ライフサイエンスコーパス: sodium-hydrogen exchanger

1 increased pHi by selective activation of the sodium/hydrogen exchanger.

2 s been previously shown to interact with the sodium hydrogen exchanger 1 (NHE1), a major regulator of

3 anilloid receptor antagonist capsazepine, or sodium-hydrogen exchanger 1 (NHE-1) inhibitor dimethyl a

4 decreases the H/R-induced phosphorylation of sodium-hydrogen exchanger 1 (NHE1), and inhibition of NH

5 We examined roles of sodium-hydrogen exchanger 1 (NHE1), protein kinase C (PK

6 This, in turn, activates sodium-hydrogen exchanger 1 (NHE1), resulting in elevate

7 The sodium/hydrogen exchanger 1 (NHE-1) is linked to the cyt

8 grin expression and impaired activity of the sodium/hydrogen exchanger 1, a known regulator of skin p

9 ecule-4, glucose transporter-4, Na-K-ATPase, sodium/hydrogen exchanger 1, glycophorin A, CD47, Duffy,

10 expressed the glucose transporter-1 and the sodium-hydrogen exchanger-1, both of which were associat

11 Inhibition of sodium hydrogen exchanger 2 (NHE2) caused significant de

12 Sodium hydrogen exchanger 2, although essential for repa

13 ocyte brush-border ion transporter proteins (sodium hydrogen exchanger 2, sodium hydrogen exchanger 3

14 ll interfering RNA (siRNA) screen identified sodium hydrogen exchanger 3 (NHE3) as required for effic

15 pical levels and diffuse subapical levels of sodium hydrogen exchanger 3 and SGLT1, which regulate tr

16 orter proteins (sodium hydrogen exchanger 2, sodium hydrogen exchanger 3, aquaporin 7, sodium iodide

17 ral observations suggesting inhibition of PT sodium hydrogen exchanger 3.

18 inistration of tenapanor or other intestinal sodium-hydrogen exchanger 3 inhibitors increased fecal p

19 ically available inhibitor of the intestinal sodium-hydrogen exchanger 3, is being evaluated in clini

20 ween the degree of upregulation of SGLT2 and sodium-hydrogen exchanger 3, the extent to which downstr

21 n a manner consistent with inhibition of the sodium-hydrogen exchanger 3.

22 mines the role of Pyk2 in acid regulation of sodium/hydrogen exchanger 3 (NHE3) activity in OKP cells

23 mma (PLC-gamma) contributes to regulation of sodium/hydrogen exchanger 3 (NHE3) in the small intestin

24 mally absorbed inhibitor of gastrointestinal sodium/hydrogen exchanger 3 (NHE3), reduces paracellular

25 inulin clearance and cortical expression of sodium/hydrogen exchanger 3 and attenuated the increased

26 ells, internalization/inactivation of NHE-3 (sodium-hydrogen exchanger-3) and Na(+)/K(+)ATPase (sodiu

27 The sodium-hydrogen exchanger 6 (NHE6), a protein mainly exp

28 Hypothesizing that a sodium-hydrogen exchanger 6 deficiency would most likely

29 As a result, we found that sodium-hydrogen exchanger 6 depletion leads to abnormal

30 Importantly, these findings show that sodium-hydrogen exchanger 6 loss of function in the Slc9

31 ly 9 isoform 6 on chromosome Xq26.3 encoding sodium-hydrogen exchanger 6, a protein mainly expressed

32 Sodium/hydrogen exchanger-6 is thought to participate in

33 y 9, isoform A6 (SLC9A6 gene), which encodes sodium/hydrogen exchanger-6 localized to endosomal vesic

34 Sodium/hydrogen exchanger and epithelial sodium channel,

35 cerate mutase B], ion regulation (members of sodium/hydrogen exchanger and sodium/bile acid cotranspo

36 ired autophagy and increased activity of the sodium-hydrogen exchanger, contribute to progressive glo

37 ride, a potent and specific inhibitor of the sodium-hydrogen exchanger, has been shown to reduce intr

38 Activation of the sodium-hydrogen exchanger in the heart and vasculature (

39 Therefore, sodium-hydrogen exchanger inhibitors may provide new opt

40 sweat gland, which most likely represents a sodium:hydrogen exchanger involved in regulation of intr

41 The activity of sodium-hydrogen exchanger is markedly increased in patie

42 sized and evaluated for activity against the sodium hydrogen exchanger isoform-1 (NHE-1).

43 t increase levels of the amiloride-sensitive sodium-hydrogen exchanger isoform 1 (NHE-1), intracellul

44 Sodium-hydrogen exchanger isoform 1 (NHE1) is a ubiquito

45 Expression of sodium-hydrogen exchanger isoform 3 (NHE3) in the intest

46 sphoprotein 50 kD/regulatory cofactor of the sodium-hydrogen exchanger isoform 3 (NHERF-1), actin, an

47 Sodium-hydrogen exchanger isoform-1 (NHE-1) activation w

48 tigate whether inhibition of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) could facili

49 Activation of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) in response

50 To investigate whether sodium-hydrogen exchanger isoform-1 (NHE-1) inhibition a

51 Inhibition of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) is emerging

52 investigated whether cariporide-a selective sodium-hydrogen exchanger isoform-1 inhibitor-could amel

53 lly absorbed small molecule inhibitor of the sodium/hydrogen exchanger isoform 3 that functions in th

54 characteristic inhibitor of plasma membrane sodium hydrogen exchanger isoforms, but was inhibited by

55 Therefore, the sodium-hydrogen exchanger may play a central role in the

56 n of proximal colon solute carrier family 9 (sodium/hydrogen exchanger), member 3 (SLC9A3) together w

57 g the monocarboxylate transporter (MCT), the sodium hydrogen exchanger (NHE), and V-Type ATPase media

58 ficacy of ischemic preconditioning (IPC) and sodium-hydrogen exchanger (NHE)-1 inhibition to reduce i

59 The type 1 sodium-hydrogen exchanger (NHE-1) is a ubiquitous electr

60 show phosphorylation of the plasma membrane sodium-hydrogen exchanger NHE1 by Akt increases exchange

61 nges at invadopodia that are mediated by the sodium-hydrogen exchanger NHE1.

62 grin expression and impaired activity of the sodium/hydrogen exchanger NHE1, a known regulator of ski

63 The "housekeeping" sodium/hydrogen exchanger, NHE1, mediates the electroneu

64 protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3.

65 Sodium/hydrogen exchangers (NHEs) are ubiquitous ion tra

66 sts involvement of a predicted P. falciparum sodium-hydrogen exchanger (pfnhe-1) on chromosome 13.

67 tudy, we have shown that an inhibitor of the sodium/hydrogen exchanger prevented calpain activation a

68 t was demonstrated that expression of murine sodium hydrogen exchanger regulatory factor (NHERF-1) la

69 odium phosphate cotransporter 2a (NPT2A) and sodium hydrogen exchanger regulatory factor-1 (NHERF1)-m

70 nase A requires a protein co-factor from the sodium-hydrogen exchanger regulatory factor (NHERF) fami

71 The sodium-hydrogen exchanger regulatory factor (NHERF) is a

72 h its interactions with scaffolding proteins sodium-hydrogen exchanger regulatory factor (NHERF)1 to

73 We examined whether the scaffolding protein sodium-hydrogen exchanger regulatory factor 1 (NHERF1) i

74 a2AR interacts with ezrin-binding protein 50/sodium-hydrogen exchanger regulatory factor, a PDZ-domai

75 of the beta2AR with ezrin-binding protein 50/sodium-hydrogen exchanger regulatory factor, N-ethylmale

76 The phosphorylation of the sodium-hydrogen exchanger regulatory factor-1 (NHERF-1)

77 rane vesicles and proximal tubule cells from sodium-hydrogen exchanger regulatory factor-1 (NHERF-1)-

78 irst PDZ domain of the Npt2a-binding protein sodium-hydrogen exchanger regulatory factor-1 (NHERF-1).

79 discs large/zona occluden-1 (PDZ) domains of sodium-hydrogen exchanger regulatory factor-1 (NHERF1) a

80 Sodium-hydrogen exchanger regulatory factor-1-deficient

81 The sodium-hydrogen exchanger regulatory factors (NHERF-1 an

82 (EBP50), a PDZ domain protein, also known as sodium/hydrogen exchanger regulatory factory type 1 (NHE

83 Deletion of Epac1 and Epac2 decreases sodium-hydrogen exchanger type 3 expression in the proxi

84 Instead, sodium-hydrogen exchanger type 3 levels in the proximal

85 dneys, SGLT2 functionally interacts with the sodium-hydrogen exchanger, which is responsible for the

86 NHA2 is a sodium/hydrogen exchanger with unknown physiological fun