ライフサイエンスコーパス: snoRNA

1 snoRNA species implicated in snRNA pseudouridylation wer

2 We found 61 miRNAs and 135 snoRNAs to be significantly changed in expression in myo

3 27 snoRNAs in young versus old serum and 18 snoRNAs in old sham versus old experimental osteoarthrit

4 nterest was the prognostic value of HBII-239 snoRNA, which was significantly over-expressed in cases

5 n serum we found differential presence of 27 snoRNAs in young versus old serum and 18 snoRNAs in old

6 identified 21 novel, noncanonical miRNAs (3 snoRNA-derived and 2 tRNA-derived miRNAs and 16 miRtrons

7 f 6 snoRNAs in young versus old joints and 5 snoRNAs in old sham versus old experimental osteoarthrit

8 identified differential expression (DE) of 6 snoRNAs in young versus old joints and 5 snoRNAs in old

9 Interestingly, the 6 snoRNAs that affect srRNA1 processing guide modification

10 3% of the canonical snoRNAs, leaving only 76 snoRNA sequences as orphan.

11 homeostasis and is the first to implicate a snoRNA in this cellular function.

12 Snord116 is a snoRNA gene cluster of unknown function that can localiz

13 first time we demonstrate implications of a snoRNA in osteoarthritis chondrocyte biology and investi

14 ings represent the first identification of a snoRNA overexpressed as a consequence of a chromosomal t

15 We determined that the profiles of H/ACA snoRNA abundance are cell-type specific, and we identifi

16 entiation, we comprehensively profiled H/ACA snoRNA abundance in multiple murine cell types and durin

17 To determine if H/ACA snoRNA levels are dynamic during differentiation, we com

18 Disruption of H/ACA snoRNA levels in stem cells impairs pluripotency, yet it

19 We describe a novel function for one H/ACA snoRNA, SNORA24, which guides two pseudouridine modifica

20 asses of small nucleolar RNAs, the box H/ACA snoRNAs and the box C/D snoRNAs.

21 oint toward a potential model in which H/ACA snoRNAs are specifically regulated during differentiatio

22 uripotency, yet it remains unclear how H/ACA snoRNAs contribute to differentiation.

23 demonstrate a functional link between H/ACA snoRNAs regulated by RAS and the biophysical properties

24 with a broad range of box C/D and box H/ACA snoRNAs.

25 required for recruitment of the late-acting snoRNAs SNORD56 and SNORD68, earlier snoRNAs are not aff

26 Here, we identify several late-acting snoRNAs that bind pre-40S particles in human cells and s

27 sing osteoarthritis-like conditions affected snoRNA expression.

28 p with the basepairing sites of the affected snoRNAs.

29 h a 5'-monophosphate, for some, but not all, snoRNAs.

30 While 53% of the sdRNAs contain an snoRNA box C motif and boxes D and D' are also common in

31 NA host genes selectively generates host and snoRNA with often different spatio-temporal expression.

32 g increased pervasive transcripts levels and snoRNA processing defects.

33 out of all the ncRNAs, only tRNA, miRNA and snoRNA can be predicted with a satisfying sensitivity an

34 affect expression of DNA damage response and snoRNA genes, respectively.

35 NA species, including mRNA, miRNA, rRNA, and snoRNA.

36 ed genomic loci that give rise to snoRNA and snoRNA-like genes.

37 Thus, coilin couples snRNA and snoRNA biogenesis, making CBs the cellular hub of small

38 /snoRNA genes, and reduces nascent snRNA and snoRNA synthesis.

39 other small RNA types like piRNA, snRNA and snoRNA.

40 dinylation depends on both site-specific and snoRNA-guided pseudouridine synthases.

41 roteins associate specifically with tRNA and snoRNA genes undergoing Pol III transcription.

42 NPP-13 is required for cleavage of tRNA and snoRNA precursors into mature RNAs, whereas Pol II trans

43 nscripts that contained miRNAs, lincRNAs and snoRNAs.

44 investigate the involvement of microRNAs and snoRNAs in the relapse-remission dynamics of MS in perip

45 as and MEG8), as well as numerous miRNAs and snoRNAs.

46 of unique sites in human and yeast mRNAs and snoRNAs.

47 cribed genes encoding ribosomal proteins and snoRNAs.

48 rDNA locus, directly contacts both rRNA and snoRNAs, and promotes rRNA transcription, processing and

49 small nuclear and nucleolar RNAs (snRNAs and snoRNAs).

50 sed into essential cellular factors, such as snoRNA and miRNA.

51 novel types of noncoding small RNAs such as snoRNAs (small nucleolar RNAs), tRNA (transfer RNA) frag

52 g for ribosome biogenesis factors as well as snoRNAs.

53 RNA Polymerase II (Pol II) transcription at snoRNAs and other noncoding RNAs in yeast.

54 We show that both the Bcd1-snoRNA and Bcd1-Snu13 interactions are critical for snoR

55 H/ACA box snoRNA classifier showed an F-score of 93 % (an improvem

56 The SNORD42A acts as a C/D box snoRNA and directs 2'-O-methylation at uridine 116 of 18

57 garding the previous version), while C/D box snoRNA classifier, an F-Score of 94 % (improvement of 14

58 nformation of these organisms, but H/ACA box snoRNAs identification was improved for the other ones.

59 fy snoRNAs in vertebrates and also H/ACA box snoRNAs in invertebrates organisms.

60 rosophilids, 69 % and 76.67 %, for H/ACA box snoRNAs were predicted, respectively, showing that snoRe

61 new features for both box C/D and H/ACA box snoRNAs; developing a more sophisticated technique in th

62 al copies of the cluster of SNORD116 C/D box snoRNAs and their host transcript, 116HG, on human chrom

63 mbalance and dysregulation of orphan C/D box snoRNAs in ASD pathogenesis.

64 Report 2.0, to predict H/ACA box and C/D box snoRNAs, an efficient method to find true positives and

65 ted but rather are terminated on each end by snoRNAs and their associated proteins.

66 s a protein complex different from canonical snoRNAs found in the insoluble nuclear fraction.

67 le modification site to 83% of the canonical snoRNAs, leaving only 76 snoRNA sequences as orphan.

68 The RNA component (snoRNA) contains guide regions that base-pair with the t

69 demonstrate that "orphan" nucleolar box C/D snoRNA SNORD97 and CB box C/D scaRNA SCARNA97 contain an

70 3-Trm112 interacts directly with the box C/D snoRNA U3-associated DEAH RNA helicase Dhr1 supposedly i

71 sulting in haploinsufficiency of the box C/D snoRNA U60.

72 s in the gene SNORD118, encoding the box C/D snoRNA U8, cause the cerebral microangiopathy leukoencep

73 One box C/D snoRNA, HBII-180C, was analysed in greater detail, revea

74 ns of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of

75 Specifically, two box C/D snoRNAs (SNORDs) and the 2'-O-methyltransferase fibrilla

76 at is required for interactions with box C/D snoRNAs and the core snoRNP protein, Snu13.

77 RNA-sequencing analysis reveals that box C/D snoRNAs as a class are present in the cytoplasm, where t

78 he nucleocytoplasmic distribution of box C/D snoRNAs from the ribosomal protein L13a (Rpl13a) locus.

79 We previously showed that box C/D snoRNAs from the Rpl13a locus are unexpected mediators o

80 and controls steady-state levels of box C/D snoRNAs through an unknown mechanism.

81 ining and test phases of boxes H/ACA and C/D snoRNAs, in both versions of snoReport, are discussed.

82 iRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D

83 ors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity

84 RNAs, the box H/ACA snoRNAs and the box C/D snoRNAs.

85 in precursors showing similarity to box C/D snoRNAs.

86 omplex but gets released upon binding to C/D snoRNAs; (c) the dynamics of the R2TP complex, which app

87 me quantitative PCR (qRT-PCR) we demonstrate snoRNA expression levels in murine ageing and OA joints

88 ata uncover an essential role of deregulated snoRNA biogenesis in tumors and a new mechanism of nucle

89 latory element analysis of these deregulated snoRNA genes identified strong enrichment of a common Et

90 ridylation at these positions using designer snoRNAs results in near complete rescue of splicing and

91 We propose that each snoRNA forms two different snoRNPs, subtly different in

92 We show that each snoRNA involved in LSU processing associates with factor

93 -acting snoRNAs SNORD56 and SNORD68, earlier snoRNAs are not affected by DDX21 depletion.

94 We demonstrate that when the elevated snoRNA pathway is suppressed, the tumor suppressor p53 c

95 e extent of the contributions of the encoded snoRNAs is unknown.

96 n, supporting our hypothesis that endogenous snoRNAs can activate PKR.

97 monstrate that this allele shifting enhances snoRNA-targeted splicing changes in ASD-related target g

98 Our results establish snoRNAs as novel markers of musculoskeletal ageing and o

99 nucleotides of the differentially expressed snoRNAs were concentrated in the 28S and 18S ribosomal R

100 vely as well as cell type specific expressed snoRNAs.

101 ction to recruit the machinery essential for snoRNA processing.

102 ther, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding

103 luminates a previously unrecognized role for snoRNAs in metabolic regulation.

104 uncovered additional non-canonical roles for snoRNAs.

105 Here, we selectively deleted four snoRNAs encoded within the introns of the ribosomal prot

106 lth of small fragments (<35 nt) derived from snoRNAs (termed sdRNAs) that stably accumulate in the ce

107 s (54%), relatively few (12%) contain a full snoRNA guide region.

108 e abundance of different sdRNAs from a given snoRNA varies.

109 Depletion of such guiding snoRNA by RNAi compromised the guided modification on sn

110 a result of increased levels of the guiding snoRNAs.

111 snRNA Psis are guided by single hairpin snoRNAs, also implicated in rRNA modification.

112 cluding numerous unannotated mouse and human snoRNAs.

113 to construct an up-to-date catalog of human snoRNAs we have combined data from various databases, de

114 lso demonstrated that a subset of identified snoRNAs bind and activate PKR in vitro; the presence of

115 owing that snoReport 2.0 is good to identify snoRNAs in vertebrates and also H/ACA box snoRNAs in inv

116 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss.

117 microarray study to identify alterations in snoRNA expression.

118 Dual-initiation in snoRNA host genes selectively generates host and snoRNA

119 reveals a broad requirement for the Paf1C in snoRNA 3'-end formation in S. cerevisiae, implicates the

120 onal regulators Bur1-Bur2, Rad6, and Set2 in snoRNA 3'-end formation.

121 Changes in snoRNAs in osteoarthritis-like conditions were studied i

122 enriched in tRNAs and rRNAs, but depleted in snoRNAs.

123 rgets of this uncharacterized snRNP included snoRNA intermediates hosted within ribosomal protein (RP

124 n promoters in thousands of genes, including snoRNA host genes.

125 were detected in all fractions, with intron, snoRNA and lncRNA interactions enriched in the nucleus.

126 ch SmD3 regulates the expression of intronic snoRNAs likely involves effects of SmD3 on the levels of

127 sdRNA profiles of many snoRNAs are specific and resemble the cleavage profiles

128 Like miRNAs, snoRNAs are globally down-regulated in tumor cells compa

129 Moreover, snoRNAs lacking specific CB retention signals traffic th

130 Although most snoRNAs reside in the nucleolus, a growing body of evide

131 hromosomal domain containing multiple mRNAs, snoRNAs, and microRNAs was activated surrounding the int

132 wn how CHH-pathogenic mutations in RNase MRP snoRNA interfere with skeletal development, and aberrant

133 anscripts in paf1Delta cells and uncover new snoRNA targets of Paf1.

134 that snoRNA expression and the abundance of snoRNA-containing intron lariats are decreased in SmD3 m

135 bservations suggest a link between levels of snoRNA that target spliceosomal RNAs, spliceosomal funct

136 t, our study characterizes the plasticity of snoRNA expression identifying both constitutively as wel

137 The dual polyadenylation of snoRNA intermediates is carried out by both PAP2 and PAP

138 response pathways through the regulation of snoRNA expression.

139 Overlapping basepairing of snoRNAs with pre-rRNAs often necessitates sequential and

140 We show that all classes of snoRNAs concentrate in CBs.

141 e for NXF3 in regulating the distribution of snoRNAs between the nuclear and cytoplasmic compartments

142 osteoarthritis through the dysregulation of snoRNAs.

143 The primary function of snoRNAs is targeting specific nucleotides of ribosomal R

144 lencing of either PAP1 or PAP2, the level of snoRNAs is reduced.

145 in in maintaining the steady-state levels of snoRNAs in the cell.

146 This study identifies the highest number of snoRNAs so far described that are involved in rRNA proce

147 U3 snoRNA was one of a number of snoRNAs with decreased expression in osteoarthritic cart

148 Overexpression of snoRNAs guiding modification on H69 provided a slight gr

149 We identified panels of snoRNAs differentially expressed due to ageing (includin

150 This study determined expression patterns of snoRNAs in joint ageing and OA and examined them as pote

151 Profiling the expression patterns of snoRNAs is the initial step in determining their functio

152 t mice resulted in strong down-regulation of snoRNAs and reversed the prometastatic phenotype of muta

153 type specific, and we identified a subset of snoRNAs that are specifically regulated during different

154 Here, we show that specific subsets of snoRNAs are differentially regulated during the earliest

155 -independent termination of transcription of snoRNAs, however, remained unaffected in the absence of

156 Li activity on snoRNA levels may pertain to bipolar disorders while Li

157 f JCI, Chu et al. find that ACA11, an orphan snoRNA encoded in an intron of the WHSC1 gene, is aberra

158 Orphans snoRNAs are encoded outside of ribosomal protein genes a

159 ufficient to downregulate RP genes and other snoRNAs implicated in the control of oxidative stress.

160 We performed snoRNA-focused CRISPR-Cas9 knockout library screenings t

161 The dual polyadenylation of the precursor snoRNAs by PAPs may function to recruit the machinery es

162 ves and false negatives, allowing to predict snoRNAs with high quality.

163 increase the average lengths of preprocessed snoRNA, CUT, and SUT transcripts, while slowed Pol II tr

164 targets aberrant nuclear RNAs and processes snoRNAs.

165 rmine how Paf1C-dependent functions regulate snoRNA formation, we used high-density tiling arrays to

166 Detailed examination of Paf1-regulated snoRNA genes revealed locus-specific requirements for Pa

167 the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosoma

168 orphan box H/ACA class small nucleolar RNA (snoRNA) encoded within an intron of WHSC1, was highly ex

169 ermination at noncoding small nucleolar RNA (snoRNA) genes.

170 spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.

171 upted allele of the U60 small nucleolar RNA (snoRNA) host gene, resulting in haploinsufficiency of th

172 ations in the RNase MRP small nucleolar RNA (snoRNA) subunit of the RNase MRP complex cause cartilage

173 pre-rRNA and causes U14 small nucleolar RNA (snoRNA) to remain associated with pre-rRNA.

174 the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggesting

175 of histone H2B-Glu35 by small nucleolar RNA (snoRNA)-activated PARP-1 inhibits AMP kinase-mediated ph

176 333-nucleotide-long U3 small nucleolar RNA (snoRNA).

177 sses (microRNA [miRNA], small nucleolar RNA [snoRNA], small nuclear RNA [snRNA], small Cajal body-spe

178 h the CUT and SUT classes of non-coding RNA, snoRNAs and, most prominently, pre-tRNAs and other Pol I

179 ch are guided by H/ACA small nucleolar RNAs (snoRNA).

180 cluding ribosomal RNA, small nucleolar RNAs (snoRNAs) and 7SK RNA.

181 on-coding RNAs such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo tra

182 Box C/D small nucleolar RNAs (snoRNAs) and small Cajal body (CB) RNAs (scaRNAs) form r

183 cessing of a subset of small nucleolar RNAs (snoRNAs) and tRNAs transcribed by RNA polymerase (Pol) I

184 Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs that guide the p

185 Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that dir

186 ear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs) are all enriched in virions.

187 found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' proce

188 Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ri

189 Small nucleolar RNAs (snoRNAs) are emerging as an important new class of genes

190 Box C/D small nucleolar RNAs (snoRNAs) are evolutionarily conserved non-protein-coding

191 Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form ribonucleoprotein

192 se mRNA and identified small nucleolar RNAs (snoRNAs) as a new class of m6A-containing non-coding RNA

193 et al. (2019) identify small nucleolar RNAs (snoRNAs) as activators of poly(ADP-ribose) (PAR) synthes

194 For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA genes, Lykke-And

195 Small nucleolar RNAs (snoRNAs) function mainly as guides for the post-transcri

196 Small nucleolar RNAs (snoRNAs) guide chemical modifications of ribosomal and s

197 Small nucleolar RNAs (snoRNAs) guide nucleotide modifications of cellular RNAs

198 H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part of a small nucl

199 evidence suggests that small nucleolar RNAs (snoRNAs) have malfunctioning roles in tumorigenesis.

200 expression patterns of small nucleolar RNAs (snoRNAs) in joint ageing and OA may provide diagnostic b

201 pression of miRNAs and small nucleolar RNAs (snoRNAs) in right ventricular myocardium from 16 infants

202 lipotoxic conditions, small nucleolar RNAs (snoRNAs) in the rpL13a gene accumulate in the cytosol an

203 he role of 10 abundant small nucleolar RNAs (snoRNAs) involved in rRNA processing.

204 ing RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs) not previously described to be modified by the

205 dentified a cluster of small nucleolar RNAs (snoRNAs) that are highly up-regulated in p53 mutant tumo

206 d the expression of 80 small nucleolar RNAs (snoRNAs) using high-throughput quantitative PCR.

207 ingly, several hundred small nucleolar RNAs (snoRNAs) were identified as coilin interactors, includin

208 The non-coding small nucleolar RNAs (snoRNAs) were subject to the greatest length-adjusted Li

209 However, whether small nucleolar RNAs (snoRNAs), a class of non-coding RNAs crucial in ribosoma

210 ation can be guided by small nucleolar RNAs (snoRNAs), and that these Nm sites can regulate mRNA and

211 l known orphan C/D box small nucleolar RNAs (snoRNAs), are particularly enriched in shifts to higher

212 coding RNAs, including small nucleolar RNAs (snoRNAs), play important roles in leukemogenesis, but th

213 NAD(+)-capped intronic small nucleolar RNAs (snoRNAs), suggesting NAD(+) caps can be added to 5'-proc

214 ic loci, which include small nucleolar RNAs (snoRNAs), transfer RNAs (tRNAs) and introns, whereas end

215 very rate </= 5%) were small nucleolar RNAs (snoRNAs).

216 a subset of associated small nucleolar RNAs (snoRNAs).

217 nation of at least two small nucleolar RNAs (snoRNAs).

218 ession of a cluster of small nucleolar RNAs (snoRNAs).

219 oduction of a wide variety of noncoding RNAs-snoRNAs, scaRNAs, and snRNAs-that are dependent on Cajal

220 XF1, decreases or increases cytosolic Rpl13a snoRNAs, respectively.

221 Islets from mice lacking Rpl13a snoRNAs demonstrated blunted oxidative stress responses.

222 Loss of Rpl13a snoRNAs altered mitochondrial metabolism and lowered rea

223 inishes cytosolic localization of the Rpl13a snoRNAs through a mechanism that is dependent on NXF3 bu

224 rapid cytoplasmic accumulation of the Rpl13a snoRNAs through a mechanism that requires superoxide and

225 ow that NXF3 associates not only with Rpl13a snoRNAs, but also with a broad range of box C/D and box

226 ion of the snoRNAs was explored by silencing snoRNAs.

227 ough controlling both mRNA elongation and sn/snoRNA synthesis, the 7SK snRNP is a key regulator of nu

228 nes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inter-chromosomal clus

229 its RNAPII recruitment to RNAPII-specific sn/snoRNA genes, and reduces nascent snRNA and snoRNA synth

230 nents of the 7SK snRNP on RNAPII-specific sn/snoRNA genes.

231 usters and suppresses the expression of U sn/snoRNA and histone genes.

232 o a 108 kb region that includes the SNORD116 snoRNA cluster and the Imprinted in Prader-Willi (IPW) n

233 The SNORD50A-SNORD50B snoRNA locus was deleted in 10-40% of 12 common cancers,

234 SNORD50A and SNORD50B snoRNAs thus directly bind and inhibit K-Ras and are rec

235 However, for the snR13 snoRNA the unusual C/D motif and extra base-pairing, whi

236 domain and functions together with the snR30 snoRNA, while human hUTP23 is associated with U17, the h

237 Utp23 interacts with the 3 half of the snR30 snoRNA.

238 -subclasses that exist in eukaryotes: snRNA, snoRNA, RNase P, RNase MRP, Y RNA or telomerase RNA.

239 trons and various RNA classes (ncRNA, snRNA, snoRNA) and less variability after degradation.

240 Surprisingly, at some snoRNAs, this function of Rad6 appears to be primarily i

241 f FGFR3 pre-mRNA, supporting a role for some snoRNAs in the regulation of splicing.

242 These findings highlight a role for specific snoRNAs in safeguarding against oncogenic insult and dem

243 We demonstrate that snoRNA expression analysis may be useful in both the dia

244 We demonstrate that snoRNA expression changes in cartilage ageing, and osteo

245 We show that snoRNA expression and the abundance of snoRNA-containing

246 Our results suggest that snoRNA expression profiles may have a diagnostic and pro

247 s are also present in the cytoplasm and that snoRNAs move between the nucleus and cytoplasm by a mech

248 d cells, followed by RT-qPCR, confirmed that snoRNAs were enriched in PKRWT samples after PA treatmen

249 s, a growing body of evidence indicates that snoRNAs are also present in the cytoplasm and that snoRN

250 We report that snoRNAs and fibrillarin (FBL, an enzymatic small nucleol

251 These findings suggest that snoRNAs may orchestrate the response to environmental st

252 target prediction methods we re-estimate the snoRNA target RNA interaction network.

253 terminal C/D and internal C/D motifs in the snoRNA, adjacent to the guide region, function as bindin

254 l types shows a dramatic perturbation of the snoRNA expression profile.

255 In the present study, the snoRNA signature was robust enough to differentiate anap

256 Major substrates of PAP1 are the snoRNAs and lncRNAs.

257 erns in fetal myocardium, especially for the snoRNAs.

258 The function of the snoRNAs was explored by silencing snoRNAs.

259 sslinked to sequences flanking A2 and to the snoRNAs U3, U14, snR30, and snR10, which are required fo

260 These snoRNAs primarily interact with Fip1, a component of cle

261 ach case, the internal C/D motifs from these snoRNAs differ from the consensus.

262 Loss of these snoRNAs also increased binding by farnesyltransferase to

263 have functionally characterized one of these snoRNAs and our results demonstrated that the U/A-rich S

264 Five of these snoRNAs interact with the intervening sequences of rRNA

265 conditions, and when the expression of these snoRNAs is altered this affects chondrogenic and hypertr

266 se) (PAR) synthesis, demonstrating that this snoRNA-PAR partnership promotes cancer cell growth indep

267 n 750 curated genomic loci that give rise to snoRNA and snoRNA-like genes.

268 PARP-1 binds to snoRNAs, which stimulate PARP-1 catalytic activity in th

269 ential for the recruitment of the exosome to snoRNAs and to human telomerase RNA.

270 e sequential recruitment of core proteins to snoRNAs.

271 ely expressed non-coding RNAs such as tRNAs, snoRNAs, rRNAs and snRNAs preferentially produce small 5

272 ional preference for small RNA genes (tRNAs, snoRNAs and snRNAs) suggesting a putative role for RNA i

273 Of particular interest are U snoRNA host genes (Uhgs), a family of diurnal cycling no

274 ponents has significant consequences for U14 snoRNA dynamics.

275 e Mpp10 protein inhibited the release of U14 snoRNA from pre-rRNA, just as was seen with Dbp4-deplete

276 lays an important role in the release of U14 snoRNA from pre-rRNA.

277 s associated with U3 snoRNA but not with U14 snoRNA.

278 U3 snoRNA and the associated Rrp9/U3-55K protein are essent

279 U3 snoRNA was one of a number of snoRNAs with decreased exp

280 mpacted U3 snoRNA expression by affecting U3 snoRNA gene promoter activity, while BMP7 was able to in

281 Altering U3 snoRNA expression resulted in changes in chondrocyte phe

282 as an RNA duplex formed by the 5' ETS and U3 snoRNA as well as the 3' boundary of the 18S rRNA.

283 In eukaryotic ribosome biogenesis, U3 snoRNA base pairs with the pre-rRNA to promote its proce

284 OA synovial fluid impacted U3 snoRNA expression by affecting U3 snoRNA gene promoter a

285 dient analyses revealed that depletion of U3 snoRNA or the Mpp10 protein inhibited the release of U14

286 al capacity, whilst induced expression of U3 snoRNA was accompanied by increased 18S and 28S rRNA lev

287 lysis revealed a global impact of reduced U3 snoRNA expression on protein translational processes and

288 We hypothesized that U3 snoRNA, a non-coding RNA involved in ribosomal RNA matur

289 oth cleavages require base-pairing by the U3 snoRNA to the central pseudoknot elements of the 18S rRN

290 the requirement of binding sites for the U3 snoRNA, it showed that a large segment of the 5' externa

291 Rrp9 beta-propeller structure opposite to U3 snoRNA.

292 tinin (HA)-tagged Dbp4 is associated with U3 snoRNA but not with U14 snoRNA.

293 Interference with U3 snoRNA expression led to reduction of rRNA levels and tr

294 rRNA in the A1 mutant suggests that the U60 snoRNA modulates cholesterol trafficking by a mechanism

295 tion and mutational studies revealed the U60 snoRNA to be the essential feature from this locus that

296 How mutations in the non-coding U8 snoRNA cause the neurological disorder leukoencephalopat

297 we demonstrated PKR activation in cells upon snoRNA transfection, supporting our hypothesis that endo

298 n unprecedented and unexpected model whereby snoRNAs play a role in the activation of PKR under metab

299 Our findings support a model in which snoRNA-guided Nm modifications of mRNA can regulate phys

300 Four yeast snoRNAs are unusual in that they are predicted to methyl

301 mal and other abundant RNAs, including yeast snoRNAs, the RNA subunit of the signal recognition parti