ライフサイエンスコーパス: smoke

1 s of nanoparticles contained in each puff of smoke.

2 (<1 day of aging) to old (>3 days of aging) smoke.

3 associated with minimal exposure to tobacco smoke.

4 is increase is further elevated by cigarette smoking.

5 e a biomarker for fetal exposure to maternal smoking.

6 , particularly in combination with cigarette smoking.

7 5) after adjustment for gender, age, BMI and smoking.

8 eages, and define cell-specific responses to smoking.

9 might influence lung function via effects on smoking.

10 ts (45.2%) reported a pre-surgery history of smoking.

11 lar to and disparate from those of cigarette smoking.

12 diseases, especially physical inactivity and smoking.

13 Adults who had smoked 1 cigarette or more within 30 days, spoke English

14 t in patients with light exposure to tobacco smoke(1-3).

15 risk factors (odds ratio(PRS+family history+smoking), 1.24 [95% CI, 1.14-1.35]; P(PRS)=1.27x10(-6)).

16 e obese, 8.7% had depression, 19.5% reported smoking, 16.1% reported drug use, and 10.9% reported har

17 Female sex (OR 2.3, 95% CI 1.5 to 3.7), smoking (2.1, 1.2 to 3.6) and hypertension (1.6, 1.0 to

18 Alcohol consumption and smoking, 2 major risk factors for cardiovascular disease

19 oconus was associated with regular cigarette smoking (38.5% vs. 14.6%; P = 0.04), but showed no assoc

20 microbiome(4), by lifestyle choices such as smoking(5), or by diet(6).

21 ple with addictions such as alcohol abuse or smoking(6,7).

22 io, 2.96; 95% CI, 2.00 to 4.40), and current smoking (9.4%, vs. 5.6% among former smokers or nonsmoke

23 However, smoking addiction assessed by the Fagerstrom test for ni

24 ing during pregnancy, and some start to quit smoking after being pregnant, although existing guidelin

25 sk and PM in smoke decrease as a function of smoke age by up to 72% from fresh (<1 day of aging) to o

26 2.757 [1.616-4.704], p < 0.001) and tobacco smoking (aHR = 2.150 [1.319-3.503], p < 0.01) were posit

27 ly focused on deterrent health factors, like smoking, alcohol intake, cheese consumption and average

28 also examined DNA methylation predictors of smoking, alcohol, body mass index, serum proteins, and c

29 for age, race/ethnicity, education, income, smoking, alcohol, menopausal hormone therapy, and hyster

30 Former smoking alone is not associated with greater spirometry

31 Smoking also causes chronic obstructive pulmonary diseas

32 ung cancer and there is strong evidence that smoking also increases the risk of several other cancers

33 Here, we investigated whether cigarette smoke alters the ability of this clinically significant

34 The relationship between smoking amount and the risk of overweight or obesity was

35 We also found that the combination of smoke and morphine inhibited the expression of IL-1alpha

36 Ever smoked and duration were associated with smaller total G

37 g on homocysteine levels, with self-reported smoking and a cotinine biomarker.

38 in support of a causal relationship between smoking and alcohol consumption and 19 site-specific can

39 d dementia, but research on the link between smoking and brain structure is nascent.

40 ould help to explain the association between smoking and diabetes risk.

41 to examine the association of the timing of smoking and doses of smoking before pregnancy and during

42 3 mortality clocks up to 5 years, driven by smoking and elevated levels of 6 age-associated proteins

43 Smoking and exposure to toxic metals are risk factors fo

44 h the responsiveness of ECFCs to FIR include smoking and gender.

45 Finally, genetic risks for smoking and high blood pressure, the two main clinical r

46 sed risk of ADA development, whereas tobacco smoking and infections during the study were associated

47 rt the well-established relationship between smoking and lung cancer and suggest that smoking may als

48 after adjustment for deprivation, ethnicity, smoking and obesity: adjusted HR 2.59 (95% CI 1.74-3.84;

49 studies from Europe and Canada with detailed smoking and occupational histories were pooled.

50 ssociation between genetic predisposition to smoking and prostate cancer in the Prostate Cancer Assoc

51 nal silica exposure and the joint effects of smoking and silica exposure on lung cancer risks.Methods

52 ification by study areas, and adjustments of smoking and solid fuel use.

53 he relationship between in utero exposure to smoking and the heightened risks for the subsequent deve

54 No association was found between smoking and the number of vessel wall lesions.

55 ral economic methods of eliciting adolescent smoking and vaping norms.

56 hods of measuring injunctive and descriptive smoking and vaping norms: (1) incentivized experiments,

57 l body mass index, be physically active, not smoke, and avoid nonsteroidal anti-inflammatory drug use

58 live births, exposure to secondhand tobacco smoke, and ever pregnant or not currently pregnant.

59 ts, built environment, green spaces, tobacco smoking, and biomarkers of chemical pollutants (persiste

60 Age, sex, dyslipidemia, hypertension, smoking, and family history of premature cardiovascular

61 Obesity, tobacco smoking, and genetic predisposition increase the risk of

62 iations with sociodemographic, reproductive, smoking, and housing characteristics over a 40-y period.

63 s (depression, obesity, harmful alcohol use, smoking, and illicit drug use; n = 4,917).

64 ody mass index, alcohol consumption, tobacco smoking, and physical activity.

65 hat were significant for both Cd and current smoking (annotated to PRSS23, AHRR, F2RL3, RARA, and 2q3

66 diabetes (aOR 3.1; 95% CI: 1.7-5.8), current smoking (aOR 3.1; 95% CI: 2.2-4.4) and prolonged history

67 cohol (ALDH2, APOA5, APOC3, CETP, LPL), gene-smoking (APOC3, CYBA, LPL, USF1), gene-pregnancy (LPL),

68 Cigarette or marijuana smoking are infrequently criteria for exclusion, althoug

69 60-77% of adults (17-48% of smokers) viewing smoking as something of which others disapproved.

70 s) for lung cancer incidence by sex, tobacco smoking, asbestos exposure, presence of asbestosis, and

71 on of SARS-CoV2 through aerosolized surgical smoke associated with energy device use is not fully und

72 first investigated the causal effects of 474 smoking-associated CpGs on forced expiratory volume in 1

73 Highly reproducible smoking-associated DNA methylation changes in whole bloo

74 Whether smoking-associated DNA methylation has a causal effect o

75 med to provide a comprehensive assessment of smoking-associated gene expression changes in healthy pa

76 We find that most of the highly reproducible smoking-associated hypomethylation signatures are more p

77 Smoking-associated LUADs showed correlation with other e

78 Smoking at time of implant placement emerged as a new ri

79 Most of the women who smoke before pregnancy continue smoking during pregnancy

80 iation of the timing of smoking and doses of smoking before pregnancy and during the first or second

81 y recommend that women who smoke should quit smoking before pregnancy.

82 ted smoking history pre-surgery, and current smoking behavior annually.

83 independently replicated the association of smoking behavior with CAD (OR 1.24, 95% CI: 1.12-1.37, P

84 d by additional risk factors correlated with smoking behavior, which have not been investigated.

85 ith (self-reported and objectively measured) smoking behavior/intentions were inspected in another st

86 socioeconomic, and sex-based differences in smoking behaviors or lung cancer risk.

87 Smoking behaviors, including amount smoked, smoking cess

88 per standard deviation increase in lifetime smoking behaviour) and an independent causal effect of a

89 qually correlated with life expectancy, with smoking being significantly worse than others.

90 ng for age, sex, ethnicity, education level, smoking, BMI, and diabetes.

91 We adjusted for age, smoking, body mass index, physical activity, alcohol con

92 The rates of tobacco smoking by people living with HIV vastly exceed that of

93 Exposure to wildfire smoke causes adverse health outcomes, suggesting the imp

94 Tobacco smoking causes lung cancer(1-3), a process that is drive

95 n of substrates for the design of innovative smoking cessation aids.

96 cant benefits of medication on likelihood of smoking cessation in 2 trials of bupropion at 26 weeks (

97 sk population and to determine the effect of smoking cessation in this genotype.Methods: We prospecti

98 This smoking cessation intervention for expectant fathers tha

99 Smoking cessation is important in patients with tubercul

100 SZ registry data to determine the effect of smoking cessation on spirometry decline (n = 60) and pla

101 ful in promoting healthier behaviors such as smoking cessation or in aiding persons with a family his

102 een behavioral interventions and controls in smoking cessation when trials were restricted to smokers

103 terventions such as lowering blood pressure, smoking cessation, and lifestyle optimisation are common

104 Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are alt

105 group received a leaflet with information on smoking cessation.

106 Rs provide a promising novel drug target for smoking cessation.

107 Most participants reported smoking cigarettes; few smoked only cigars.

108 otine kinetics were compared with those from smoking combustible cigarettes (C-cigs).

109 ting the importance of accurately estimating smoke concentrations.

110 elial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at conce

111 perception of AM fungi, and also detects the smoke constituent karrikin.

112 s of e-cigarette users who successfully quit smoking continued to use e-cigarettes.

113 al cancer (LC) patients who meet the age and smoking criteria of the U.S. Preventive Services Task Fo

114 ) mice following acute exposure to cigarette smoke (CS).

115 Cigarette smoking (CS) can exacerbate the incidence and severity o

116 ociation study of urine Cd and self-reported smoking (current and former vs. never, and cumulative sm

117 It is widely known that cigarette smoke damages host defenses and increases susceptibility

118 of deaths among smokers are avoidable at non-smoking death rates, and former smokers have about only

119 nd chronic cancer HAPs health risk and PM in smoke decrease as a function of smoke age by up to 72% f

120 and vascular risk factors (body mass index, smoking, diabetes mellitus and total cholesterol).

121 ECFCs from CAD patients that smoke did not respond to FIR in most cases.

122 al regression models adjusted for age, race, smoking, diet, alcohol, physical activity, menopausal ho

123 d risk of colorectal cancer due to cigarette smoking differed by anatomical subsite or sex.

124 current and former vs. never, and cumulative smoking dose) with blood DNAm in 790,026 CpGs (methylati

125 whose mother had a lower education level or smoked during pregnancy.

126 re asthma if both mother and grandmother had smoked during their pregnancies.

127 hermore, we studied interactions of PRS with smoking during pregnancy and childhood life events in re

128 al weight gain, diet, physical activity, and smoking during pregnancy to create a lifestyle score ran

129 he women who smoke before pregnancy continue smoking during pregnancy, and some start to quit smoking

130 entury hazards reveal that smokers who start smoking early in adult life and do not quit lose a decad

131 ined baseline data on body mass index (BMI), smoking, education, and previous disorders.

132 king EWAS results in blood, to identify DNAm smoking effects that are unique (tissue-specific) vs. sh

133 e extended our NAc findings, using published smoking EWAS results in blood, to identify DNAm smoking

134 Smoking expectant fathers who registered with their preg

135 Tobacco smoke exposure also reduces vaccine efficacy.

136 hand smoke for 8 wk, followed by a period of smoke exposure cessation, and the mice were immunized wi

137 Tobacco smoke exposure is associated with multiple diseases incl

138 at avoiding childhood/adolescence secondhand smoke exposure promotes adulthood cognitive function.

139 notypes in subjects with significant tobacco smoke exposure using deep gene resequencing and alpha-1

140 ine cotinine levels indicative of secondhand smoke exposure, and residence in more densely populated

141 reby generate a score for in utero cigarette smoke exposure.

142 against emphysema development independent of smoke exposure.

143 Smoking exposure during the prenatal period was directly

144 risk factors (primary and secondhand tobacco smoke exposures, occupational and environmental pollutan

145 We studied the association of Cd and smoking exposures with human blood DNA methylation (DNAm

146 We found that cigarette smoke extract (CSE) exposure enhances resistance to huma

147 table intake ameliorating effects of alcohol-smoking-fatty food.

148 cresol, eugenol, isoeugenol and guaiacol) in smoked food samples.

149 We exposed mice to secondhand smoke for 8 wk, followed by a period of smoke exposure c

150 men and > 30 g/day for men was combined with smoking habit (OR = 7.30 [95% CI: 6.1-8.73]).

151 position, BMI, physical activity level, and smoking habit, as well as when participants without card

152 aimed to investigate the association between smoking habits (focusing on the age when smokers started

153 ise, walking/cycling, height, energy intake, smoking habits, baseline Charlson's weighted comorbidity

154 , female sex, use of oral contraceptives and smoking habits.

155 The average age at which people start smoking has been decreasing in many countries, but insuf

156 Smoking has been widely studied as a susceptibility fact

157 is was associated with antenatal exposure to smoking, higher maternal education levels, and wheezing

158 Amongst women with >=20 pack year smoking history (n = 19,286), 2148 (11.1%) had premature

159 Disease stage and smoking history are often used in current clinical trial

160 edian body mass index 47 kg/m) self-reported smoking history pre-surgery, and current smoking behavio

161 orating tumor staging, treatment status, and smoking history revealed that treatment status had the m

162 med by statistically adjusting atopy status, smoking history, and disease duration.

163 ignificant changes about lung function test, smoking history, sex and the levels of D-dimer among two

164 for stage, human papillomavirus status, and smoking history.

165 f colonoscopy, age, sex, race/ethnicity, and smoking history.

166 sex (HR 2.52, 95% CI 1.04-6.10), history of smoking (HR 3.42, 95% CI 1.40-8.45), and thymic abnormal

167 ,548) at Y7 were associated with black race, smoking, hypertension, and higher body mass index.

168 iable risk factors assessed at baseline were smoking, hypertension, diabetes, obesity and physical in

169 factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline diseas

170 xists on the adult hazards of having started smoking in childhood and, especially, in early childhood

171 t epigenome-wide association study (EWAS) of smoking in human postmortem brain, focusing on nucleus a

172 cting responses to nicotine in zebrafish and smoking in humans.

173 ody mass index z scores, maternal education, smoking in pregnancy, and prenatal particulate matter wi

174 echanisms of Networks and Norms Influence on Smoking in Schools (MECHANISMS) study baseline data, fro

175 red to nonsmoking during pregnancy, quitting smoking in the first trimester is associated with the sa

176 port a model whereby genetic determinants of smoking increase type 2 diabetes risk indirectly through

177 ng cancer screening with CT require detailed smoking information and miss many incident lung cancers.

178 d BhGLM were able to detect a rare haplotype-smoking interaction in this region.

179 Exposure of lung tissues to cigarette smoke is a major cause of human disease and death worldw

180 We conclude that tobacco smoke is a major source of isoprene exposure in the US p

181 Cigarette smoke is the first complex odor whose in vivo receptor r

182 Smoking is a well-established cause of lung cancer and t

183 Cigarette smoking is associated with increased risk for myriad hea

184 Smoking is considered a risk factor for periodontitis ge

185 Interaction between rs8192575 and smoking is significantly replicated with two additional

186 Cigarette smoking is the leading cause of preventable morbidity an

187 Nicotine addiction, through smoking, is the principal cause of preventable mortality

188 of alcohol consumption when controlling for smoking (IVW OR 2.1, 95% CI = 1.1, 3.8 per standard devi

189 ed at both time points for prenatal parental smoking, life events, and negative affect and substance

190 , a positive family history of dementia, non-smoking, low alcohol consumption, depression, daytime so

191 rijuana is becoming increasingly potent, and smoking marijuana carries many of the same cardiovascula

192 een smoking and lung cancer and suggest that smoking may also be a risk factor for cancer of the head

193 s support that treating VRF and cessation of smoking may be important in the management of MS.

194 Persistent smoking may cause adverse outcomes among patients with c

195 In conclusion, smoking may cause suppression of appetite but smokers te

196 Maternal smoking may induce such long-term effects through persis

197 Other smoking phenotypes, such as current smoking, may be suitable for future Mendelian randomisat

198 A total of five smoking measurements were investigated, including active

199 of HNC was 7.61% for a 60-year-old woman who smoked more than 20 cigarettes per day for over 20 years

200 nutrient intake, participants from Barcelona smoked more, were less educated, and had lower baseline

201 Our results show that smoke, morphine, and the combination promotes the declin

202 This regulation by smoking/nicotine will increase interindividual variation

203 In conclusion, perceived descriptive non-smoking norms are not held by the majority of adults in

204 Injunctive non-smoking norms were more prevalent, with 60-77% of adults

205 A genetic predisposition, smoking, obesity and hormonal factors are established ae

206 lation did not clearly mediate the effect of smoking on FEV(1), although DNA methylation at some site

207 ether DNA methylation mediates the effect of smoking on FEV(1).

208 etic variants interacting with pack-years of smoking on FEV(1)/FVC ratios in individuals with normal

209 e consider the possible effects of cigarette smoking on homocysteine levels, with self-reported smoki

210 t focused on explaining the ramifications of smoking on maternal and child health was effective and f

211 limited evidence for a meaningful effect of smoking on MS susceptibility as measured using summary s

212 We investigated effects of HIV and smoking on oral HPV risk.

213 evidence for an independent causal effect of smoking on oral/oropharyngeal cancer (IVW OR 2.6, 95% CI

214 articipants reported smoking cigarettes; few smoked only cigars.

215 nonsmoking mothers, maternal first trimester smoking only was not associated with adverse birth outco

216 trated that COPD at baseline, but not former smoking or AAT concentrations, predicted greater spirome

217 cer was identified for the variables of sex, smoking or study design.

218 er of teeth <=14 (OR = 1.78; P = 0.034), and smoking (OR = 2.19; P = 0.001).

219 associations were not modified by age, BMI, smoking, or red meat intake (All P(interaction) > 0.055)

220 raised blood glucose, raised blood pressure, smoking, overweight, and obesity) at the household, comm

221 x (P = 0.68), level of education (P = 0.26), smoking (P = 0.11), alcohol consumption (P = 0.52), hist

222 PAF 16.5% ELSA; 16.7% SIGa-Bage) and current smoking (PAF 4.9% for both cohorts) having the strongest

223 was carried out, adjusting for maternal age, smoking, parity, ethnicity, neonate sex, and predicted c

224 mized crossover design, nontreatment seeking smoking participants (N = 30) completed two imaging sess

225 Tobacco and marijuana smoke particles are quantitatively similar in volatility

226 findings provide new insights into how wood smoke particulate matter and other transient receptor po

227 status, pack-years, years as a smoker, packs smoked per day, and hours as a passive smoker per week.

228 de association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Milli

229 Other smoking phenotypes, such as current smoking, may be suit

230 or emissions and the chemical environment of smoke plumes.

231 Many adolescent smoking prevention programmes target social norms, typic

232 ized metabolism of inhaled drugs and tobacco smoke procarcinogens.

233 prevalence of elevated blood pressure, lower smoking rates, and lower prevalence of elevated choleste

234 Moreover, increases in smoking-related Cd exposure were associated with differe

235 verall density, supporting a role for IMs in smoking-related disease.

236 increase the risk of tobacco dependence and smoking-related diseases in human smokers.SIGNIFICANCE S

237 istically significant contributions of Cd to smoking-related DNAm.

238 ents alive today will die prematurely from a smoking-related illness.

239 signalling in young and aged mice disrupted smoking-related inducible bronchus-associated lymphoid t

240 Decreased lung CYP2A expression may alter smoking-related lung cancer risk and tissue damage from

241 Cigarette smoking remains one of the leading public health threats

242 on, after adjusting for alcohol consumption, smoking retained its association with several CVD outcom

243 the extent that rapid brain uptake promotes smoking reward, E-cigs might maintain a degree of nicoti

244 e in PRS), independent of family history and smoking risk factors (odds ratio(PRS+family history+smok

245 9 trials, n = 2516; 80.7% vs 84.1% continued smoking; RR, 0.97 [95% CI, 0.93-1.01]).

246 ation) and maternity (maternal age, maternal smoking, sex-gestation-specific birth weight centile, ge

247 lines for pregnancy recommend that women who smoke should quit smoking before pregnancy.

248 for BMI, and xenobiotic stimuli response for smoking, showed >1.5 times larger associations with >95%

249 Exposure to cigarette smoke significantly affected the patterns of cytosine me

250 cells; 3) ACE2 is upregulated in the SAE by smoking, significantly in men; 4) levels of miR-1246 exp

251 weight loss in late life, physical exercise, smoking, sleep, cerebrovascular disease, frailty, atrial

252 Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases,

253 mass and volume of the particles from either smoke source are comprised of semi-volatile compounds.

254 We estimated sex- and smoking-specific incidence trends of pre-bronchodilator

255 rvals (CIs) of preterm birth associated with smoking status and the number of cigarettes consumed, ad

256 health outcomes were found between different smoking status groups, suggesting that smoking/vaping pr

257 We also examined the impact of smoking status on AGER (encodes RAGE) and TLR4 bronchial

258 compared to controls, independent of active smoking status or poor oral hygiene.

259 Smoking status was biochemically verified (exhaled air C

260 Smoking status was validated by cotinine assay.

261 h radiomic and clinical features (gender and smoking status) reached a diagnostic accuracy of 88.1% i

262 for age, race, WIHS site, education, income, smoking status, and baseline ART regimen.

263 egression models adjusted for age, sex, BMI, smoking status, and hypertension.

264 ons with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.

265 After adjustment for age, gender, smoking status, hepatitis C and hepatitis B virus coinfe

266 urements were investigated, including active smoking status, pack-years, years as a smoker, packs smo

267 , family history of gastrointestinal cancer, smoking status, previous negatives and whether a GP had

268 aphics, year of consultation, comorbidities, smoking status, recent hospitalizations, recent accident

269 haracterized by differences in asthma onset, smoking status, residential locations, percentage of blo

270 x, body mass index, race, surgical approach, smoking status, Zubrod and American Society of Anesthesi

271 of pocket depth, gingival bleeding, ACH, and smoking status.

272 by PD-L1 expression, choice of platinum, and smoking status.

273 ance imaging data from healthy and cigarette-smoking subjects performing the Iowa Gambling Task.

274 the offspring of smokers are more likely to smoke than the offspring of nonsmokers, this sets the st

275 ven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA(4,5).

276 ery day about 1600 youth aged 12 to 17 years smoke their first cigarette and that about 5.6 million a

277 ear regression models adjusted for age, sex, smoke, time living in Sao Paulo, daily commuting, socioe

278 bly act as intermediates on the pathway from smoking to ALS.

279 We found smoking to be a risk factor for many CVDs even after adj

280 is approach to study the causal pathway from smoking to overall survival among lung cancer patients p

281 pliffs (95%CI: 0.605-0.988); those who never smoked tobacco and did not use spliffs (95%CI: 0.489-0.8

282 nt within 60 minutes after waking: those who smoked tobacco and used spliffs (95%CI: 0.605-0.988); th

283 pliffs (95%CI: 0.489-0.892); those who never smoked tobacco and used spliffs (95%CI:0.022-0.915).

284 Compared to those who smoked tobacco and used spliffs, the following spliff us

285 of the same cardiovascular health hazards as smoking tobacco.

286 tion; epithelial colonization; and cigarette smoke toxin exposure; as well as to elucidate genes requ

287 Conclusion Except for smoking, traditional common cardiovascular risk factors

288 .6%) is genetically correlated with 18 other smoking traits (r(g) = 0.40-1.09) and co-morbidities.

289 rogram (MVP) where we identified 18 loci for smoking trajectory of current versus never in European A

290 erent smoking status groups, suggesting that smoking/vaping produces differential effects on oral hea

291 Ever smoked was associated with reduced volume of the right V

292 Multivariable OR for current smoking was 1.93 (1.27-2.92), dyslipidemia OR=1.92 (1.41

293 sociated with compassion satisfaction, while smoking was a negative factor; these five factors explai

294 Our results suggest that smoking was associated with a reduction in human lung CY

295 Current smoking was associated with significantly lower AGER and

296 A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increa

297 Tobacco smoking was the major influence on mutational burden, ty

298 icans, and 90 Hispanics with >=20 pack-years smoking were resequenced for the identification of rare

299 Clinical observations have linked tobacco smoking with increased type 2 diabetes risk.

300 and without nicotine aerosolized at 40 W (E-smoke) with respect to particle number concentrations, c