ライフサイエンスコーパス: social isolation

1 rs (such as parental depression, stress, and social isolation).

2 nterpersonal experiences and outcomes (e.g., social isolation).

3 h wounding and infection may be more likely (social isolation).

4 endent manner, and this effect is blocked by social isolation.

5 d not contribute to the risk associated with social isolation.

6 ar context to understand the consequences of social isolation.

7 r mouse model of depression, prolonged adult social isolation.

8 ocial anxiety-like behavior after early-life social isolation.

9 treatment alleviates anxiety symptoms after social isolation.

10 ed with substantial levels of disability and social isolation.

11 ange in total GABA(A)-R number occurs during social isolation.

12 d that can mitigate negative consequences of social isolation.

13 th decreased physical activity and increased social isolation.

14 economic status, psychological distress, and social isolation.

15 e adopted a mouse model involving protracted social isolation.

16 s drug intoxication, maternal separation, or social isolation.

17 all measures of functioning examined except social isolation.

18 latory activity when rat pups were tested in social isolation.

19 by interruptions in health-care delivery and social isolation.

20 xperienced 10 h of mandated fasting or total social isolation.

21 -dwelling older adults in the US experienced social isolation.

22 the findings support an effect of smoking on social isolation.

23 ronmental risk factors are closely linked to social isolation.

24 ice demonstrated robust social seeking after social isolation.

25 ealth due to transmission fears, stigma, and social isolation.

26 evice therapies, coinciding with measures of social isolation.

27 ine, and have complete data on loneliness or social isolation.

28 g responses to visual threat precipitated by social isolation.

29 facilities were located in areas of highest social isolation.

30 ng rescues this myelination defect caused by social isolation.

31 ic and contextual factors that contribute to social isolation.

32 we observe synaptic changes following acute social isolation.

33 n vitro, for 2 weeks in adult mice following social isolation.

34 idance behavior in mice undergoing prolonged social isolation.

35 from no SI states was the chronic stress of social isolation.

36 se, a painful loss, exposure to violence, or social isolation.

37 their patients find strategies for avoiding social isolation.

38 fears (21 [40%]), dependence (23 [43%]), and social isolation (19 [36%]).

39 rrel monkeys and macaque monkeys showed that social isolation [2, 3], deafness [2], cross-fostering [

40 Mice subjected to social isolation (3-4 weeks) exhibit enhanced contextual

41 y prevalence was 3.38%, loneliness 4.75% and social isolation 9.04%.

42 In a mouse model of chronic social isolation, a known risk factor for depressive ill

43 In contrast, during social isolation, a separate test for anxiety,beta4-/- m

44 in modulating behavioral changes induced by social isolation across a wider range of species, includ

45 Frailty and loneliness/social isolation affect individuals across a wide age sp

46 pocampus of piglets at 12 days of age, while social isolation affected frontal cortex regardless of a

47 After 6 weeks of social isolation, ALLO and 5alpha-DHP biosynthesis rates

48 Social isolation also exacerbated CA/CPR-induced depress

49 nt (CRE)-LacZ reporter mice, that protracted social isolation also reduces CRE-dependent transcriptio

50 es had uninterrupted access to food, chronic social isolation altered the expression of metabolic gen

51 Chronic social isolation alters behavior across animal species.

52 se in group housed mice, which suggests that social isolation alters emotional responses by reducing

53 roendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of thes

54 The intervention improved depression and social isolation, although the relative improvement in t

55 Moreover, adolescent social isolation, an environmental stressor, failed to i

56 ron activation restores RGL quiescence after social isolation, an experience that induces RGL activat

57 , but the association between loneliness and social isolation and adverse outcomes was attenuated in

58 hat were not reported in controls, including social isolation and aggression.

59 omparison of the brain networks activated by social isolation and by urine stimuli to those upstream

60 ntal risk factors for schizophrenia, such as social isolation and childhood trauma, also affect presy

61 skewing, which may both propagate perceived social isolation and contribute to its associated health

62 Associations between social isolation and CRP were inconsistent and unidirect

63 It causes social isolation and depression and has recently been id

64 nd downstream effects of COVID-19, including social isolation and disruption of education.

65 l (weekends and holidays) and psychological (social isolation and drinking intention) correlates.

66 longitudinal association between loneliness, social isolation and falls amongst older adults in Engla

67 idity and mortality independent of objective social isolation and health behavior.

68 n artifact of the strong association between social isolation and increased mortality rate in combina

69 ve and debilitating hearing loss, leading to social isolation and increased rates of depression.

70 ance, as well as the neurocognitive basis of social isolation and its deep consequences for mental an

71 Both social isolation and loneliness are associated with incr

72 This will increase our understanding of how social isolation and loneliness relate to cognitive decl

73 for CVD were calculated for women with high social isolation and loneliness scores (midpoint of the

74 Continuous scores of social isolation and loneliness were analyzed.

75 Both social isolation and loneliness were associated with inc

76 sess the extent to which the associations of social isolation and loneliness with mortality were attr

77 The associations of social isolation and loneliness with premature mortality

78 , subjective wellbeing, less depression, low social isolation and loneliness, more close relationship

79 ion in human society, as is evidenced by the social isolation and loss of occupational opportunities

80 riety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian

81 the extent to which the association between social isolation and mortality is mediated by loneliness

82 r adjusting for age, sex, educational level, social isolation and multiple testing, time use was sign

83 Despite additive effects of paternal social isolation and paternal predation risk, we found n

84 ty, atonic episodes, restricted mobility) to social isolation and placidity.

85 ical factors such as stress, depression, and social isolation and progression of cancer.

86 es were age, sex, education, marital status, social isolation and social support, chronic medical con

87 ception of acute social isolation as chronic social isolation and thereby results in sleep loss and i

88 ersonality factors and character traits, (4) social isolation, and (5) chronic life stress.

89 dels in mice: chronic variable stress, adult social isolation, and chronic social defeat stress.

90 self-rated health, impaired quality of life, social isolation, and depressive symptoms.

91 fe smoking, depression, physical inactivity, social isolation, and diabetes) account for 35% of world

92 the medial prefrontal cortex, social reward, social isolation, and drug use.

93 proach can help promote active aging, reduce social isolation, and ensure a better quality of life fo

94 eriences in combination with discrimination, social isolation, and exclusion in the host country lead

95 d in the prefrontal cortex of mice following social isolation, and is associated with reduced express

96 Frailty, social isolation, and loneliness have individually been

97 used to assess frailty (frailty phenotype), social isolation, and loneliness.

98 tion, psychiatric history, COVID-19 history, social isolation, and low perceived quality of informati

99 r the elderly, leading to cognitive decline, social isolation, and lower quality of life.

100 disorder, smoking, diet, cognitive activity, social isolation, and marriage), environmental factors (

101 s (energy, pain, emotional reactions, sleep, social isolation, and mobility) and seven aspects of dai

102 hip between loneliness, different aspects of social isolation, and physical performance over time.

103 r anxiety, depression, global mental health, social isolation, and positive affect after FFS.

104 roblems, life events, neighborhood problems, social isolation, and social support.

105 ated with functional impairment, feelings of social isolation, and suicidal ideation.

106 Loneliness and social isolation are a growing public health concern, ye

107 nisms underlying the exacerbating effects of social isolation are unclear.

108 chological factors, including depression and social isolation, are important determinants of cardiova

109 these neurons causes misperception of acute social isolation as chronic social isolation and thereby

110 monstrated that a rodent model of adolescent social isolation (aSI) produces robust and persistent in

111 Chronic variable stress and adult social isolation better reproduce differentially express

112 while chronic social defeat stress and adult social isolation better reproduce gene networks characte

113 n stabilize fragile brokerage relationships: social isolation, broker capture, and organizational gra

114 Our observations demonstrate that social isolation, but not acute physical stress has sex-

115 not seem to act by reducing the distress of social isolation, but they have notable prosocial effect

116 ed the hypothesis that even brief periods of social isolation can alter gene expression and DNA methy

117 , as social interaction can be rewarding and social isolation can be aversive.

118 Social isolation can exacerbate the negative consequence

119 Adolescent chronic social isolation can precipitate stress-related psychiat

120 We found that postweaning social isolation caused a decrease of in vivo firing act

121 physiological studies found that postweaning social isolation caused a presynaptic impairment of exci

122 In this study, we tested whether postweaning social isolation caused abnormal activity of MeA neurons

123 In rodents, postweaning social isolation causes a range of deficits in sexual an

124 TTING, AND PARTICIPANTS: In a cohort design, social isolation changes in 4 years and subsequent risk

125 health, positive affect, emotional support, social isolation, companionship, and meaning and purpose

126 The hazard ratio for all-cause mortality for social isolation compared with no social isolation was 1

127 oup differences in the influence of specific social isolation components were identified.

128 tic analyses in a macaque model of perceived social isolation confirmed CTRA activation and identifie

129 older aged adults, we provide evidence that social isolation contributes to human brain atrophy and

130 ary perspective, these findings suggest that social isolation could be adaptive in some contexts and

131 Juvenile social isolation decouples dmPFC-PVI activation from sub

132 Social isolation decreased gene expression (P < 0.05) in

133 In these experiments, peri-ischemic social isolation decreases poststroke survival rate and

134 people with SMI are strongly associated with social isolation, depression, cognitive impairment, and

135 rcentile), and controlling for indicators of social isolation did not affect the finding.

136 Mice undergoing prolonged social isolation display impaired myelination in the pre

137 We reveal that prolonged social isolation disrupts the specific serotonin respons

138 ed increased loneliness, anxiety and greater social isolation due to social distancing policies.

139 In a rat model, we examined how social isolation during adolescence impacts stress react

140 Chronic social isolation during adolescence is an early life adv

141 etic deletion of IL-1R1 rescues self-imposed social isolation during systemic inflammation.

142 Social isolation during the juvenile critical window is

143 eported criminality, substance use problems, social isolation, early sexual behavior, and psychiatric

144 domains included social context (Black race, social isolation); education (educational attainment); e

145 n be observed in animals that have undergone social isolation, especially in species having important

146 Mice housed in social isolation exhibit a decreased response to gamma-a

147 Surprisingly, social isolation facilitated accumulation of stem cells,

148 ontinence has been associated with increased social isolation, falls, fractures, and admission to lon

149 umber of hours spent caregiving, depression, social isolation, financial stress, and lack of choice i

150 in peer activities, placing them at risk for social isolation from their peers and psychosocial adjus

151 m rats reared in either groups of five or in social isolation from weaning.

152 s of age, gender, education, marital status, social isolation, functional impairment, financial strai

153 By contrast, social isolation generates an aversive state ('lonelines

154 s, rearing rodents in persistent postweaning social isolation has been established as a widely used a

155 Social isolation has been recognized as a major risk fac

156 Social isolation has dramatic long-term physiological an

157 Prolonged social isolation has negative effects on brain and behav

158 Thus, social isolation has rapid consequences on gene activity

159 ift to remote work, compounded by stress and social isolation, has posed significant mental health ch

160 Loneliness and social isolation have been identified as important predi

161 Although loneliness and social isolation have been linked to an increased risk o

162 tyle, comorbidities, impaired cognition, and social isolation, HL in standard frequency was associate

163 pensity to intense psychological pain (e.g., social isolation, hopelessness), often in the context of

164 ines has made it abundantly clear: perceived social isolation (i.e., loneliness) may be the most pote

165 We found that, in male mice, 2 weeks of social isolation immediately following weaning leads to

166 presents the emotional pathway through which social isolation impairs health.

167 gnitive problems, neighborhood problems, and social isolation in 1994 all were significant predictors

168 Using a model of protracted social isolation in adult rats, we observed increased an

169 ehavioral abnormalities induced by prolonged social isolation in adult rodents.

170 orphic functional connection is increased by social isolation in both sexes, suggesting that it may b

171 ross 48 countries) suggested lower levels of social isolation in individuals receiving nonbiologic sy

172 Future studies should consider measures of social isolation in long-term care and identify the cont

173 and others have previously demonstrated that social isolation in mice induced behavioral, transcripti

174 Protracted social isolation in mice may provide a model to investig

175 the effects of acute morphine dependence and social isolation in non-anxious Sprague Dawley (SD) rats

176 Social isolation in old age has been associated with ris

177 Social isolation in rodents has been used extensively to

178 We assessed social isolation in terms of contact with family and fri

179 esent study investigated the hypothesis that social isolation increases aggression by increasing the

180 These data support the hypothesis that social isolation increases aggression by increasing the

181 hat may be involved suggest that (a) chronic social isolation increases the activation of the hypotha

182 Furthermore, early-life social isolation increases the levels of corticotropin-r

183 Social isolation induced both anxiety- and anhedonia-lik

184 A probable player in the mechanism of social isolation-induced anxiety is astrocytes, speciali

185 at inhibiting SK channels normalizes chronic social isolation-induced anxiety/depressive-like behavio

186 hether oxidative stress is implicated in the social isolation-induced exacerbation of schizophrenia-l

187 nsequences; however, the mechanisms by which social isolation influences disease outcome are largely

188 Social isolation is a passive, naturalistic form of chro

189 Social isolation is associated with higher mortality in

190 The present study suggests that in men, social isolation is not only an important risk factor fo

191 mal models, how normal sleep is perturbed by social isolation is unknown.

192 h as gender, age, marital status, education, social isolation, labor market status, and material depr

193 viders, diversion of hospital resources, and social isolation leading to psychological decompensation

194 loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB

195 ngitudinal research indicates that perceived social isolation (loneliness) is a risk factor for morbi

196 al response in people experiencing perceived social isolation (loneliness), we conducted integrative

197 re transcriptionally sensitive to subjective social isolation (loneliness).

198 , which may contribute to the development of social isolation, loneliness, and consequent cognitive d

199 growing body of research on the link between social isolation, loneliness, and health outcomes in lat

200 mortality and hospitalisation regardless of social isolation/loneliness.

201 depression, as were being female, older age, social isolation, low education, financial strain, and f

202 ough traffic exposure, noise, air pollution, social isolation, low physical activity, and sedentary b

203 Social isolation, male sex, and older age were associate

204 by a live predator, suggesting that paternal social isolation may have maladaptive effects on how off

205 cumulative burden of social needs, including social isolation, medical care insecurity, medication no

206 Older adults with social isolation, medical comorbidity, and physical impa

207 ming stimuli can be observed after 2 days of social isolation, mice can also rapidly learn that such

208 ortex and hippocampus, protracted (>4 weeks) social isolation of adult male mice alters the subunit e

209 Protracted social isolation of adult mice induced behavioral, trans

210 iety of psychosocial reactions, ranging from social isolation of clinical depression and attempted su

211 These data suggest that post-weaning social isolation of female rats sensitizes a DR-basolate

212 ortunities in school settings to prevent the social isolation of individuals and facilitate integrati

213 revious studies have shown that post-weaning social isolation of male rats leads to sensitization of

214 Thus, protracted social isolation of mice combined with tests of fear con

215 Results suggest that social isolation of non- and early-weaned piglets may im

216 Here, we show that social isolation of rats during a critical period of ado

217 Social isolation of rats during the early part of develo

218 Post-weaning social isolation of rats produces psychological and phys

219 ress-induced behavioral deficits, we imposed social isolation on a genetically vulnerable mouse model

220 a result, understanding the consequences of social isolation on a mechanistic level has become incre

221 tionally, the seemingly protective effect of social isolation on AF incidence may be simply an artifa

222 e zebrafish was used to assess the impact of social isolation on behaviour and brain function.

223 o the molecular and physiological effects of social isolation on brain cells and circuits.

224 n integrated understanding of the impacts of social isolation on brain circuits and behavior.

225 sent study was to investigate the effects of social isolation on neuronal damage, neuroinflammation,

226 SD paradigm in mice to assess the impact of social isolation on sleep, wakefulness and delta electro

227 s to investigate the effects of post-weaning social isolation on subsequent responses of an anxiety-r

228 Never before have we experienced social isolation on such a massive scale as we have in r

229 estigated the effects of age, weaning and/or social isolation on the expression of genes regulating g

230 owever, little is known about the effects of social isolation on the function of MeA neurons.

231 mplementary perspectives on the influence of social isolation on the progression of schizophrenia, fr

232 LX) stereospecifically reverse the effect of social isolation on the PTB-induced loss of righting ref

233 Even in social isolation, optogenetic stimulation of Mrgprb4-lin

234 The increase in FSL following either social isolation or acute physical stress was blocked by

235 y risk factors for secondary depression (eg, social isolation or exclusion, and unemployment), our fi

236 ions (47 [36%]), family problems (44 [34%]), social isolation or withdrawal (33 [25%]), child abuse o

237 Perceived social isolation, or loneliness, affects physical and me

238 By contrast, impaired social relationships, social isolation, or the loss of a bonded partner lead t

239 Furthermore, social isolation over the course of development impaired

240 19, only IW-PAFs of low education (p=0.001), social isolation (p=0.034), and smoking (p=0.007) showed

241 able an evidenced-based approach to national social isolation policies.

242 ment of multiple comorbid medical illnesses, social isolation, polypharmacy, and factors associated w

243 Adolescent social isolation prolonged glucocorticoid elevation, lea

244 onditions (n = 22) and chickens exposed to a social isolation protocol (n = 24) were used to identify

245 Postweaning social isolation (PWSI) augmented the ROS levels in KO m

246 al magnetic resonance imaging of postweaning social isolation rats (N = 23) 9 weeks after isolation.

247 ty in posterior brain regions of postweaning social isolation rats.

248 Chronic social isolation reduces sleep and promotes feeding thro

249 Juvenile social isolation reduces sociability in adulthood, but t

250 get people living with frailty or loneliness/social isolation, regardless of age.

251 for demographic factors and baseline health, social isolation remained significantly associated with

252 Depression, anxiety, anger, and social isolation remained unchanged.

253 Chronic social isolation renders 5-HT neurons insensitive to SK2

254 These results show that social isolation results from a combination of intrinsic

255 Early social isolation results in adult behavioral and cogniti

256 Among diabetes patients, loneliness, but not social isolation scale, is associated with a higher risk

257 lness severity, each 1-point increase in the social isolation score (from 0-6) was associated with a

258 were estimated for associations of a 5-point social isolation score with risk of death.

259 ss (sHR 1.58, 1.12-2.23), as well as chronic social isolation (sHR 1.41, 1.02-1.94).

260 Similarly, rats reared in social isolation (SI) during adolescence exhibit augment

261 Accumulating evidence indicates that social isolation (SI) in humans and rodents is associate

262 Social isolation (SI) increases stroke-related mortality

263 Social isolation (SI) of male mice lasting >4 weeks is a

264 rs, and male rodents subjected to adolescent social isolation (SI) stress form stronger preferences f

265 mRNA expression was unchanged by protracted social isolation (Si).

266 conceptual model, were examined: Black race, social isolation, social network and/or caregiver availa

267 oss the lifespan of zebrafish (Danio rerio), social isolation specifically decreased the level of tra

268 ese behavioral phenotypes are exacerbated by social isolation stress.

269 Many of these behaviors were exacerbated by social isolation stress.

270 Remarkably, visual deprivation and social isolation strongly impact the structural and func

271 By contrast, social isolation substantially increases the risk that t

272 er of the aru mutant are restored upon adult social isolation, suggesting a causal relationship betwe

273 ted contextual fear responses resulting from social isolation, suggesting that selective activation o

274 strain, depression, hostility, anxiety, and social isolation tend to cluster in certain individuals.

275 me of the interviewees experienced even more social isolation than they did before.

276 tely leading to new approaches to combat the social isolation that often ensues.

277 studies on SD were conducted in a setting of social isolation, the impact of the social contextual se

278 Hsp60 levels, low socioeconomic status, and social isolation, together with an association with psyc

279 executive functions) were linked to greater social isolation, too.

280 'Loneliness' refers to the perceived social isolation triggered by unsatisfying relationships

281 tality for social isolation compared with no social isolation was 1.73 (95% CI 1.65-1.82) after adjus

282 Adolescent social isolation was associated with a significant incre

283 Social isolation was associated with all-cause mortality

284 Social isolation was associated with cardiovascular dise

285 Greater social isolation was associated with higher levels of 11

286 Co-occurrence of frailty and loneliness or social isolation was most common in participants with hi

287 ratio [HR] 1.12 [95% CI 1.07-1.16]), whereas social isolation was not (HR 1.01 [95% CI 0.97-1.04]).

288 By contrast, social isolation was not explained by the identity of an

289 During the hard lockdown, perceived social isolation was significantly higher (beta = 0.12;

290 n) leading to communication difficulties and social isolation (Weinstein & Ventry).

291 ofiles; specifically, social subordinance or social isolation were associated in our study with hyper

292 Educational attainment and social isolation were associated with Medicaid expenditu

293 Depression, anxiety, and social isolation were commonly reported.

294 ious primate, we found that some measures of social isolation were modestly repeatable within individ

295 physical functioning, vitality, emotion, and social isolation were significantly worse in patients co

296 levated Depression score may be a marker for social isolation, which could play a role in immune func

297 ticoid receptor (GR) antagonist RU486 during social isolation, which implicates the role for glucocor

298 stressors such as inescapable tailshock and social isolation, while no changes in IL-1 have been obs

299 study, we evaluated whether associations of social isolation with all-cause, cardiovascular disease,

300 The association of social isolation with mortality was unchanged when lonel