ライフサイエンスコーパス: small heat-shock protein

1 s an intracellular Golgi membrane-associated small heat shock protein.

2 ontaining Arabidopsis (Arabidopsis thaliana) small heat shock protein.

3 ulin, and beta-catenin, were identified in a small heat shock protein.

4 nderlying the cytoprotective effects of this small heat shock protein.

5 promoter of ibpA, which encodes a universal small heat-shock protein.

6 r as cochaperones of Hsp90 or as independent small heat shock proteins.

7 ld-type levels of heat shock protein 101 and small heat shock proteins.

8 n genes, which encode proteins homologous to small heat shock proteins.

9 ppears to be a novel member of the family of small heat shock proteins.

10 5) encoding a cytoplasmic antigen related to small heat shock proteins.

11 amic interaction between the major mammalian small heat shock proteins.

12 tallin and HSP27 are mammalian intracellular small heat shock proteins.

13 smic protein inclusions containing GFAP, and small heat shock proteins.

14 controversial role of ATP in the function of small heat-shock proteins.

15 in the process of recognition and binding by small heat-shock proteins.

16 te filament protein GFAP in association with small heat-shock proteins.

17 inhibitor-1 of protein phosphatase 1 and the small heat shock protein 20, which affect the overall SE

18 nterior IX (posterior zone; PZ), whereas the small heat shock protein 25 (HSP25) is expressed in stri

19 Here we show that the small heat shock protein 27 (Hsp27) associates with casp

20 The small heat shock protein 27 (hsp27) increases in express

21 Here we describe how the expression of the small heat shock protein 27 (HSP27) is correlated with n

22 aling events revealed phosphorylation of the small heat shock protein 27 (HSP27) that was abolished b

23 The small heat shock protein 27, which interacts with Rpp20

24 erone function that proposes the coupling of small heat shock protein activation to the substrate fol

25 re we demonstrate that the expression of the small heat shock protein alpha B-crystallin is selective

26 An R120G missense mutation in the small heat shock protein alpha-B-crystallin (CryAB(R120G

27 An R120G missense mutation in the small heat shock protein alpha-B-crystallin (CryAB) caus

28 riptome revealed a striking induction of the small heat shock protein alpha-basic-crystallin (alphaB-

29 Here we report that the small heat shock protein alpha-basic-crystallin (alphaB-

30 abilized mutant of T4 lysozyme (T4L) and the small heat shock protein alpha-crystallin.

31 roach to characterize the interaction of the small heat-shock protein alpha-Crystallin with two subst

32 ause MKK6 increases levels of the protective small heat shock protein, alpha B-crystallin (alpha BC),

33 The small heat shock protein alphaA-crystallin is a molecula

34 Molecular chaperones, including the small heat shock protein alphaA-crystallin, have recentl

35 Mice with deletion of genes for small heat shock proteins alphaA- and alphaB-crystallin

36 We have shown previously that the small heat shock protein alphaB-crystallin (alphaB) is e

37 The small heat shock protein alphaB-crystallin (CRYAB) has b

38 The small heat shock protein alphaB-crystallin (Cryab) regul

39 The therapeutic benefit of the small heat shock protein alphaB-crystallin (HspB5) in an

40 Genetic mutations in the human small heat shock protein alphaB-crystallin have been imp

41 We report here that the small heat shock protein alphaB-crystallin inhibits both

42 The small heat shock protein alphaB-crystallin interacts wit

43 The small heat shock protein alphaB-crystallin is an oligome

44 lococcus aureus-induced endophthalmitis, the small heat shock protein alphaB-crystallin is upregulate

45 The human small heat-shock protein alphaB-crystallin (alphaB) resc

46 e anti-stress properties established for the small heat-shock protein alphaB-crystallin, perhaps in r

47 The small heat shock protein, alphaB-crystallin, which accum

48 The small heat shock protein, alphaB-crystallin, which is ex

49 ins were identified as modified forms of the small heat shock protein, alphaB-crystallin.

50 The small heat-shock proteins also delay the onset of polygl

51 an agonist-dependent relationship between a small heat shock protein and beta-arrestin to form a pre

52 alphaA-crystallin (Cryaa/HSPB4) is a small heat shock protein and molecular chaperone that pr

53 factor to activate transcription of both the small heat shock protein and the large heat shock protei

54 heat shock proteins include ATP-independent small heat shock proteins and the larger ATP-dependent p

55 ation of many antiapoptotic genes, including small heat shock proteins and transcription factors.

56 tibility-1 on wheat chromosome 3AS encodes a small heat-shock protein and is a major susceptibility g

57 alphaB-crystallin, a ubiquitously expressed small heat shock protein (and a crystallin) in the ocula

58 Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined component

59 tain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins ar

60 of these mice are hypertrophic, up-regulate small heat-shock proteins, and contain inclusion bodies

61 se transcription-PCR analysis shows that the small heat shock proteins are also transcriptionally ind

62 sults show that the highly conserved E. coli small heat shock proteins are dispensable and that their

63 Small heat shock proteins are known to stabilize several

64 Small heat shock proteins are ubiquitous molecular chape

65 Small heat shock proteins are ubiquitous molecular chape

66 ast to the existing paradigm that classifies small heat-shock proteins as ATP-independent chaperones.

67 in the alpha-crystallin domain of mammalian small heat-shock proteins assemble a basic building bloc

68 rms heat shock granules containing canonical small heat shock proteins at high temperatures.

69 ons in neurofilament light (NFL) subunit and small heat-shock protein B1 (HSPB1) cause autosomal-domi

70 issense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) t

71 e therapeutic activity of alphaB crystallin, small heat shock protein B5 (HspB5), was shared with oth

72 mers are commonly observed in experiments on small heat-shock proteins, but their connection to the b

73 ion of metallothioneins and alpha-crystallin/small heat shock proteins by different metals indicates

74 TP hydrolysis and substrate binding, and the small heat shock protein can suppress protein aggregatio

75 ation, both at the RNA and protein level, of small heat shock proteins, chaperones, proteases, and pr

76 CryAB and HSPB2 are small heat shock proteins constitutively expressed in th

77 determine the roles of chloroplast-localized small heat shock proteins (CP-sHSPs) in heat tolerance.

78 The majority, all of which were small heat shock proteins, decreased in heat-shocked ale

79 ring with the chaperone activity of a barley small heat shock protein essential for defense and stres

80 AlphaB-crystallin (alphaBC), a small heat shock protein expressed in high levels in the

81 Here we demonstrate that two small heat shock proteins expressed in embryonic zebrafi

82 alphaA-crystallin is a small heat-shock protein expressed preferentially in the

83 alphaB-crystallin is a member of the small heat shock protein family and can act as a molecul

84 AlphaB-crystallin is a member of the small heat shock protein family and is known to have cha

85 possibility that the S1R is a member of the small heat shock protein family is discussed.

86 In contrast, neither the closely related small heat shock protein family member Hsp27 nor Hsp70 i

87 nserved arginine in the ACD of several human small heat shock protein family members causes many comm

88 nd a protein with meaningful homology to the small heat shock protein family of chaperones.

89 As a member of the small heat shock protein family possessing chaperone-lik

90 ny proteins including Hsp27, a member of the small heat shock protein family that has cytoprotective

91 hat human alphaB-crystallin, a member of the small heat shock protein family, actively participates i

92 Mutations in HSPB1 and HSPB8, members of the small heat shock protein family, have recently been show

93 Two members of the small heat shock protein family, IbpA and IbpB, are pres

94 Hsp12 (heat shock protein 12) belongs to the small heat shock protein family, partially characterized

95 alphaB-crystallin, a member of the small heat shock protein family, possesses chaperone-lik

96 B-crystallin is a chaperone belonging to the small heat shock protein family.

97 It is a member of the small heat-shock protein family and possesses chaperone-

98 ession of alphaB-crystallin, a member of the small heat-shock protein family, blocks activation of RA

99 ence that alphaB-crystallin, a member of the small heat-shock protein family, suppresses thermal unfo

100 Methanococcus jannaschii, is a member of the small heat-shock protein family.

101 ary structure between distant members of the small heat-shock protein family.

102 Small heat shock proteins form large cytosolic assemblie

103 , we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in

104 on conformation and dynamics of the 16.9 kDa small heat shock protein from wheat have been studied us

105 Here we report the crystal structure of a small heat-shock protein from Methanococcus jannaschii,

106 We have characterized a novel small heat shock protein gene, viscosity 1 (vis1) from t

107 n fluorescent protein (GFP)-tagged inducible small heat-shock protein gene (hsp-16-2).

108 ne world, but now the crystal structure of a small heat shock protein has been solved and mutation of

109 We investigated whether this archetypical small heat-shock protein has the ability to interact wit

110 Small heat shock proteins have been associated with cyto

111 Small heat shock proteins have been the Cinderellas of t

112 agues present data supporting a role for the small heat shock protein (HSP) 27 in keratinocyte termin

113 In this study, we demonstrate that the small heat shock protein (Hsp) 27 is a key regulator of

114 In vitro, small heat shock protein (Hsp) alphaB-crystallin suppres

115 phaB-crystallin (CryAB) is the most abundant small heat shock protein (HSP) constitutively expressed

116 titutive neuronal expression of HSP-16.48, a small heat shock protein (HSP) homolog of human alpha-cr

117 A maize (Zea mays L.) small heat shock protein (HSP), HSP22, was previously sh

118 orylate the PKC delta-preferential substrate small heat shock protein (HSP-27).

119 P70 family, three alpha B-crystallin-related small heat shock proteins (HSP-16s), and a putative orth

120 In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with inc

121 me (T4L) bound to engineered variants of the small heat shock protein Hsp16.5.

122 stingly, both CSEPs interact with the barley small heat shock proteins, Hsp16.9 and Hsp17.5, in a yea

123 The small heat shock protein Hsp20 protects cardiomyocytes a

124 ulates dosage-sensitive proteins such as the small heat shock protein Hsp20, which exists in a dodeca

125 the cofactors DnaJ1, DnaJ2, and GrpE and the small heat shock protein Hsp20.

126 The small heat shock proteins HSP20, HSP25, alphaB-crystalli

127 ransiently increased expression of a cardiac small heat-shock protein Hsp20.

128 Babesia bovis small heat shock protein (Hsp20) is recognized by CD4+ T

129 eron with two downstream genes that encode a small heat shock protein, Hsp20, and cdc48, an AAA+ ATPa

130 r, little is known about the role of another small heat-shock protein, Hsp20, which regulates activit

131 eases in expression and phosphorylation of a small heat-shock protein, Hsp20.

132 to resolve the structures of two forms of a small heat shock protein (Hsp26) that vary slightly in d

133 The small heat shock proteins, Hsp26 and Hsp42, also functio

134 The small heat shock protein HSP27 (or HSPB1) has multiple c

135 ation in all adult axotomized neurons of the small heat shock protein Hsp27 and the failure of such i

136 The small heat shock protein Hsp27 has been shown to confer

137 The small heat shock protein Hsp27 is expressed at high leve

138 iously identified high concentrations of the small heat shock protein hsp27 within podocytes as well

139 Mutations in the small heat shock protein Hsp27, encoded by the HSPB1 gen

140 ha B-crystallin, but not the closely related small heat shock protein Hsp27, renders C2C12 myoblasts

141 te the phosphorylation and expression of the small heat shock protein HSP27.

142 ones also showed increased expression of the small heat shock protein HSP27; and reporter assays reve

143 promotes the interaction between p53 and the small heat shock proteins HSP27 (also known as HSPB1) an

144 However, it is unclear whether the small heat shock proteins hsp27 and alphaB-crystallin pr

145 aternary structure and dynamics of the human small heat-shock protein Hsp27 are linked to its molecul

146 The small heat-shock protein HSP27 is a redox-sensitive mole

147 larly enhances chaperone function of another small heat shock protein, Hsp27.

148 n the macromolecular associations of another small heat shock protein, HSP27.

149 TR), F508del, is initiated by binding of the small heat shock protein, Hsp27.

150 ewly synthesized Btn2 can associate with the small heat shock protein Hsp42 to promote the sorting of

151 belonging to four major insect Hsp families (small heat-shock proteins, Hsp60, Hsp70, and Hsp90) in S

152 Here we show that the small heat shock protein HspB1 (hsp25/27) is phosphoryla

153 Our data suggest that down-regulation of small heat shock protein HSPB1 and disintegration of neu

154 In SCA17 transgenic mice, the small heat shock protein HSPB1, a potent neuroprotective

155 Mutations in the small heat-shock protein HSPB1 (HSP27) are responsible f

156 Small heat shock protein HSPB7 is highly expressed in th

157 Here, we investigated the small heat shock protein Hspb8, which, because of its pl

158 AG3(Ile81) displayed improved binding to the small heat shock protein (HspB8) in ischemic skeletal mu

159 erminal region with high similarity to plant small heat shock proteins (HSPs).

160 we show that in Mycobacterium smegmatis, the small heat shock protein HspX plays a critical role in t

161 f the stress-response regulon, including the small heat shock proteins IbpA and IbpB that protect E c

162 r genetics evidence for a critical role of a small heat shock protein in cell traction and motility.

163 unsuspected and critical role for a specific small heat shock protein in directly modulating actin th

164 phaB-crystallin (CryAB) is the most abundant small heat shock protein in the heart.

165 This results in the selective induction of small heat shock proteins in adulthood, thereby protecti

166 abundance of transcripts of a catalase and a small heat-shock protein in the silenced flowers.

167 binding capacity has been observed in other small heat shock proteins including lens alpha-crystalli

168 were identified: (i) fragmentation caused by small heat shock proteins, including alpha B-crystallin,

169 The specificity of the immunoreactivity to small heat shock proteins, including alpha-crystallins a

170 ular weight in patients with glaucoma was to small heat shock proteins, including alpha-crystallins a

171 Since homologs of the small heat shock protein inhibit F-actin polymerization

172 ith Hsp16.9 and Hsp17.5, confirming the CSEP-small heat shock protein interaction.

173 Crystallin-alphaB (CryAB) is a small heat shock protein involved in preventing protein

174 ased formation of aggregates associated with small heat-shock proteins is observed.

175 Upregulation of alphaB-crystallin (CryAB), a small heat shock protein, is associated with a variety o

176 c reticulum (ER) chaperone, and HSP26.5-P, a small heat shock protein, is attenuated in the bZIP28 nu

177 aB-crystallin is a developmentally regulated small heat shock protein known for its binding to a vari

178 tive substances, heat shock protein 101, and small heat shock protein levels were determined.

179 rs of circulating antibodies against retinal small heat shock proteins may have pathogenic significan

180 n chaperone activity and complex assembly of small heat shock proteins need to be characterized to un

181 The small heat shock protein of Neurospora crassa, Hsp30, wh

182 Owing to the dynamic nature of small heat shock protein oligomers, elucidating the stru

183 Here, we investigate the effect of small heat shock proteins on the keratin 8/18 intermedia

184 One model for chaperone activity of small heat shock proteins proposes that ATP causes small

185 data are consistent with the hypothesis that small heat shock proteins recognize ENaC subunits at ER

186 Hsp27, a member of the family of the small heat-shock proteins, showed a similar interaction

187 The small heat shock protein (sHSP) alphaB-crystallin (alpha

188 How does the sequence of a single small heat shock protein (sHSP) assemble into oligomers

189 AlphaB-Crystallin is a small heat shock protein (sHsp) expressed at high levels

190 Eye lens alpha-crystallin is a member of the small heat shock protein (sHSP) family and forms large m

191 HspB5 is a well-characterized member of the small heat shock protein (sHsp) family that reduces muta

192 alphaA-Crystallin, a member of the small heat shock protein (sHsp) family, is a large multi

193 The small heat shock protein (sHSP) from the hyperthermophil

194 To investigate the mechanism of small heat shock protein (sHsp) function, unbiased by cu

195 Two mutations (K141E, K141N) in the small heat shock protein (sHSP) HSP22 (HSPB8) are associ

196 ulus alba) through overexpression of a major small heat shock protein (sHSP) with convenient features

197 er was identified by peptide sequencing as a small heat shock protein (sHSP).

198 have compared the tissue specificity of the small heat shock protein (shsp)/alphaB-crystallin promot

199 Mammalian small heat shock proteins (sHSP) are abundant in muscles

200 Mammalian small heat shock proteins (sHSP) form polydisperse and d

201 Small heat shock proteins (sHSP) make up a remarkably di

202 Small heat shock proteins (sHSP), HSP27 and alpha-B-crys

203 to the core "alpha-crystallin" domain of the small heat-shock protein (sHsp) and molecular chaperone,

204 her develop the mechanistic understanding of small heat-shock protein (sHSP) chaperone activity, we i

205 Clustered class-I small heat-shock protein (sHSP) chaperone genes, SlHSP17

206 alpha-Crystallin is a member of the small heat-shock protein (sHSP) family and consists of t

207 The small heat-shock protein (sHSP) from Methanococcus janna

208 sage corresponding to HSP26, which encodes a small heat-shock protein (sHsp) in yeast was up-regulate

209 AlphaB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chapero

210 We report that two members of the family of small heat-shock proteins (sHsp) (alpha-crystallin and S

211 lpha-crystallin is a member of the family of small heat-shock proteins (sHSP) and is composed of two

212 cing as the alpha-crystallin-related, 16-kDa small heat shock protein, sHsp16.

213 uppressors restored solubility of aggregated small heat shock proteins (sHsps) after heat stress, rev

214 The small heat shock proteins (sHSPs) and alpha-crystallins

215 e chaperone activity and subunit dynamics of small heat shock proteins (sHSPs) and establishes a work

216 Small heat shock proteins (sHSPs) and the related alpha-

217 Small heat shock proteins (sHSPs) are a class of ATP-ind

218 Small heat shock proteins (sHsps) are a diverse group of

219 Small heat shock proteins (sHsps) are a family of ATP-in

220 Small heat shock proteins (sHsps) are a family of large

221 Small heat shock proteins (sHsps) are a family of ubiqui

222 Small heat shock proteins (sHsps) are a ubiquitous and a

223 Small heat shock proteins (sHSPs) are a ubiquitous class

224 The small heat shock proteins (sHSPs) are a ubiquitous class

225 Small heat shock proteins (sHsps) are a ubiquitous famil

226 Small heat shock proteins (sHSPs) are an ubiquitous prot

227 Small heat shock proteins (sHSPs) are chaperones that ar

228 Small heat shock proteins (sHsps) are conserved, ubiquit

229 Small heat shock proteins (sHSPs) are dynamic oligomeric

230 Small heat shock proteins (sHSPs) are essential 'holdase

231 Small heat shock proteins (sHsps) are molecular chaperon

232 Small heat shock proteins (sHsps) are molecular chaperon

233 Small heat shock proteins (sHSPs) are nature's 'first re

234 Small heat shock proteins (sHsps) are oligomers that per

235 In myocytes, small heat shock proteins (sHSPs) are preferentially tra

236 Small heat shock proteins (sHSPs) are ubiquitous chapero

237 Small heat shock proteins (sHsps) are ubiquitous low-mol

238 Small heat shock proteins (sHsps) are virtually ubiquito

239 Small heat shock proteins (sHSPs) are virtually ubiquito

240 The ubiquitous small heat shock proteins (sHSPs) are well documented to

241 Small heat shock proteins (sHSPs) belong to a family of

242 Small heat shock proteins (sHsps) bind destabilized prot

243 Small heat shock proteins (sHsps) constitute a diverse c

244 Small heat shock proteins (sHSPs) delay protein aggregat

245 rn more about the function and regulation of small heat shock proteins (sHSPs) during seed developmen

246 Small heat shock proteins (sHSPs) exist as large polydis

247 Small Heat Shock Proteins (sHSPs) have important roles i

248 tailed understanding of the evolution of the small heat shock proteins (sHSPs) in plants, we have exa

249 How small heat shock proteins (sHsps) might empower proteost

250 Small heat shock proteins (sHSPs) play a central role in

251 nder conditions promoting protein unfolding, small heat shock proteins (sHsps) prevent the irreversib

252 Small heat shock proteins (sHsps) regulate cellular func

253 Small heat shock proteins (sHSPs) serve as a first line

254 Oligomerization is an essential property of small heat shock proteins (sHSPs) that appears to regula

255 The ability of small heat shock proteins (sHSPs) to prevent thermal agg

256 nant protein in the lens, is a member of the small heat shock proteins (sHSPs) which are a ubiquitous

257 Small heat shock proteins (sHSPs), as ubiquitous molecul

258 Molecular chaperones, such as the small heat shock proteins (sHsps), maintain normal cellu

259 /Zn-superoxide dismutase), and mitochondrial small heat shock proteins (sHsps).

260 ls and inducing those of the ATP-independent small heat shock proteins (sHSPs).

261 HSP 16.3 displays several characteristics of small heat shock proteins (sHsps): its expression is inc

262 ne families Hsp70, Hsp104, Hsp90, Hsp60, and small heat-shock proteins (sHsps) apparently act as unfo

263 Small heat-shock proteins (sHSPs) are a conserved group

264 Small heat-shock proteins (sHSPs) are a ubiquitous famil

265 Small heat-shock proteins (sHSPs) are a widely conserved

266 Small heat-shock proteins (sHSPs) are molecular chaperon

267 Small heat-shock proteins (sHsps) are molecular chaperon

268 Mammalian small heat-shock proteins (sHSPs) are molecular chaperon

269 Small heat-shock proteins (sHSPs) are ubiquitously expre

270 Small heat-shock proteins (sHsps) compose the most wides

271 The small heat-shock proteins (sHSPs) form a diverse family

272 Small heat-shock proteins (sHsps) prevent aggregation of

273 In vivo, molecular chaperones, such as the small heat-shock proteins (sHsps), normally act to preve

274 classes: HSP100, HSP90, HSP70, HSP60 and the small heat-shock proteins (sHSPs).

275 ing rat lens alphaA is a membrane-associated small heat shock protein similar to alphaB but with rema

276 ress-activated kinase that can phosphorylate small heat shock protein, suggesting a potential role fo

277 er size, symmetry, and polydispersity in the small heat shock protein super family.

278 As a member of the small heat shock protein superfamily, alpha-crystallin h

279 hsp20 appears to encode a new member of the small heat shock protein superfamily, DR1314 is predicte

280 on substrate recognition and binding by the small heat shock protein superfamily.

281 eterminants of structure and function in the small heat-shock protein superfamily, was determined in

282 ndicated that HSP22 is a member of the plant small heat-shock protein superfamily.

283 Small heat shock proteins, superoxide dismutase, quinone

284 ons of passive molecular chaperones, such as small heat-shock proteins, suppress thermodynamic instab

285 e to the study of the 200-kDa complex of the small heat shock protein TaHSP16.9, revealing both its d

286 AlphaA-crystallin is a small heat shock protein that functions as a molecular c

287 our knowledge, the first evidence of a plant small heat shock protein that has both developmental and

288 AlphaB-crystallin (alphaBC) is a small heat shock protein that is constitutively expresse

289 eased the expression of alphaB-crystallin, a small heat shock protein that is enriched in astrocytes

290 alpha-Crystallins are small heat shock proteins that regulate cellular damage

291 Human alphaB-crystallin is a small heat-shock protein that functions as a molecular c

292 e molecular chaperone alphaB-crystallin is a small heat-shock protein that is upregulated in response

293 in domain conserved in nearly all identified small heat-shock proteins that act as molecular chaperon

294 heat shock proteins proposes that ATP causes small heat shock proteins to release substrates, which a

295 ha-crystallin domain, typically conserved in small heat shock proteins, was found in Mx Hsp16.6.

296 in human alphaB crystallin, the archetype of small heat-shock proteins, was identified and characteri

297 The direct effects of antibodies specific to small heat shock proteins were then studied in isolated

298 of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevi

299 Crystallins are small heat shock proteins with chaperone function that p

300 pletion of cytokinesis, suggesting that this small heat shock protein, with its chaperone-like activi