ライフサイエンスコーパス: small vessel disease

1 with progression of WMH burden (a marker of small vessel disease).

2 , which belongs to the continuum of cerebral small vessel disease.

3 whole brain atrophy in symptomatic cerebral small vessel disease.

4 finding appears to be related to underlying small vessel disease.

5 ibutions to quality of life in patients with small vessel disease.

6 ld identify a homogeneous subpopulation with small vessel disease.

7 ebrovascular diseases secondary to large and small vessel disease.

8 bnormalities, resemble symptoms and signs of small vessel disease.

9 function over time in patients with cerebral small vessel disease.

10 EPVS) are a promising neuroimaging marker of small vessel disease.

11 rns of brain injury supported both large and small vessel disease.

12 ascular risk factors known to cause sporadic small vessel disease.

13 sation of the arterial pathology in cerebral small vessel disease.

14 ew target for prevention of ICH and cerebral small vessel disease.

15 betaine, and carnitine) are associated with small vessel disease.

16 ding of the biological mechanisms underlying small vessel disease.

17 e and the severity of the underlying chronic small vessel disease.

18 een considered a major mechanism of cerebral small vessel disease.

19 e of an underlying cause other than cerebral small vessel disease.

20 future disease severity and dementia risk in small vessel disease.

21 ine protease implicated in familial forms of small vessel disease.

22 sion is the leading risk factor for cerebral small vessel disease.

23 , DM was associated with increased large and small vessel disease.

24 PD without neocortical Lewy bodies, ADNC, or small vessel disease.

25 -decrease' pattern in patients with cerebral small vessel disease.

26 ge for verbal memory performance in cerebral small vessel disease.

27 g 2109 patients, 1234 (59%) were treated for small vessel disease.

28 f older persons for gene-mapping of cerebral small vessel disease.

29 percutaneous coronary revascularization for small vessel disease.

30 improve risk prediction for individuals with small vessel disease.

31 ith lacunar infarct (LI), a type of cerebral small vessel disease.

32 (MRI) are a neuroimaging marker of cerebral small vessel disease.

33 r spaces may reflect the underlying cerebral small vessel disease.

34 d venular diameter, and markers for cerebral small vessel disease.

35 dase pathway in the pathogenesis of cerebral small vessel disease.

36 neuroimaging and genetic markers of cerebral small vessel disease.

37 Disease-type disease rather than to cerebral small vessel disease.

38 shown mixed results, with a major benefit in small-vessel disease.

39 resting-state CBF is a marker of CMB-related small-vessel disease.

40 other magnetic resonance imaging markers of small-vessel disease.

41 bal brain atrophy and an increased burden of small-vessel disease.

42 arge-vessel and cardioembolic stroke but not small-vessel disease.

43 the brain are important markers of aging and small-vessel disease.

44 ent type of stroke caused mainly by cerebral small-vessel disease.

45 ied a COL4A1 mutation in a human family with small-vessel disease.

46 tify CTEPH patients with significant distal, small-vessel disease.

47 n the settings of vascular calcification and small-vessel disease.

48 l large-vessel disease compared with that of small-vessel disease.

49 inding and may be a useful endophenotype for small vessel diseases.

50 because of chronic joint pain or evidence of small-vessel disease (0.7%).

51 7.2% versus 24.1+/-15.9%, P<0.0001; and mean small-vessel disease, 11.7+/-14.6 versus 14.1+/-8.7, P=0

52 coma is associated with evidence of cerebral small vessel disease; 2) that imaging biomarkers of cere

53 The most common abnormal finding was small vessel disease (20%).

54 Development of cerebral small vessel disease, a major cause of stroke and dement

55 erintensities on MRI are markers of cerebral small vessel disease, a major risk factor for dementia a

56 ss of Notch signaling with ischemic cerebral small-vessel disease, a prevalent human condition.

57 n midlife was associated with development of small vessel disease (adjusted odds ratio [OR] = 1.47 [9

58 for precisely how amyloid-beta and cerebral small vessel disease affect cognitive impairment remain

59 rly during sleep, and in the pathogenesis of small vessel disease, Alzheimer disease and other neurod

60 79 participants (62 with sporadic small vessel disease and 17 with CADASIL) entered the pr

61 amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of

62 Lacunar stroke is a marker of cerebral small vessel disease and accounts for up to 25% of ischa

63 Cerebral small vessel disease and Alzheimer disease are the two m

64 ne separately for participants with sporadic small vessel disease and CADASIL.

65 we scored the severity of arteriolosclerotic small vessel disease and cerebral amyloid angiopathy, an

66 to strongly correlate with other measures of small vessel disease and cognitive impairment at 1 year

67 investigations into the connections between small vessel disease and delayed seizures are warranted.

68 of cognitive dysfunction in stroke, cerebral small vessel disease and dementia.

69 The resulting cerebral small vessel disease and heart failure may contribute to

70 middle-age may increase the risk in diffuse small vessel disease and lower brain perfusion.

71 non-demyelinating disorders such as chronic small vessel disease and other inflammatory, granulomato

72 ho were APOEepsilon4 carriers, greater brain small vessel disease and poorer cognitive performance.

73 continuum between genes underlying Mendelian small vessel disease and those contributing to the commo

74 ear if and how associations between cerebral small-vessel disease and Alzheimer disease (AD) patholog

75 ebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for co

76 CADASIL and their mechanistic connection to small-vessel disease and GOM accumulation remain enigmat

77 luable technique for assessing the degree of small-vessel disease and postoperative outcome after PEA

78 artery atherosclerosis, cardioembolism, and small vessel disease, and defined shared genetic influen

79 , hypertension, lacunar stroke and ischaemic small vessel disease, and have generated interest as a m

80 validated mutations that cause porencephaly, small vessel disease, and hereditary angiopathy, nephrop

81 sights into the longitudinal pathogenesis of small vessel disease, and imply that therapies aimed at

82 erivascular spaces are a feature of cerebral small vessel disease, and it has been hypothesized that

83 abetes, dyslipidemia, smoking, infarcts from small-vessel disease, and "other definite" causes and wo

84 neuroimaging and genetic markers of cerebral small vessel disease: APOE variants epsilon2/epsilon4, c

85 ion, white matter microstructural changes in small vessel disease are associated with apathy but not

86 Y ON THIS ARTICLE: Amyloid-beta and cerebral small vessel disease are the two major causes of cogniti

87 an age at which white matter findings due to small-vessel disease are common.

88 atter lesions (WMLs)-an imaging surrogate of small vessel disease-are associated with a higher rate o

89 mportance of features like brain atrophy and small vessel disease, as opposed to chronological age al

90 id angiopathy (CAA) is an important cerebral small vessel disease associated with brain haemorrhage a

91 pathy and depression can be distinguished in small vessel disease both in terms of their relative rel

92 dentification of genetic variants underlying small vessel disease, both common variants and those wit

93 uent measurements of MRI markers of cerebral small vessel disease, brain tissue volumes, and white ma

94 98, 95% CI = 0.97 to 0.999), and lower total small vessel disease burden (OR = 0.98, 95% CI = 0.96 to

95 ctural imaging features to gauge total brain small vessel disease burden in CAA.

96 The cerebral small vessel disease burdens were assessed with white ma

97 ovascular reactivity in people with sporadic small vessel disease but did result in differential trea

98 evelopment of vascular dementia and cerebral small vessel disease but not between atherosclerosis and

99 e considered for the prevention of ischaemic small vessel disease but the net benefit of such an appr

100 bidities, cognition, hippocampal volume, and small-vessel disease but not on gait speed (0.85 vs 0.92

101 e potential neuroimaging markers of cerebral small vessel disease, but their functional significance

102 posite MRI-derived phenotype for extremes of small vessel disease can facilitate the identification o

103 ysis, we applied the ASCOD (atherosclerosis, small vessel disease, cardiac pathology, other causes, a

104 sms remain unclear, but may include cerebral small vessel disease caused by COPD.

105 core features of CADASIL, a common cerebral small vessel disease caused by highly stereotyped domina

106 CADASIL is a small vessel disease caused by mutations in NOTCH3 that

107 CADASIL is a genetic paradigm of cerebral small vessel disease caused by NOTCH3 mutations that ste

108 e severity of structural vascular pathology (small vessel disease, cerebral amyloid angiopathy or VWF

109 d with conditions such as vascular dementia, small vessel disease, cerebral amyloid angiopathy, and A

110 In small vessel disease, cerebrospinal fluid (CSF) markers

111 pathy (CAA) is a common age related cerebral small vessel disease, characterised by progressive depos

112 l amyloid angiopathy (CAA) is an age-related small vessel disease, characterised pathologically by pr

113 with ischemic stroke attributed to large- or small-vessel disease, CHF and LAE were associated with a

114 patients, 33% of stroke was due to cerebral small vessel disease compared with 14% in the white stro

115 cognitive impairment, but also for cerebral small vessel disease (CSVD) and Abeta-positivity.

116 heterozygous HTRA1 mutation-related cerebral small vessel disease (CSVD) are the two types of dominan

117 lic fatty liver disease (NAFLD) and cerebral small vessel disease (CSVD) burden, especially according

118 Cerebral small vessel disease (cSVD) causes lacunar stroke (LS) a

119 Cerebral small vessel disease (cSVD) encompasses a heterogeneous

120 Cerebral small vessel disease (cSVD) is a common cause of stroke

121 Cerebral small vessel disease (cSVD) is a heterogeneous group of

122 Cerebral small vessel disease (cSVD) is a leading cause of ischae

123 Cerebral small vessel disease (cSVD) is a leading cause of stroke

124 Cerebral small vessel disease (cSVD) is the broadly accepted term

125 pression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms

126 port a Col4a1 mutant mouse model of cerebral small vessel disease (cSVD) with age-dependent defects i

127 etween gut dysbiosis and markers of cerebral small vessel disease (cSVD), a major contributor to ADRD

128 In a rat model of cerebral small vessel disease (cSVD), solute transport in the per

129 gnitive impairment is a hallmark of cerebral small vessel disease (cSVD).

130 A1 and COL4A2 manifest hallmarks of cerebral small vessel disease (cSVD).

131 ), an animal model for hypertensive cerebral small vessel disease (CSVD).

132 ospinal fluid waste accumulation in cerebral small vessel disease (CSVD).

133 Patients with cerebral small-vessel disease (CSVD) exhibit perturbed end-artery

134 s (ePVSs) have been associated with cerebral small-vessel disease (cSVD).

135 Cerebral small vessel diseases (CSVDs) account for one-fifth of s

136 Cerebral small vessel diseases (cSVDs) are a major cause of strok

137 splay brain pathology that typifies cerebral small vessel diseases (cSVDs), including white matter hy

138 nges, which may contribute to post-stroke or small vessel disease dementia.

139 nal study, TMAO was associated with cerebral small vessel disease determined by WMHV and acute lacuna

140 us early and late manifestations of cerebral small vessel disease (eg, microbleeds and white matter h

141 to detect novel genetic factors for cerebral small vessel disease, elucidating underlying disease mec

142 appears aggravated in patients with cerebral small-vessel disease, especially in apolipoprotein E eps

143 nt membrane and COL4A1 mutations cause adult small vessel disease, familial porencephaly and heredita

144 cts of cerebrovascular disease, particularly small vessel disease, from those of Alzheimer's disease

145 ee of apathy and depression found within the small vessel disease group.

146 alent CMBs, and markers of cerebral ischemic small-vessel disease, heavy alcohol consumption (vs ligh

147 imaging markers of the severity and type of small-vessel disease (hypertensive arteriopathy or cereb

148 Early life factors are associated with worse small vessel disease in later life, independent of each

149 ut suggest that an excess burden of cerebral small vessel disease in multiple sclerosis may explain t

150 kely harbor a more advanced form of cerebral small vessel disease in need of efficacious therapeutic

151 ease; 2) that imaging biomarkers of cerebral small vessel disease in POAG and NTG will show different

152 Evidence of small vessel disease in the retina increases the likelih

153 is Review, we examine the roles of large and small vessel disease in VCID, considering the underlying

154 ns in older adults with and without cerebral small vessel disease in vivo.

155 sought to assess the presence and degree of small-vessel disease in patients with chronic thromboemb

156 adjuvant therapies and subclinical cerebral small-vessel disease in survivors of breast cancer.

157 gnitive impairment, and other MRI markers of small vessel disease, in a patient cohort of ischaemic s

158 and to magnetic resonance imaging markers of small-vessel disease including increased white matter hy

159 nce of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and

160 Cerebral small vessel disease, including microvascular lesions, i

161 BI was not associated with other measures of small vessel disease, including WMH.

162 1q22 as a susceptibility locus for cerebral small vessel diseases, including non-lobar intracerebral

163 FOXF2 in ECs, a major risk gene for cerebral small vessel disease, induced key features of BBB dysfun

164 Cerebral small vessel disease is a common condition associated wi

165 Small vessel disease is a disorder of cerebral microvess

166 Cerebral small vessel disease is a leading cause of stroke and a

167 Cerebral small vessel disease is a major cause of stroke and deme

168 Cerebral small vessel disease is a major cause of vascular cognit

169 Small vessel disease is a stroke subtype characterized b

170 Small vessel disease is associated with high rates of ap

171 cally atherosclerosis, is lower and cerebral small vessel disease is higher in multiple sclerosis cas

172 es underlying the cause of sporadic cerebral small vessel disease is limited.

173 Because cerebral small vessel disease is often associated with endothelia

174 fected by pathological changes when cerebral small vessel disease is present.

175 suggest that apathy, but not depression, in small vessel disease is related to damage to cortical-su

176 tween systemic vascular disease and cerebral small vessel disease is stronger in patients with multip

177 MR evidence of cerebral small vessel disease is strongly associated with a diagn

178 This radiological detection of small vessels disease is important because there are no

179 Although cerebral small-vessel disease is an important cause of cognitive

180 of frontal-subcortical circuits by cerebral small-vessel disease is thought to predispose to depress

181 velopment of therapies for NOTCH3-associated small-vessel disease is urgently needed.

182 antineutrophil cytoplasmic antibody-positive small vessel diseases, is largely restricted to case rep

183 lopathy (CADASIL), the most common inherited small-vessel disease, is associated with vascular aggreg

184 thy (CARASIL), an inherited form of cerebral small vessel disease leading to early-onset stroke and p

185 The most common monogenic cause of small-vessel disease leading to ischemic stroke and vasc

186 sphingolipids were associated with increased small vessel disease load as evidenced by higher white m

187 tinct histopathological variants of cerebral small vessel disease (lobar for cerebral amyloid angiopa

188 have become appealing for treatment of ISR, small-vessel disease, long lesions, simplification of bi

189 Small vessel disease (mainly hypertensive arteriopathy a

190 (BP) control with microstructural changes in small vessel disease markers.

191 =3 sulci; disseminated, >/=4 sulci), and key small vessel disease markers.

192 we hypothesized that CSF markers related to small vessel disease may also be applicable as biomarker

193 pril 28, 2022, 75 participants with sporadic small vessel disease (mean age 64.9 years [SD 9.9]) and

194 en study drugs in participants with sporadic small vessel disease (mean change in CVR 1.8 x 10(-4)%/m

195 on testing for acquired causes, on excluding small vessel disease mimics, and detailed advice on meta

196 patients with stroke attributed to large- or small-vessel disease, monitoring with an ICM compared wi

197 ere protein mutations (ie, myocyte disarray, small vessel disease, myocardial scarring).

198 Participants with small vessel disease (n = 118; mean age = 68.9 years; 65

199 nes known to harbour mutations for Mendelian small vessel disease: NOTCH3, HTRA1, COL4A1, COL4A2 and

200 Moreover, small vessel disease of the brain has been estimated to

201 Small-vessel diseases of the brain underlie 20 to 30 per

202 integrity; and (iii) the effect of cerebral small vessel disease on cognition.

203 predict concurrent beta-amyloid deposition, small vessel disease or Alzheimer's disease-pattern neur

204 Although severe small vessel disease or cerebral amyloid angiopathy may

205 e lowest in cortex from patients with severe small vessel disease or cerebral amyloid angiopathy, nei

206 se (i.e. atherosclerosis) and/or of cerebral small vessel disease or worse multiple sclerosis patholo

207 types cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52).

208 ouse models of Alzheimer's disease, cerebral small vessel disease, or Piezo1 gain-of-function mutatio

209 rs than the large artery disease (p<0.0001), small vessel disease (p=0.001), and cardioembolic (p=0.0

210 meability, an important hallmark of cerebral small vessel disease pathology.

211 Fifty-four symptomatic sporadic cerebral small vessel disease patients were studied.

212 with SVS, we assessed its influence on other small vessel disease phenotypes, as well as on messenger

213 , and targets for lipid-modifying drugs with small vessel disease phenotypes.

214 shift and premature stop codons, can lead to small-vessel disease phenotypes of variable severity or

215 ation, and their potential role in promoting small-vessel disease, progress in the development of the

216 bnormal vascular development, which triggers small-vessel disease, recurrent hemorrhagic strokes, and

217 n candidate gene studies with other cerebral small vessel disease-related traits strengthens the cred

218 atherosclerosis, but their role in cerebral small vessel disease remains largely elusive.

219 thrombotic material or coexistent intrinsic small-vessel disease, remains a major determinant of poo

220 evidence of concept validity of a total MRI small vessel disease score in CAA.

221 nd pons was used to obtain a global cerebral small vessel disease score that captured the presence an

222 corporated into a prespecified ordinal total small vessel disease score, ranging from 0 to 6 points.

223 independently associated with the total MRI small vessel disease score.

224 us on systemic vascular disease and cerebral small vessel disease scores and, in the multiple scleros

225 in the brain and blood vessels and extensive small vessel disease severity.

226 ischaemic and haemorrhagic manifestations of small vessel disease [small vessel stroke: 11 710 cases,

227 l changes, including MRI markers of cerebral small vessel disease, smaller brain tissue volumes, and

228 e gave a higher estimate of the frequency of small vessel disease stroke, particularly in white patie

229 Our results also support the view that small vessel diseases such as CAA can cause cortical atr

230 es of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are

231 Manifestations of cerebral small vessel disease, such as covert brain infarcts, whi

232 Background Lesions of cerebral small vessel disease, such as white matter hyperintensit

233 Imaging markers of small vessel disease (SVD) (white matter hyperintensitie

234 Small vessel disease (SVD) and amyloid deposition may pr

235 Associations between cerebral small vessel disease (SVD) and inflammation have been la

236 atility is strongly associated with cerebral small vessel disease (SVD) and may be increased by lower

237 led 23 patients with MS and 11 patients with small vessel disease (SVD) and performed standardized 3-

238 t evidence suggests that various features of small vessel disease (SVD) are part of and covertly modi

239 Patients with cerebral small vessel disease (SVD) can present as isolated lacun

240 Cerebral small vessel disease (SVD) causes focal lacunar infarcti

241 dy was undertaken to assess whether cerebral small vessel disease (SVD) computed tomographic (CT) bio

242 tients with late-onset AD have more comorbid small vessel disease (SVD) contributing to clinical seve

243 The term cerebral small vessel disease (SVD) describes a range of neuroima

244 ollected risk factors, RSSI characteristics, small vessel disease (SVD) features, and microstructural

245 Cerebral small vessel disease (SVD) is a common accompaniment of

246 Cerebral small vessel disease (SVD) is a common cause of vascular

247 Cerebral small vessel disease (SVD) is a leading cause of stroke

248 Cerebral small vessel disease (SVD) is a major cause of stroke an

249 Cerebral small vessel disease (SVD) is a vascular disorder that i

250 Cerebral small vessel disease (SVD) is associated with various ce

251 Cerebral small vessel disease (SVD) is characterised by progressi

252 Cerebral small vessel disease (SVD) is characterized by changes i

253 Cerebral small vessel disease (SVD) is common during ageing and c

254 Cerebral small vessel disease (SVD) is frequently comorbid with A

255 Cerebral small vessel disease (SVD) is highly prevalent and a com

256 ular smooth muscle, is a genetic paradigm of small vessel disease (SVD) of the brain.

257 to assess whether and how single markers of small vessel disease (SVD) or a combination thereof expl

258 A cross-sectional study in cerebral small vessel disease (SVD) reported an association with

259 with loss of microvascular function, termed small vessel disease (SVD) underlying different potentia

260 arterioles (PAs), a major target of cerebral small vessel disease (SVD), and determined whether relax

261 ct future dementia risk not only in cerebral small vessel disease (SVD), but also in mild cognitive i

262 aneous intracerebral hemorrhage (ICH) due to small vessel disease (SVD), but the association between

263 Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain,

264 ost common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main

265 clerosis, cerebral amyloid angiopathy, mixed small vessel disease (SVD), other rare forms of SVD (gen

266 is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cogniti

267 association is possibly mediated by cerebral small vessel disease (SVD), which has been associated wi

268 lacunar strokes are associated with cerebral small vessel disease (SVD), which is the commonest vascu

269 e of white matter lesion related to cerebral small vessel disease (SVD).

270 ingly recognized, particularly from cerebral small vessel disease (SVD).

271 -associated manifestations of human cerebral small vessel disease (SVD).

272 (WM) injury in older individuals is cerebral small vessel disease (SVD).

273 rly population, and considered indicators of small vessel disease (SVD).

274 he brain and may reflect underlying cerebral small vessel disease (SVD).

275 Cerebral small vessel diseases (SVDs) are a central link between

276 Cerebral small vessel diseases (SVDs) are associated with cerebro

277 Several hereditary small vessel diseases (SVDs) of the brain have been repo

278 Dementia resulting from small vessel diseases (SVDs) of the brain is an emerging

279 leukoencephalopathy (CADASIL) is a cerebral small vessel disease that results from mutations in NOTC

280 wever, deep ICHs are rare in some aggressive small vessel diseases that are characterized by signific

281 WMHs) are a common manifestation of cerebral small vessel disease, that is increasingly studied with

282 have an impact in diseases such as cerebral small vessel disease, the leading cause of vascular deme

283 oke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cogn

284 ith the hypothesis that PVS reflect cerebral small vessel disease; the different associations for bas

285 The mechanisms linking small-vessel disease to cognitive impairment are not wel

286 mes throughout 5 years between patients with small vessel disease treated with ultrathin-strut BP-SES

287 ICH location and underlying small vessel disease type.

288 A relative excess of small vessel disease was observed in black patients with

289 Eighty-two patients with MRI evidence of small vessel disease were assessed using a behavioural p

290 ee participants (50-85 yr old) with cerebral small vessel disease were included and followed for 9 ye

291 y, percentage of fibrosis, and percentage of small-vessel disease were correlated with the genotype.

292 SIVD results from small-vessel disease, which produces either arteriolar o

293 al microbleeds and other markers of cerebral small vessel disease (white matter hyperintensities [WMH

294 hy and magnetic resonance imaging markers of small vessel disease (white matter hyperintensities or l

295 dinal cohort of 99 subjects with symptomatic small vessel disease, who were followed-up for >/=1 year

296 Treatment of small-vessel disease with a paclitaxel DEB was associate

297 re the most acute manifestations of cerebral small vessel disease, with no established preventive app

298 y volume (WMHV) on MRI, a marker of cerebral small vessel disease, with subsequent longitudinal chang

299 es at known pathogenic variants for familial small vessel disease within NOTCH3 and HTRA1.

300 had an index stroke attributed to large- or small-vessel disease within 10 days prior to insertable