ライフサイエンスコーパス: slug

1 , SM22alpha, calponin, phospho-vimentin, and Slug.

2 or-promoting transcription factors, Sox9 and Slug.

3 e expression of the EMT transcription factor slug.

4 how that SOX2 is a transcriptional target of SLUG.

5 sed by joint knockdown of BMPR2 and HMGA1 or Slug.

6 ll as expression of the transcription factor Slug.

7 mesenchymal transition regulators: snail and slug.

8 E-cadherin subsequent to decreased levels of SLUG.

9 ent upregulation of the transcription factor SLUG.

10 on of the proapoptotic gene, Puma (Bbc3), by Slug.

11 brogating the expression of the EMT mediator SLUG.

12 ition by regulating the transcription factor SLUG.

13 ligands for the NmU/PRXamide receptor in the slug.

14 functionality of the chloroplasts inside the slugs.

15 euopisthobranch and panpulmonate snails and slugs.

16 tic activity in kleptoplasts retained by sea slugs.

17 relative lengths of the sender and receiver slugs.

18 osal glands using mucus vesicles from banana slugs.

19 to the rise and burst of conduit-filling gas slugs.

20 In contrast, nonphosphorylatable Slug-4SA is not degraded by CHIP.

21 ssing the expression of transcription factor Slug, a key regulator of EMT.

22 illin affects the expression and activity of Slug, a key transcriptional regulator of EMT.

23 expansion, clonogenicity, and expression of Slug, a master regulator of MaSCs.

24 SNAI2/SLUG, a metastasis-promoting transcription factor, is a

25 he up-regulation of the EMT master regulator Slug, a process that is dependent on both MEK/ERK signal

26 alphavbeta3 was necessary and sufficient for Slug activation, tumorsphere formation, and tumor initia

27 TGF-beta treatment enhanced Slug activity and thus increased miR-221 level in MCF-7

28 ed the expression of the mesenchymal markers SLUG and ARF6.

29 the expression of the EMT program components Slug and Axl.

30 ition could be associated with activation of slug and CD87 gene by their promoter demethylation.

31 Expression of slug and CD87 genes was activated following treatment wi

32 te sequencing indicated DNA demethylation of slug and CD87 genes.

33 TGF-beta1-induced up-regulation of Snail and Slug and down-regulation of VE-cadherin.

34 ee, without changes in EMT markers vimentin, slug and E-cadherin.

35 Levels of slug and fascin correlated in PDAC cells; slug was found

36 EMT and mesenchymal differentiation through Slug and functions in tumor-suppressive programs by regu

37 We found that PBT-1 reduced the level of Slug and inhibits the migration, invasion, and filopodia

38 ctin-bundling protein fascin is regulated by slug and involved in late-stage PanIN and PDAC formation

39 Thus, transgenic mice expressing Slug and Kras in acinar cells were generated.

40 tly greater expression of Ki67, p53, VEGFR1, SLUG and SNAIL in the metastases compared with the prima

41 cadherin, N-cadherin, fibronectin, vimentin, slug and snail) and stem cell markers (CD44 and CD87) in

42 luminal layer exploit the paralogous EMT-TFs Slug and Snail, respectively, which induce distinct EMT

43 GFR1, and FGFR2 as well as mesenchymal genes SLUG and SNAIL.

44 inding with ten endogenous peptides from the slug and some insect PRXamide and vertebrate NmU peptide

45 Correlation between SLUG and SOX9 levels was observed remarkably, we therefo

46 residue thus leading to the upregulation of Slug and tumor progression.

47 panel, H2A.X levels correlate inversely with Slug and ZEB1 levels.

48 ing activation of EMT transcription factors, Slug and ZEB1, in HCT116 human colon cancer cells.

49 ly reverses these changes, as does silencing Slug and ZEB1.

50 in 3D growth, accompanied by upregulation of SLUG and ZEB2 and increased invasive properties.

51 We identified Slug and ZEB2 as direct functional targets of miR-218.

52 o cisplatin treatment through suppression of Slug and ZEB2.

53 s include migration vectors (such as snails, slugs and isopods) and pathogens (such as microsporidia,

54 chatinoid clades of the Stylommatophora (and slugs and shelled slugs), which diverged 90-130 MYA.

55 ct and systemic molluscicide for controlling slugs and snails in a wide range of agricultural and hor

56 ft-bodied aquatic invertebrates, such as sea slugs and snails, are capable of diverse locomotion mode

57 ents, we explore a new mechanism to form gas slugs and strombolian explosions.

58 cterial isolates acquired from a sponge, sea slug, and coral to examine the functional landscape of t

59 ibiting N-cadherin and transcription factors Slug, and pluripotency maintaining factors Nanog, c-Myc,

60 ion of miR-34a and its direct targets Notch, Slug, and Snail.

61 mal transition (EMT) genes including TWIST1, SLUG, and SNAIL.

62 tochemical examination of E-cadherin, Snail, Slug, and Twist2 expression was performed.

63 ransition (EMT) including E-cadherin, Snail, Slug, and Twist2, in the Egyptian population.

64 initiates antitumor activities by affecting Slug- and AKT-mediated metastasis and tumorigenesis.

65 echanically isolated from the CNS of the sea slug Aplysia californica, a well characterized neurobiol

66 5-500 mum in diameter) isolated from the sea slug (Aplysia californica) central and rat (Rattus norve

67 adherin transcriptional repressors Snail and Slug are not implicated.

68 Sacoglossan sea slugs are able to maintain functional chloroplasts insid

69 Some sea slugs are capable of retaining functional sequestered ch

70 Snail1 (Snail) and Snail2 (Slug) are transcription factors that share a similar DNA

71 erative and invasive properties, implicating Slug as a critical driver of disease progression.

72 uman geriatric SCs, these findings highlight Slug as a potential therapeutic target for aging-associa

73 ue of the JCI, Liu and Lin et al. identified Slug as an epigenetic regulator of lipogenesis.

74 n (EMT) markers as N-cadherin, vimentin, and Slug, as well as metastasis-related integrins (integrin-

75 Separation of the alternating aqueous slugs at the outlet was performed by switching a couple

76 operating the reactor with multiple reaction slugs at the same time.

77 Surprisingly, Slug attenuated Kras-induced ADM development, ERK1/2 pho

78 In addition, Slug attenuated TGF-alpha-induced acinar cell metaplasia

79 Interestingly, depletion of Snail, but not Slug, attenuated TGF-beta1-induced down-regulation of VE

80 t cancer through the estrogen receptor alpha/Slug axis and that it is a potential noninvasive biomark

81 a is obtained by cycling a discrete reaction slug back and forth between two residence coils, with an

82 nducible factor 1alpha (Hif-1alpha), Snail1, Slug, basic fibroblast growth factor (bFgf), and retinal

83 SLUG, beyond its known function as an epithelial-mesench

84 -encoding genes were highly expressed in the slug brain, while the receptor gene was expressed at low

85 vely at the surface until the next explosive slug-bursting event.

86 When the gas slug bursts, liquid is drawn up in its wake, which exsol

87 ver, miR-221 was specifically upregulated by Slug but not Snail.

88 Finally, endothelial Slug (but not Snail) is activated by the pro-angiogenic

89 lated E-cadherin, beta-catenin, vimentin and Slug, but it partially rescued Twist1-silenced ERalpha a

90 ncreased expression of a known EMT regulator Slug, but not TWIST or Snail.

91 MAR1-dependent transcriptional repression of Slug by direct recruitment of SMAR1/HDAC1 complex to the

92 f ductal markers and reversed the effects of Slug by inducing ductal structures.

93 Slug chloroplasts also rapidly build up a strong proton-

94 lgae, we show that the plastoquinone pool of slug chloroplasts remains oxidized, which can suppress r

95 nk4a) depletion partially rescues defects in Slug-deficient SCs.

96 VEGFA stimulates Sox2- and Slug-dependent cell invasion.

97 The ensuing Slug-dependent serine 139 phosphorylation of the DNA dam

98 rst molluscan NmU/PRXamide receptor from the slug, Deroceras reticulatum.

99 pment stages of D. discoideum when migrating slugs differentiate into fruiting bodies that contain pe

100 ntactless" mass transfer between two aqueous slugs (droplets) separated by an oil slug in Taylor flow

101 ylase 1 (HDAC1) recruitment and antagonizing Slug E-box binding.

102 We found that the slug Elysia timida induces changes to the photosynthetic

103 nthophyll cycle were investigated in the sea slugs Elysia viridis and E. chlorotica using chlorophyll

104 Similarly, restoring paracrine TGF-beta-Slug-EMT signaling reactivated the transdifferentiation

105 We identify two proteins, SLUG (encoded by SNAI2 gene) and SOX9, which are associa

106 e and others previously established that the Slug epithelial-to-mesenchymal transition-inducing trans

107 Vimentin, ERK, and Slug exhibited overlapping subcellular localization in c

108 inhibited bone marrow homing/engraftment of Slug-expressing K562 cells.

109 In addition, blocking ROCK1/2 activity in Slug-expressing Kras mice reversed the inhibitory effect

110 SLUG expression and binding are necessary for SOX9 promo

111 RasN17), significantly inhibited RCP-induced Slug expression and cancer cell invasion.

112 We then investigated how HER2 induced Slug expression and found, for the first time, that ther

113 ockdown of HSF-1 expression by siRNA reduced Slug expression and HRG-induced EMT.

114 some number control, spindle pole formation, Slug expression and satellite RNA suppression.

115 1 integrin efficiently inhibited RCP-induced Slug expression and subsequent cancer cell invasion.

116 31 cells impaired the induction of Snail and Slug expression by EGF, and this effect was associated w

117 omoter independent of heat shock, leading to Slug expression in breast cancer cells.

118 we provide evidence that hTERT links Src to Slug expression in NE-induced ovarian cancer EMT and met

119 High SLUG expression in tumors of lung cancer patients was as

120 Furthermore, reduced Slug expression is accompanied by p16(Ink4a) accumulatio

121 In addition, silencing of Slug expression significantly inhibited NE- and hTERT-in

122 Utilizing a doxycycline-controlled SLUG expression system, we found that high expression of

123 In contrast, Snail and Slug expression was positively associated with the stage

124 Notably, in an orthotopic tumor model, Slug expression was sufficient to induce collective inva

125 s where its expression level correlates with Slug expression, enhanced invasiveness, and poor clinica

126 ockdown reduced the ability of Akt to induce Slug expression, indicating an essential role that HSF-1

127 s/NF-kappaB signaling cascade and subsequent Slug expression.

128 n of beta1 integrin was sufficient to induce Slug expression.

129 Ectopic expression of RCP induced Slug expression.

130 nduced ovarian cancer cell invasion, EMT and Slug expression.

131 active Akt induced HSF-1 phosphorylation and Slug expression.

132 s prevented HRG-induced HSF-1 activation and Slug expression.

133 nRNP A2/B1 reduced the activation of AKT and Slug expression.

134 elated with fibronectin matrix formation and Slug expression.

135 GSK3beta-mediated phosphorylation of Slug facilitates Slug protein turnover.

136 he development of a single-step method using slug-flow microextraction and nano-electrospray ionizati

137 We have developed slug-flow nanoextraction (SFNE), a method based on dropl

138 gas-driven oscillatory motion of a biphasic slug for high-throughput in situ measurement and screeni

139 nce 1 (GFI1) is comprised of conserved Snail/Slug/Gfi1 (SNAG) and zinc finger motifs separated by a l

140 ge continuous laboratory culture of both the slugs (>500 individuals) and their prey algae, we show t

141 This finding is significant because SLUG has been implicated in breast CSCs and TNBC.

142 directly binds to the DNA-binding domain of Slug, impeding histone deacetylase 1 (HDAC1) recruitment

143 ranscription factor -2 ( SNAI2) (also called SLUG), implicating LGR4 in regulation of epithelial-mese

144 ts increase our understanding of the role of Slug in ADM, an early event that can eventually lead to

145 This study demonstrates a pivotal role for Slug in carcinoma cell survival, implying that disruptio

146 1b expression highly correlated with that of Slug in clinical samples of advanced disease.

147 ry stem cells, and that forced expression of Slug in collaboration with Sox9 in breast cancer cells c

148 gether, our data support a critical role for Slug in determining the angiogenic response during devel

149 e critical EndMT transcription factors Snail/Slug in involuting hemangiomas.

150 9 level is associated with the expression of Slug in non-small cell lung cancer.

151 aqueous slugs (droplets) separated by an oil slug in Taylor flow inside milli-channels.

152 These results delineate a novel role for Slug in the nutrient stress response and provide insight

153 ntified the zinc-finger transcription factor Slug in WNK1-mediated control of endothelial functions.

154 t on radio-tracking of individual grey field slugs in an arable field and associated data modelling d

155 inc finger transcriptional repressor protein Slug, in vimentin-deficient (VIM(-/-)) wounds.

156 Sea slugs increase the longevity of the chloroplasts they st

157 ed that a low level of mucus was secreted by slugs indicating moderate mucosal irritation.

158 dherin transcriptional repressors, snail and slug, induced by transforming growth factor-beta1 or ext

159 vation of a signaling cascade culminating in Slug induction, epithelial-to-mesenchymal transition and

160 Depletion of Slug inhibited EMT during tumorigenesis, whereas forced

161 In support of this idea, Slug inhibition by shRNA sensitized tumor cells to apopt

162 SLUG interacts directly with SOX9 and prevents it from u

163 Importantly, we decipher that Slug is associated with nutrient stress in PDAC tumors a

164 Here, we show that Slug is critical for the pathological angiogenesis neede

165 rt that the zinc-finger transcription factor Slug is highly expressed in quiescent SCs of mice and fu

166 ictyostelium discoideum into a multicellular slug is known to result from single-cell chemotaxis towa

167 We find that Slug is required in PDAC cells for glutamine deprivation

168 Each two-phase slug is segmented from the others by immiscible carrier

169 Their findings suggest that Slug is stabilized by insulin signaling, and that it pro

170 Consistent with a role in metastasis, Slug knockdown in carcinoma cells suppressed lung coloni

171 onfirmed in human breast cancer cells, where Slug knockdown increased Puma expression and inhibited l

172 s, inhibition of Puma by RNA interference in Slug-knockdown cells rescued lung colonization, whereas

173 linositol 3'-kinase)/Akt phosphorylation and Slug level.

174 Attempts to group these slug-like taxa into a single 'halwaxiid' clade neverthel

175 We assessed whether blocking Snail/Slug-LSD1 interaction by treatment with Parnate, an enzy

176 exhibited nuclear localization of Twist and Slug, markers of epithelial-mesenchymal transition (EMT)

177 The accumulation of nondegradable Slug may further lead to the repression of E-cadherin ex

178 nd its transcriptional regulators; Snail and Slug may serve as indicators for assessing the stage of

179 a repressor in controlling HIF-1alpha/HDAC1/Slug-mediated cancer cell invasion and is a potential th

180 rast, SOX9 bound the SLUG promoter to induce SLUG-mediated cell invasion with a spindle-like phenotyp

181 downregulated during tumorigenesis via Snail/Slug-mediated E-cadherin transcriptional reduction.

182 herin and occludin expression and suppresses Slug-mediated epithelial-mesenchymal transition (EMT) an

183 Daxx also suppresses Slug-mediated lung cancer metastasis in an orthotopic lu

184 er cells results in a coordinative action of Slug-mediated repression of E-cadherin transcription, as

185 methylation-specific PCR further revealed a SLUG-mediated temporal regulation of epigenetic modifica

186 ive (GABA-ir) neurons in four species of sea slugs (Mollusca, Gastropoda, Opisthobranchia, Nudibranch

187 The analysis revealed that all components of slug movement (mean speed, turning angles and movement/r

188 at population density is a factor regulating slug movement.

189 discovered that IMP3 binds avidly to SNAI2 (SLUG) mRNA and regulates its expression by binding to th

190 on and elevated the levels of VIM, ZEB1, and SLUG mRNAs.

191 The slug mucosal irritation assay revealed that a low level

192 y regulated the expression of EndMT markers (Slug, N-cadherin, alpha-SMA) in EC exposed to low shear

193 expression of the mesenchymal markers Snail, Slug, N-cadherin, and vimentin in the recipient cells, w

194 2) induced alphavbeta3 expression, enhancing Slug nuclear accumulation and MaSC clonogenicity.

195 stal-rich plug en masse, producing a growing slug of gas.

196 Kras mice reversed the inhibitory effects of Slug on ADM, ERK1/2 phosphorylation, proliferation and f

197 lated by the usual increase in expression of Slug or Snail, the transcriptional regulators for E-cadh

198 Inhibition of either SLUG or SOX9 sufficiently inhibits CSCs in human lung ca

199 hand, genetic deletion or acute depletion of Slug, or Lsd1 inhibition, reduced lipogenesis and protec

200 stage larvae from primary hosts, snails and slugs, or paratenic hosts.

201 ic expression of hTERT induced expression of Slug, ovarian cancer cell epithelial-mesenchymal transit

202 g prevents excessive angiogenic sprouting of Slug overexpressing EC.

203 Slug overexpression ameliorates aged muscle regeneration

204 mples, we confirmed that the HIF-1alpha/Daxx/Slug pathway is an outcome predictor.

205 provide evidence of a de novo GSK3beta-CHIP-Slug pathway that may be involved in the progression of

206 ciated MaSCs require a TGF-beta2/alphavbeta3/Slug pathway, which may contribute to breast cancer prog

207 invasion by inhibiting the HIF-1alpha/HDAC1/Slug pathway.

208 ome-team offensive performance, for example, slugging percentage, but did not similarly affect away-t

209 gregation of amoeboid cells into a migratory slug phase in cellular slime molds at times of starvatio

210 scaffold to recruit Slug to ERK and promote Slug phosphorylation at serine-87.

211 s established a requirement for ERK-mediated Slug phosphorylation in EMT initiation.

212 elling designed to investigate the effect of slug population density in their movement.

213 herin is post-transcriptionally regulated by Slug-promoted miR-221, which serves as an additional blo

214 HSF-1 bound to and transactivated the Slug promoter independent of heat shock, leading to Slug

215 matrix attachment region site present in the Slug promoter restores E-cadherin expression, SMAR1 also

216 In contrast, SOX9 bound the SLUG promoter to induce SLUG-mediated cell invasion with

217 ranscriptional corepressor and ligand of the Slug promoter, ZBRK1.

218 heat shock factor-1 (HSF-1), located in the Slug promoter.

219 T1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes.

220 Loss of Slug promotes derepression of p16(Ink4a) in SCs and acce

221 mediated phosphorylation of Slug facilitates Slug protein turnover.

222 ncer cells up-regulate classic EMT regulator Slug, providing a link between nutrient stress and metas

223 arian cancer aggressiveness through inducing Slug, providing novel biomarkers and potential therapeut

224 Consistent with a pivotal role for a Slug-Puma axis in metastasis, inhibition of Puma by RNA

225 ll survival, implying that disruption of the Slug-Puma axis may impinge on the survival of metastatic

226 The survival function of the Slug-Puma axis was confirmed in human breast cancer cell

227 Both EC-specific Slug re-expression and reduced Notch signaling, either b

228 xpression of mesenchymal proteins (VIMENTIN, SLUG), reduced migration and tumor sphere formation, and

229 on transcription factor Snai2 (also known as Slug) regulated HSCs autonomously.

230 On average, the slugs released as a group disperse more slowly than slug

231 eleased as a group disperse more slowly than slugs released individually and their turning angle has

232 finger-containing transcriptional repressor, Slug, represses E-cadherin transcription and enhances ep

233 In some cases, aqueous slugs separated by oil, merged catching on each other du

234 trolling fibroblast proliferation, TGF-beta1-Slug signaling, collagen accumulation, and EMT processin

235 uppression of MARCKS phosphorylation and AKT/Slug signalling pathway but not the expression of total

236 t, the contribution of Snail-related protein Slug (Snai2) to ADM development is not known.

237 del that N-cadherin (Cdh2) expression causes Slug (Snai2) upregulation, which in turn promotes carcin

238 Slug (SNAI2), a member of the well-conserved Snail famil

239 EMT master regulator Snail (SNAI1), but not Slug (SNAI2), shows evidence of Pol II pausing before ac

240 at regulates the transcriptional activity of Slug (SNAI2).

241 expression in sh-AhR cells reduced Snail and Slug/Snai2 levels and cell migration and restored E-cadh

242 on of the EMT-promoting transcription factor SLUG/SNAI2, repressing its transcription by recruiting H

243 sed expression of mesenchymal markers Snail, Slug/Snai2, vimentin, fibronectin, and alpha-smooth musc

244 rkers and transcription factors (N-cadherin, Slug, Snail and Zeb1), and upregulation of E-cadherin.

245 richment in mesenchymal markers (N-cadherin, slug, snail, fibronectin) and cell invasiveness, relativ

246 E-cadherin, and decreased those of vimentin, Slug, Snail, matrix metalloproteinase (MMP)-2, -9, and a

247 TS subpopulation expresses higher levels of SLUG, SNAIL, VIMENTIN and N-CADHERIN while show a lack o

248 Sacoglossans are sea slugs, some of which eat algae, digesting the cells but

249 stic insight into the regulation of CSCs via SLUG-SOX9 regulatory axis, which represents a potential

250 ir) neurons in the buccal ganglia of six sea slug species (Mollusca, Gastropoda, Euthyneura, Nudipleu

251 that Sentinel (S) cells of the multicellular slug stage of the social amoeba Dictyostelium discoideum

252 a3, Src kinase, and the transcription factor Slug suppresses PUMA in these cells, promoting tumor ste

253 peptide corresponding to the SNAG domain of Slug, suppresses the motility and invasiveness of cancer

254 helial mesenchymal transition, expression of Slug, TGF-beta3, phospho-AKT and phospho-PRAS40, but inc

255 s and an unanticipated link between WNK1 and Slug that is important for angiogenesis.

256 consumption (reactions performed in 300 muL slugs), this represents an improvement in efficiency for

257 -mesenchymal transition transcription factor SLUG to directly repress pro-apoptotic BMF, limiting dru

258 ent, vimentin acted as a scaffold to recruit Slug to ERK and promote Slug phosphorylation at serine-8

259 perates with the transcription factor Snail2/Slug to modulate neural crest development in Xenopus.

260 a pivotal step in controlling the ability of Slug to organize hallmarks of EMT.

261 1ph and epigenetic reprogramming to suppress Slug transcription to inhibit EMT.

262 Mutation of the putative HSEs ablated Slug transcriptional activation induced by HRG or HSF-1

263 eness by inhibiting expression of the SNAI2 (Slug) transcriptional repressor, which leads to expressi

264 Injection of the bioactive peptides into slugs triggered defensive behavior such as copious mucus

265 IP stabilizes the wtSlug protein and reduces Slug ubiquitylation and degradation.

266 our results provide the first evidence that Slug-upregulated miR-221 promotes breast cancer progress

267 novel Akt-HSF-1 signaling axis that leads to Slug upregulation and EMT, and potentially contributes t

268 We find that Slug upregulation in angiogenic endothelial cells (EC) r

269 Chemical or genetic inhibition of SLUG upregulation prevented EMT following the acute IL-1

270 genitor like properties, involving Snail and Slug upregulation, mammosphere formation and aldehyde de

271 ll expansion, together with miR-452 loss and Slug upregulation, providing a novel mechanism whereby c

272 sential role that HSF-1 plays in Akt-induced Slug upregulation.

273 ed oncogenes, including c-MYC, CD44, CDKN1B, SLUG, VDR, SMAD3, VEGFA, and XBP1.

274 mesenchymal transition (EMT) markers (Snail, Slug, vimentin and N-cadherin) were induced in human pro

275 The positive association between HSF-1 and Slug was confirmed by immunohistochemical staining of a

276 Slug was dramatically upregulated in metastases relative

277 The prosurvival effect of Slug was found to be caused by direct repression of the

278 of slug and fascin correlated in PDAC cells; slug was found to regulate transcription of Fascin along

279 high expression of the transcription factor SLUG was indispensable for the establishment of EMT memo

280 sfer activity at the rear end of the aqueous slugs was found on the course of the experiment.

281 ymol blue (BTB) from acidic to basic aqueous slugs was performed for demonstration.

282 Each of the slugs was radio-tracked for approximately 10 h during wh

283 ned that transcriptional induction of SNAI2 (Slug) was essential for cyclin D1b-mediated proliferativ

284 Slugs were collected in a commercial winter wheat field

285 Eleven tagged slugs were released as a group (dense release).

286 Seventeen tagged slugs were released singly (sparse release) on the same

287 The slugs were taken to the laboratory, radio-tagged using a

288 cesses (pPI3K, pAKT, pERK, Bcl2, Zeb, Snail, Slug) were significantly changed in response to alterati

289 teady gas flux into a series of discrete gas slugs which cause explosions.

290 f the Stylommatophora (and slugs and shelled slugs), which diverged 90-130 MYA.

291 y expression of the EMT transcription factor Slug whose expression is dependent on CBFbeta.

292 Co-expression of Slug with Kras also attenuated chronic pancreatitis-indu

293 ting protein (CHIP) interacts with wild-type Slug (wtSlug).

294 ility and expression of beta-catenin, Snail, Slug, Zeb1 and N-cadherin, and upregulated E-cadherin.

295 ression of key transcription factors (Snail, Slug, Zeb1) or by acquiring drug resistance produces a s

296 n of metastasis-associated markers VIMENTIN, SLUG, ZEB1, and MMP9, with a concurrent decrease in mRNA

297 d miR-96 repressed common targets, including SLUG, ZEB1, ITGB1, and KLF4.

298 are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, and Twist1) involved in EMT.

299 ons were observed between miR-218 levels and Slug/ZEB2 levels in cancer tissue samples.

300 asis of lung cancer in part by modulation of Slug/ZEB2 signaling, and provide a potential therapeutic