ライフサイエンスコーパス: small ribosomal subunit

1 F-G binding-induced ratcheting motion of the small ribosomal subunit.

2 osome that clamp P-site tRNA and mRNA on the small ribosomal subunit.

3 action of mutations affected assembly of the small ribosomal subunit.

4 iates the recruitment of capped mRNAs by the small ribosomal subunit.

5 3 is required for recruitment of eIF1 to the small ribosomal subunit.

6 re GTPases that bind Met-tRNA(i)(Met) to the small ribosomal subunit.

7 eins and Var1p, a hydrophilic protein in the small ribosomal subunit.

8 interactions with the decoding center of the small ribosomal subunit.

9 in eukaryotes, involves mRNA scanning by the small ribosomal subunit.

10 slocation relative to the body domain of the small ribosomal subunit.

11 lects and delivers the initiator tRNA to the small ribosomal subunit.

12 g site located in the decoding center of the small ribosomal subunit.

13 n the ribosome includes that of the isolated small ribosomal subunit.

14 tRNA, appears to be an essential core of the small ribosomal subunit.

15 r these conditions, BipA associates with the small ribosomal subunit.

16 binding of eIF4G and the recruitment of the small ribosomal subunit.

17 nit, and is required for the assembly of the small ribosomal subunit.

18 16S rRNA mapped the AMI binding site to the small ribosomal subunit.

19 enger RNA codon present in the A site of the small ribosomal subunit.

20 14, YqeH, has been linked to assembly of the small ribosomal subunit.

21 pre-rRNA that results in the assembly of the small ribosomal subunit.

22 he factor's interaction with 18S rRNA of the small ribosomal subunit.

23 tiple translation initiation factors and the small ribosomal subunit.

24 the translational GTPases on the body of the small ribosomal subunit.

25 orm for the interactions between both of the small ribosomal subunits.

26 tation of a key bridge between the large and small ribosomal subunits.

27 ectly binds ribosomes and isolated large and small ribosomal subunits.

28 in that is required for joining of large and small ribosomal subunits.

29 ch its binding specificity from ribosomes to small ribosomal subunits.

30 parates the rRNA components of the large and small ribosomal subunits.

31 cilitating the assembly of the mitochondrial small ribosomal subunits.

32 Methylation of the bacterial small ribosomal subunit (16S) rRNA on the N1 position of

33 Here we demonstrate the engineering of the small-ribosomal subunit (16S) RNA of Mycoplasma mycoides

34 the final processing step to produce mature small ribosomal subunit 18S rRNA.

35 sts is a multigenic cluster that encodes the small ribosomal subunit 2 followed by four ATP synthase

36 Previous work revealed that rps28bDelta (small ribosomal subunit-28B) mutants do not form PBs und

37 s on the binding of IF3(mt) to mitochondrial small ribosomal subunits (28S) was studied using derivat

38 In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs

39 The movement of the small ribosomal subunit (30S) relative to the large ribo

40 t, and domain II is oriented more toward the small ribosomal subunit (30S).

41 l Ribosomal Entry Site (CrPV-IRES) binds the small ribosomal subunit (40S) and the translocation inte

42 Two conformational rearrangements in the small ribosomal subunit, a closing of the head and body

43 Upon joining of the large and small ribosomal subunits, a 100-nt long expansion segmen

44 itive noncoding ribosome, proto-mRNA and the small ribosomal subunit acted as cofactors, positioning

45 in IV of EF-G moves toward the A site of the small ribosomal subunit and facilitates the movement of

46 PS20, which encodes a component (S20) of the small ribosomal subunit and is a new colon cancer predis

47 The A/U-tail enables mRNA binding to the small ribosomal subunit and is essential for translation

48 itiator methionyl-tRNA (tRNA(i)(Met)) to the small ribosomal subunit and is necessary for protein syn

49 ze such C-terminal tails in the absence of a small ribosomal subunit and mRNA has remained unknown.

50 rate a strong interaction between 2A and the small ribosomal subunit and present a cryo-EM structure

51 mRNA and initiator transfer RNA bound to the small ribosomal subunit and provide insights into the de

52 ethionyl initiator tRNA (Met-tRNA(i)) to the small ribosomal subunit and releases it upon GTP hydroly

53 th previous in vitro assembly studies of the small ribosomal subunit and six 50S assembly groups that

54 Escherichia coli protein Y (pY) binds to the small ribosomal subunit and stabilizes ribosomes against

55 TFB1M mediates an rRNA modification in the small ribosomal subunit and thus plays a role analogous

56 llular protein synthesis by sequestering 30S small ribosomal subunits and 70S ribosomes in nonfunctio

57 r resulted in accumulation of both large and small ribosomal subunits and also affected the stability

58 urs in a preinitiation complex that includes small ribosomal subunits and multiple translation initia

59 CSIT2 binds to the large and small ribosomal subunits and ubiquitinates 80S ribosomes

60 eference only occurs when both ppGpp and the small ribosomal subunit are present.

61 Initial recruitment of the small ribosomal subunit as well as two translocation ste

62 The small ribosomal subunit assembles cotranscriptionally on

63 Protein S4 is essential for bacterial small ribosomal subunit assembly and recognizes the 5' d

64 is of the concerted early and late stages of small ribosomal subunit assembly.

65 PS19-mutated iPSCs exhibited defects in 40S (small) ribosomal subunit assembly and production of 18S

66 uring eukaryotic translation initiation, the small ribosomal subunit, assisted by initiation factors,

67 L31, which forms intersubunit bridges to the small ribosomal subunit, assumes different conformations

68 espectively, and bind to the same regions of small ribosomal subunits, between the platform and initi

69 We report that eIF3 and the small ribosomal subunit bind HIV RNA within gag open rea

70 ng translation initiation in eukaryotes, the small ribosomal subunit binds messenger RNA at the 5' en

71 Nop9 is a conserved small ribosomal subunit biogenesis factor, essential in

72 IO kinases (Rio1, Rio2 and Rio3) function in small ribosomal subunit biogenesis.

73 (<3-A diffraction) and Thermus thermophilus small ribosomal subunit bound to the antibiotic paromomy

74 The latter then interacts with small ribosomal subunit-bound proteins, thereby promotin

75 aryotic protein S4 initiates assembly of the small ribosomal subunit by binding to 16 S rRNA.

76 le, organizes the assembly of the eukaryotic small ribosomal subunit by coordinating the folding, cle

77 processome mediates early maturation of the small ribosomal subunit by coupling RNA folding to subse

78 elated conformational changes induced in the small ribosomal subunit by factor binding.

79 Here we show that stable rRNA domains of the small ribosomal subunit can independently recruit their

80 The eukaryotic small ribosomal subunit carries only four ribosomal (r)

81 Because the 40S small ribosomal subunit contains the key regulatory ribo

82 the initiator Met-tRNA to the P site on the small ribosomal subunit during a rate-limiting initiatio

83 to the outer mitochondrial membrane via the small ribosomal subunit during cellular stress.

84 A to interact with both the ribosome and the small ribosomal subunit during stress response.

85 universally conserved rRNA structure of the small ribosomal subunit essential for protein synthesis.

86 n interact with the mRNA channel exit on the small ribosomal subunit for translation initiation.

87 ssors, enabling the factor to engage the 40S small ribosomal subunit for translation initiation.

88 cts to switch the decoding preference of the small ribosomal subunit from elongator to initiator tRNA

89 subunit from Haloarcula marismortui and the small ribosomal subunit from Thermus thermophilus has pe

90 y with the distinctive ability to mature the small ribosomal subunit from within.

91 ribosomes was accompanied by the release of small ribosomal subunits from the ER membrane; the major

92 in NusE (identical to the protein S10 of the small ribosomal subunit) from the pathogenic mycobacteri

93 versus S4/S5) in two distinct regions of the small ribosomal subunit function independently to promot

94 teins of the large and three proteins of the small ribosomal subunit have been analyzed in this manne

95 bosome is sufficient to lock the head of the small ribosomal subunit in a single conformation, thereb

96 ansfers methionyl-initiator tRNA(Met) to the small ribosomal subunit in a ternary complex with GTP.

97 15 is a key component in the assembly of the small ribosomal subunit in bacteria.

98 re required for complete modification of the small ribosomal subunit in Escherichia coli.

99 ified KRIPP1 and KRIPP8 as components of the small ribosomal subunit in mammalian and insect forms, b

100 bly of the entire 3' domain of the bacterial small ribosomal subunit in real time.

101 o dimethylate two adjacent adenosines of the small ribosomal subunit in the normal course of ribosome

102 e prone to misfolding during assembly of the small ribosomal subunit in vivo.

103 olvement of RNAs from both the large and the small ribosomal subunits in catalysis of peptidyl-tRNA h

104 s two pseudouridine modifications within the small ribosomal subunit, in RAS-induced senescence in vi

105 ne the structure of human Pdcd4 bound to 40S small ribosomal subunit, including Pdcd4-40S and Pdcd4-4

106 -LRP, also termed p40, is a component of the small ribosomal subunit indicating that it may be a mult

107 ational switch in the decoding center of the small ribosomal subunit induced by cognate but not by ne

108 It interacts with the small ribosomal subunit interacting protein, eIF3, and t

109 After export, the 20S rRNA in the small ribosomal subunit is cleaved to yield 18S rRNA and

110 st that the timely removal of ERAL1 from the small ribosomal subunit is essential for the efficient m

111 uitment of several components, including the small ribosomal subunit, is thought to allow migration o

112 ited a high-affinity binding to the isolated small ribosomal subunit (K(d) of 1.1 microM).

113 Stress granules are aggregates of small ribosomal subunits, mRNA, and numerous associated

114 In the small ribosomal subunit of budding yeast, on the 18S rRN

115 and NOC4L, and the KSHV ORF11 protein, with small ribosomal subunit precursor complexes during lytic

116 ration of ribosomal RNAs in the large or the small ribosomal subunit production pathway, expanding th

117 f all genes and were predominantly large and small ribosomal subunit protein components.

118 Sud1 to catalyze prolyl-hydroxylation of the small ribosomal subunit protein RPS23.

119 eat protein Yar1 directly interacts with the small ribosomal subunit protein Rps3 and accompanies new

120 enhancer is ribosome-dependent and that the small ribosomal subunit protein S1 interacts with the en

121 Finally, depletion of small ribosomal subunit protein S1, known to help resolv

122 the 18S rRNA-containing 40S subunit and the small ribosomal subunit protein S27a in the presence of

123 ceptor for activated C kinase 1 (RACK1) is a small ribosomal subunit protein that is phosphorylated b

124 The small ribosomal subunit protein uS9 (formerly called rpS

125 lates serine/threonine residues in the human small ribosomal subunit protein, receptor for activated

126 ing that the sedimentation properties of the small ribosomal subunit protein, S6, are dramatically al

127 NPM interacts with rRNA and large and small ribosomal subunit proteins and also colocalizes wi

128 proteins and also colocalizes with large and small ribosomal subunit proteins in the nucleolus, nucle

129 methylation of Rps2, Rps3, and Rps27a, three small ribosomal subunit proteins in the yeast Saccharomy

130 lar mRNA metabolism, including the large and small ribosomal subunit proteins L10a and S6, the stress

131 ant mRNAs and monoubiquitination of distinct small ribosomal subunit proteins.

132 a nonpermissive temperature, both large and small-ribosomal-subunit proteins accumulate in the nucle

133 iation linked the evolution of the large and small ribosomal subunits, proto-mRNA, and tRNA.

134 on of factors required for maturation of the small ribosomal subunit (Rcl1, Fcf1/Utp24, Utp23) and th

135 ects of PABP-eIF4G on cap binding to promote small ribosomal subunit recruitment.

136 eukaryotes relies largely on analyses of the small ribosomal subunit RNA (SSU rRNA).

137 smortui and Deinococcus radiodurans, and the small ribosomal subunit RNA of Thermus thermophilus and

138 ose phylogenetic relationships inferred from small ribosomal subunit RNA sequences, and to examine mo

139 udoknot encompassing residues 500-545 of the small ribosomal subunit RNA was used as a target in scre

140 processome is required for production of the small ribosomal subunit RNA, the 18S rRNA.

141 Upon peptidyl transfer, the small ribosomal subunit rotates counterclockwise relativ

142 ions in its ATPase motifs lead to defects in small ribosomal subunit rRNA maturation, the absence of

143 E-BPs) and protein kinases that act upon the small ribosomal subunit (S6 kinases).

144 structure to automatically retrieve and link small ribosomal subunit sequences with locality informat

145 Ribosomal protein S5 is critical for small ribosomal subunit (SSU) assembly and is indispensa

146 the high mobility group protein Hmo1 and the small ribosomal subunit (SSU) processome complex.

147 The small ribosomal subunit (SSU) processome is a large ribo

148 (pre-rRNA) processing as a component of the small ribosomal subunit (SSU) processome.

149 KsgA, a universally conserved small ribosomal subunit (SSU) rRNA methyltransferase, ha

150 own to be required for the generation of the small ribosomal subunit (SSU).

151 While localization of KsgA on 30S subunits [small ribosomal subunits (SSUs)] and genetic interaction

152 , our findings reveal KSG as an example of a small ribosomal subunit-targeting antibiotic with a well

153 es) to be located in separate regions of the small ribosomal subunit that are important for domain cl

154 ine the structures of three complexes of the small ribosomal subunit that represent distinct steps in

155 A) and initiator transfer tRNA (tRNA) to the small ribosomal subunit, thereby preventing initiation o

156 he binding of initiator tRNA and mRNA to the small ribosomal subunit to form the initiation complex,

157 cells begins with the ordered binding of the small ribosomal subunit to messenger RNA (mRNA) and tran

158 arkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA st

159 e cap-binding protein eIF4E, it recruits the small ribosomal subunit to the 5'-end of mRNA and promot

160 in all cells begins with recruitment of the small ribosomal subunit to the initiation codon in a mes

161 initiation complex, i.e., recruitment of the small ribosomal subunit to the messenger RNA (mRNA).

162 Finally, Ribo-STAMP leverages small ribosomal subunits to measure transcriptome-wide r

163 volution of the large ribosomal subunit, the small ribosomal subunit, tRNA, and mRNA.

164 n complexes and does not dissociate from the small ribosomal subunit upon mRNA recruitment, as previo

165 ranslocation, relative to protein S12 of the small ribosomal subunit using single-molecule FRET.

166 erein peptidyl-tRNA enters the P site of the small ribosomal subunit via reversible, swivel-like moti

167 agment as an indicator for the export of the small ribosomal subunit, we have identified genes that a

168 which both function during maturation of the small ribosomal subunit, we show here that Rrp5 provides

169 hat lariocidins bind at a unique site in the small ribosomal subunit, where they interact with the 16

170 ailed mRNA preferentially interacts with the small ribosomal subunit, whereas edited substrates and c

171 The creation of orthogonal large and small ribosomal subunits, which interact with each other

172 vel sites of protein modification within the small ribosomal subunit will now allow for an analysis o

173 sis factor important for the assembly of the small ribosomal subunit with an uncommon dual ATPase and

174 ise and clockwise rotations of the large and small ribosomal subunits with respect to each other.