ライフサイエンスコーパス: small molecule

1 S)-a rapidly and reversibly photoisomerizing small molecule.

2 ic synthesis of a noncanonical atrop-defined small molecule.

3 could be quickly degraded upon addition of a small molecule.

4 nd ecological significance of these biogenic small molecules.

5 ructured regions that could be targeted with small molecules.

6 ctures that can be selectively targeted with small molecules.

7 aining DNA anchors to capture DNA-conjugated small molecules.

8 and preferences in the RNA motifs that bind small molecules.

9 any natural products and biologically active small molecules.

10 mputational costs limit their application to small molecules.

11 s, a frequent target of structurally diverse small molecules.

12 biotechnology for the synthesis of drugs or small molecules.

13 eve their activity by transferring sugars on small molecules.

14 ical state of cells and its perturbations by small molecules.

15 binding interactions with nucleic acids and small molecules.

16 es it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo[3,4-d]pyrimidine-4-amine (PP)

17 hRBP4 when loaded with the orally available small molecule A1120.

18 the identification of 16, the first reported small molecule able to prevent rejection of transplanted

19 f the novel NMR-based machine learning tool "Small Molecule Accurate Recognition Technology" (SMART 2

20 ive system for studying the translocation of small molecules across biological membranes.

21 ach for determination of the permeability of small molecules across the membranes of lipid vesicles a

22 These intercalated small molecules act as "crystal modulators" to modulate

23 Several small molecules activate PKM2 by binding to its intersub

24 tial to participate in tandem or cooperative small-molecule activation and catalysis.

25 rmacologically activating PKM2 via ML-265, a small molecule activator of PKM2, during acute outer ret

26 discovered that Akt inhibition or a specific small-molecule activator of PP2A (SMAP) efficiently atte

27 e of the protein lysine deacetylase SIRT1 to small-molecule activators.

28 The development of small-molecule active pharmaceutical ingredients (APIs)

29 ted this off-target overlabeling by adding a small-molecule additive during the TMT labeling as a dec

30 d drug products contain diverse and abundant small-molecule additives (excipients) with unclear impac

31 trated that both adiponectin and AdipoRon, a small-molecule adiponectin receptor agonist, suppress co

32 in the adduct; the first demonstration of a small molecule affecting conformational changes on a HS

33 doxin isoforms and to identify mutations and small molecules affecting the oligomeric state inside ce

34 rtunities to predict mutations and to design small-molecule agents to control protein function and ce

35 Importantly, a small-molecule Alkbh5 inhibitor enhanced the efficacy of

36 omophores controlled by selective binding of small-molecule "anchor" groups to a specific binding sit

37 coincides with low passive permeability for small molecules and a slow lateral diffusion of proteins

38 ability of MBLAC2 to hydrolyze a variety of small molecules and acylprotein substrates.

39 ential since they can bridge the gap between small molecules and antibodies by combining a low molecu

40 y harbor pockets that are only accessible to small molecules and constitutes a rich subset of binding

41 ized protocol to eliminate interference from small molecules and degraded proteins.

42 Enrichments above 95% were observed for small molecules and highly charged species at velocities

43 omimetics represent the middle space between small molecules and large proteins-they retain the relat

44 al characteristics and the identification of small molecules and organelles in mammalian cells.

45 We used small molecules and peptide modulators to inhibit BMP, T

46 heir place as a main drug category alongside small molecules and proteins.

47 aqueous samples (>=90% H(2)O) and tested on small molecules and proteins.

48 ons related to the storage and separation of small molecules and the incorporation of these porous an

49 protein (TSPO), the reported target for this small molecule, and instead were driven by a metabolic s

50 man body temperature, and manipulatable with small molecules, and therefore presents a screenable pro

51 monstrate that targeting FPR1 by a selective small molecule antagonist, such as ICT12035, can provide

52 tial for targeting this kinase in developing small-molecule antivirals against SARS-CoV-2.

53 substitution patterns of benzenoid rings in small molecule APIs approved by the FDA through 2019 and

54 Furthermore, we used these small molecules as chemical probes to characterize the r

55 phosphate donors transfer prenyl groups onto small molecules as well as large proteins.

56 nducing pheromone has identified a family of small molecules, ascarosides, which act potently to comm

57 able the development of potent and selective small-molecule AspH inhibitors and contribute towards th

58 g activity (that is, reacting diversely with small molecules at one extreme or selectively with prote

59 A small molecule, AX-024, was reported to inhibit the Nck/

60 enation reactions are often complementary to small molecule based synthetic approaches, providing a p

61 ie in identifying virus-specific targets for small molecule-based interventions.

62 een fluorometrically imaged with protein- or small-molecule-based probes.

63 ermodynamic insight into the partitioning of small molecules between lipid domains and its relation t

64 suggests that PrP is a difficult target for small-molecule binders.

65 The RNA targets that contain preferred small molecule binding sites can be identified from sequ

66 al design methods typically rely on existing small molecule binding sites or protein scaffolds with e

67 pes, following protein aggregation, locating small molecule binding, measuring ligand-binding affinit

68 ssay can be readily expanded to characterize small-molecule-binding aptamers in an automated, high-th

69 ed format for high-throughput engineering of small-molecule-binding aptamers to acquire those with im

70 rization with Grubbs catalyst or degraded to small molecules by hydrolysis under acidic conditions.

71 Atogepant is an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) r

72 ation of different cellular components using small molecules can disrupt these rhythms, causing a pha

73 Small molecules can possibly prevent the spreading infec

74 ed 883 FDA approved or investigational stage small molecule cancer drugs that target 1,434 different

75 (2020) demonstrate for the first time that small-molecule cancer therapeutics are selectively parti

76 Our assay, compound characterization, and small-molecule candidate should further stimulate the di

77 330-fold increase inw the transport rate of small-molecule cargo.

78 that this can be achieved in the context of small-molecule catalysts has had sizable impact on the f

79 e designed a series of novel monophosphonate small-molecule CD73 inhibitors.

80 We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebra

81 ven mode of action SMIRNAs into event-driven small molecule chemical probes, such as RNA cleavers and

82 inatorial screening, revealed preferences in small-molecule chemotypes that bind RNA and preferences

83 ical space and unclear design principles for small-molecule combinations, computational drug-combinat

84 nd the "geometric packing parameter" dictate small molecule compatibility with 3HM's alkyl tail core.

85 cal screening strategy, we have identified a small molecule compound, C35, as a first-in-class TET in

86 Development of small molecule compounds that target several cancer driv

87 ntify such targets, we conducted a screen of small molecule compounds with known pharmacology using h

88 ific metabolic vulnerabilities targetable by small molecule compounds.

89 y that we previously reported, we identified small-molecule compounds that modulate the skeletal musc

90 ical-inducible dimerization domain, allowing small molecule control of alternative splicing.

91 Such maps allow a detailed understanding of small-molecule coordination, visualization of solvent mo

92 A chromene-based small molecule, CXL146, selectively eliminates cancer ce

93 interacts with engineered hRBP4 binders in a small molecule-dependent manner.

94 in speed, accessibility and affordability of small molecule detection.

95 Importantly, we also identify a small molecule dicarboxylate that acts as an essential c

96 Both small molecule differentiated and induced patient neuron

97 Toxoplasma gondii, Shigella flexneri and the small molecule DPP8/9 inhibitor Val-boroPro, focusing on

98 es, initiating the downstream release of the small molecule drug by a retro DA reaction.

99 Identifying the target proteins of small-molecule drug candidates is important for determin

100 omparison to current pharmacotherapy such as small molecule drugs or antibodies.

101 e imaged and quantified the flow and flux of small molecule drugs through the layers and structures o

102 Small-molecule drugs and toxicants commonly interact wit

103 l and pain management, effective targets for small-molecule drugs.

104 Here, we reveal how a small molecule, DT-061, specifically stabilizes the B56a

105 We incubated small molecules, each bearing a sulfuramidimidoyl fluori

106 Here we report that the small molecule elesclomol escorted copper to the mitocho

107 ed N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged

108 drug target in cancer and inflammation, and small-molecule ERK5 kinase inhibitors have been develope

109 his assay, termed here "manganese-extracting small molecule estimation route" (MESMER), can accuratel

110 new paradigm is emerging, however, in which small molecules exert a biological effect by interacting

111 In this work, we have developed a small molecule fluorescent turn-on probe for labeling sp

112 PSMA), such as (68)Ga-PSMA-11, are promising small molecules for targeting prostate cancer (PCa).

113 ere, we demonstrate that covalently tethered small molecule fragments can be used to stabilize specif

114 idual variability in the action of bioactive small molecules from the diet is poorly understood and p

115 Here, we report two potent small-molecule FTO inhibitors that exhibit strong anti-t

116 A recently developed small-molecule G-quadruplex ligand, the trisubstituted n

117 d chimeras, RIBOTACs) and direct cleavage by small molecules have also been developed.

118 Small molecules have been classically developed to inhib

119 Furthermore, less than a dozen small molecules have been incorporated and approved for

120 However, to date, only a very few bona fide small molecules have been reported against the HA.

121 We also show that the small molecules ICCB-19 and Apt-1 bind to a pocket on th

122 structure to expand reference libraries for small molecule identification.

123 The small molecule imatinib inhibits KIT and has been a main

124 one of these Cas13a-based methods to detect small molecules in a one-batch assay.

125 for establishing the mechanism-of-action of small molecules in living systems.

126 t the maternal microbiome regulates numerous small molecules in the maternal serum and the brains of

127 Among these, small molecules including the drug-like compound PF-0644

128 imeric porins control the cellular uptake of small molecules, including nutrients and antibacterial a

129 plied to screen approximately 1500 bioactive small-molecules, including natural products and active p

130 and olaparib-resistant cancers, making fully small-molecule-induced synthetic lethality an innovative

131 Both small molecules inhibit STAT3 phosphorylation, increase

132 Small molecule inhibition of HSL activity and siRNA-medi

133 ISPR-based knockout, single cell clones, and small-molecule inhibition.

134 sphatase 2A (PP2A) or its inhibition using a small molecule inhibitor (1,10-phenanthroline-5,6-dione

135 gical inhibition of the TLR4 pathway using a small molecule inhibitor (TAK-242) as well as genetic de

136 ctivation or BMP signaling inhibition with a small molecule inhibitor are also sufficient to delay pr

137 ined the effects of oral administration of a small molecule inhibitor for CCR2, CCR2i, which blocks C

138 s of antibody against CDH11, gemcitabine, or small molecule inhibitor of CDH11 (SD133) and tumor grow

139 injury injections of Plerixafor (AMD3100), a small molecule inhibitor of CXCR4.

140 , to inhibit p53 signaling, and nutlin-3a, a small molecule inhibitor of MDM2 (mouse double minute 2

141 , NLRP3, or IL18 and in mice given MCC950, a small molecule inhibitor of the NLRP3-inflammasome.

142 ed that a potent, reversible, first-in-class small molecule inhibitor of the oncogenic phosphatase pr

143 plications for the development of TIPTP as a small molecule inhibitor of the p22phox-Rubicon axis for

144 GSK3368715 is a small molecule inhibitor of type I PRMTs currently in cl

145 ciated with increased sensitivity to the OGT small molecule inhibitor OSMI-1.

146 g matched parental and transformed cells for small molecule inhibitor studies by validating both prev

147 We utilized the small molecule inhibitor, pifithrin-alpha, to inhibit p5

148 nhibition of FGFR1 function by the selective small-molecule inhibitor BGJ398 enhanced EGFR TKI sensit

149 Abs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796.

150 This was further confirmed using a small-molecule inhibitor of ferroptosis that prevents CZ

151 herapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mod

152 ell width and increased resistance to A22, a small-molecule inhibitor of MreB assembly.

153 escribe and characterize a potentially novel small-molecule inhibitor of TYK2 that blocked IL-23 sign

154 The NPT2a-selective small-molecule inhibitor PF-06869206 was previously show

155 Using CRISPR and small-molecule inhibitor screens combined with comprehen

156 r receptors, can be useful for the design of small molecule inhibitors and vaccine development.

157 Recent efforts to develop small molecule inhibitors for these lipid kinases result

158 The future of small molecule inhibitors is promising as there is the p

159 active therapeutic strategy with a number of small molecule inhibitors now under investigation in the

160 reviews recent advances in the discovery of small molecule inhibitors of p97, their optimization and

161 C to its target genes and reported the first small molecule inhibitors of the WDR5-MYC interaction us

162 To date, small molecule inhibitors of these proteins typically bi

163 iew some of the most recent developments for small molecule inhibitors of transcription factors empha

164 tic approaches and improved selectivity over small molecule inhibitors.

165 say will enable the development of selective small-molecule inhibitors for AspH and other human 2OG o

166 Combination therapy with small-molecule inhibitors of AKT and HER2 was conducted

167 aiming to destabilize MYCN protein, such as small-molecule inhibitors of Aurora A and mTOR, are curr

168 med and extended previous findings that some small-molecule inhibitors of filovirus entry destabilize

169 Small-molecule inhibitors of non-canonical IkappaB kinas

170 This study aimed to discover small-molecule inhibitors targeting RANKL trimer formati

171 ent-induced apoptosis with two MYCN-targeted small-molecule inhibitors, Aurora A kinase inhibitor ali

172 These small-molecule inhibitors, collectively termed JAK inhib

173 disease, supporting the need to discover new small-molecule inhibitors.

174 hiro-Inositol ribophostin is the most potent small-molecule Ins(1,4,5)P(3) receptor agonist without a

175 emical synthesis to predict and then produce small molecules inspired by biosynthetic gene clusters.

176 Known ATP-competitive small-molecule IRE1 kinase inhibitors either allosterica

177 erein, biomaterial-assisted sequestration of small molecules is described to localize pro-regenerativ

178 Protein binding to small molecules is fundamental to many biological proces

179 oying functional probes such as proteins and small molecules is paramount in decoding the molecular b

180 This Minireview highlights key examples of small-molecule isoform-selective probes with a focus on

181 Small-molecule kinase inhibitors have the potential for

182 Combining menin-MLL inhibition with specific small-molecule kinase inhibitors of FLT3 phosphorylation

183 Conducting a screen of small molecules known to alter cellular Mn levels, we re

184 es, we present the design and synthesis of a small-molecule label comprising both fluorogenic and sel

185 DNA-encoded small molecule libraries (DELs) have enabled discovery o

186 screening identified NSC622608 as the first small-molecule ligand for VISTA.

187 A qualitative pharmacophore hypothesis for small molecule ligands at GPVI is also presented.

188 Small molecule ligands can thus promote RNA folding in c

189 diated degradation of BRD4 by a bifunctional small molecule linking the KEAP1-Nrf2 activator bardoxol

190 e limitation of SPR methods for detection of small molecules, making it suitable for clinical diagnos

191 Porous membranes derivatized with such small molecules may provide an attractive target-identif

192 s small molecule, named manganese-extracting small molecule (MESM).

193 Emerging evidence suggests that small-molecule metabolites derived from bacterial breakd

194 cs indicates that the number of unidentified small-molecule metabolites may exceed the number of prot

195 A small molecule MIF inhibitor and an allosteric CXCR4 inh

196 or therapeutic blockade of E-selectin using small molecule mimetic GMI-1271/Uproleselan effectively

197 Small molecule mitochondrial uncouplers have recently ga

198 e, spheroids were treated with auristatin as small molecule (MMAE) or as antibody-drug conjugate cont

199 ibody, sGC or PDE activity and the effect of small molecules modulating their function can be studied

200 inding sites partially overlap with those of small molecule modulators, including a vestibule binding

201 t efforts have focused on the development of small molecule modulators.

202 athways, including relevant biomolecules and small-molecule modulators regulating them.

203 he role of MPC in disease, and to screen for small-molecule MPC modulators.

204 implementation of an assay centered on this small molecule, named manganese-extracting small molecul

205 atalysis to the synthesis of complex organic small molecules, natural products and materials are show

206 ins and protein complexes are separated from small molecule non-volatile buffer components using an a

207 intra-cartilage delivery of a broad array of small molecule OA drugs and their combinations to chondr

208 Syrian hamsters to evaluate the efficacy of small molecules on both infection and transmission.

209 This includes small molecules on surfaces.

210 A synthetic small molecule optimized to bind the TAR GS also partial

211 groups with highly selective reactivity into small molecules or protein modifications without perturb

212 hibitor has entered clinical trial; however, small-molecule orally available antiviral drugs have yet

213 Relative to the rich library of small-molecule organics, few examples of ordered extende

214 Here, we describe small-molecule PAPD5 inhibitors that demonstrate telomer

215 Due to dose-limiting toxicity of the small molecule payload, antibody-drug conjugates (ADCs)

216 ore, host defense antimicrobial peptides and small-molecule peptide mimetics also activate mast cells

217 LRR-RKs can sense small molecule, peptide, or protein ligands and may be a

218 This is demonstrated for small molecules, peptides, and proteins up to 66 kDa on

219 in the presence of the capsid destabilising small molecule PF-74 also induced a cGAS-dependent IFN r

220 e describe phosphorylation-inducing chimeric small molecules (PHICS), which enable two example kinase

221 affect other Plk members in contrast to many small molecule Plk1 inhibitors.

222 Small molecule polyamines are abundant in all life forms

223 Next, we generated an activity-based small-molecule probe (ABP) to track target engagement in

224 mia and pharmaceutical companies to generate small-molecule protein inhibitors and drug candidates.

225 ing a broad range of single analytes such as small molecules, proteins, nanoparticles, exosomes, and

226 e discovery of CG416 and CG428 as two potent small-molecule proteolysis-targeting chimera (PROTAC) de

227 Furthermore, we have demonstrated how small molecule proteostasis regulators can drive formati

228 at a naphthoquinone/quinolinedione family of small molecules (Q compounds) acts as RET agonists.

229 s, HYAL2 interacts with the GTPase-signaling small molecule ras homolog family member A (RhoA).

230 there is significant interest in developing small-molecule receptors that can bind selectively to th

231 acy of previously published state-of-the-art small-molecule relative binding affinity calculations, w

232 Several small molecule RGS protein inhibitors have been identifi

233 nstrates a pipeline that effectively filters small-molecule RyR1 modulators towards clinical relevanc

234 hiazole-cysteine condensation reaction-based small molecule scaffold that can undergo rapid condensat

235 We performed a small molecule screen based on competition between isoge

236 e validated by a high hit rate in a targeted small molecule screen in our iAT2 ALI system.

237 ranslation inhibitors from a high-throughput small-molecule screen for fragile X tremor ataxia syndro

238 duce tau burden in human neurons and, from a small-molecule screen, identify the mTOR inhibitors OSI-

239 p38alpha MAPK-derived, phosphopeptide-based small-molecule screen.

240 During small molecule screens, we observed binding of carbamaze

241 Mavorixafor is an oral small molecule selective antagonist of the CXCR4 recepto

242 ield Effect Transistors (EGOFETs) based on a small molecule semiconductor.

243 Specifically, non-fullerene small-molecule solar cells have recently shown a high po

244 on was investigated using a newly identified small molecule, soticlestat (TAK-935/OV935).

245 w host-agnostic biosensors with user-defined small-molecule specificities and transfer functions.

246 Our findings demonstrate that a small molecule such as BI-3802 can induce polymerization

247 ing multiple pathways by selected individual small molecules, such as RepSox, may be an effective str

248 it is only an order of magnitude larger than small molecules, such that cargo loading is better descr

249 d in the synthesis of densely functionalized small molecules suitable for fragment-based drug discove

250 We previously described the discovery of a small molecule, (+)SW033291, that binds with high affini

251 apyrroles represent some of the most complex small molecules synthesized by cells and are involved in

252 Small molecule targeted degradation of RNA targets (ribo

253 nding offers an exciting new opportunity for small-molecule targeted covalent inhibitor design.

254 Small-molecule targeted RNA degradation will thus provid

255 e transcriptional modulators and amenable to small molecule targeting.

256 reased DeltaG4R levels are more sensitive to small molecules targeting G4 DNA.

257 While several small molecules targeting Na(V)1.7 have been advanced to

258 Cell-permeable photoswitchable small molecules, termed optojasps, are introduced to opt

259 Leupeptin is a bacterial small molecule that is used worldwide as a protease inhi

260 -4,5-dihydropyridazin-3(2H)-one (DNMDP) is a small molecule that kills cancer cells by generation of

261 have been reported, the identification of a small molecule that targets both homologs of cGAS has be

262 cal composition and the main features of the small molecules that are included in the EML, spanning f

263 oped a machine-learning approach to identify small molecules that broadly correct gene networks dysre

264 (1)AR provide a foundation for the design of small molecules that could bias signalling in the beta-a

265 bit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via

266 ngly, there is great interest in identifying small molecules that modulate LLPS.

267 feasibility of inhibiting RNA activity using small molecules that preferentially bind and stabilize t

268 e drug libraries, researchers can prioritize small molecules that present high potency to reverse exp

269 Nagpal and colleagues identified small molecules that restore telomere maintenance in pat

270 Small molecules that selectively kill senescent cells (S

271 Therefore, identifying small molecules that specifically modulate regulatory co

272 but also offer a path forward in developing small molecules that target CDK8 in its MED12-bound form

273 ement of cholesterol-derived metabolites and small-molecules that were linked to Alzheimer's patholog

274 eding and exchange of electron acceptors and small molecules, that modify the growth and virulence of

275 val, indicating a bright future for targeted small molecule therapeutics that affect RNA function.

276 oclonal antibodies (mAb) with the potency of small molecule therapeutics, are one of the fastest grow

277 s that are normally difficult to target with small molecule therapies.

278 cture-activity relationships for a series of small-molecule thiophenes resulted in potent and selecti

279 challenging because of the inability of most small molecules to accumulate inside GN bacteria.

280 hin different DCC applications, ranging from small molecules to dynamic polymer materials.

281 Food and Drug Administration (FDA)-approved small molecules to identify candidate therapeutic drugs

282 lso may permit the cell-specific delivery of small molecules to improve the post-MI healing process.

283 otein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradatio

284 BP nMOF for the co-delivery of a hydrophobic small-molecule toll-like receptor 7 agonist, imiquimod (

285 ophore in the pharmacophore in PSMA-targeted small-molecule tracers.

286 ern epidermal integrity while GJs facilitate small molecule transfer across cell membranes.

287 Short-chain fatty acids (SCFAs) are small molecules ubiquitous in nature.

288 ecules is designed to sequester adenosine, a small molecule ubiquitously present in the human body.

289 include those involved in barrier function, small molecule uptake, and integrity of transcription an

290 A novel approach to chiral recognition of small molecules using the classical ninhydrin agent is i

291 The use of small-molecule viral inhibitors that allosterically bloc

292 Inhibition of TRPCs by small molecules was shown to be promising in treating re

293 ly small size and synthetic accessibility of small molecules while providing high binding specificity

294 virtual samples-mixtures of a protein and a small molecule with defined rate constants and, thus, K(

295 as a tool for structural characterization of small molecules with a wide variety of functional groups

296 Ynamides are fascinating small molecules with complementary reactivities under ra

297 Establishing the effects of small molecules with different chemical properties on th

298 receptors targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary ex

299 ure for the detection of clinically relevant small molecules with its facile, cheap, and highly sensi

300 lti-species approach can be used to identify small molecules with properties that might prove useful