ライフサイエンスコーパス: small intestinal

1 cidence of critical illness was greatest for small intestinal (17.2% [95% CI, 13.3%-21.8%]) and color

2 arance and clearance in plasma indicative of small intestinal absorption.

3 re plays an important role in the process of small intestinal absorption.

4 ficantly reduced both the number and size of small intestinal adenomas arising in this model, and it

5 intestinal-specific Bmi1 deletion suppressed small intestinal adenomas in a manner that was indisting

6 ired for both progression and maintenance of small intestinal adenomas.

7 omal macrophage Cox-2 in colorectal (but not small intestinal) adenomas from cLys-Cox-2 x Apc (Min/+)

8 nflammation and oxidative stress that limits small intestinal alpha-tocopherol absorption and/or impa

9 gulation of genes encoding components of the small intestinal (alpha-defensins Defa24 and Defa-rs1) a

10 Surprisingly, the ischemically damaged small intestinal and ascending colonic tissue showed a c

11 nohistochemical approach in normal adult rat small intestinal and ascending colonic tissue.

12 ntal localization of the two proteins in the small intestinal and ascending colonic tissue.

13 A patient received a deceased-donor small intestinal and colon allograft with standard immun

14 ts of genes in these two DC subsets, both in small intestinal and colon-draining LNs.

15 loxVillinCre) had undetectable AC6 levels in small intestinal and colonic epithelial cells.

16 KRIT1 is expressed in both small intestinal and colonic epithelium, and KRIT1 knock

17 EPEC had a significantly greater severity of small intestinal and colonic lesions and were significan

18 We observed marked differences in the small intestinal and fecal microbiota composition betwee

19 pounds significantly reduced accumulation in small intestinal and hepatic microsomes, which influence

20 Liver, small intestinal, and kidney exposure were slightly, but

21 exacerbated hepatic IR injury with increased small intestinal apoptosis and inflammation.

22 as expressed strongly in epithelial cells of small intestinal as well as ascending colonic tissue.

23 40331]), gastrostomy (5.8% [$21227436]), and small-intestinal atresia (5.1% [$18840546]).

24 Gastroschisis and small-intestinal atresia may be particularly high-yield

25 t terminals along the entire proximal-distal small intestinal axis had similar morphology to those pr

26 Small intestinal bacteria exhibit distinct gluten metabo

27 s no evidence for high prevalence of SIBO or small intestinal bacterial alterations in IBS.

28 y is to summarize the recent developments in small intestinal bacterial infections.

29 Small intestinal bacterial overgrowth (SIBO) and changes

30 Small intestinal bacterial overgrowth (SIBO) has been hy

31 Small intestinal bacterial overgrowth (SIBO) has been im

32 to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now comm

33 Altered bacterial composition and small intestinal bacterial overgrowth (SIBO) may be asso

34 To critically review recent literature on small intestinal bacterial overgrowth (SIBO).

35 Additionally, small intestinal bacterial overgrowth and Helicobacter p

36 Small intestinal bacterial overgrowth is one of the caus

37 We did not evaluate breath tests for small intestinal bacterial overgrowth, as they are not p

38 charides (e.g., lactose or fructose) and for small intestinal bacterial overgrowth.

39 Primary outcomes were changes in VH, in vivo small intestinal barrier dysfunction assessed by confoca

40 Hepatic fat accumulation, small intestinal barrier impairment and components of th

41 tryptophan supplementation had no impact on small intestinal barrier or fatty liver disease.

42 infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before

43 Endoscopic small intestinal biopsies was recommended for all POCT-

44 with HIV status and morphometric analysis of small intestinal biopsies.

45 and February 12, 2008, we collected data on small-intestinal biopsies performed at Sweden's 28 patho

46 Lnc13 levels are significantly decreased in small intestinal biopsy samples from patients with celia

47 ve qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN pr

48 CD was mainly diagnosed from small intestinal biopsy, available in all centers.

49 the same area could be identified without a small intestinal biopsy.

50 s) for future ASDs in individuals undergoing small intestinal biopsy.

51 We have constructed a small intestinal bioreactor using 3-D printing and polym

52 he present study we examined the role of the small intestinal brush-border enzyme, intestinal alkalin

53 -out mice exhibited a significantly impaired small intestinal calcium absorption that resulted in sec

54 ere similar in magnitude to WT mice, whereas small intestinal cAMP DeltaI(sc) responses were reduced.

55 Hereditary small intestinal carcinoid has not been recognized and g

56 tion was detected in all 11 individuals with small intestinal carcinoids and in 17 of 35 family membe

57 Small intestinal carcinoids are rare and difficult to di

58 We found that small intestinal carcinoids can occur as an inherited au

59 erformed a genetic analysis of families with small intestinal carcinoids to establish a hereditary ba

60 tudy of 33 families with at least 2 cases of small intestinal carcinoids.

61 c treatment of neonates restored LPS-induced small intestinal cell shedding, whereas adult fecal micr

62 (150min) of digestion under simulated gastro-small intestinal conditions that decreased to approximat

63 centration of nitroso compounds in feces and small intestinal content.

64 Homeostatic adult small intestinal crypt cell proliferation, survival, and

65 The epithelium of the small intestinal crypt, which has a vital role in protec

66 the pyloric glands of the stomach and in the small intestinal crypts differ in their differentiation

67 Cell proliferation within small intestinal crypts is the principal driving force f

68 We found that small intestinal crypts of Villin(Cre);Dclk1(f/f) mice w

69 Small intestinal crypts were isolated and subsequently c

70 s of quiescent and cycling stem cells in the small intestinal crypts, respectively.

71 elf-regenerating human epithelial cells from small intestinal crypts, which contain both intestinal s

72 Small intestinal damage induced by nonsteroidal anti-inf

73 esulting in the aggravation of NSAID-induced small intestinal damage.

74 Small-intestinal damage was analyzed by serial VCE at 6

75 lipid-mucin interactions were evident in all small intestinal digesta.

76 fold decrease in the IC50 value of FVJ after small intestinal digestion (p<0.05).

77 cs of glucose release during in vitro gastro-small intestinal digestion of freshly cooked and refrige

78 nutrient exposure to the brush border due to small intestinal dysmotility.

79 B and R-SFB showed host-specific adhesion to small intestinal ECs, accompanied by host-specific induc

80 fat that might be responsible for triggering small-intestinal endocannabinoid signaling.

81 nt sera, is required for efficient access to small intestinal enterocytes and for the optimal deliver

82 TAG synthesis in small intestinal enterocytes utilizes 2-monoacylglycerol

83 T1 localized in the brush border membrane of small intestinal enterocytes, it is unclear whether func

84 sorptive microvilli (MV) from the surface of small intestinal enterocytes.

85 The origin of inclusions in small-intestinal enterocytes in microvillus inclusion di

86 vitro observations, the results suggest that small intestinal enterocytic epithelial differentiation

87 nd that these effects may be specific to the small intestinal enterocytic phenotype as opposed to tha

88 We used human small intestinal enteroids to study neutral Na(+) absorp

89 und oral Bif195 to safely reduce the risk of small-intestinal enteropathy caused by ASA.

90 s under conditions mimicking the adult human small intestinal environment.

91 hesion molecules (CEACAMs) on the surface of small intestinal epithelia, where they serve as critical

92 We report that small intestinal epithelial cells (IECs) in Crohn's dise

93 asured in human colonic epithelial cells and small intestinal epithelial cells after knockdown of MIR

94 a illustrate that dietary adjustments affect small intestinal epithelial cells and can be used to mod

95 owed that the expression levels of RALDH1 in small intestinal epithelial cells correlated with the ac

96 Deficiency of either UPR or autophagy in small intestinal epithelial cells promotes each other's

97 are three-dimensional structures of primary small intestinal epithelial cells that contain all diffe

98 In infected mice, proliferation of small intestinal epithelial cells was compromised in an

99 impaired cAMP generation in acutely isolated small intestinal epithelial cells, and significantly imp

100 Intestinal stem cells (ISCs) drive small intestinal epithelial homeostasis and regeneration

101 sequencing (RNAseq) of IL-22-treated murine small intestinal epithelial organoids.

102 x vivo and to infect polarized monolayers of small-intestinal epithelial cells derived from DAF trans

103 plain why Giardia trophozoites adhere to the small intestinal epithelium during human and animal infe

104 t its physiologic functions in the mammalian small intestinal epithelium remain poorly defined.

105 ocarcinoma and have similar functions to the small intestinal epithelium.

106 cohabitate in the crypts and rejuvenate the small intestinal epithelium.

107 f bacteria or bacterial products through the small intestinal epithelium.

108 neth cells mediate immunity and maintain the small intestinal epithelium; defects in activities of th

109 , we identified several abnormalities in the small-intestinal epithelium of Nod2(-/-) mice including

110 critically ill patients on insertion of the small intestinal feeding catheter and examined for disac

111 cies corresponding to major chymotrypsin- or small intestinal fluid-generated NanI fragments possesse

112 t (corresponding to esophageal, gastric, and small intestinal function evaluation, respectively) befo

113 ing gastric emptying, although its impact on small intestinal function is unknown.

114 We show that the small intestinal GALT are the essential early sites of p

115 Together, these data demonstrate that the small intestinal GALT are the major early sites of prion

116 ity was dramatically reduced in mice lacking small intestinal GALT.

117 Resistant starch escapes digestion by host small intestinal glucoamylases and transits the colon wh

118 on these data, we conclude that the rate of small intestinal glucose exposure (i.e., glucose load) i

119 dulate Asc bioavailability via inhibition of small intestinal GLUT2 and GLUT8.

120 Ammonia was generated through increased small intestinal glutaminase activity with concomitantly

121 Oocytes injected to express small intestinal GLUTs were inhibited by teas, but SGLT1

122 us preferentially infects actively secreting small intestinal goblet cells, specialized epithelial ce

123 All subjects had normal small intestinal histology.

124 s were correlated with significantly reduced small intestinal HRV IgA Ab responses in EcN-colonized c

125 and directly obtaining control and infected small intestinal human tissue.

126 ce in addition to anoctamin-1 may develop in small intestinal ICC with ageing and contribute to pacem

127 Mechanistically, butyrate induced small intestinal IL-10 expression and downregulated the

128 we found that NOD2 was required for optimal small intestinal IL-10 production, in particular from CD

129 Here, we show that small-intestinal ILC3s had lower Ikaros expression than

130 Moreover, we observed increased small intestinal inflammation and apoptosis after hepati

131 These findings demonstrate that small intestinal inflammation in Rc3h1(san/san) and Rc3h

132 y patients remain symptomatic and still have small intestinal inflammation.

133 Celiac disease is a common small intestinal inflammatory condition induced by wheat

134 CKGROUND & AIMS: Celiac disease is a chronic small intestinal inflammatory disorder mediated by an im

135 in modulating genotoxic chemotherapy-induced small intestinal injury in vitro and in vivo.

136 aPC) mice also showed high susceptibility to small intestinal injury induced by indomethacin, a nonst

137 cerbated inflammation in Nod2(-/-) mice upon small-intestinal injury.

138 NKT cells (iNKT), CD8alphaalphaTCRalphabeta small intestinal intraepithelial lymphocytes, and innate

139 lls: hepatic iNKT, CD8alphaalphaTCRalphabeta small intestinal intraepithelial lymphocytes, and innate

140 found in five puppies, of which two also had small intestinal intussusception.

141 perfusion generally has a milder course than small intestinal ischemia-reperfusion.

142 ILC subset, as residual cells persist in the small intestinal lamina propria (siLP) of adult and neon

143 quired for optimal steady-state migration of small intestinal lamina propria CD103(+) DCs into the ML

144 rance) rely on the steady-state migration of small intestinal lamina propria dendritic cells (DCs) in

145 re activated CD8(+) alphabeta T cells in the small intestinal lamina propria, this increase was absen

146 l-characterized network of phagocytes in the small intestinal lamina propria.

147 ) weeks, birth weight of 1423 (895, 2445) g, small intestinal length of 41.0 (24.0, 65.0) cm, and pre

148 derwent transplant or died, the median (IQR) small intestinal length was 55.0 (28.0, 75.0) cm in wean

149 Small intestinal length was found to be the primary pred

150 ed three small mesenteric LNs, distinct from small intestinal LNs, which drain lymph specifically fro

151 he study was repeated in vivo using a rabbit small intestinal loop assay, preincubation or coincubati

152 amage and luminal fluid accumulation in both small intestinal loops and colonic loops after as little

153 mulation and severe tissue damage in ligated small intestinal loops of rabbits and other animals.

154 ns caused enteropathogenic effects in rabbit small intestinal loops, which is significant since CPE i

155 and STa toxin-induced fluid accumulation in small intestinal loops, with IC50 down to 0.1 mg/kg.

156 ccumulation and histologic lesions in rabbit small intestinal loops.

157 lso acted together synergistically in rabbit small intestinal loops; however, only higher doses of ei

158 Small intestinal LPLs had increased numbers of CD44(hi),

159 rodialysis and metabolic parameters from the small intestinal lumen indicate onset of ischemia earlie

160 ratching, caused expansion and activation of small intestinal MCs, increased intestinal permeability,

161 Small intestinal microbial composition, on the other han

162 riggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing sm

163 SIBO is our limited understanding of normal small intestinal microbial populations-progress in sampl

164 gical methods to the characterization of the small intestinal microbiome will tell us, once and for a

165 Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointe

166 ps in the literature, particularly regarding small intestinal microbiota abundance and diversity, hig

167 etween growth stunting and components of the small intestinal microbiota and enteropathy and offer a

168 served in normal diet-fed mice that received small intestinal microbiota from HFD-fed mice.

169 ice, accompanied by significant increases in small intestinal microsomal lovastatin-hydroxylase activ

170 apidly than large droplets using a simulated small intestinal model (pH stat), which was attributed t

171 the many advantages of using TC-7 cells as a small intestinal model to study host-pathogen interactio

172 s such as Caco-2 - the most extensively used small intestinal model.

173 from pluripotent stem cells and demonstrate small intestinal morphology and physiology, could be use

174 IBS patients underwent small intestinal motility (manometry; fasted and fed con

175 th groups with exenatide, but suppression of small intestinal motility and flow was observed even in

176 study aimed to evaluate the effect of SNS on small intestinal motility in IBS patients.

177 The inhibition of small intestinal motor function represents a novel mecha

178 i-diabetic agent metformin, while inhibiting small intestinal mTOR alone lowers plasma glucose levels

179 econd, we found that molecular activation of small intestinal mTOR blunts the glucose-lowering effect

180 se findings illustrate that inhibiting upper small intestinal mTOR is sufficient and necessary to low

181 per small intestine is sufficient to inhibit small intestinal mTOR signaling and lower glucose produc

182 sly unappreciated glucose-lowering effect of small intestinal mTOR.

183 compared these data to RNA-Seq from both the small intestinal mucosa and colonic mucosa of healthy co

184 d by the difficulty in directly sampling the small intestinal mucosa and microbial community (microbi

185 impact on the structure and function of the small intestinal mucosa and suggest signaling through th

186 Growth inhibition of the small intestinal mucosa by fasting in mice was associate

187 studies reveal that growth inhibition of the small intestinal mucosa is associated with increased exp

188 formed in vitro AMG uptake measurements into small intestinal mucosa of mice and human.

189 n (GFP)-tagged gammadelta T cells within the small intestinal mucosa of mice infected with DsRed-labe

190 Vagal afferents innervating the small intestinal mucosa regulate feeding, gastrointestin

191 M d-glucose, hSGLT1-mediated AMG uptake into small intestinal mucosa was decreased by 40% to 50%.

192 on's terminals and their distribution in the small intestinal mucosa were examined by quantitatively

193 , dramatic, and reversible remodeling of the small intestinal mucosa with significant villus shorteni

194 tandard for successful treatment is a healed small intestinal mucosa, and therefore, the outcome meas

195 me closely mirrored the transcriptome of the small intestinal mucosa.

196 ease in mice, likely by a dysfunction of the small intestinal mucosal barrier.

197 y Nod2 is an important mechanism to regulate small intestinal mucosal damage following acute T cell a

198 ctivation with anti-CD3 mAb induced stronger small intestinal mucosal damage in NOD2(-/-) mice compar

199 tients, possibly indicating an impairment of small intestinal mucosal function.

200 ed by combining coeliac disease serology and small intestinal mucosal histology during a gluten-conta

201 AIMS: Gluten ingestion leads to symptoms and small intestinal mucosal injury in patients with celiac

202 Gluten ingestion leads to symptoms and small intestinal mucosal injury in patients with celiac

203 Gluten ingestion leads to small intestinal mucosal injury in patients with celiac

204 e ALV003 appears to attenuate gluten-induced small intestinal mucosal injury in patients with celiac

205 free diet continue to have symptoms and have small intestinal mucosal injury.

206 Our findings suggest the majority of small intestinal mucosal innervation labeled in Na(v) 1.

207 , with lactulose/rhamnose ratio, a marker of small intestinal mucosal permeability.

208 ed to investigate sexual dimorphism in human small intestinal mucosal responses to IR.

209 t the direct impact of high-fat (HF) diet on small-intestinal mucosal defenses and spatial distributi

210 performance of antibody tests in predicting small-intestinal mucosal status in diagnosis vs. follow-

211 ading MUC2, the major protein present in the small intestinal mucous layer, and that removal of this

212 This work validates the use of porcine small intestinal mucus collected from fully-grown pigs f

213 y used to simulate difficult-to-obtain human small intestinal mucus for investigating the intramucus

214 The small intestinal mucus is a complex colloidal system tha

215 ability characteristics of human and porcine small intestinal mucus secretions to sub-micron sized pa

216 t GI tract integrity or the thickness of the small-intestinal mucus layer but, in contrast to P9 wild

217 ntagonists in inhibiting slow waves in adult small intestinal muscles suggest that a conductance in a

218 tagonists on muscles from juvenile and adult small intestinal muscles suggests that conductances in a

219 In contrast, small intestinal neoplasia development significantly cor

220 Small intestinal neuroendocrine tumors (SI-NETs) are ser

221 Patients with small intestinal neuroendocrine tumors (SI-NETs) frequen

222 Common serious adverse events included small intestinal obstruction (10 [5%] of 204 patients),

223 eatment-emergent serious adverse events were small intestinal obstruction (34 [7%] of 463 patients),

224 n in one patient, intestinal perforation and small intestinal obstruction in one patient; colitis in

225 ganoids expressing characteristic markers of small intestinal or colonic epithelium.

226 Gastric and small intestinal organoids differentiated from human plu

227 We generated 3-dimensional small intestinal organoids from mice and studied the eff

228 n polymerase chain reaction and RNAscope) of small intestinal organoids incubated with the Notch inhi

229 PTMs in >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-s

230 dult Lgr5-positive stem cells, isolated from small intestinal organoids, require Cdx2 to maintain the

231 ed to the more promiscuous transformation of small intestinal organoids.

232 Current knowledge suggests that small intestinal overgrowth participates in the pathogen

233 icient in intestinal epithelial TLR9 develop small intestinal Paneth cell hyperplasia and higher Pane

234 Since small intestinal Paneth cells and IL-17A play critical r

235 Small intestinal Paneth cells supply Wnt3, EGF, and Notc

236 Giardia duodenalis is a small intestinal parasite responsible for diarrheal dise

237 The small intestinal peppermint oil did, however, produce gr

238 o 0.5, consistent with values encountered in small intestinal permeability tests.

239 estinal microbial diversity while increasing small intestinal permeability.

240 mature ILC2s can enter the circulation after small intestinal perturbation by migratory helminths and

241 follicular dendritic cells (FDC) within the small intestinal Peyer's patches is essential to establi

242 However, the small intestinal pGP3-deficient Chlamydia sp. failed to

243 nificantly higher than that in both oral and small intestinal phases.

244 Additionally, small intestinal pIgR was decreased ~50% in EdnrB(NCC-/-

245 normal conditions, the vast majority of the small intestinal pTreg cells are induced by dietary anti

246 of patients with IBS, we found that neither small-intestinal-release nor ileocolonic-release pepperm

247 The small-intestinal-release peppermint oil did, however, si

248 and placebo groups: 29 of 62 patients in the small-intestinal-release peppermint oil group had a resp

249 We studied the efficacy and safety of small-intestinal-release peppermint oil in patients with

250 ere randomly assigned to groups given 182 mg small-intestinal-release peppermint oil, 182 mg ileocolo

251 Extensive small intestinal resection was the major predictor for l

252 esponse durability correlated with increased small intestinal rotavirus-specific, immunoglobulin A-pr

253 The individual small intestinal segments studied revealed comparable st

254 as assessed using everted rings of different small intestinal segments.

255 erein, we demonstrate that fasting preserves small intestinal (SI) architecture by maintaining SI ste

256 ed the difference between WT and LCN mice in small intestinal (SI) CYP3A levels at 6 hours after the

257 and COX-2-derived prostaglandins and caused small intestinal (SI) damage.

258 e dependent on migration of T cells into the small intestinal (SI) lamina propria.

259 Small intestinal (SI) neuroendocrine tumors (NETs) have

260 In this study, we utilize mice, small intestinal (SI) organoids, and ISC-Paneth cell co-

261 To summarize our current understanding of small intestinal stem cell biology and the current tools

262 n intestinal tissues of mice, PRC2 maintains small intestinal stem cells by promoting proliferation a

263 Clonal descendants of Cdx2(null) small intestinal stem cells enter the gastric differenti

264 iferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of di

265 9H is not responsible for the differences in small intestinal sterol transporter expression.

266 performed a high-resolution analysis of the small intestinal stroma and determined that lacteals res

267 vides a spatially-resolved cell atlas of the small intestinal stroma and exposes Lgr5+ villus tip tel

268 sue engineered vessels (A-TEVs) comprised of small intestinal submucosa (SIS) immobilized with hepari

269 Small intestinal submucosa-derived extracellular matrix

270 we show that combinatory transplantation of small intestinal submucosa-extracellular matrix (SIS-ECM

271 e corrected UABCs on an FDA-approved porcine small intestinal submucosal membrane (pSIS), and they re

272 the effects of teas and tea catechins on the small intestinal sugar transporters, SGLT1 and GLUTs (GL

273 No eYFP expression was detected in small intestinal Th17 cells, and they did not expand in

274 (SFB), pentanoate inhibits the generation of small-intestinal Th17 cells and ameliorates SFB-promoted

275 activation and proliferation in response to small intestinal tissue damage induced by the chemothera

276 nterochromaffin and enteroendocrine cells in small intestinal tissue.

277 pitated hypersecretion in morphine-dependent small intestinal tissue.

278 Small-intestinal tissue was harvested for analysis of ti

279 onversely, TLR2 activation failed to protect small intestinal tissues genetically deficient in MDR1A

280 e fatty acid and lipophilic nutraceutical in small intestinal tissues was highest when they were enca

281 ly better than plasmid-free Chlamydia sp. in small intestinal tissues.

282 Administration of IL1B to mice increased small intestinal TJ permeability, compared with mice giv

283 antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from

284 Lrig1-null mice had significant delays in small intestinal transit compared with control mice.

285 Slowed small intestinal transit observed in Lrig1-null mice may

286 nd mixed IBS, it has no detectable effect on small intestinal transit patterns.

287 a combined manometry-impedance catheter and small intestinal transit using scintigraphy.

288 measured total GI transit, gastric emptying, small intestinal transit, and propulsive colorectal moti

289 al levels of succinate, increased numbers of small intestinal tuft cells, and evidence for activation

290 mation while having no discernable effect on small intestinal tumor formation.

291 P and colon cancer, diminished the number of small intestinal tumors generated.

292 y impairs the progression and maintenance of small intestinal tumors in a cell autonomous and highly

293 Enteropathy and small-intestinal ulcers are common adverse effects of no

294 ucing antioxidant power was increased in the small intestinal vessel for PM09.960 and in the ascendin

295 ore anthocyanin species were detected in the small intestinal vessel relative to other vessels for ac

296 CoV antigen was found in epithelial cells of small intestinal villi in all puppies and the colon in 2

297 Proteobacteria and Firmicutes penetrated small intestinal villi, and flagellated bacteria breache

298 eliac disease was defined by the presence of small intestinal villus atrophy on histopathology specim

299 uncovered drainage of absorbed molecules in small intestinal villus lacteals and the involvement of

300 Small intestinal wash fluid was collected and IgA was qu