ライフサイエンスコーパス: small GTPase

1 icantly increased the activation of the RhoA small GTPase.

2 the expression of 131 genes including Ral, a small GTPase.

3 regulatory principles and functions of this small GTPase.

4 of Rab7, a late endosome/lysosome-associated small GTPase.

5 , while SmgGDS-558 interacts with prenylated small GTPases.

6 s (mitoribosomes) involves several conserved small GTPases.

7 aling by prenylating Rho A, Rho G, and CDC42 small GTPases.

8 pigenetic regulators, metabolic enzymes, and small GTPases.

9 ons for merlin-dependent regulation of other small GTPases.

10 nate pathway, crucial for the prenylation of small GTPases.

11 rentially regulates farnesylation of several small GTPases.

12 actile ring that is controlled by Rho-family small GTPases.

13 the ARF (ADP-ribosylation factor) family of small GTPases.

14 ssential roles in regulating the activity of small GTPases.

15 proach to target the currently "undruggable" small GTPases.

16 Golgi and that this process is regulated by small GTPases.

17 merization, and interactions with a suite of small GTPases.

18 and enters the cytosol where it glucosylates small GTPases.

19 ly of proteins involved in the activation of small GTPases.

20 ght be the main downstream effector of these small GTPases.

21 the MRM quantification results for selected small GTPases.

22 ulated specificity for other closely-related small GTPases.

23 R8-WDR41 acts as a GAP for the ARF family of small GTPases.

24 ogy is applicable to many other farnesylated small GTPases.

25 inhibit the malignant phenotype generated by small GTPases.

26 se, requiring the small G protein RAC family small GTPase 1 (RAC1) and protein kinase C (PKC), and a

27 Reactive oxygen species and Rac family small GTPase 1 (Rac1) function in the upstream and downs

28 ell division cycle 42 (CDC42) and Rac family small GTPase 1 (RAC1) than did WT IQGAP1.

29 Rho family members, including Rac family small GTPase 1 (RAC1), were identified as candidates.

30 ediated through the inhibition of Rac family small GTPase 1 and cell division cycle 42 activation, as

31 downstream cell division cycle 42/Rac family small GTPase 1 signaling, increased epithelial cell migr

32 , WDPCP, JBTS17 and RSG1 (REM2- and RAB-like small GTPase 1), whose genes are mutated in ciliopathies

33 but not chronic mTBI, including ras-related small GTPase 10, 73% decrease; annexin VII, 8.8-fold inc

34 Among the 83 quantified small GTPases, 25 exhibited at least a 1.5-fold differen

35 e relative levels of expression of 55 and 49 small GTPases accompanied by adipogenic differentiation

36 er, the signaling events linking JAKs to rho small GTPase activation by chemokines is still incomplet

37 tion significantly reduces HSC migration and small GTPase activation, and induces apoptotic signaling

38 demonstrates the importance of coordinating small GTPase activities during engulfment of more comple

39 ocesses of receptor recycling, regulation of small GTPase activities, cell-ECM interactions, and cell

40 LF2 manipulation, permeability measurements, small GTPase activity, luciferase assays, chromatin immu

41 The ADP-ribosylation factor-like 4C (Arl4C) small GTPase acts as a molecular switch to regulate morp

42 ut not LC3b specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate

43 Pharmacologic or genetic blockade of the small GTPase ADP-ribosylation factor 6 (arf6) that regul

44 Small GTPases alternatively bind GDP/GTP guanine nucleot

45 roteins are chaperones that bind and traffic small GTPases, although their exact cellular function is

46 n through inhibiting the recruitment of Rab1 small GTPase and endoplasmic reticulum-derived COPII ves

47 syndecan endosomal budding, upstream of ARF6 small GTPase and its effector phospholipase D2, directly

48 , a member of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton,

49 es that SmgGDS-607 binds to a broad range of small GTPases and does not require a PBR for recognition

50 polybasic region and the CAAX box of several small GTPases and inhibits prenylation by impeding their

51 lysosomal signalling complex containing Rag small GTPases and mammalian target of rapamycin complex

52 , PTMs may exert conformational control over small GTPases and may add another previously unrecognize

53 -607-mediated regulation of farnesylation of small GTPases and suggest that SmgGDS-607 has multiple m

54 signals regulate a common set of components: small GTPases and the actin cytoskeleton, which implies

55 Lipidated small GTPases and their regulators need to bind to membr

56 We considered that FliI interacts with small GTPases and their regulators to mediate assembly o

57 eta and the membrane localization of several small GTPases and this was potentiated by zoledronic aci

58 Thus, the interaction between small GTPases and WASP is more complex than previously t

59 realized in part via changes in the Ca(2+)-, small GTPase, and catenin signaling.

60 kinases, which act as effectors for several small GTPases, and has been specifically identified to f

61 Ras and Rho small GTPases are critical for numerous cellular process

62 Small GTPases are essential signaling molecules for regu

63 The Ras superfamily of small GTPases are guanine-nucleotide-dependent switches

64 Signaling networks comprising small GTPases are highly connected, and there is some ev

65 The members of the Rab family of small GTPases are molecular switches that regulate disti

66 As small GTPases are pivotal for cellular survival, GGPPS w

67 lution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Go

68 of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to

69 de exchange factor GBF1, which activates the small GTPase Arf1 to induce COPI transport processes, is

70 we show that constitutive activation of the small GTPase ARF6 (ARF6(Q67L)) is sufficient to accelera

71 guanine nucleotide exchange factors for the small GTPase ARF6 and their loss affects a variety of ac

72 in recycling between both sites requires the small GTPase Arf6 but neither caveolin1 (Cav1) nor Cavin

73 In this study, we examined the role of the small GTPase Arf6 in the activation of the PLD isoforms

74 y, we showed that the ubiquitously expressed small GTPase Arf6 is required for normal ethanol-induced

75 Interestingly, a known ACAP2 target, the small GTPase Arf6, supported histamine-evoked WPB exocyt

76 brane, which, in turn, bind and activate the small GTPase ARF6.

77 control dendrite branching by regulating the small GTPase ARF6.

78 The conserved ARF-like small GTPase ARL-8 is localized to SVPs and directly act

79 at the trans-Golgi and was regulated by the small GTPases Arl1 and Arl8, suggesting a role in trans-

80 Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to photoreceptor impairme

81 afficking of the Joubert syndrome-associated small GTPase Arl13b into kidney cilia.

82 eins such as Unc119 or PDE6delta, as well as small GTPases Arl13b and Arl3 in the cilium.

83 tissues and showed that it tightly binds the small GTPase ARL2 but appears to be inactive.

84 d Kif17 as novel interaction partners of the small GTPase Arl3 and its regulatory GTPase activating p

85 The small GTPase ARL4C participates in the regulation of cel

86 rt with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across

87 e lysosome dispersal through coupling to the small GTPase Arl8 and the kinesins KIF1B and KIF5B.

88 entional egress is regulated by the Arf-like small GTPase Arl8b and can be blocked by the Rab7 GTPase

89 urthermore, we propose that the G-domains of small GTPases behave autonomously in solution and that n

90 , we present highly sensitive intensiometric small GTPase biosensors visualizing the activity of mult

91 ed activities of multiple Ras and Rho family small GTPases, but how their activities are integrated a

92 Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine

93 The small GTPase Cdc42 governs the formation and distributio

94 ands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis

95 The ability of the small GTPase Cdc42 to regulate diverse cellular processe

96 YAP positively regulated the activity of the small GTPase CDC42, deletion of which caused severe defe

97 ing of a UAA to generate a biosensor for the small GTPase Cdc42.

98 Here, we show that the small GTPases Cdc42 and RhoA act as a regulatory circuit

99 ts biologic effects through an activation of small GTPase cell division control protein 42 homolog (C

100 The small GTPase cell division cycle 42 (CDC42) plays essent

101 coded by several paralog families, including small GTPases, coiled-bundle proteins, and proteins with

102 Rab6, the most abundant Golgi associated small GTPase, consists of 2 equally common isoforms, Rab

103 ses, but unsuccessful attempts to target the small GTPases directly have resulted in them being class

104 , it is important to know which specific GEF-small GTPase dyad functions in a given cellular process.

105 ther RAS isoforms and a subset of prenylated small GTPase family members using a live-cell quantitati

106 Members of the ADP-ribosylation factor (ARF) small GTPase family regulate membrane trafficking and cy

107 rs of the Rho-like GTPases from Plants (ROP) small GTPase family.

108 at the competitive binding affinities of the small GTPase for SmgGDS-607 and FTase dictate the extent

109 The Rab family of small GTPases functions in multiple aspects of cellular

110 ylation factor (Arf)-like 4A (Arl4A), an Arf small GTPase, functions in cell morphology, cell migrati

111 r (Arf)-like 4D (Arl4D), one of the Arf-like small GTPases, functions in the regulation of cell morph

112 Mutations in the small GTPase gene RAB39b are associated with X-linked ma

113 The small GTPases H, K, and NRAS are molecular switches indi

114 behavioral plasticity, but the Ras family of small GTPases has not been extensively examined in drug-

115 Small GTPases have been recognized as important molecule

116 Here we identify Rab7A, a small GTPase important for endocytic trafficking, as a n

117 Furthermore, R-Ras, a small GTPase important for vascular normalization and ve

118 lysis, and effector interactions of multiple small GTPases in a single complex system.

119 The involvement of small GTPases in adipogenesis, however, has not been sys

120 itive and reproducible quantifications of 80 small GTPases in brain tissue samples from 15 patients.

121 ulates targeted exocytosis as an effector of small GTPases in polarized cell growth.

122 sensors visualizing the activity of multiple small GTPases in single cells in vivo.

123 bacterial toxin glucosylates and inactivates small GTPases in the cytosol of target cells, ultimately

124 pe of potential approaches for targeting the small GTPases in the future through their regulatory pro

125 conducted for assessing the implications of small GTPases in the metastatic transformation of colore

126 O Ex5 suppresses the prenylation of multiple small GTPases in the Ras, Rho, and Rab families and inhi

127 SmgGDS proteins also regulate prenylation of small GTPases in vivo in a substrate-selective manner.

128 itor cells is the preferential expression of small GTPases, including Kras, suggesting that they migh

129 ine kinases through direct interactions with small GTPases, including Rap1A and Ras.

130 epresent promising candidates for Rho-family small GTPase inhibitors and therapeutics targeting Ras-d

131 the ADP-ribosylation factor (ARF) family of small GTPases initiates intracellular transport pathways

132 numerous GEFs and also a host of Ras family small GTPases, it is important to know which specific GE

133 t, three peptide substrates derived from the small GTPase K-Ras and the inhibitory alpha-subunit of t

134 Recent studies have shown that the small GTPase KRAS adopts multiple orientations with resp

135 Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers,

136 The small GTPase KRAS is localized at the plasma membrane wh

137 tudy identifies a complex role for ARL13B, a small GTPase linked to Joubert syndrome and visual impai

138 hing motility is under the dependence of the small GTPase MglA, but the underlying molecular mechanis

139 The Ras family of small GTPases modulates numerous essential processes.

140 le information on the new functional role of small GTPase, NOG1, in guard cell signaling and early pl

141 Here we report the newly identified small GTPase, Nucleolar GTP-binding protein 1 (NOG1), fu

142 xneri effectors, IpaJ and VirA, which target small GTPases of the Arf and Rab families, consequently

143 In uninfected cells, GBF1 activates small GTPases of the Arf family and coordinates multiple

144 aryotic endomembrane system is controlled by small GTPases of the Rab family, which are activated at

145 Small GTPases of the RAS and RHO families are related si

146 ggered IKC intracellular signals mediated by small GTPases of the Ras subfamily and protein kinase B

147 Genes encoding the small GTPases of the Ras superfamily are among the most

148 Small GTPases of the Ras superfamily are essential regul

149 Small GTPases of the Rho and Ras families are important

150 The small GTPases of the Rho family (RhoA, Rac1, and Cdc42)

151 Small GTPases of the Rho family are binary molecular swi

152 ed immune receptors, such as CD40, with RAB7 small GTPase on mature endosomes, in addition to signals

153 cells they are hypersensitive to Rac family small GTPases or to the upstream kinases spleen-associat

154 Emc10 signaled through small GTPases, p21-activated kinase, and the p38 mitogen

155 The Rap1 small GTPase pathway has emerged as a commonly disrupted

156 ure suggests a possible universal system for small GTPase patterning involving both protein and lipid

157 ne nucleotide exchange factor for Rho family small GTPases, PDZ-RhoGEF.

158 e high 607:558 ratio is required for optimal small GTPase prenylation, and validate this innovative a

159 otide exchange factor that activates RHOA, a small GTPase protein that is a key component of tight ju

160 ERK signaling through direct interference of small GTPases protein prenylation.

161 re, we explored how the expression levels of small GTPase proteins are regulated by m(6)A modulators.

162 ptides, to identify differentially expressed small GTPase proteins during adipogenesis of cultured mu

163 eomic method, the differential expression of small GTPase proteins in a matched pair of primary/metas

164 fy systemically the changes in expression of small GTPase proteins in cells upon genetic ablation of

165 r high-throughput targeted quantification of small GTPase proteins in other tissue and cellular sampl

166 method to examine the altered expression of small GTPase proteins in post-mortem frontal cortex tiss

167 ted expression, respectively, of a subset of small GTPase proteins, including RHOB and RHOC.

168 develop a targeted quantification method for small GTPase proteins, where the method involves schedul

169 comprehensive analysis of the alterations in small GTPase proteome during adipogenesis, and we reveal

170 mprehensively the relative expression of the small GTPase proteome in a pair of matched primary/metas

171 comprehensive analysis of the alterations in small GTPase proteome regulated by epitranscriptomic mod

172 substantially increased the coverage of the small GTPase proteome.

173 Switches I and II, which in classical small GTPases provide a mechanism for nucleotide-depende

174 etry breaking, which alongside the monomeric small GTPases provides a core mechanism for the biogenes

175 Here, we present evidence that the small GTPase RAB-5 acts to inhibit axonal fusion, a func

176 Here, we show that the small GTPase RAB-5 is a key cell-intrinsic regulator of

177 mediated epithelial remodeling involving the small GTPase Rab11 and localized extracellular matrix de

178 o associate with decreased expression of the small GTPase Rab11 and the Rab7 effector RILP.

179 Mechanistically, we identify the small GTPase RAB11 as an interactor of the guanine nucle

180 rumbs complex component MPP5a interacts with small GTPase Rab11 in Golgi to transport cadherin and Cr

181 The small GTPase Rab11-Rab8 cascade is required for ciliogen

182 ocytic protein, it also colocalizes with the small GTPases Rab11 and Arf6, components of the exocytic

183 found nudC interacts with rhodopsin and the small GTPase rab11a.

184 Such targeting of the small GTPase RAB13 generated tight spatial coupling of m

185 Here, we reveal the role of the small GTPase Rab18 as a positive regulator of directiona

186 Here we show that another small GTPase, Rab2, is also required for autophagosome a

187 specific oncogenic phenotypes.The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogeni

188 mmon genetic variant that corresponds to the small GTPase, Rab27, a protein involved in vesicular tra

189 Here, we reconstituted the patterning of the small GTPase Rab5 and its GEF/effector complex Rabex5/Ra

190 Various lines of evidence suggest that the small GTPase Rab5 plays a role in neuronal signaling via

191 Here we show that the small GTPase Rab5, a known regulator of endocytosis, is

192 The small GTPase Rab7 is a key organizer of receptor sorting

193 revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late

194 C-based ubiquitome profiling we identify the small GTPase Rab7-the logistical centerpiece of LE biolo

195 endosomes, reconstituting split-GFP with the small GTPase RAB7.

196 n kinase Unc-51-like kinase 1 (Ulk1) and the small GTPase Rab9 to clear damaged mitochondria independ

197 The roles of protein kinase C and the small GTPase, Rab9, in alpha1B-AR vesicular traffic were

198 The small GTPase RABL3 is an oncogene of unknown physiologic

199 a catalytic GAP domain that inactivates the small GTPase Rac.

200 engers, but inhibit global activation of the small GTPase Rac.

201 are serine/threonine kinase effectors of the small GTPases Rac and Cdc42 and major participants in ce

202 which leads to activation of the Rho family small GTPase Rac1 and Rac1-induced axonal regeneration.

203 is study, we found that mutant p53 activates small GTPase Rac1 as a critical mechanism for mutant p53

204 1 integrin-dependent local activation of the small GTPase RAC1 at the plasma membrane to control the

205 ditionally, RvE1-triggered activation of the small GTPase Rac1 led to increased intracellular reactiv

206 ion, as well as signaling via ERK1/2 and the small GTPase Rac1); however, CXCL14 bound to CXCR4 with

207 ation was sensitive to the inhibition of the small GTPase RAC1, an upstream activator of the WRC.

208 We find that Sema3A activates the small GTPase Rac1, and that Rac1 activity is required fo

209 ype secondary to increased activation of the small GTPase Rac1.

210 in polymerization by directly activating the small GTPase Rac1.

211 ctin cytoskeleton by local activation of the small GTPase Rac1.

212 al activation of actin regulators, including small GTPases Rac1, Cdc42 and Ras, in the presence or ab

213 reg cell-specific ablation of the Rag family small GTPases RagA and RagB impairs amino acid-induced m

214 ucleotide exchange factor that activates the small GTPase Rap-1.

215 gh an RNAi screen, we further identified the small GTPase RAP-3 (Rap1) as a pharyngeal-specific PAT-2

216 sensor to study the rapid 3D dynamics of the small GTPase Rap1 in vesicles and cell protrusions.

217 Membrane-anchored mammalian small GTPase Rap1 is known to bind talin-F0 domain but t

218 nhancement of PAR-mediated activation of the small GTPase RAP1, a regulator of integrin activation an

219 emodeling induced by low CS was dependent on small GTPase Rap1.

220 a guanine nucleotide exchange factor of the small GTPase Rap1.

221 ated by cAMP promotes exchange of GTP in the small GTPase Rap1.

222 beta1 and beta4, and altered activity of the small GTPase Rap1.

223 Proteomic analysis revealed that the small GTPase, Rap1 was overexpressed in lEVs from MetS p

224 ing complex containing ZO-2, Afadin, and the small GTPase Rap2.

225 ion has been linked to the activation of the small GTPase Ras homolog family member A (RhoA) by the G

226 The activation of Raf kinases by the small GTPase Ras requires two major sets of phosphorylat

227 Such mutations reduce the ability of the small GTPase RAS to hydrolyze GTP, keeping this molecula

228 ut signaling to integrins is mediated by the small GTPase Ras-proximate-1 (Rap1).

229 KLF2 is a novel activator of small GTPase Ras-related C3 botulinum toxin substrate 1

230 The small GTPase Ras-related protein Rab-7a (Rab7a) serves a

231 Raf kinases are downstream effectors of small GTPase Ras.

232 we describe signaling cross-talk between the small GTPases RAS and RAP1A, member of RAS oncogene fami

233 R-ketorolac is a selective inhibitor of the small GTPases Ras-related C3 botulinum toxin substrate 1

234 The small GTPase, Ras-related protein Rab-7A (Rab7), is esse

235 the protein phosphatase calcineurin, and the small GTPase Ras1, as well as with divergent stress resp

236 Gc reduced the activity of the pro-migratory small GTPase regulator Rac1.

237 acterized the role of the activity-regulated small GTPase Rem2 in both arbor development and the main

238 telets promoted the activation of Cdc42, the small GTPase responsible for filopodia formation.

239 mTORC1 is activated by the small GTPase RHEB (Ras homologue enriched in brain) and

240 In many eukaryotes, the small GTPase Rheb functions as a switch to toggle activi

241 GTPase-activating protein (GAP) towards the small GTPase Rheb.

242 an activator-inhibitor network, in which the small GTPase Rho amplifies its activity by recruiting it

243 cells is regulated by signaling through the small GTPase Rho and by calcium-activated pathways.

244 The small GTPase Rho and its downstream Rho-associated coile

245 ation by phosphorylating and destabilizing a small GTPase, Rho1.

246 mine neurons by increasing activation of the small GTPase RhoA and of protein kinase A.

247 The small GTPase RhoA is a central regulator, activating cor

248 The small GTPase RhoA is a central signaling enzyme that is

249 sis, polo-like kinase 1 (PLK1) activates the small GTPase RhoA to assemble a contractile actomyosin r

250 (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remod

251 Instead, BAI1 couples to the small GTPase RhoA, driving late RhoA activation in dendr

252 early step involves local activation of the small GTPase RhoA, which triggers assembly of an actomyo

253 te focal adhesion assembly by activating the small GTPase RhoA.

254 ontrol of the actin cytoskeleton through the small GTPase RhoA.

255 development by differentially regulating the small-GTPase RhoA and actin-associated protein Cortactin

256 Here, we show that the small GTPase RhoJ integrates these opposing signals in d

257 Here, we report that the small GTPase ROP2, if activated by the phytohormone auxi

258 Thus, these intensiometric small GTPase sensors enable the spatiotemporal dissectio

259 ts reveal an unusual regulatory mechanism in small GTPase signaling by which the effector molecule is

260 of cancers, and inhibition of the Rho family small GTPase signaling has been shown to combat Ras-driv

261 odulate the signaling between RABs and other small GTPases, some of which have a crucial role in the

262 GTPase--activating protein toward Rho family small GTPases) SPV-1 was previously identified as a nega

263 s), G protein-coupled receptors (GPCRs), and small GTPases such as Rac1 and Rab5.

264 ctivation potential for any given GTPase, as small GTPases such as RAS-like proto-oncogene A (RALA) o

265 he fusion kinase to facilitate activation of small GTPases such as the Ras homology gene family, memb

266 Small GTPases, such as Rab7 and Arl8b, recruit their dow

267 Cellular movement is controlled by small GTPases, such as RhoA.

268 ion of trans-endocytosis by silencing of the small GTPase TC21 or expression of a dominant-negative T

269 epithelial cell line, we show that RanGTP, a small GTPase that dictates nuclear transport, regulates

270 RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic

271 Arf-like protein 13b (ARL13b) is a small GTPase that functions as a guanosine nucleotide ex

272 -associated Ras-related GTPase 1 (SAR1) is a small GTPase that is part of COPII and, upon GTP binding

273 Rab6, a small GTPase that regulates a number of endosomal traffi

274 The ADP-ribosylation factor 6 (Arf6) is a small GTPase that regulates endocytic recycling processe

275 ain showed significantly decreased Rab27a, a small GTPase that regulates MVB-PM docking.

276 on as a guanine exchange factor for Rab26, a small GTPase that specifically directs synaptic vesicles

277 py also depends on RAB-A5c, a plant-specific small GTPase that specifies a membrane trafficking pathw

278 H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell

279 RalA and RalB are small GTPases that are involved in cell migration and me

280 Those small GTPases that are targeted by METTL3 and/or ALKBH5

281 ed by expressing DiRas1 or DiRas2, which are small GTPases that bind SmgGDS and act as tumor suppress

282 d a complex interplay between PKCepsilon and small GTPases that contributes to regulation of NSCLC ce

283 oteins which belong to the protein family of small GTPases that function as binary molecular switches

284 ole in the post-translational prenylation of small GTPases that perform a plethora of cellular functi

285 and KRAS4A/KRAS4B comprise the RAS family of small GTPases that regulate signaling pathways controlli

286 genic members of the Ras and Rho families of small GTPases through membrane trafficking via regulatio

287 ecule and biologics strategies to target the small GTPases through their regulators.

288 ations, can reliably dissect the response of small GTPases to site-specific modifications.

289 actin cytoskeleton regulation by controlling small GTPase translation in neutrophils at wound sites.

290 trafficking, activity of the Rab3 and Rab27 small GTPases, tumour necrosis factor-alpha (TNF-alpha)-

291 Ras family small GTPases undergo prenylation (such as farnesylation

292 Decades ago, Rap1, a small GTPase very similar to Ras, was observed to suppre

293 letal regulation, and that expression of the small GTPases was markedly increased in miR-142(-/-) neu

294 terestingly, overall a significant number of small GTPases were down-regulated during adipogenesis.

295 effects on AQP2 phosphorylation and RhoA (a small GTPase, which under resting conditions, maintains

296 core COPII components, is a highly conserved small GTPase, which, upon GTP binding, recruits the othe

297 mediated activation of downstream Ras family small GTPases, which ultimately lead to ERK, JNK, and p3

298 teracts with newly synthesized preprenylated small GTPases, while SmgGDS-558 interacts with prenylate

299 display elevated levels of activated Rac1, a small GTPase widely implicated in cytoskeleton reorganiz

300 We also identify the small GTPase Ypt1 as a recruiter for Gea1 and Gea2.