation (PSD), a condition distinct from total sleep loss and one experienced by millions on a daily an

93 es in cognitive performance and sleep during sleep loss and recovery, as well as a new approach for p

94 omnography was performed to measure baseline sleep loss and responses to isoflurane anesthesia at 1%

95 nt with a body of literature suggesting that sleep loss and sleep fragmentation are associated with b

96 OA) and hippocampal CA2 region, resulting in sleep loss and social memory deficits, respectively.

97 r modern society suffers from both pervasive sleep loss and substance abuse-what may be the indicatio

98 ules may apply across the brain during acute sleep loss and that sleep need may broadly alter excitat

99 miological studies have shown a link between sleep loss and the obesity 'epidemic,' and several obser

100 ents in performance are exaggerated by prior sleep loss and the time of day in which a person awakens

101 echanism that underlies the relation between sleep loss and weight gain.

102 exposed to the shifting schedule revealed no sleep loss, and stress measures were not altered in shif

103 ting effects of stimulants in the context of sleep loss, and the conflicting findings of stimulants f

104 r-individual differences in vulnerability to sleep loss, and these inter-individual differences const

105 nic and hormonal factors to overeating after sleep loss are a matter of ongoing controversy.

106 nt temperature, the homeostatic responses to sleep loss are COX-2-independent.

107 e homeostatic factors that impel sleep after sleep loss are imperfectly understood.

108 sms by which these two cell types respond to sleep loss are not yet clearly understood.

109 Sleep and sleep loss are thought to impact synaptic plasticity, an

110 Ultimately, these findings characterize sleep loss as a metabolic disorder.

111 d, Kv3.1/Kv3.3-deficient mice display severe sleep loss as a result of unstable slow-wave sleep.

112 We investigated whether mild sleep loss-as typical for many adults throughout the wor

113 n hormonal versus hedonic factors underlying sleep-loss-associated weight gain, we rigorously tested

114 multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposit

115 It reflects every-day sleep loss better than acute sleep deprivation, but its

116 We demonstrate that sleep loss, but not sleep fragmentation, in healthy mice

117 nd recovery differ between acute and chronic sleep loss, but the physiological basis for these time c

118 e earliest animals, and the fact that severe sleep loss can be lethal.

119 tal animal and human studies have found that sleep loss can impair metabolic control and body weight

120 Sleep loss can modify energy intake and expenditure.

121 Sleep loss can severely impair the ability to perform, y

122 We conclude that the sleep loss caused by ablation of VLPO neurons sensitizes

123 Acute sleep loss causes mixed behavioral states, featuring hyp

124 Sleep loss causes profound cognitive impairments and inc

125 signed to predict performance changes due to sleep loss compared to objective performance.

126 al variability exists in the degree to which sleep loss compromises learning, the mechanistic reasons

127 Sleep loss decreased the expression of genes encoding ch

128 different lights as a countermeasure against sleep-loss decrements in alertness, melatonin and cortis

129 ow-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostaticall

130 Sleep loss/disruption has been shown to suppress adult h

131 Sleep loss disrupts a broad spectrum of affective proces

132 Sleep loss disrupts consolidation of hippocampus-depende

133 reviously appreciated.SIGNIFICANCE STATEMENT Sleep loss-driven changes in transcript and protein abun

134 This mechanism could act as a sleep loss-driven inhibitory gate on hippocampal informa

135 We previously found that sleep loss drives accumulation of the active zone scaffo

136 more complete understanding of the issues of sleep loss during residency training can inform innovati

137 Sleep loss dysregulates cellular metabolism and energy h

138 t cause the expected homeostatic response to sleep loss (e.g., increases in sleep time or intensity).

139 in A1AR availability were more resilient to sleep-loss effects than those with a subtle increase.

140 he most widely consumed stimulant to counter sleep-loss effects.

141 Our results indicate that sleep loss, either by overnight (12-h) mechanical stimul

142 of the sympathetic nervous system (SNS) from sleep loss elevates blood pressure to promote vascular s

143 Bruchpilot (BRP) abundance in the MB lobes; sleep loss elevates BRP while sleep induction reduces BR

144 Sleep loss elevates mitochondrial reactive oxygen specie

145 We are suffering a global sleep-loss epidemic.

146 eep) on neurobehavioral response to moderate sleep loss (evaluated at 20 hours awake two days later)

147 Importantly, these data reveal that sleep loss exacerbates Abeta-induced hyperexcitability a

148 le of a single species with a convergence on sleep loss exhibited by several independently evolved po

149 ictors of individual responses to subsequent sleep loss exposures chronically or intermittently, acro

150 The reduced HCVR after sleep loss found in previous studies may have been affec

151 ns in Drosophila melanogaster can dissociate sleep loss from subsequent homeostatic rebound, offering

152 ng mutants with very different mechanisms of sleep loss: fumin (fmn), redeye (rye), and sleepless (ss

153 or driver of AD progression, suggesting that sleep loss further accelerates AD through a vicious cycl

154 To date it is not known whether sleep or sleep loss has any effect on proliferation of cells in t

155 g prevalence of obesity and type 2 diabetes, sleep loss has become common in modern societies.

156 Sleep loss has been associated with increased seizure ri

157 Consistently, sleep loss has been linked to behavioral and attention p

158 Sleep loss has been shown to cause impairments in a numb

159 die from one form of sleep deprivation, but sleep loss has not been shown to cause death in well-con

160 acteristics, sleep duration, and response to sleep loss have been identified.

161 Brief periods of sleep loss have long-lasting consequences such as impair

162 However, society-specific consequences of sleep loss have rarely been explored, and no function of

163 Given that sleep loss impairs monitoring performance and there is a

164 These results collectively indicate that sleep loss impairs motivation and cognitive performance,

165 ive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult populati

166 ability of an animal to compensate for prior sleep loss in a process called sleep homeostasis.

167 reinstates hierarchical BOLD dynamics after sleep loss in an independent sleep deprivation study.

168 emory consolidation deficits associated with sleep loss in an object-location task.

169 Sleep loss in attending physicians has an unclear effect

170 studies are warranted to better characterize sleep loss in eczema and develop strategies for treatmen

171 ioral and neuronal manipulations that induce sleep loss in males.

172 ain-induced insomnia and sufficient to mimic sleep loss in naive mice.

173 ated neural processing of food rewards after sleep loss in reward-processing areas such as the anteri

174 ep regulation to quantify performance during sleep loss in the absence of caffeine and a dose-depende

175 splay elevated calcium levels in response to sleep loss in the morning, but not the evening consisten

176 ons, which also show decreased activity upon sleep loss, in a Hugin peptide-dependent fashion.

177 Sleep loss increased inactivity, decreased play and aler

178 The aim was to determine whether mild sleep loss increases EAH in children.

179 tudies in humans and rodents also found that sleep loss increases peripheral markers of inflammation,

180 Sleep loss increases the cerebrospinal fluid concentrati

181 Sleep loss increases the experience of pain.

182 Sleep disorders are common in humans, and sleep loss increases the risk of obesity and diabetes.

183 leep duration on the weekend to recover from sleep loss incurred during the workweek.

184 d the degree of such neural vulnerability to sleep loss: individuals with highest trait anxiety showe

185 mechanisms for the observed changes comprise sleep loss-induced changes in appetite-signaling hormone

186 myo-inositol and glycine levels, suggesting sleep loss-induced modifications downstream of mGluR5 si

187 estigated potential underlying mechanisms of sleep-loss-induced changes in behavior by high-density e

188 Despite sleep-loss-induced cognitive deficits, little is known a

189 PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that thi

190 The reversibility of mild sleep-loss-induced pain by wake-promoting agents reveals

191 hat brain-wide dopaminergic pathways control sleep-loss-induced polymodal affective state transitions

192 Acute sleep loss induces DA-dependent enhancement in dendritic

193 , our aim was to investigate whether and how sleep loss influences microglial function in mice.

194 Although sleep loss is a normative psychosocially and biologicall

195 Sleep loss is an adaptive response to nutrient deprivati

196 Sleep loss is associated with cognitive decline in the a

197 To examine whether evolved sleep loss is associated with DNA damage, we compared DN

198 In humans, acute sleep loss is associated with increased appetite and ins

199 Sleep loss is associated with increased obesity risk, as

200 s for behavioral change), suggesting that if sleep loss is corrected, it could save lives-including B

201 suggest that increased food valuation after sleep loss is due to hedonic rather than hormonal mechan

202 Significance statement: Sleep loss is known as a robust modulator of emotional r

203 We demonstrate that the anxiogenic impact of sleep loss is linked to impaired medial prefrontal corte

204 Importantly, sleep loss is modifiable via organization-level changes

205 Here, we report that postmating nighttime sleep loss is modulated by diet and sleep deprivation, d

206 to perform, yet the ability to recover from sleep loss is not well understood.

207 Similar resistance to sleep loss is observed with Notch(spl-1) gain-of-functio

208 Sleep loss is often regarded as an early manifestation o

209 e molecular mechanisms underlying effects of sleep loss is only in its nascent stages.

210 Moderate daily repeated sleep loss leads to a progressive accumulation of sleep

211 Even though the overall consensus is that sleep loss leads to metabolic perturbations promoting th

212 Because chronic sleep loss leads to performance decrements, our findings

213 ulation and disrupted attention of ELS mice, sleep loss likely underlies cognitive deficits in ELS mi

214 ed on-call workload was associated with more sleep loss, longer shift duration, and a lower likelihoo

215 We propose that sleep loss may be one of the ways that inflammatory proc

216 During sleep loss, metabolically active cells shunt energetic r

217 suggest that increased food valuation after sleep loss might be due to hedonic rather than hormonal

218 These findings demonstrate that sleep and sleep loss modify experience-dependent cortical plastici

219 It is not yet clear how acute and chronic sleep loss modify neuronal activities and lead to adapti

220 ty, longer episode duration, less subjective sleep loss, more guilt, and more work/activity impairmen

221 Sleep loss negatively impacts performance, mood, memory,

222 However, the effect of sleep loss on actual communication is unknown.

223 euronal excitability underlie the effects of sleep loss on AD pathogenesis.

224 ruption and anxiety disorders, the impact of sleep loss on affective anticipatory brain mechanisms, a

225 few studies have investigated the effect of sleep loss on aspects of prospect theory, specifically t

226 way may underlie both the adverse effects of sleep loss on cognition and the subsequent changes in co

227 e reviewed studies addressing the effects of sleep loss on cognition, performance, and health in surg

228 he negative effects of shiftwork and chronic sleep loss on health and productivity are now being appr

229 may be involved with the negative effects of sleep loss on health, and highlight the interrelatedness

230 We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP)

231 esults delineate the adverse consequences of sleep loss on hippocampal function at the network level

232 omeostatic sleep response and the effects of sleep loss on memory, previous studies have not determin

233 ional notions about the effects of sleep and sleep loss on neurobehavioral performance.

234 e a novel framework underlying the impact of sleep loss on pain and, furthermore, establish that the

235 ld be separated when assessing the effect of sleep loss on risky behaviour.

236 In this study, the impact of chronic sleep loss on sleep homeostasis was examined in C57BL/6J

237 To better appreciate the effects of sleep loss on synaptic connectivity across a memory-enco

238 re, but little is known about the effects of sleep loss on the behavior of the species.

239 ies to critically test the lasting impact of sleep loss on the brain.

240 leep and affective regulation, the impact of sleep loss on the discrimination of complex social emoti

241 Across species, chronic sleep loss or deprivation is associated with increased c

242 Sleep loss or disturbances are likely to signal an incre

243 noninferiority trial showed no more chronic sleep loss or sleepiness across trial days among interns

244 ty in caudate, which was not attributable to sleep loss or so-called social jet lag, whereas physical

245 conclude that circadian disruption, but not sleep loss or stress, are associated with jet lag-relate

246 ble from the energy-balance perturbations of sleep loss or the potentially stressful effects of the f

247 ogressively increased despite of accumulated sleep loss over days.

248 However, during sleep restriction (partial sleep loss) performance predictions based on such models

249 Across species, sleep loss perturbs mitochondrial gene expression, incre

250 We defined each participant's response-to-sleep-loss phenotype based on the number of attentional

251 ly central accumulation of fat indicate that sleep loss predisposes to abdominal visceral obesity.

252 Sleep loss produces well-characterized cognitive deficit

253 Chronic sleep loss profoundly impacts metabolic health and short

254 lesion size were associated with cumulative sleep loss (r=0.77 and r=0.62, respectively), and cumula

255 We examined sleep-loss-related attentional vulnerability by consider

256 Our results link higher sleep-loss-related attentional vulnerability to cortical

257 pses, increased after both acute and chronic sleep loss relative to sleep and wake.

258 plicating studies, here, we demonstrate that sleep loss represents one previously unrecognized factor

259 Across multiple measures, prior sleep loss responses are strong predictors of individual

260 ults may also provide insight for predicting sleep loss responses in patients with schizophrenia and

261 Sleep loss resulting from physiological and pathological

262 Specific to the central nervous system, sleep loss results in impaired synaptogenesis and long-t

263 use and effect association are still scarce, sleep loss seems to be an appealing target for the preve

264 mmunication may be one detrimental effect of sleep loss shared by social organisms.

265 understand the association between workload, sleep loss, shift duration, and the educational time of

266 memory and cognitive deficits that accompany sleep loss.SIGNIFICANCE STATEMENT The lack of sufficient

267 correlations in neurobehavioral responses to sleep loss suggest that these trait-like differences are

268 sed to a similar extent after short and long sleep loss, suggesting that astrocytic phagocytosis may

269 nificant increase after prolonged and severe sleep loss, suggesting that it may promote the housekeep

270 beta' GABAA and GABABR3 receptors results in sleep loss, suggesting these receptors are the sleep-rel

271 tes these EB neurons are highly sensitive to sleep loss, switching from spiking to burst-firing modes

272 This resilience may be due to a less extreme sleep loss than in previous studies, but also indicates

273 re susceptible to weight gain resulting from sleep loss than women and whites, respectively.

274 ay be more susceptible to weight gain during sleep loss than women due to a larger increase in daily

275 In contrast, sleep loss that does not induce rebound sleep was not ac

276 y insult, these results suggest that chronic sleep loss, through microglia priming, may predispose th

277 osure, sex differences in recovery from NREM-sleep loss; thus, suggesting an underlying sex-differenc

278 ind that increased mGluR5 availability after sleep loss tightly correlates with behavioral and electr

279 stress as a novel mechanism linking chronic sleep loss to adverse health outcomes-and perhaps for li

280 Our findings directly link sleep loss to changes in neuronal excitability and Abeta

281 These findings suggest a mechanism for sleep loss to increase risk of Alzheimer disease.

282 mechanisms linking circadian dysfunction and sleep loss to neurodegenerative diseases, with a focus o

283 urbance numerical rating scale (range, 0 [no sleep loss] to 10 [unable to sleep at all]) at week 4 (3

284 Moreover, sleep loss triggers an increase in the amplitude of thes

285 First, at an individual level, 1 night of sleep loss triggers the withdrawal of help from one indi

286 The dynamics of recovery from sleep loss vary across sleep variables: SWA and immediat

287 ment of cognitive performance in response to sleep loss was significantly greater in the PER3(5/5) in

288 77 and r=0.62, respectively), and cumulative sleep loss was the strongest predictor of high sensitivi

289 e indeed costs associated with resiliency to sleep loss, we challenged natural allelic variants of th

290 ve CSR that mimics a common pattern of human sleep loss, we quantified a new procedure of sleep disru

291 To characterize effects of learning and sleep loss, we quantified activity-dependent phosphoryla

292 The mania-like behaviors, including the sleep loss, were reversed by valproate, and re-emerged w

293 nd sufficient to suppress starvation-induced sleep loss when animals encounter nutrient-poor food sou

294 r, this mutation in oca2 fails to complement sleep loss when surface fish harboring this engineered m

295 s, enter a catabolic state during periods of sleep loss, which consequently disrupts physiological fu

296 onfer protection against the consequences of sleep loss while simultaneously allowing for the increas

297 xhibited attenuated female-induced nighttime sleep loss yet normal daytime courtship, which suggests