ライフサイエンスコーパス: social defeat

1 e resident-intruder model for social stress (social defeat).

2 no effect was observed on other symptoms of social defeat.

3 d immobility in the forced swim test, as did social defeat.

4 could elicit avoidance after, but not before social defeat.

5 th addiction and depression models including social defeat.

6 d decreased neurogenesis are consequences of social defeat.

7 conomic status) and mice subject to repeated social defeat.

8 red for restoration of normal behavior after social defeat.

9 ls, none of these molecules were affected by social defeat.

10 precipitating the depressive phenotype after social defeat.

11 that were susceptible, but not resilient to social defeat.

12 scimol on aggression were dependent on prior social defeat.

13 ith a novel intruder 24 hours after an acute social defeat.

14 or not a hamster has previously experienced social defeat.

15 gs of miniature EPSCs (mEPSCs) in mice after social defeat.

16 an increase in the frequency of mEPSCs after social defeat.

17 TLR4) and macrophages (CD14 and CD86) after social defeat.

18 e to reverse behavioral pathology induced by social defeat.

19 n male and female California mice exposed to social defeat.

20 ojections mimicked the behavioral effects of social defeat.

21 d signaling molecules in response to chronic social defeat, 2) brain reward function during social de

22 o subthreshold stress (i.e., single cycle of social defeat) 24 days after RSD, and immune and behavio

23 DRN GABA and 5-HT neurons in mice exposed to social defeat, a model that induces long-lasting avoidan

24 ses in IkappaB kinase (IKK) in the NAc after social defeat, a molecular pathway that has been shown t

25 Repeated social defeat also increased the presence of deramified

26 Repeated social defeat also significantly increased the number of

27 about how a behavioral interaction, such as social defeat, alters the development of adaptive immuni

28 Here we show that social defeat, although not producing depression by itse

29 social avoidance in mice exposed to chronic social defeat and concurrently prevented the electrophys

30 Importantly, for both social defeat and environmental enrichment, how glucocor

31 day), and 3) forced swim test behavior after social defeat and fluoxetine treatment.

32 edonia was assessed in adult male rats using social defeat and intracranial self-stimulation, while c

33 cial defeat, 2) brain reward function during social defeat and long-term treatment with the antidepre

34 These effects emerge after social defeat and require Oxtr specifically coupled to t

35 in neurogenesis drive changes in mood after social defeat and that glucocorticoids secreted during e

36 L-6 knockout mice were subjected to repeated social defeat, and immune and behavioral parameters were

37 te) granulocytes in mice subject to repeated social defeat, and these effects were blocked by pharmac

38 substitution to study social affiliation and social defeat behaviors.

39 ce that are repeatedly subjected to bouts of social defeat by a larger and aggressive CD-1 mouse resu

40 Social defeat caused a weakening of functional connectiv

41 We observed that social defeat caused anxiety-like behaviors in mice and

42 Chronic social defeat (CSD) in male mice can produce anxiety and

43 The chronic social defeat (CSD) paradigm in mice produces mood alter

44 ffected with MDD and rats exposed to chronic social defeat (CSD) stress, which is used to model depre

45 After chronic social defeat, D2-MSNs exhibit increased spine density t

46 missive behavior and exhibited resilience to social defeat, demonstrated by a lack of subsequent soci

47 cial disruption (SDR) that involves repeated social defeat during intermale aggression results in inc

48 Our results revealed that social defeat engaged DRN GABA neurons and drove GABAerg

49 ol group, and active coping behaviors during social defeat episodes were associated with subsequent r

50 sters that achieve social dominance prior to social defeat exhibit greater defeat-induced neural acti

51 e, which typically are excluded from classic social defeat experiments.

52 caine seeking in stressed animals long after social defeat exposure.

53 hibited an increase in BDNF levels following social defeat, HR individuals did not.

54 According to the social defeat hypothesis, the long-term experience of ex

55 Protection from social defeat in G-allele carriers was associated with a

56 ere we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribut

57 Here we show that repeated social defeat in mice increased c-Fos staining in brain

58 ents compared behavioral effects of repeated social defeat in mice with forebrain GR deletion and in

59 Subthreshold social defeat in RSD-sensitized mice increased periphera

60 R), a social stressor that involves repeated social defeat in subordinate mice.

61 Furthermore, social defeat increased anxiety-like behavior and caused

62 Last, repeated social defeat increased c-Fos activation in IL-1 recepto

63 nalysis of microglia indicated that repeated social defeat increased levels of interleukin (IL)-1beta

64 Moreover, subthreshold social defeat increased social avoidance in RSD-sensitiz

65 Finally, we found that social defeat induced a functional reorganization of neu

66 These findings indicate that repeated social defeat-induced anxiety-like behavior and enhanced

67 (mPFC) neuronal activity is associated with social defeat-induced depression- and anxiety-like behav

68 Repeated social defeat-induced macrophage recruitment to the brai

69 bition of Rac1 activity in the NAc increases social defeat-induced social avoidance and anhedonia in

70 e gyrus of the hippocampus of LR rats led to social defeat-induced social avoidance, whereas its acti

71 Social defeat induces long-lasting increases in OT produ

72 The combined data suggest that chronic social defeat induces molecular changes that reduce myel

73 activation of IKK signaling pathways during social defeat is both necessary and sufficient to induce

74 Conditioned defeat is a social defeat model in Syrian hamsters in which individu

75 A robust female social defeat model is a critical first step in the iden

76 Ac), a key brain reward region, in the mouse social defeat model of depression.

77 ute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflamm

78 The ES mice were exposed to the social defeat of a PS mouse by a larger, more aggressive

79 We characterized the longitudinal effect of social defeat on goal-directed actions and prefrontal co

80 e examined acute and long-lasting effects of social defeat on OT neurons in male and female Californi

81 e and social stressors (PD35-44), namely the social defeat or vicarious defeat stress paradigms-proce

82 We report a new version of the social defeat paradigm that works in female mice.

83 Adoption of this modified social defeat paradigm will help advance the initiative

84 tine's antidepressant effects in the chronic social defeat paradigm, whereas inhibition of CaMKII act

85 and MS-275, in the tail suspension test and social defeat paradigm.

86 C57BL/6 mice by subjecting them to a 10-day social defeat paradigm.

87 decreased resilience to repeated stress in a social defeat paradigm.

88 ne neurons of mice undergoing a subthreshold social-defeat paradigm rapidly induced a susceptible phe

89 expression, reveals clear differences in the social defeat phenotype induced by Fosb gene manipulatio

90 the pVTA and CRF-R2 in the aVTA during each social defeat prevented escalated cocaine self-administr

91 social threat as well as by a chamber where social defeat previously occurred.

92 demonstrates that the experience of repeated social defeat prior to a primary viral infection signifi

93 c stress, mice were subjected to the chronic social defeat procedure.

94 We tested whether chronic social defeat produces structural alterations in the mPF

95 Social defeat profoundly and persistently decreased brai

96 , chronic, but not a short and subthreshold, social defeat protocol was necessary to increase CA1 eng

97 At the end of the social defeat protocol, body weights, food and water int

98 We found that CNO treatment during social defeat reduced the acquisition of CD in subordina

99 In the ventral tegmental area, social defeat, regardless of susceptibility or resilienc

100 enetic approaches to activate and inactivate social defeat-related CA1 engram cells enhanced and supp

101 onic social defeat stress model, we examined social defeat-related hippocampal engrams in mice that a

102 TetTag mice were used to label social defeat-related hippocampal ensembles by LacZ.

103 ible mice exhibited a higher reactivation of social defeat-related LacZ-labeled cells (i.e., engram c

104 Despite social defeats, resilient mice with normal sociability s

105 In Syrian hamsters, even a single social defeat results in conditioned defeat, which inclu

106 Previous work showed that repeated social defeat (RSD) in mice promoted stress-sensitizatio

107 Our previous work using repeated social defeat (RSD) in mice showed that recruitment of p

108 Repeated social defeat (RSD) is a mouse model of psychosocial str

109 Repeated social defeat (RSD) is a murine stressor that primes per

110 Repeated social defeat (RSD) is a murine stressor that recapitula

111 Repeated social defeat (RSD) stress in mice increases the release

112 In a model of repeated social defeat (RSD), elevated IL-1beta expression in the

113 behavioral patterns associated with repeated social defeat (RSD).

114 Using a chronic social defeat (SD) stress model, learned helplessness (L

115 ehavioral analysis confirmed that the 14-day social defeat sessions resulted in induction of depressi

116 Mice adrenalectomized before social defeat showed enhanced behavioral resiliency and

117 e socially avoidant by the stress of chronic social defeats showed depressed neural activity in the l

118 racterize a novel chronic non-discriminatory social defeat stress (CNSDS) paradigm that results in co

119 the NAc of male mice that underwent chronic social defeat stress (CSDS) and in patients with major d

120 rate that adult mice which underwent chronic social defeat stress (CSDS) displayed elevated anxiety-l

121 Exposure of Ghsr-null mice to chronic social defeat stress (CSDS) elicits more severe depressi

122 curcumin at promoting resilience to chronic social defeat stress (CSDS) in 129/SvEv mice, a strain t

123 We performed chronic social defeat stress (CSDS) in mice and evaluated behavi

124 Animal studies using chronic social defeat stress (CSDS) in mice showed that brain-de

125 Chronic social defeat stress (CSDS) is a well-established rodent

126 pproach in combination with a 10-day chronic social defeat stress (CSDS) model in male mice to invest

127 nt-like activity of vmPFC DBS in the chronic social defeat stress (CSDS) model of depression (n = 8-1

128 e behaviors in adult mice, using the chronic social defeat stress (CSDS) model of depression.

129 Chronic social defeat stress (CSDS) produces persistent behavior

130 monitored in mice after exposure to chronic social defeat stress (CSDS), a model of prolonged psycho

131 educed in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces be

132 Here we examined the effects of chronic social defeat stress (CSDS), an ethological form of stre

133 osome transgenic mice that underwent chronic social defeat stress (CSDS).

134 ts to NAc regulate susceptibility to chronic social defeat stress (CSDS).

135 -like behaviors in mice subjected to chronic social defeat stress (CSDS).

136 an subjects and in mice subjected to chronic social defeat stress (CSDS).

137 was microinjected into the VTA 20 min before social defeat stress (or handling) on days 1, 4, 7, and

138 Repeated social defeat stress (R-SDS) reduces the expression of D

139 ter exposure to either subthreshold repeated social defeat stress (RSDS) or a purely emotional stress

140 Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological

141 mmatory and behavioral responses to repeated social defeat stress (RSDS), a mouse model of stress vul

142 Single social defeat stress (S-SDS) induces D1 receptor-mediate

143 ubmissive behavioral traits developed during social defeat stress (SD).

144 nd predicted susceptibility or resilience to social defeat stress (SDS) in mice and 2) administration

145 Using social defeat stress (SDS) in mice, here we identified a

146 iciency leads to increased susceptibility to social defeat stress (SDS), a model of psychosocial stre

147 ed enhanced susceptibility to a subthreshold social defeat stress (SSDS) as observed by reduced socia

148 We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CA

149 We hypothesized that chronic social defeat stress alters synaptic strength or connect

150 Here, we employed chronic mild social defeat stress and 16S rRNA gene metagenomic seque

151 ifferentially expressed genes, while chronic social defeat stress and adult social isolation better r

152 a2 subunit knockdown decreased resilience to social defeat stress and c-fos immunoreactivity in the B

153 tal period increases susceptibility to adult social defeat stress and causes long-lasting transcripti

154 oth the decrease in Rac1 transcription after social defeat stress and depression-related behavior, su

155 r, we find that female mice undergo repeated social defeat stress and develop social avoidance, decre

156 Both social defeat stress and environmental enrichment stimul

157 VL function renders mice more susceptible to social defeat stress and promotes depression-like behavi

158 e-induced behaviors, indicating that chronic social defeat stress and repeated cocaine exposure regul

159 l cortex (mPFC) is activated by subthreshold social defeat stress and suppresses the induction of dep

160 e exposed mice to chronic cocaine or chronic social defeat stress and used two-photon laser scanning

161 C57BL/6 mice underwent 10 days of social defeat stress and were subsequently tested for so

162 ate that depression-like behavior induced by social defeat stress arises from disrupted DOR signaling

163 nd those susceptible or resilient to chronic social defeat stress at multiple time points.

164 rring transcriptional phenomena that control social defeat stress behavior.

165 Social defeat stress causes dendritic morphological chan

166 We show here that repeated social defeat stress causes increased pain sensitivity d

167 Episodic social defeat stress consists of four brief confrontatio

168 Here we show that chronic social defeat stress decreases messenger RNA and protein

169 Our results suggest that experience of social defeat stress during adolescent development can c

170 ult male rats previously exposed to repeated social defeat stress during mid-adolescence.

171 Intermittent social defeat stress escalates later cocaine self-admini

172 Mice subjected to chronic social defeat stress exhibited similar reductions in lev

173 adolescence associate with vulnerability to social defeat stress in adulthood, with high levels asso

174 D2-MSNs after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artif

175 dure allows researchers to perform vicarious social defeat stress in males or females and in juvenile

176 Here we show that repeated social defeat stress in mice activated threat appraisal

177 We have reported that repeated social defeat stress in mice caused recruitment of proin

178 Chronic social defeat stress in mice produces a susceptible phen

179 We show that chronic social defeat stress in mice produces progressive altera

180 Here, we show that repeated social defeat stress in rats causes persistent enhanceme

181 Chronic social defeat stress increased hyperpolarization-activat

182 h wild-type mice; and 5) exposure to chronic social defeat stress induces blood glucocorticoids and a

183 Intermittent social defeat stress induces both locomotor and dopamine

184 Social defeat stress induces persistent cross-sensitizat

185 Chronic social defeat stress induces the formation of stubby exc

186 differences exist in stress responsivity and social defeat stress is a key approach for identifying c

187 The susceptibility to chronic social defeat stress is regulated by hippocampal CA1 eng

188 this study we show that a single episode of social defeat stress is sufficient to specifically induc

189 The chronic social defeat stress model has been instrumental in shap

190 In a social defeat stress model of depression, depressed (sus

191 In the chronic social defeat stress model of depression, we report that

192 Using the chronic social defeat stress model, we examined social defeat-re

193 Using a chronic social defeat stress model, we explored whether the susc

194 Chronic social defeat stress of mice increases IkappaK activity

195 1, 14, 17, and 20, animals were subjected to social defeat stress or a nonstressful control condition

196 at DeltaFosB is induced in NAc after chronic social defeat stress or after chronic antidepressant tre

197 a separate group of rats underwent a single social defeat stress or control handling and were challe

198 ue-Dawley rats underwent a single episode of social defeat stress or control handling, followed by am

199 Lymphocytes from mice undergoing chronic social defeat stress or from unstressed control mice wer

200 t into enkephalin function we used a chronic social defeat stress paradigm, where animals are either

201 d cocaine administration prior to subchronic social defeat stress potentiated depressive-like behavio

202 and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.

203 However, the classic chronic social defeat stress procedure is limited by its exclusi

204 We have recently developed a novel vicarious social defeat stress procedure wherein one mouse witness

205 Social defeat stress produced social avoidance (a model

206 Chronic social defeat stress regulates the expression of Fosb in

207 enhanced alcohol consumption in response to social defeat stress relative to their wild-type litterm

208 Repeated social defeat stress resulted in repeated episodes of dr

209 h Rho-kinase inhibitor Y-27632 after chronic social defeat stress reverses depression-like behaviors

210 active Rac1 in the NAc of mice after chronic social defeat stress reverses depression-related behavio

211 entate gyrus neurogenesis is increased after social defeat stress selectively in mice that display pe

212 velop depressive-like symptoms after chronic social defeat stress show distinct changes in the activi

213 Here, we show that chronic (10 d) social defeat stress significantly increased the in vivo

214 These findings indicate that social defeat stress specifically activates neurons in d

215 Here we show that social defeat stress specifically increased c-Fos expres

216 rd-associated region, in response to chronic social defeat stress was both necessary and sufficient f

217 Mice subjected to chronic social defeat stress were stratified into resilient and

218 ptible male mice that have undergone chronic social defeat stress, a mouse model of depression, at bo

219 We investigated the effect of chronic social defeat stress, a mouse model of depression, on bl

220 efrontal cortex (mPFC) of mice after chronic social defeat stress, a mouse model of depression.

221 sant, ketamine, in mice subjected to chronic social defeat stress, a validated depression model, and

222 Using chronic social defeat stress, an animal model of mood and anxiet

223 We found that chronic social defeat stress, an animal model recapitulating som

224 induced relapse to cocaine use in rats using social defeat stress, an ethologically valid psychosocia

225 In the present study, we show that chronic social defeat stress, an ethologically validated model o

226 We applied chronic social defeat stress, an ethologically validated mouse m

227 and synaptic results were obtained following social defeat stress, and intracerebroventricular inject

228 gia (NIH), novelty-suppressed feeding (NSF), social defeat stress, and learned helplessness.

229 electively in susceptible mice after chronic social defeat stress, and overexpression of DeltaFosB in

230 vivo, ACY-738 promoted resilience to chronic social defeat stress, and serotonin-selective viral over

231 In a murine model of acute social defeat stress, Asb1 gene expression was significa

232 After chronic social defeat stress, chronic administration of imiprami

233 downregulated in NAc of mice susceptible to social defeat stress, effects not seen in resilient mice

234 (P70), reactivity to aversive stimuli (i.e., social defeat stress, forced swimming, and elevated plus

235 Mice resilient to social defeat stress, however, exhibit stable normal fir

236 rimental approaches for studying depression, social defeat stress, in particular, has been shown to h

237 the induction of depressive-like symptoms by social defeat stress, low-novelty-seeking rats [low resp

238 hat of the mouse that physically experiences social defeat stress, modeling multiple aspects of major

239 After chronic social defeat stress, NAc MSNs exhibit increased dendrit

240 After chronic social defeat stress, resilient animals displayed an upr

241 yed increased susceptibility to subthreshold social defeat stress, suggesting that neuronal VGF, expr

242 Using a model of chronic social defeat stress, we identified region-specific diff

243 ctrophysiological adaptations in response to social defeat stress, which are normalized by antidepres

244 course of cross-sensitization after a single social defeat stress, which normally produces transient

245 males as one commonly used paradigm-chronic social defeat stress-has proven challenging to implement

246 e (CORT)-induced escape deficits and chronic social defeat stress-induced anhedonia.

247 in areas, D1 knockdown in the mPFC decreased social defeat stress-induced c-Fos expression in the int

248 K signaling results in a reversal of chronic social defeat stress-induced social avoidance behavior.

249 Fosb gene in NAc regulates susceptibility to social defeat stress.

250 d in the NAc of resilient mice after chronic social defeat stress.

251 rons prevents social avoidance after chronic social defeat stress.

252 ours of cocaine withdrawal and after chronic social defeat stress.

253 lf-administration, and resilience to chronic social defeat stress.

254 uding in vivo recordings in mice and chronic social defeat stress.

255 mice and mice that are resilient to chronic social defeat stress.

256 phe nucleus of vulnerable mice after chronic social defeat stress.

257 uces social avoidance following subthreshold social defeat stress.

258 l mediator of depression-related outcomes to social defeat stress.

259 stress, adult social isolation, and chronic social defeat stress.

260 increases after mice are exposed to chronic social defeat stress.

261 behavioral abnormalities seen after chronic social defeat stress.

262 ty to stress using a murine model of chronic social defeat stress.

263 thin the ventral tegmental area (VTA) during social defeat stress.

264 substrate 1 (Rac1) expression after chronic social defeat stress.

265 ke inhibitor antidepressant, fluoxetine; and social defeat stress.

266 spine morphology in mice undergoing an acute social defeat stress.

267 depressive-like behaviors induced by chronic social defeat stress.

268 ve mutant of GSK3beta promoted resilience to social defeat stress.

269 regulation of this pathway in the NAc due to social defeat stress.

270 ted with social avoidance in mice subject to social defeat stress.

271 oral susceptibility vs resilience to chronic social defeat stress.

272 ey behavioral abnormality induced by chronic social defeat stress.

273 ens (NAc) by chronic cocaine use and chronic social defeat stress.

274 patients and in mice chronically exposed to social defeat stress.

275 biome in mediating vulnerability to repeated social defeat stress.

276 PFC) of rats regulates resilience to chronic social defeat stress.

277 orylation of ERK, which was downregulated by social defeat stress.

278 d to inhibit RhoA activity following chronic social defeat stress.

279 educed excitatory input to D1-MSNs caused by social defeat stress.

280 ng depression-related behavior after chronic social defeat stress.

281 residents in an ethological model of female social defeat stress.

282 in the NAc and enhanced susceptibility to a social defeat stress.

283 eptor containing MSNs of mice susceptible to social defeat stress.

284 reverse translated in a mouse model of acute social defeat stress.

285 of these neurons mediates susceptibility to social-defeat stress in freely behaving mice.

286 in levels in plasma are reduced in a chronic social-defeat stress model of depression, which correlat

287 e reward signals, is upregulated by repeated social-defeat stress, a highly validated mouse model of

288 tal cortex (mPFC), induced susceptibility to social-defeat stress.

289 ent mice that had been subjected to repeated social-defeat stress.

290 Immediately after social defeat, stress-exposed mice (irrespective of whet

291 class III histone deacetylase, after chronic social defeat suggest a role for this enzyme in mediatin

292 w reliable territorial aggression, but after social defeat they exhibit a conditioned defeat (CD) res

293 as MDL 11,939 blocks 5-HT2A receptors during social defeat to disrupt the development of the conditio

294 , or 2.0 mg/kg) was injected either prior to social defeat training or prior to conditioned defeat te

295 , or 3.0 mg/kg) was injected either prior to social defeat training or prior to conditioned defeat te

296 h SHI reported experiencing more feelings of social defeat (U=109, z=-2.09, P=.04) and loneliness (U=

297 Using a rodent model of social defeat, we have previously shown that rats with s

298 reases susceptibility to a single session of social defeat, whereas overexpression of miR-218 selecti

299 an IL-to-BLA neural projection during acute social defeat will reduce the CD response in subordinate

300 antagonist directly into the VTA before each social defeat would prevent the development of later (1)