ライフサイエンスコーパス: sodium bicarbonate

1 y (epinephrine, midazolam, 10% dextrose, and sodium bicarbonate).

2 nents of SP (notably inorganic phosphate and sodium bicarbonate).

3 ravenous administration of a known amount of sodium bicarbonate.

4 ECG technique, the catheter was flushed with sodium bicarbonate.

5 er when the mineral acid was scavenged using sodium bicarbonate.

6 s the proportion of patients treated with IV sodium bicarbonate.

7 ng of niobium-tantalum bearing minerals with sodium bicarbonate.

8 ved N-acetylcysteine, physiologic saline, or sodium bicarbonate.

9 ion is currently directed toward statins and sodium bicarbonate.

10 y assigned to placebo or one of two doses of sodium bicarbonate (0.5 or 0.8 mEq/kg lean body weight p

11 ign, with calcium chloride (0.1 mmol/kg) and sodium bicarbonate (1 mmol/kg) as the interventions.

12 e of investigational product administered in sodium bicarbonate 15 minutes after each meal.

13 n, and used stable isotope tracing (4 mM 13C sodium bicarbonate; 4.5 h) to quantify metabolite exchan

14 2% lidocaine with epinephrine 1:100 000 with sodium bicarbonate 8.4% offers a clinically and statisti

15 were: 96% for the standard of care, 97% for sodium bicarbonate, 90% for 1% lidocaine, and 90% for so

16 Adenosine triphosphate (ATP) inhibits sodium bicarbonate absorption in the proximal tubule, Na

17 1035aa) mediates the majority of basolateral sodium bicarbonate absorption.

18 ization of arterial acidosis via intravenous sodium bicarbonate (ACZ + HCO(3)(-) ; pH: -0.01 0.04 and

19 out acute restoration of pH (via intravenous sodium bicarbonate; ACZ+HCO(3)(-) ).

20 Hydration with 0.9% sodium chloride or 1.4% sodium bicarbonate administered with the same infusion p

21 respect to the timing and appropriateness of sodium bicarbonate administration during resuscitation.

22 n to supportive treatment with hydration and sodium bicarbonate administration, all patients were tre

23 ze eGFR Pilot Trial, we investigated whether sodium bicarbonate affects serum levels of bone turnover

24 Sodium bicarbonate, an alternative therapy used in Easte

25 bicarbonate (n=35), 1% lidocaine (n=35), or sodium bicarbonate and 1% lidocaine (n=35).

26 y weight per min of epinephrine, 2 mEq/kg of sodium bicarbonate and 10 mg/kg of calcium chloride) wer

27 There was no interaction between sodium bicarbonate and acetylcysteine with respect to th

28 oxygen-carrying compound or the components (sodium bicarbonate and hydrogen peroxide) of 1 mg/mL SPO

29 consecutive patients receiving prophylactic sodium bicarbonate and meeting the same inclusion criter

30 Intravenous sodium bicarbonate and oral acetylcysteine are widely us

31 randomized to receive tOPV with or without a sodium bicarbonate and sodium citrate buffer at age 6, 1

32 ripheral vertigo types that can benefit from sodium bicarbonate and the underlying mechanisms.

33 L volume of aqueous sample was buffered with sodium bicarbonate and treated with triethyloxonium tetr

34 ntrol group) and after drug (epinephrine and sodium bicarbonate) and saline infusions via one of the

35 oride (CPC), hydrogen peroxide (H(2) O(2) ), sodium bicarbonate, and antioxidants on periodontal/oral

36 ation was performed with drugs (epinephrine, sodium bicarbonate, and heparin), ventilation, either ca

37 apy administered consisted of ethyl alcohol, sodium bicarbonate, and nutritional supplements, with he

38 ine with a continuous flow of (13)C-enriched sodium bicarbonate, and the sodium persulfate oxidation

39 deficient propargylic alcohol to enone using sodium bicarbonate as a catalyst.

40 Sodium bicarbonate as a CO2-generating buffer, Carbicarb

41 ts (123/150) indicated they would administer sodium bicarbonate as part of ongoing resuscitation for

42 eived 154 mEq/L of either sodium chloride or sodium bicarbonate, as a bolus of 3 mL/kg per hour for 1

43 eved prediction accuracies exceeding 91% for sodium bicarbonate-based patterns.

44 e recovery of oil bodies from rapeseed using sodium bicarbonate-based soaking and grinding media (pH

45 Hydration with sodium bicarbonate before contrast exposure is more effe

46 he percentages of uranium desorbed by anoxic sodium bicarbonate between AH(2)DS-reacted and unreacted

47 lized by secretion into a high concentration sodium bicarbonate buffer (~100 mM).

48 nhancer of viral infection fibrils formed in sodium bicarbonate buffer remain stable over time, but s

49 ther CVD 1203 vaccine or placebo, along with sodium bicarbonate buffer, on days 0 and 14, as follows.

50 pressure-generating effervescent excipients (sodium bicarbonate, citric acid) and drug in a biodegrad

51 ese membrane regions CA IX co-localizes with sodium bicarbonate co-transporter (NBCe1) and anion exch

52 thepsin K activity, and both were reduced by sodium bicarbonate co-transporter (P </= 0.0001) and car

53 , persons with mutations in the electrogenic sodium bicarbonate co-transporter NBCe1 and mice lacking

54 The electrogenic sodium bicarbonate co-transporter NBCe1 has been localiz

55 and net hydrogen ion exporters, particularly sodium bicarbonate co-transporters and carbonic anhydras

56 ctivation, they modulate the activity of the sodium-bicarbonate co-transporter, leading to a hyperpol

57 helate iron, as iron chelation combined with sodium bicarbonate completely protected endothelial cell

58 verpotential was dependent on the catholyte (sodium bicarbonate) concentration, but not the salinity

59 both pNBC1- and kNBC1-mediated electrogenic sodium bicarbonate cotransport function were transfected

60 tubule cell line, deficient in electrogenic sodium bicarbonate cotransport function, was transfected

61 mosomal localization of the human pancreatic sodium bicarbonate cotransport protein (pancreatic NBC (

62 Sodium bicarbonate cotransport was studied in freshly di

63 on of pNBC in Xenopus laevis oocytes induced sodium bicarbonate cotransport.

64 d functional analysis of a new member of the sodium bicarbonate cotransporter (NBC) family, NBC3, fro

65 The electrogenic sodium bicarbonate cotransporter (NBC) is expressed in g

66 Anion exchanger (AE), sodium bicarbonate cotransporter (NBC), and CA were exam

67 d conclude that it is the renal electrogenic sodium bicarbonate cotransporter (NBC).

68 to and out of astrocytes by the electrogenic sodium bicarbonate cotransporter (NBCe1) played a crucia

69 The SLC4A4 gene encodes electrogenic sodium bicarbonate cotransporter 1 (NBCe1).

70 on exchanger 1 [hAE1] and human electrogenic sodium bicarbonate cotransporter 1 [hNBCe1]) with differ

71 a [K(+)], [Na(+)], but lower proximal (NHE3, sodium bicarbonate cotransporter 1, NaPi2) and higher di

72 ward HCO(3)(-) transport by the electrogenic sodium bicarbonate cotransporter 1, NBCe1.

73 These data demonstrate that pNBC encodes the sodium bicarbonate cotransporter in the mammalian pancre

74 he N terminus from the recently cloned human sodium bicarbonate cotransporter isolated from kidney (k

75 the renal proximal tubule, the electrogenic sodium bicarbonate cotransporter kNBC1 (1035aa) mediates

76 vitro to the C-terminus of the electrogenic sodium bicarbonate cotransporter kNBC1 (kNBC1-ct).

77 otransport stoichiometry of the electrogenic sodium bicarbonate cotransporter kNBC1 determines the re

78 The electrogenic sodium bicarbonate cotransporter kNBC1 mediates basolate

79 rminal transcripts of the human electrogenic sodium bicarbonate cotransporter NBC1 are encoded by the

80 requirement for H+ disposal mediated by the sodium bicarbonate cotransporter NBC3.

81 The electrogenic sodium bicarbonate cotransporter NBCe1 (SLC4A4) is a rob

82 mutations to the SLC4A4 gene (coding for the sodium bicarbonate cotransporter NBCe1), have pRTA, grow

83 SLC4A4 encodes the electrogenic sodium bicarbonate cotransporter NBCe1, a membrane prote

84 at encodes the widely-expressed electrogenic sodium bicarbonate cotransporter NBCe1, results in the b

85 The electrogenic sodium bicarbonate cotransporter NBCe1-A mediates the ba

86 of the Slc4a5 gene encoding the electrogenic sodium bicarbonate cotransporter NBCe2 results in signif

87 In pancreatic ducts, the electrogenic sodium bicarbonate cotransporter pNBC1 (1079aa) mediates

88 The electrogenic sodium bicarbonate cotransporter pNBC1 is believed to pl

89 ography of the human pancreatic electrogenic sodium bicarbonate cotransporter pNBC1 was investigated

90 he selective translational regulation of the sodium bicarbonate cotransporter SLC4A7.

91 he voltage dependence of the kinetics of the sodium bicarbonate cotransporter was studied in proximal

92 t evidence that a complex of an electrogenic sodium bicarbonate cotransporter with CAII functions as

93 The pancreatic variant of the sodium bicarbonate cotransporter, pNBC1, mediates basola

94 acterization of the membrane topography of a sodium bicarbonate cotransporter.

95 -(N-ethyl-N-isopropyl)-amiloride-inhibitable sodium bicarbonate cotransporter.

96 and 2 (NBCe1 and NBCe2), the electroneutral sodium-bicarbonate cotransporter (NBCn1), and the sodium

97 ansport by genetic knockdown of electrogenic sodium-bicarbonate cotransporter 1 (NBCe1) expression in

98 , and HS695T - and included the electrogenic sodium-bicarbonate cotransporter isoforms 1 and 2 (NBCe1

99 o the chloride channel CFTR and activate the sodium-bicarbonate cotransporter NBCe1-B by IRBIT.

100 the past year, cDNA for the human pancreatic sodium-bicarbonate cotransporter was cloned, and the exp

101 ysiological properties of the electroneutral sodium/bicarbonate cotransporter (NBCn1) that is present

102 ferent isoforms; NBCn1 [electrically neutral sodium/bicarbonate cotransporter 1] and NBCe1 [electroge

103 ate cotransporter 1] and NBCe1 [electrogenic sodium/bicarbonate cotransporter 1]), and a proton chann

104 lled by carbonic anhydrase 9 (CA9) and CA12, sodium bicarbonate cotransporters and an intracellular H

105 derstanding disorders involving electrogenic sodium bicarbonate cotransporters and facilitates the el

106 Several electrogenic sodium bicarbonate cotransporters have been cloned from

107 NBC1 (SLC4A4) gene encodes the electrogenic sodium bicarbonate cotransporters kNBC1 and pNBC1, which

108 tion of blood and urine using an infusion of sodium bicarbonate did not result in a decrease in the p

109 We found that alkaline pH or presence of sodium bicarbonate displays a synergistic effect with co

110 and more frequently received epinephrine and sodium bicarbonate during CPR.

111 f apical Na(+)-H(+) exchange and basolateral sodium bicarbonate efflux, through activation of protein

112 by in vivo intragastric titration with 0.3N sodium bicarbonate for 10 hours (1 hour before and 9 hou

113 ns or animals have evaluated the efficacy of sodium bicarbonate for prophylaxis against contrast-indu

114 We focused on use of N-acetylcysteine or sodium bicarbonate for the prevention of contrast-induce

115 AM appears to be an effective alternative to sodium bicarbonate for treating acidosis during ALI.

116 n aqueous DMSO in the presence of oxygen and sodium bicarbonate gave heteroaryl- (aryl-) 1,2-ethanedi

117 common in diphenhydramine groups than in the sodium bicarbonate group (moderate lethargy: group A, 38

118 he primary end point was met in 13.3% of the sodium bicarbonate group and 14.6% of the sodium chlorid

119 215 patients (47% [95% CI, 40%-53%]) in the sodium bicarbonate group and 93 of 212 patients (44% [95

120 curred in 110 of 2511 patients (4.4%) in the sodium bicarbonate group as compared with 116 of 2482 (4

121 standard-of-care group, 15.4 (14.4) for the sodium bicarbonate group, 4.6 (4.5) for the 1% lidocaine

122 Injection discomfort was more common with sodium bicarbonate (group A, 8.0% [6 of 75]; group B, 17

123 oup A), 66.4 mEq (approximately 1 mEq/kg) of sodium bicarbonate (group B), or both agents (group C).

124 oL was decreased in both the control and the sodium bicarbonate groups of the BICAR-ICU trial and was

125 Sodium bicarbonate has been suggested as a possible stra

126 scent formulations of paracetamol containing sodium bicarbonate have been reported to associate with

127 or HC (80 Torr), +/- tromethamine (THAM) or sodium bicarbonate (HCO3) +/- AC probes in a micropunctu

128 KIC, sodium pyruvate (PYR), or sodium bicarbonate (HCO3) was infused continuously intra

129 ock, whereas 58.3% (88/151) would administer sodium bicarbonate in a cardiac arrest scenario (p=0.004

130 ntly accelerated in alkaline buffers such as sodium bicarbonate in combination with elevated temperat

131 Sodium bicarbonate increased serum levels of alpha-kloth

132 While sodium bicarbonate increases the strong ion difference b

133 Sodium bicarbonate induced a dose-dependent increase in

134 Previous studies have shown that sodium bicarbonate induces CT expression in the V. chole

135 nsporter pNBC1 (1079aa) mediates basolateral sodium bicarbonate influx.

136 O(2) reactivity) prior to and following i.v. sodium bicarbonate infusion (NaHCO(3)(-) ) to acutely el

137 Sodium bicarbonate versus no sodium bicarbonate infusion according to the randomizati

138 if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of ca

139 only (n = 6), saline infusions only (n = 6), sodium bicarbonate infusions only (n = 8), and epinephri

140 s only (n = 8), and epinephrine, saline, and sodium bicarbonate infusions through the same site (n =

141 with nonoliguric renal failure and isotonic sodium bicarbonate infusions to prevent radiocontrast me

142 Despite lack of evidence, sodium bicarbonate is frequently used to correct pH; how

143 Pretreatment with sodium bicarbonate is more protective than sodium chlori

144 his study do not suggest that hydration with sodium bicarbonate is superior to hydration with sodium

145 ride but in only 1 (1.7%) of those receiving sodium bicarbonate (mean difference, 11.9%; 95% confiden

146 hold at or below which they would administer sodium bicarbonate (mean, 6.94+/-0.013; median, 7.00; ra

147 receive either sodium chloride (n = 178) or sodium bicarbonate (n = 175) administered at the same ra

148 ts were randomly allocated to receive either sodium bicarbonate (n = 215) or sodium chloride (n = 212

149 ction of Tc-sulfur colloid containing either sodium bicarbonate (n=35), 1% lidocaine (n=35), or sodiu

150 Prospective interventional trials with sodium bicarbonate (NaHCO 3 ) are lacking.

151 randomized, controlled trial, treatment with sodium bicarbonate (NaHCO 3 ) did not improve vascular e

152 ease in arterial pH generated by infusion of sodium bicarbonate (NaHCO(3) ), and completely abrogated

153 a: +5, +10 mmHg) prior to and following i.v. sodium bicarbonate (NaHCO(3)(-) ; 8.4%, 50 mEq 50 mL(-1)

154 Oral sodium bicarbonate (NaHCO(3)) may preserve kidney functi

155 (NaOH), chromium sulphate (Cr(2)SO(4)), and sodium bicarbonate (NaHCO(3)).

156 ctic regimes (1) N-acetylcysteine (NAC), (2) sodium bicarbonate (NaHCO3) infusion, (3) NAC in combina

157 On a separate day, group II also received a sodium bicarbonate (NaHCO3) infusion, thus serving as th

158 ies: saline, statin, N-acetylcysteine (NAC), sodium bicarbonate (NaHCO3), NAC+NaHCO3, ascorbic acid,

159 e the main ingredient of the Archean sea was sodium bicarbonate, neither archeobacteria nor eubacteri

160 apy, acetylsalicylic acid, N-acetylcysteine, sodium bicarbonate, off-pump coronary revascularization,

161 cant effect of treatment with either dose of sodium bicarbonate on any of the other bone biomarkers,

162 We investigated the effect of treatment with sodium bicarbonate on bone turnover markers and other fa

163 valuate the efficacy of calcium chloride and sodium bicarbonate on return of spontaneous circulation

164 for angiography to receive intravenous 1.26% sodium bicarbonate or intravenous 0.9% sodium chloride a

165 0 mmol/L to either supplementation with oral sodium bicarbonate or standard care for 2 yr.

166 Administration of N-acetylcysteine, sodium bicarbonate, or physiologic saline did not influe

167 ography, there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or o

168 y associated with the decision to administer sodium bicarbonate (p<0.0001).

169 9 [0.69] mg/dL [167.1 [61.0] micromol/L] for sodium bicarbonate; P =.09).

170 cardiovascular events from short-term use of sodium bicarbonate paracetamol in routine clinical pract

171 he 1% lidocaine group, and 3.4 (5.1) for the sodium bicarbonate plus 1% lidocaine group (p<0.0001).

172 carbonate, 90% for 1% lidocaine, and 90% for sodium bicarbonate plus 1% lidocaine group (p=0.56).

173 Rapid intravenous hydration with sodium bicarbonate plus N-AC before contrast injection i

174 6 patients (group A) received an infusion of sodium bicarbonate plus N-acetylcysteine (N-AC) started

175 Effect of no prehydration vs sodium bicarbonate prehydration prior to contrast-enhanc

176 Paratyphi A following sodium bicarbonate pretreatment at 1 of 2 dose levels (g

177 Sodium bicarbonate protected tryptophan hydroxylase from

178 stable renal function, the benefit of using sodium bicarbonate rather than isotonic sodium chloride

179 II (AngII) directly affects proximal tubular sodium-bicarbonate reabsorption in a biphasic manner, wh

180 AT1 receptor subtype mediates AngII-induced sodium-bicarbonate reabsorption primarily through adenyl

181 elect components, notably sodium acetate and sodium bicarbonate, restored the levels of several prote

182 o mucormycosis, but not aspergillosis, while sodium bicarbonate reversed this susceptibility.

183 To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscita

184 Current evidence regarding the effect of sodium bicarbonate (SB) on patients with out-of-hospital

185 ecursor consisting of ethanol and FeCl2, and sodium bicarbonate (SBC) as a bubble-generating agent.

186 The 2017 sodium bicarbonate shortage occurred between 8 June and

187 Administration of sodium bicarbonate significantly increased the number of

188 Sodium bicarbonate significantly increased the number of

189 h-flux hemodialysis membranes, interdialytic sodium bicarbonate, SNF472, spironolactone, sotatercept,

190 aine, methylene blue, naloxone, pralidoxime, sodium bicarbonate, sodium nitrite, sodium thiosulfate,

191 cit inclusion of the base (in situ generated sodium bicarbonate/sodium biphosphate) is found to be en

192 of Ph3P, alpha-bromoesters, and aldehydes in sodium bicarbonate solution (at 20 degrees C for 40 min

193 on the molarity of medium used; the use of a sodium bicarbonate solution (pH 9.5, 0.1M) in the grindi

194 typhoid-naive volunteers when ingested with sodium bicarbonate solution.

195 received a high dose of N-acetylcysteine and sodium bicarbonate solution.

196 N-acetylcysteine, sodium bicarbonate, statins, and ascorbic acid have been

197 lysis was also prevented by feeding CRF rats sodium bicarbonate, suggesting that activation depends o

198 In the golden Syrian hamster model, p.o. sodium bicarbonate supplementation (5 mg/ml in drinking

199 o studies support intestinal alkalization by sodium bicarbonate supplementation as a preventive mecha

200 gastrointestinal lumen, unlike current oral sodium bicarbonate therapy for metabolic acidosis that o

201 cal characteristics and treatment (including sodium bicarbonate therapy) between the two groups.

202 uential infusions of fluid, epinephrine, and sodium bicarbonate through a single intraosseous site.

203 infusions of epinephrine, fluid boluses, or sodium bicarbonate through the intraosseous sites on the

204 Reduction in sodium bicarbonate titrant use in the 2 treatment groups

205 help them in deciding whether to administer sodium bicarbonate to critically ill patients, and 84% w

206 PS was treated with acetic acid and sodium bicarbonate to improve pallatability.

207 Sodium bicarbonate to improve physical function in patie

208 ecommend administrating calcium chloride and sodium bicarbonate to patients with hyperkalemia-induced

209 ng a colleague's likelihood of administering sodium bicarbonate to the same patient under the same ci

210 ift in the direction of basolateral membrane sodium bicarbonate transport from efflux to influx.

211 SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted e

212 odium-potassium ATPase transporter (ATP1A1), sodium-bicarbonate transporter (NBC), and carbonic anhyd

213 e chloride-bicarbonate exchanger AE2 and the sodium-bicarbonate transporter NBC1.

214 cent report suggests that the acid-extruding sodium/bicarbonate transporter NBCn1 (Slc4a7) in rat bra

215 the mechanism for ion transport through the sodium/bicarbonate transporter SLC4A4 (NBCe1), we examin

216 tatistically different in patients receiving sodium bicarbonate treatment (mean [SD], 1.71 [0.42] mg/

217 ividuals with CKD and total CO2 20-28 mEq/L, sodium bicarbonate treatment increased serum klotho leve

218 alizing the acidic extracellular tumor pH by sodium bicarbonate treatment suppresses IFN-gamma-induce

219 onate were associated with a reduction in IV sodium bicarbonate use among critically ill patients wit

220 gment of disparate practices with respect to sodium bicarbonate use.

221 ence that was not statistically significant: sodium bicarbonate versus IV saline in patients receivin

222 Sodium bicarbonate versus no sodium bicarbonate infusion

223 The difference (sodium bicarbonate versus placebo) in mean change of eac

224 In patients randomized to receive sodium bicarbonate vs sodium chloride, the rates of deat

225 e pH-corrected group (n = 5), 14.4 mEq/kg of sodium bicarbonate was given intravenously as a bolus to

226 ance of our findings, oral administration of sodium bicarbonate was sufficient to increase peritumora

227 that accompanied a worldwide shortage of IV sodium bicarbonate were associated with a reduction in I

228 In the presence of 25 mM sodium bicarbonate, which is known to accelerate the rat

229 ssion was reduced by systemic treatment with sodium bicarbonate, which raises intratumoral pH.

230 s, P+ was reduced by iron in the presence of sodium bicarbonate with dissociation constants of approx

231 containing the cold precursors THP-PSMA and sodium bicarbonate, with no further manipulation.

232 ction of blood pH with the administration of sodium bicarbonate, without adverse effects on hemodynam