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3 the probability of successful PK predictions so that 83% of AstraZeneca drug development projects pro
4 the cytoskeleton is extensively reorganized so that a bipolar mitotic spindle can be correctly assem
5 c requirement from the specific sensor node, so that a body sensor network with hybrid power supply i
6 y, we describe how the frontier is expanding so that a broad audience can appreciate the profound inf
7 airings: (1) to decentralise research skills so that a broader range of people are able to access/use
9 of FimH, albeit with negative cooperativity, so that a molar excess of accessible N-glycans over FimH
10 ve trait locus (QTL) were separately scanned so that a negative logarithm P-value curve against genom
11 ing to the principle of minimal frustration, so that a sequence can spontaneously fold, but local vio
12 female refractoriness to further copulation, so that a significant proportion of females mate again.
13 rientation and distance between nucleobases, so that a similar charge transfer (CT) mechanism governs
14 och electrons large orbital magnetic moments so that a small current can generate a large orbital mag
15 coded by two disjoint codon sets (TCN & AGY) so that a tandem substitution of two nucleotides is requ
18 ntial for adaptive gene flow between species so that adaptive introgression is not simply happenstanc
19 to cellular structure and function, so much so that alterations in FA are often associated with cell
20 of their vergence and accommodative systems so that an accurate diagnosis can be made and appropriat
21 that peanut allergy be accurately diagnosed so that an appropriate treatment plan can be developed.
22 person compute a function in his or her head so that an eavesdropper with a powerful computer-who see
23 uped according to the eye and the medication so that an eye treated with a particular medication was
24 ene complexes can be manipulated and managed so that an olefin metathesis reaction may occur more eff
25 th the delivery of either 1 or 3 juice drops so that animals learned to expect 2 juice drops on avera
26 nce, enclosure type/size and visitor numbers so that appropriate steps can be taken to achieve self-s
27 m average photosynthetic capacity (V(cmax) ) so that available environmental resources can be most ef
28 antibiotic resistance is therefore necessary so that bacterial infectious diseases can be diagnosed r
29 less portable automated calibration platform so that biosensors can be calibrated away from the labor
30 taxial Fe(0.52) Rh(0.48) thin films designed so that both ferromagnetic and antiferromagnetic phases
32 mixed with a panel of DNA-barcoded antigens so that both the antigen barcode(s) and BCR sequence are
33 d simultaneously boosts its open probability so that Ca(V) 1.2 is mostly active when appropriately lo
34 h other and to the availability of nutrients so that cells achieve and maintain an appropriate size.
36 g prophase, centrosomes and nucleus reorient so that centrosomes are positioned on the shortest nucle
37 or genetic and other laboratory test results so that clinically stable patients are assigned the best
38 dient is created in the electrochemical cell so that CO(2) is desorbed at a low pH, while an alkaline
39 eads to limited interactions within a group, so that collective behavior is achieved by following onl
40 eveloped to accurately calculate the P-value so that computationally extensive procedures (e.g. permu
41 r force generators from the short cell axis, so that cortical motors pulling on astral microtubules a
42 domains, and adjusts the pK(a) of SDHA(R451) so that covalent attachment of the flavin adenine dinucl
43 mall number of cysteines that can be deleted so that cysteines can then be introduced at specific sit
45 s are connected by Wess-Zumino-Witten terms, so that defects of one order contain quanta of another o
46 evolutionary dynamics of genetic variation, so that deleterious genetic variants, including antibiot
47 rrangement with single-cell and bulk samples so that developers of analysis methods can assess accura
48 presenting tissue-restricted antigens (TRA), so that developing T cells can assess the self-reactivit
49 monolayers with enhanced barrier integrity, so that directional (basal or apical) 5HT secretion was
50 hat stabilizes and tethers DYRK1A to Pol II, so that DYRK1A-DCAF7 can co-migrate with and phosphoryla
52 etina projects to separate layers of the LGN so that each LGN neuron is innervated by a single eye.
53 ive material must exhibit wider colour gamut so that each of the vast pixels maintains the colour acc
54 up time was right-censored on April 28, 2020 so that each patient had at least 28 days of observation
55 actuators prior to any DREADD transduction, so that effects of DREADDs can be attributed to the chem
56 nic states away from being sharply localized so that efficient resonant tunneling across long distanc
57 re forced to reach atomically close distance so that electron transitions are possible through strong
58 inguishes PGCs from their somatic neighbours so that emerging PGCs become refractory to Bmp signallin
59 n, stem-cell scale-up protocols are provided so that even ultrasmall primary samples can be used as s
60 s how seeding density affects clonality loss so that experimental protocols can be optimised to meet
61 arked performance on a wide range of systems so that experimentalists can easily decide what hardware
62 tocrine development of the androgenic glands so that females differentiate instead: feminization shou
64 nal reproducibility means providing software so that for the same input anyone obtains the same resul
65 roton conductivity diminishes exponentially, so that, for example, monolayer MoS(2) that is just thre
66 ves genes at these loci are largely unknown, so that functional investigation and clinical translatio
67 pair require nucleosomal DNA to be unwrapped so that functional proteins can access their target site
68 racteristic electrophysiology versus spores, so that germination can be assessed after just 4 h of cu
69 ross a broader range of independent studies, so that greater insights on HIV infection and treatment
70 nds require careful ecohydrologic evaluation so that green and blue water trade-offs are properly add
71 p the new method, conditions were identified so that high enantioselectivity would be attained and th
74 hydrophilicity of the copper-ligand complex, so that hydro-phobic or -philic catalysts are used in co
75 ions of bond survival that must be addressed so that improved quantitative forecasts become possible.
76 MR spectra are often extensively overlapped, so that in practice only a minority of sites can be sele
77 each of WT and disease-causing mutant genes, so that, in vivo, p97 molecules can be heterogeneous in
78 etic diagnosis is imperative for WT families so that individuals harboring a predisposing germline va
79 d clothing during clinical care is important so that infection control measures, such as Contact Prec
80 in game playing to ensure their propagation, so that initially nonessential processes secure a geneti
81 he ambiguity in the signal-decoding process, so that interfering sensor signals due to coincidently-d
82 r an otherwise uninvolved research associate so that investigators and clinicians were fully masked t
83 ivity, cost effectiveness and quantification so that it becomes more user friendly and affordable tec
84 e activation energies for this rearrangement so that it becomes potentially competitive with the cycl
85 repressor activity is dramatically improved so that it behaves as a "super-repressor." In vitro, Par
86 GAPS Bayesian matrix factorization algorithm so that it can analyze 1000 times more cells, enabling f
87 from the embrace of TPR at the nuclear pore so that it can be recruited to kinetochores before nucle
88 environment-sensitive biosensor fluorophore so that it can pass through cell membranes without stain
90 c may have adapted to its native environment so that it can undergo a conformational change that swit
91 residue, Asp276, positions beta-C-Fapy*dGTP so that it distorts the geometry of critical catalytic a
96 nsferase (LPAT) to the endoplasmic reticulum so that it functions within the cytosolic glycerolipid b
97 n compared with the simple exponential model so that it generalizes the linear mixed effects paradigm
99 anges the direction of the ortho-cyclization so that it occurs via the cis/anti form of nitroso oxide
100 e patterned porous membranes as the support, so that it optimizes hydrodynamics while maintaining eve
101 nted to the patient in an understandable way so that it triggers behavior change and effectively info
102 a greater concentration of carboxylic groups so that it was negative across the entire pH range inves
103 level increased with the addition of quinoa so that it would be necessary to incorporate less nitrit
104 ume this efficiency to be constant over time so that its dynamical and collective aspects remain poor
106 acity to respond anisotropically to tension, so that its microtubule-binding domains bind microtubule
108 continuously away from the cooling junction, so that Joule heating in the bulk element does not dimin
109 head, we can give our brains a "head start," so that language comprehension is faster and more effici
110 iation test, a CNV locus needs to be defined so that locus-specific effects can be retained during ag
111 the estimation of oligomeric distributions, so that low abundance monomers display a much higher app
113 enome instability, and further tumorigenesis so that LRPPRC knockout mice develop more and larger hep
114 hat industry emissions could double by 2030, so that methane emissions from the charcoal industry cou
115 chain having terminal alkene functionalities so that MOPs can be cross-linked via olefin metathesis u
116 our study was to improve sample preparation so that MSI could provide comprehensive and reproducible
117 on of task performance by the nervous system so that muscles with similar contributions to task varia
118 ated N-glycans in real time in the capillary so that N-glycan structures containing alpha2-6-linked s
119 usion is completed, RHD3 is degraded by LNPs so that nascent three-way junctions can be stabilized an
120 ributions of the currents to neural activity so that neurons and networks undergo graceful transition
121 clude (i) support is required for logistics, so that new instructors can focus on their teaching; (ii
122 esults indicate that MSE attenuates OKN gain so that OKN can be used as an objective proxy for patien
123 s through various intermediates to products, so that one could optimize the efficiency of the reactiv
124 support, should occur before randomization (so that only 1 subgroup is randomized) or after randomiz
125 contamination showed ratios up to 1:900,000, so that only about one out of 900,000 RNA copies was of
126 t AgR loci, V(D)J recombination is regulated so that only one allele assembles a functional gene, ens
130 describe the sample and setting sufficiently so that others can draw conclusions about generalizabili
132 perbases offered record-holding GB/PA values so that PA magnitudes higher than 300 kcal mol(-1) are n
133 r model includes various dispersal behaviors so that penguins could modulate climate effects through
134 rous current and emerging therapies for PsD, so that precision medicine can be applied to rapidly imp
135 and an artificial neural network (ANN) model so that predictions of the hybrid model surpass those of
136 y define the IBD segments that are reported, so that program correctness can be confirmed by users.
137 cell mechanics and enhance mitotic rounding, so that Ras(V12)-expressing cells are softer in interpha
138 ted in the presence of excess Notch activity so that re-emergence of NSC properties occurs only in ol
139 ly driven by diversifying positive selection so that relative fitness of different amino acid variant
140 m chelation rigidifies the reaction systems, so that remote stereocenters position the ester-directin
141 ss to genetic information for most organisms so that research utilizing a genome or transcriptome of
142 actively maintain and improve existing tools so that researchers across disciplines can rely on a sta
143 eria under homoscedasticity were constructed so that researchers can choose a statistically grounded
145 r major issues are explored and demonstrated so that researchers may use the z-factor appropriately.
146 ardizing changes to the period of 1978-2015, so that results are comparable between genera, we detect
147 h for the application of greedy optimization so that results from this algorithm are used as the base
148 nt and commonly screened at room temperature so that results require extrapolation to physiological t
150 ipt levels returned more slowly to baseline, so that roles in either promoting or preventing bleachin
151 ole neurite branch by only one initial seed, so that RRS is proficient at quantifying extensive amoun
153 remains bound to Scap but must be eliminated so that Scap can be recycled to bind and transport addit
154 diversity of our research agendas and teams, so that science benefits people of all identities and ba
155 efs have undergone an ecological phase shift so that seaweeds now dominate previously coral-rich reef
156 teins are naturally chiral molecular systems so that sensing their structure and conformation with ch
157 grated with the device as a proof-of-concept so that sensor's response can be trained and characteriz
158 suggest strategies for achieving these goals so that SER can better include, support, and elevate mem
159 e use of DEBs eliminates the need for stents so that serious side effects including in-stent restenos
161 inimum population is required for survival), so that small perturbations can have major ecological ef
162 deteriorates with increasing heterogeneity, so that some small-effect heterogeneous loci might go un
163 activation by UV-A irradiation was measured, so that spore viability and mortality on Ephestia kuehni
164 have been limited by the microfluidics used so that stable, long-term operation needed for high-thro
165 utcome in patients with psoriatic arthritis, so that stratified medicine approaches can be taken; ano
166 step, hands-on workshop with a sample image so that students can try some of these functions themsel
167 were insufficient to explain the highstand, so that substantial Antarctic Ice Sheet (AIS) reduction
168 glycerides were decreased pharmacologically, so that subtracting pre-treatment from post-treatment tr
169 ual reality, visual feedback can be withheld so that swim attempts fail to trigger expected visual fl
172 rom the active site allows the 3'SS to bind, so that the 5' exon attacks the 3'SS to produce mature m
173 at this protein only weakly attaches to ACE2 so that the activation of CoV-2 RBD might be inhibited i
175 ributed apical and basal to the CG membrane, so that the apical SGs are not prevented from contacting
176 eld moved in the same direction as the pull, so that the apparent velocity of the body was reduced (S
178 ates from secondary organic aerosol material so that the BaP-rich layer at the surface shields the in
179 of escape rates is, in principle, unbounded so that the barrier optimization has to be regularized.
180 tion is much faster than migratory insertion so that the barriers for insertion of individual isomers
181 cer cells and their microenvironment in situ so that the cancer cells can act as tumor-associated ant
182 facilitates opening up the catalytic pocket so that the collagen chains come closer to the MMP1 acti
183 STM upon the sentence representation vectors so that the contextual information from surrounding sent
185 We manipulated the communicative context so that the default pointing response of apes would have
186 ransitions in C. elegans larvae under stress so that the developmental schedule of cell fates remains
188 mer components to the termini are engineered so that the dimer forms over the appropriate binding sur
189 halves of the molecule can be distinguished, so that the effects of 11S RP binding, or the introducti
190 e sufficiently quick to ensure fast imaging, so that the evolution of these parameters can be visuali
191 olutionarily optimized to aggregate, so much so that the extreme robustness of functional amyloid mak
192 cture with a forest feature graph extractor, so that the feature graph can be learned in a supervised
195 DNs), which alter leg motor circuit dynamics so that the fly walks backwards, exemplify the command-t
196 ggots to be made by rearing them to maturity so that the gross morphological features of the adult ca
197 ulate the expression of the ectophosphatase, so that the iA process leads to the formation of cell sp
198 me is valued and influences future decisions so that the impact of both choice success and failure is
199 y not surrounded by surface-active compounds so that the impact of PIN-lipid interactions on LV could
200 s of surveillance and public health response so that the important gains can be maintained and advanc
201 uires modulation of their surface properties so that the interaction with biological systems is regul
202 aced inside an electrostatic linear ion trap so that the ions oscillate back and forth through the cy
203 around the catalytically active Pmh moiety, so that the light-induced change in the catalyst shape a
205 red by a solvothermal process with pyridine, so that the material shows a "memory effect" during the
206 nalyzed by X-ray imaging, before dissembling so that the materials used to manufacture each cartridge
207 n geophysical flows tends to organize itself so that the mean flow remains close to a stability bound
208 to project sequences into an embedding space so that the mean square error between alignment distance
209 ANN to finalize the hybrid model development so that the model will possess generalized prediction ca
210 aborations between groups should be promoted so that the most promising biomarkers can be validated a
211 record numbers were found to be duplicated, so that the number of endophthalmitis cases was unclear
213 al behaviours are also highly heterogeneous, so that the number of partners reported by individuals o
214 pes by wrapping unfamiliar forms in textile, so that the observable surface relief was the result of
215 f seasonal malaria transmission is regulated so that the parasite decreases its endothelial binding c
216 der whether sufficient tumour can be removed so that the patient can enjoy the benefits of decompress
218 ell counts improved over time (Ptrend <.001) so that the percentage of WLWH with CD4 counts of >=500
219 gher-layer weights in a usual supervised way so that the performance of the full network is comparabl
220 ocks generally favour parallel orientations, so that the perpendicular orientation could only be obta
221 ymes at the head of the separation capillary so that the presence of alpha2-6-linked sialic acids cor
222 and optimize the timing of clinical screens so that the probability is maximal that a patient is scr
223 ne system over the entire regeneration time, so that the propensity for mechanical failure is minimiz
224 -based solar photovoltaics is presented here so that the recent advances of 2D materials for solar ce
226 essing tool for decreasing the dynamic range so that the relative variance of smaller but more import
227 n the resting and activated forms ~200-fold, so that the resting form of R68S PheH is ~70% in the act
228 completed within the fluorescence lifetime, so that the rotational time constants could be obtained
229 e reference standards, which are stereotypic so that the same structure can be imaged everywhere, eve
230 thium-ion conducting glass-ceramic separator so that the species formed at each electrode could be id
231 t-modulated white noise that was constructed so that the standard template-matching (TM) observer per
232 reliable detection and segmentation of cells so that the subsequent steps of analyses, for example, e
233 ntation of its substrate in the ground state so that the substrate needs to only undergo minimal stru
234 nput fluctuations in both intensity and time so that the system only responds to input signals that a
235 dopamine receptor kinetics are instantaneous so that the time courses of changes in dopamine concentr
236 does not have functional groups for bonding, so that the two hydrogels by themselves adhere poorly.
237 e impose both spatial and temporal structure so that the types of realizable system dynamics are cons
238 tration be reduced to low levels in diastole so that the ventricle can relax and refill with blood.
239 the estimated effect and the standard error so that the Wald test of ORR is brought back to the same
240 ce of obesity is rapidly increasing, so much so that the World Health Organization has declared obesi
242 t desired loci in mouse embryonic stem cells so that their fate after DNA replication could be follow
243 l platforms to downstream signaling proteins so that their transient interactions in a crowded and he
244 capabilities have improved in recent years, so that theory is better represented by the structures t
245 ctice these measurements are not exhaustive, so that there is a need for techniques to impute values
246 to condition DCs not exposed to the material so that these cannot upregulate CD40 in full in response
247 n of patients at especially high risk of CVD so that these individuals can undergo preventive interve
248 ly depending on the presynaptic compartments so that these output neurons can dynamically rebalance i
250 formance for the task at hand, or automatic, so that they alter the featural representation similarly
251 on the risk differences according to parity so that they are able to make an informed choice for IOL
252 timuli are presented in a lateralized manner so that they are incongruous with the response informati
253 lating isoprenoid diphosphate concentrations so that they are maintained below toxic thresholds.
254 lung units that close during each expiration so that they are not forced to rerecruit during the subs
255 ures by a photodriven cross-linking reaction so that they can be affinity purified and identified by
256 tions, co-designed with community therapists so that they can be delivered in community settings.
257 concentrations of the insects on the ground so that they can be destroyed before they take flight.
258 ed sites associated with molecular function, so that they can be mapped onto user queries in support
259 cking boxes in the electronic medical record so that they can devote their energies to managing popul
260 red in MHP based tandem PVs are highlighted, so that they can hopefully be avoided in the future.
264 reductions and rebates on healthy food items so that they consistently become more preferable than un
265 rated to the tumors and activated arginase-1 so that they could be detected by bioluminescence imagin
268 opposing sides of the mitochondrial tubules so that they form extended opposing distribution bands.
269 s finely tune their fixational eye movements so that they greatly contribute to normal visual acuity.
270 and convergence among distinct myeloid cells so that they may act as a functional unit rather than as
271 behavior of these oligomers to be controlled so that they may be manipulated and characterized withou
272 dian clock orchestrates biological processes so that they occur at specific times of the day, thereby
273 e products efficiently at high temperatures, so that they outperform the state-of-the-art CO(2) captu
274 once they have been developed and validated so that they used by clinicians outside the research con
275 d to success despite challenging conditions, so that this resilient performance can be supported.
276 tiple balls with flexible relative positions so that this structure could deform under force field.
277 ld be selected for global monitoring efforts so that training and interpretation can be standardized.
278 etwork needs to be trained in a specific way so that transferring the digitally trained weights to th
279 ch is largely unfolded, lacking the PK helix so that translation can be initiated at the ribosome bin
280 is an electroneutral H(+)/Fe(2+) antiporter so that transport of each Fe(2+) is coupled to transport
281 s for screening individuals at a younger age so that treatment can be initiated before disease progre
282 esia or hyperaesthesia, and CSF eosinophilia so that treatment can be started early, which is particu
283 rt distances and preserved at long distances so that two objects can remain without contact at a spec
284 t remains to be done over the next few years so that, ultimately, the benefits of genetic and genomic
285 tion, cells must be kept in a state of ready so that upon the return of nutrients, activities such as
286 ary statistics for each step in the pipeline so that users can better understand pre-processing and a
287 e, Brian2GeNN, that connects the two systems so that users can make use of GeNN GPU acceleration when
289 materials were linked to these collections, so that users could browse and analyse these to derive c
290 ne-preventable diseases are sufficiently low so that vaccination is no longer perceived as a necessar
291 nd prior work, and how it can be implemented so that valid scientific messages are more likely to be
292 ying phase of a Ca(2+) wave) to be extracted so that various types of Ca(2+) events can be detected a
293 ey must also improve democratic institutions so that vulnerable populations themselves can push their
294 pathway and optimize fermentation conditions so that we are able to redirect 89% of acyl-CoAs from th
295 ll biological, and evolutionary perspectives so that we can better understand how, when, and why moon
296 patterns and analyzing agent-based dynamics so that we can now answer critical questions in pattern
297 between natural and artificial intelligence, so that we can separate more superficial differences fro
298 eet vs. the coffee shop on Peachtree Street) so that we can use them as landmarks to orient ourselves
299 on to uncover the correct cause is performed so that, when possible, specific therapies to treat the
300 features associated with magnetic skyrmions, so that XRD, TEM, EDS, SAED and HREM investigations were