ライフサイエンスコーパス: snail

1 geting EMT-promoting factors ZEB1, cdk6, and Snail.

2 vimentin, N-cadherin, ROCK1, RhoA, ZEB1, and Snail.

3 ss S. mansoni larvae are present in the same snail.

4 or-promoting genes, such as Runx2, MMP9, and Snail.

5 (EMT)-associated genes, including MMP-9 and Snail.

6 cy, characterized by increased expression of Snail.

7 ty of the SET9 promoter in coordination with Snail.

8 was specifically upregulated by Slug but not Snail.

9 eta receptor 1, and the transcription factor Snail.

10 9.84 +/- 0.79 amplicon sequence variants per snail.

11 ilizes the nephrin transcriptional repressor SNAIL.

12 recruits TGF-beta-activated SMAD factors to SNAIL.

13 n levels of the mesenchymal markers ZEB1 and Snail.

14 driven by the levels of transcription factor SNAIL.

15 mansoni in their shared Biomphalaria vector snails.

16 rough contact with water containing infected snails.

17 interactions with animals such as isopods or snails.

18 alter size distributions by targeting small snails.

19 water containing infected Biomphalaria spp. snails.

20 at would enable precision targeting of these snails.

21 sustained were 0.006, 0.009, 0.028 and 0.020 snails/0.11 m(2), respectively.

22 control of stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homo

23 The EMT markers assessed were Snail-1, Snail-2, N-cadherin, Twist and vimentin.

24 f stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homologs are

25 ression of key metastatic markers, vimentin, snail-2, beta-catenin and stathmin-1 (STMN1) in patient

26 The EMT markers assessed were Snail-1, Snail-2, N-cadherin, Twist and vimentin.

27 Our study reveals a critical Snail-4E-BP1 signaling axis in tumorigenesis, and provid

28 the developmental regulatory genes twist and snail [7-10].

29 quencing and functional studies confirm that Snail, a key transcription factor of EMT, is involved in

30 anophosphate class of insecticides increased snail abundance (first intermediate host) and thus trema

31 While a similar pattern in snail abundance and trematode exposure was observed with

32 Snail abundance fosters disease transmission, and thus t

33 also more diverse, and that across all sites snail abundance generally increased with coral cover.

34 ds based on model averaging provide reliable snail abundance projections.

35 tive relationships between intermediate host snails (abundance, density, and prevalence) and human ur

36 ng protein (AChBP), a humanized chimera of a snail AChBP, which has 71% sequence similarity with the

37 mad3, STAT3, beta-catenin, and expression of Snail after ureteral obstruction.

38 r cells overactivating FAK_SRC to upregulate SNAIL and acquire a mesenchymal phenotype and (ii) FAK_S

39 xpression changes, including upregulation of Snail and beta-catenin, and increased cell migration and

40 RNA) mediates a physical interaction between Snail and enhancer of zeste homolog 2 (EZH2), an enzymat

41 -SMAD and RREB1 directly drive expression of SNAIL and fibrogenic factors stimulating myofibroblasts,

42 rator-activated receptor gamma, and reducing Snail and matrix metalloproteinase 9.

43 AD and RREB1 combine to induce expression of SNAIL and mesendoderm-differentiation genes that drive g

44 Mesenchymal markers snail and MMP14 were upregulated in cancer cells maintai

45 induced expression of cyclin-D1, cyclin-E1, snail and MMP2 and inhibited the expression of P53 and P

46 rocedures for tracing the labels in aquatic (snail and mussel) and terrestrial (earthworm) organisms

47 anslational activation of a subset of NANOG, SNAIL and NODAL mRNA isoforms akin to hypoxia, engenderi

48 We report that in breast cancer cells NANOG, SNAIL and NODAL transcripts manifest multiple isoforms c

49 n MDA-MB-231 cells impaired the induction of Snail and Slug expression by EGF, and this effect was as

50 In contrast, Snail and Slug expression was positively associated with

51 cadherin and its transcriptional regulators; Snail and Slug may serve as indicators for assessing the

52 ty of E-cadherin transcriptional repressors, snail and slug, induced by transforming growth factor-be

53 There was increased binding of CUX1 to Snail and the E-cadherin promoter in mesenchymal cells c

54 ation of Cat L, decreased binding of CUX1 to Snail and the E-cadherin promoter, reversed EMT, and dec

55 tive samples demonstrated high expression of Snail and Vimentin with relatively low expression of E-c

56 Snail and Zeb transcription factors induce epithelial-to

57 and transcription factors (N-cadherin, Slug, Snail and Zeb1), and upregulation of E-cadherin.

58 -sbid impaired the ability of HOTAIR to bind Snail and, in turn, trigger H3K27me3/EZH2-mediated repre

59 to break open hard-shelled foods like marine snails and bivalves.

60 rotoxic peptides in the venom of marine cone snails and have broad therapeutic potential for managing

61 ortion of large, warm-adapted species (i.e., snails and predatory dipterans) relative to small-bodied

62 ng the 3 rd stage larvae from primary hosts, snails and slugs, or paratenic hosts.

63 n by parasites has also been shown for mice, snails and zebrafish as well as for insects.

64 prostate (ARCaP-M and ARCaP-E overexpressing Snail) and breast (MDA-MB-468, MDA-MB-231, and MCF-7 ove

65 N-cadherin, fibronectin, vimentin, slug and snail) and stem cell markers (CD44 and CD87) in both BEA

66 d3, STAT3, and beta-catenin, upregulation of Snail, and downregulation of BMP7 and Klotho.

67 vated the expression of mRNA for N-cadherin, Snail, and GHRH GHRH antagonist reduced the average volu

68 lopment, and genetics of chiral variation in snails, and place it in context with other animals.

69 In the hermaphroditic marine-snail, Aplysia californica, synaptic input to the neuroe

70 aeological shellmounds, many species of land snails are found abundantly distributed throughout the o

71 Biomphalaria snails are instrumental in transmission of the human blo

72 Cone snails are venomous marine gastropods that hydraulically

73 aquatic invertebrates, such as sea slugs and snails, are capable of diverse locomotion modes under wa

74 Here we identify Snail as a strong transcriptional repressor of 4E-BP1.

75 Schistosomes use aquatic snails as intermediate hosts.

76 chanism illustrating how the SATB2-AS1-SATB2-Snail axis is involved in epigenetic modification that r

77 m, named HOTAIR-sbid, including the putative Snail-binding domain but depleted of the EZH2-binding do

78 Snail binds to three E-boxes present in the human 4E-BP1

79 provide timely and important information on snail biology.

80 CPPB leads to a reduced expression level of Snail but does not reduce E-cadherin expression level at

81 C. sukari would increase S. mansoni-infected snails by two-fold.

82 ocal populations of the common corallivorous snail C. abbreviata.

83 we demonstrate that susceptible B. glabrata snails can be made resistant to infection with S. manson

84 t normal development in molluscs, especially snails, can flip between two chiral types without pathol

85 ch patterns, like the Levy walks made by mud snails, can have their mechanistic origins in chaotic ne

86 MB-468, MDA-MB-231, and MCF-7 overexpressing Snail) cancer cells expressed lower E-cadherin activity,

87 Infective larvae released from snails carry a handful of stem cells that serve as the l

88 rces for aquatic consumers like tadpoles and snails, causing bottom-up effects on wetland ecosystems.

89 m(6)A in Snail CDS, but not 3'UTR, triggers polysome-mediated tra

90 Although the land snail Cepaea nemoralis is one of the most thoroughly inv

91 t make up the shell polymorphism of the land snail Cepaea nemoralis.

92 Here we focused on the freshwater viviparid snails (Cipangopaludina chinensis chinensis and C. c.

93 ome detection by conventional snail surveys (snail collection and cercariae shedding) with eDNA (wate

94 lla spp.; sea anemones, Actinia equina; cone snails, Conidae; male platypus, Ornithorhynchus anatinus

95 iation of snail population density and human-snail contact patterns can affect the dynamics of Schist

96 Marine cone snails contain a high diversity of toxins in their venom

97 quantel alone (arm 1) or in combination with snail control (arm 2), or behaviour change activities (a

98 liminate schistosomiasis, it is time to give snail control another look.

99 Snail control can complement preventive chemotherapy by

100 rgeting of both mass drug administration and snail control efforts.

101 Although snail control or behaviour change activities did not sig

102 on (MDA) applied alone or with complementary snail control or behaviour change interventions for the

103 The model predicted that the addition of snail control to the proposed adaptive strategy would ac

104 We also explored the addition of snail control to this modified strategy.

105 Seasonal snail control, implemented alone, was less effective tha

106 present ideas for modernizing and scaling up snail control, including spatiotemporal targeting, envir

107 stration (MDA) and, in 2017, on supplemental snail control.

108 em by 2025, there is now renewed emphasis on snail control.

109 In the fish-hunting cone snail Conus catus, the radular harpoon is also utilized

110 The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin

111 ion by corallivores, such as the short coral snail Coralliophila abbreviata, are one such threat to c

112 riguing problem; the edible operculated land snail Cyclophorus volvulus (Muller, 1774) is a good exam

113 Here, we studied the effect of Twist or Snail deficiency in endothelial cells on EndMT in kidney

114 Shoreline cleanup further reduced adult snail density as well as snail size.

115 mean of estimated thresholds of Oncomelania snail density below which the schistosomiasis transmissi

116 ctility can strengthen junctions to override Snail-dependent junctional disassembly and postpone EMT

117 g/kg) and BAF values (0.05) obtained for the snail directly exposed to contaminated soil were lower t

118 However, we also found that snail distributions were so patchy in space and time tha

119 Snail drives an EMT in tumor cells, which, although reta

120 itinous operculum and periostracum of fossil snails due to their poor preservation potential.

121 on of EMT in cancer cells and translation of Snail during this process.

122 Snails, earthworms and flatworms are remarkably differen

123 nd snail populations and includes aspects of snail ecology and parasite biology.

124 anti-formin drug treatment converts dextral snail embryos to a sinistral phenocopy, and in frogs, dr

125 asymmetric gene expression in 2- and 4-cell snail embryos, preceding morphological asymmetry.

126 Gene silencing also revealed that Snail enhanced the permeability of endothelial monolayer

127 (Zn) associated with natural particles using snails enriched with a less common Zn stable isotope.

128 trigger H3K27me3/EZH2-mediated repression of Snail epithelial target genes.

129 tes with hard exoskeletons (e.g. beetles and snails), exhibit rougher microwear textures than reptile

130 al sensitivity of metabolic rate compared to snails exposed for short durations, highlighting the nee

131 Instead, late snail expression can be supported by action of the Twist

132 n complex 2 (mTORC2) and thereby upregulates Snail expression.

133 flow revealed that low shear stress induced Snail expression.

134 to Snail2/P-cadherin in the chick, but both Snail factors and Zeb2 fulfil a similar role in chick an

135 Therefore, the Snail family could be a promising target for designing e

136 etalloproteinases (Mmp3 and -9; P < 0.01), a snail family member (Snai3; P < 0.001), and osteopontin

137 Slug (SNAI2), a member of the well-conserved Snail family of transcription factors, has multiple deve

138 Ingression is independent of the Snail family of transcriptional repressors and down-regu

139 and invasion by promoting degradation of the SNAIL family protein SNAI1.

140 sed by the reintroduction of either WISP1 or snail family transcriptional repressor 1 (SNAI1).

141 scription factors that regulate EMT, such as snail family transcriptional repressor 2 (SNAI2), are we

142 Schistosomiasis or snail fever is an endemic parasitic infection caused by

143 nt in mesenchymal markers (N-cadherin, slug, snail, fibronectin) and cell invasiveness, relative to S

144 , cotransmission of larval clonemates from a snail first host to an ant second host is presumed to le

145 Additionally, we collected snails from a cold stream (5 degrees C) and measured the

146 We sampled hemolymph from five snails from six different laboratory populations of B. g

147 We collected snails from streams that have been differentially heated

148 y, genetic and pharmacological inhibition of Snail function restores 4E-BP1 expression and sensitizes

149 pment of most digeneans takes place within a snail (Gastropoda).

150 The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture and de

151 ter; marine sediments; marine invertebrates (snails, green shore crab, great spider crab, and edible

152 uman infection: the area covered by suitable snail habitat (i.e., floating, nonemergent vegetation),

153 t vegetation), the percent cover by suitable snail habitat, and size of the water contact area.

154 n neurobiology, the value of this freshwater snail has been also recognised in fields as diverse as h

155 Cone snails have evolved a variety of insulin-like molecules

156 Our findings suggest that cone snails have evolved diverse strategies to activate the v

157 ody plans, with asexual proliferation in the snail host and sexual proliferation in the vertebrate ho

158 ld and may define this species as a suitable snail host for S. mansoni.

159 ty, depends on the formation of a tripartite Snail/HOTAIR/EZH2 complex.

160 tivated expression of the EMT regulator gene Snail in a SMAD3/Stat3-dependent manner.

161 Ectopic expression of Snail in cancer cell lines lacking Snail profoundly repr

162 consistent with the role of beta-catenin and SNAIL in epidermal stem cell maintenance.

163 tigated the role of the transcription factor Snail in low shear stress-induced EndMT.

164 ow that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors lead

165 Overexpression of Vimentin and Snail in SHH/GLI1 positive patients was also associated

166 nternalized, despite the early expression of Snail in that primordium.

167 temic molluscicide for controlling slugs and snails in a wide range of agricultural and horticultural

168 Snails in mesocosms enriched with nitrogen and phosphoru

169 ers, as the majority ( approximately 75%) of snails in oiled habitats never reached standing unoiled

170 uctural domains expressed by venomous marine snails in the superfamily Conoidea.

171 which encodes Twist) or Snai1 (which encodes Snail) in VE-cadherin(+) or Tie1(+) endothelial cells in

172 s increased chemoresistance-inducing factor, Snail, in recipient epithelial cells and promote prolife

173 g expression of the EMT transcription factor Snail increased TF, coagulant properties, and early meta

174 lasticity and that miR302 regulates EZH2 and Snail independently.

175 Mechanistically, Snail induces extracellular matrix degradation in synovi

176 ercaria infective stages) and the parasite's snail intermediate host (growth and reproduction).

177 s that rotifers colonizing the schistosome's snail intermediate host produce a water-soluble factor t

178 nd also increased cercaria production by the snail intermediate hosts, causing opposing effects on ta

179 y elements of the biology and ecology of the snail intermediate hosts, together with an improved unde

180 a density- and trait-mediated effects on the snail intermediate hosts.

181 increased in more southeastern wetlands, and snail (intermediate host) community composition had stro

182 The transcription factor Snail is a master regulator of cellular identity and epi

183 We conclude that Snail is an essential driver of EndMT under low shear st

184 Although Snail is essential for disassembly of adherens junctions

185 cal mechanism of action within the recipient snail is to close off the entrance to the sperm digestio

186 I argue that the natural variation of snails is a crucial resource towards understanding the i

187 Finally, endothelial Slug (but not Snail) is activated by the pro-angiogenic factor SDF1alp

188 ions: movements of an endangered raptor, the snail kite (Rostrhamus sociabilis plumbeus), and human m

189 r an endangered, wetland-dependent bird, the snail kite (Rostrhamus sociabilis plumbeus).

190 geographic range of an endangered bird, the snail kite (Rostrhamus sociabilis plumbeus).

191 ignificant modularity in annual dispersal of snail kites (all adults, males only, females only, and j

192 For snail kites, our method reveals substantial differences

193 hypothesis that asexual reproduction in the snail leads to a high abundance of clonemates in the sam

194 4E-BP1 expression inversely correlates with Snail level in cancer cell lines and clinical specimens.

195 Periwinkle snails (Littoraria irrorata) are a critical component of

196 quencies in isolated populations of a marine snail (Littorina saxatilis), re-established with perturb

197 disciplines: one of these is the great pond snail, Lymnaea stagnalis.

198 Snail, master inducer of EMT, requires HOTAIR to recruit

199 erin protein levels; increased expression of SNAIL, matrix metalloproteinase 2, and integrin beta1; a

200 these results suggest that marsh periwinkle snails may have been adversely affected following exposu

201 highlight HOTAIR as a crucial player in the Snail-mediated EMT.

202 ing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

203 Snail microbiomes were dominated by Proteobacteria and B

204 thicknesses of 0.1 and 0.5 cm, while 73% of snails moved in unoiled chambers after 4h.

205 The observed changes in snail movement at higher temperatures should lead to hig

206 In a second movement assay, there was no snail movement standing unoiled structure in chambers wi

207 Here, we have shown that oil impeded snail movement to clean habitat over a short distance an

208 In the first movement assay, snail movement to standing unoiled vegetation was signif

209 R, triggers polysome-mediated translation of Snail mRNA in cancer cells.

210 HDF1 mediates m(6)A-increased translation of Snail mRNA.

211 uggest that a positive feedback loop between Snail-nuclear Cat L-CUX1 drives EMT, which can be antago

212 Snails of conspicuous colours (white, red, banded) are n

213 Snails of conspicuous colours (white, red, banded) are n

214 Surprisingly, the high-threshold target gene snail only requires Dorsal input early but not late when

215 ive accumulation and speciation in different snail organs.

216 , together with an improved understanding of snail-parasite interactions, will aid to identify, plan,

217 ignificance, and review current knowledge of snail-parasite interplay.

218 uce human schistosomiasis have evolved from 'snail picking' campaigns, a century ago, to modern wide-

219 environment including seasonal variation of snail population density and human-snail contact pattern

220 osoma infection that couples local human and snail populations and includes aspects of snail ecology

221 mposition at the level of individual snails, snail populations and species.

222 sease transmission, and thus the dynamics of snail populations are critically important for schistoso

223 k of it) of ecological growth rates of local snail populations by contrasting novel ecological and en

224 sing gene silencing it was demonstrated that Snail positively regulated the expression of EndMT marke

225 verished asexual populations of a freshwater snail, Potamopyrgus antipodarum, from distinct habitats

226 rematode exposure by increasing mortality of snail predators (top-down mechanism).

227 coral cover, and the abundance of potential snail predators across six protected and six unprotected

228 Venomous marine cone snails produce peptide toxins (conotoxins) that bind ion

229 ession of Snail in cancer cell lines lacking Snail profoundly represses 4E-BP1 expression, promotes c

230 Such groups of hyperdiverse snail proteins may mediate host-parasite interaction at

231 Here, we show that fish-hunting cone snails provide a rich source of minimized ligands of the

232 Of the 3544 snails recovered across all sites, none were naturally i

233 3 ligases, including FBW7, a known MMP-9 and Snail regulator.

234 enhance ADM development, the contribution of Snail-related protein Slug (Snai2) to ADM development is

235 The Snail-repressive activity, here monitored on genes with

236 derm due to transcriptional quenching by the Snail repressor, which precludes recruitment of CBP and

237 ides, this effect was driven by increases in snail resources (periphytic algae, bottom-up mechanism).

238 ent of temperature, however, suggesting that snails retained the same movement strategy.

239 alpha-SMA, vimentin, CK7, N-cadherin, ZEB1, Snail, ROCK1, and RhoA.

240 ations of W compartmentalization were in the snail's hepatopancreas based on wet chemistry and synchr

241 We report here that the cone snail's prey strike is one of the fastest in the animal

242 calculations of (66)Zn assimilation into the snail's soft tissues.

243 critical, but unexplored intermediary in the snail-schistosome interaction as hemolymph is in very cl

244 osome presence at two additional sites where snail shedding failed, demonstrating a higher sensitivit

245 Bivalve, ammonite and snail shells are described by a small number of geometri

246 the apparent 'recombinant' phenotype of some snail shells.

247 rther reduced adult snail density as well as snail size.

248 ese processes (pPI3K, pAKT, pERK, Bcl2, Zeb, Snail, Slug) were significantly changed in response to a

249 munohistochemical examination of E-cadherin, Snail, Slug, and Twist2 expression was performed.

250 hymal transition (EMT) including E-cadherin, Snail, Slug, and Twist2, in the Egyptian population.

251 nduced expression of the mesenchymal markers Snail, Slug, N-cadherin, and vimentin in the recipient c

252 helial-mesenchymal transition (EMT) markers (Snail, Slug, vimentin and N-cadherin) were induced in hu

253 ell motility and expression of beta-catenin, Snail, Slug, Zeb1 and N-cadherin, and upregulated E-cadh

254 of the critical EndMT transcription factors Snail/Slug in involuting hemangiomas.

255 izing a cis-regulatory module (CRM) from the snail (sna) gene, sna-DP (for dorsal primordia).

256 epithelial-mesenchymal transition regulator Snail (Snai1) can cooperate with Kras in acinar cells to

257 biome composition at the level of individual snails, snail populations and species.

258 rm an in vitro screen of venoms from 18 cone snail species to identify toxins targeting ASICs.

259 nstrumental to its activity are recruited to Snail-specific binding sites is unclear.

260 th modern and fossilized species of the land snail superfamily Cyclophoroidea.

261 A refreshing empirical experiment with snails supports this long-standing hypothesis.

262 son of schistosome detection by conventional snail surveys (snail collection and cercariae shedding)

263 Unlike snail surveys, which require hundreds of person-hours pe

264 Snail survival decreased with increasing exposure time,

265 d Bacteroidetes while water microbiomes from snail tank were dominated by Actinobacteria.

266 Snail target enhancers were attached to an MS2 reporter

267 us of Physella acuta, a ubiquitous pulmonate snail that grazes heavily on periphyton, exposed to eith

268 control emphasizes targeting the freshwater snails that transmit schistosome parasites.

269 n the hemolymph (i.e. blood) of Biomphalaria snails, the intermediate host for Schistosoma mansoni, u

270 In comparison to untreated snails, the shells are open-coiled and the whorls are un

271 esis, and provides a rationale for targeting Snail to improve mTOR-targeted therapies.

272 dular harpoon is also utilized to tether the snail to its prey, rapidly paralyzed by neuroexcitatory

273 explanation for the capacity of this asexual snail to spread by adaptive evolution or plasticity to d

274 py by reducing the risk of transmission from snails to humans.

275 oxicity assay was then conducted by exposing snails to oil coated Spartina stems in chambers for peri

276 n and decreased expression of N-cadherin and snail transcription factor -2 ( SNAI2) (also called SLUG

277 BR2 and the EMT inducers ZEB1, ZEB2, and the snail transcriptional repressor SNAI2, each crucial fact

278 pid cell rearrangement in both wild-type and snail twist mutant embryos, where our theoretical predic

279 thelial G(2)/M arrest; reduced expression of Snail, Twist, and Notch1; and inactivated several profib

280 enhanced expression of EZH2 coincident with Snail upregulation.

281 mental proxies that were more effective than snail variables for predicting human infection: the area

282 leveraging innate host mechanisms to reduce snail vectorial capacity.

283 ed a monomeric, insulin-like peptide in cone-snail venom with moderate human insulin-like bioactivity

284 S1 (Cs1), a peptide toxin isolated from cone snail venom, binds at the turrets of K(v)1.2 and targets

285 Peptides from cone snail venoms have served as invaluable molecules to targ

286 bpopulation expresses higher levels of SLUG, SNAIL, VIMENTIN and N-CADHERIN while show a lack of expr

287 expressed lower E-cadherin activity, higher Snail, vimentin, and Cat L activity, and a p110/p90 acti

288 Snail was also expressed in EC overlying atherosclerotic

289 Snail was also required for recovery.

290 d with flow-altering cuffs demonstrated that Snail was expressed preferentially at low shear stress s

291 Previously, research on snails was used to show that left-right signaling of Nod

292 e association study of Biomphalaria glabrata snails, we identify genomic region PTC2 which exhibits t

293 The snails were genotyped using a set of RAD-seq-derived loc

294 Snails were placed in chambers containing either unoiled

295 Isotopically enriched snails were subsequently exposed to algae mixed with inc

296 kingly, some early-recovery mRNAs, including Snail, were elevated first during apoptosis, implying th

297 nervation of eyes is reduced in dark-adapted snails when compared with the innervation of cephalic te

298 in, and decreased expression of vimentin and snail, which is partially attributed to inhibiting Akt/G

299 s of the Cavu River harbour many B truncatus snails, which are capable of transmitting S haematobium-

300 itual is the "love" dart shooting of helicid snails, which has courted many theories regarding its pr

301 EMTs are driven by SNAIL, ZEB and TWIST transcription factors(5,6) together