ライフサイエンスコーパス: solubility

1 anges other properties of the peptide (e.g., solubility).

2 NC-45B mutants showed changes in folding and solubility.

3 e been hampered due to its unexpectedly poor solubility.

4 ion or permeation, noting the impact of poor solubility.

5 n (ADME) data showed relatively poor aqueous solubility.

6 ous hydrolysis in the dark, and good aqueous solubility.

7 erivatives with reduced toxicity or enhanced solubility.

8 nly controlled by the influence of pH on AFO solubility.

9 followed by fractionation based on size and solubility.

10 actions which benefit from enhanced hydrogen solubility.

11 side] with excellent metabolic stability and solubility.

12 the polarity, sensitivity to light, heat and solubility.

13 ysis was 5.4% corresponding to 55.2% protein solubility.

14 lation technique for drugs with poor aqueous solubility.

15 uct was achieved with a noteworthy change of solubility.

16 ith NP and MP42 greatly improved the protein solubility.

17 nry's Law constant, vapor pressure and water solubility.

18 ations have been limited by its poor aqueous solubility.

19 e bacterial surface and truncated to improve solubility.

20 pplications are restricted by its poor water solubility.

21 y normalization of TDP-43 ubiquitylation and solubility.

22 rrestin 2), metabolic stability, and aqueous solubility.

23 ir standard reduction potentials and aqueous solubility.

24 reomeric borates as a result of differential solubilities.

25 half-life in rodents (1.7 h) and low aqueous solubility (27 muM), limiting its use in animal models o

26 oaccessibility (-56%, p <= 0.05) and mineral solubility (-28% for iron, p <= 0.05) compared with meal

27 after extraction in this condition had good solubility (40-80% at pH 5-8), functional properties (fo

28 To improve its aqueous solubility, 5 and its two enantiomers were synthesized a

29 protein content (69.08% d.b) as well as high solubility (98.71% at pH 7.5).

30 age-dependent loss of intracellular protein solubility, a delayed and rapid appearance of high molec

31 Protein solubility, accessible thiols and secondary structures w

32 alkynyl substituent favorably tunes catalyst solubility, aggregation, and conformation while modulati

33 ation is sometimes limited due to poor water solubility, aggregation, photodegradation, and slow clea

34 ate, hydrofurimazine, whose enhanced aqueous solubility allows delivery of higher doses to mice.

35 hesis directly from biomass itself and their solubility allows for good interactions with the insolub

36 n order to predict drug exposure relative to solubility along the nephron.

37 Also, this film had the lowest solubility among all of them.

38 AITC surface exchange rate and the AITC fat solubility, an overall picture of the factors influencin

39 onide weak acids have relatively low aqueous solubilities and high protein binding values.

40 both molecules that show tendencies of good solubilities and molecules that do not.

41 The low solubility and aggregation properties of HIV-1 integrase

42 bile in soil and groundwater due to its high solubility and anionic nature, yet little is known about

43 the drug at high dose, improvements in both solubility and antibacterial activity in vivo were prior

44 ive than HP-beta-CyD in order to enhance the solubility and antioxidant property of curcumin in Curcu

45 s as well as Fe and S species, affecting the solubility and bioavailability of each other.

46 ss of Antares in mice is limited by the poor solubility and bioavailability of the NanoLuc substrate

47 ortionation-can have a drastic effect on the solubility and consequently the bioavailability of a dru

48 ms hemihydrate crystal, which has much lower solubility and dissolution rate than commercial powder r

49 al efforts to generate analogs with improved solubility and enhanced potency.

50 drugs is a significant challenge due to poor solubility and formulation difficulty.

51 Control of hardness, flexibility, solubility and function of the material were also demons

52 subunits significantly compromises ferritin solubility and function, providing a rationale for the p

53 Additional solubility and in vitro metabolic stability profiling re

54 Cooking significantly lowered protein solubility and induced exposure of thiol groups as well

55 easurements of water binding capacity, water solubility and intrinsic viscosity, that OSA addition ch

56 n structure but led to a decrease in protein solubility and iron storage.

57 However, reb B suffers from poor aqueous solubility and low dissolution rate, which greatly limit

58 XR-induced liver toxicity, poor drug aqueous solubility and low levels of endogenous HDL acceptors in

59 tical limitations (aggregate formation, poor solubility and low stability) when included in the aqueo

60 Darapladib has very low solubility and mainly exists in solutions as complexes w

61 ghly polar functional groups leading to high solubility and metabolic stability but occasionally at t

62 e spiroadamantane substructure increased the solubility and metabolic stability, but in all cases dec

63 , ligand efficiency > 0.43, and good aqueous solubility and metabolic stability, thus offering excell

64 exed to organic ligands, which increase iron solubility and microbial availability, understanding the

65 roduced physicochemical relationship between solubility and molecular properties in different solvent

66 and multiple pharmacophores while retaining solubility and oral bioavailability, and achieving circu

67 data clearly showed improvements in aqueous solubility and other properties compared with those for

68 icated by inhibition of cholesterol micellar solubility and pancreatic lipase activity, was recorded.

69 Consequently, the 2019 deck relies on solubility and permeability to select preferred compound

70 a in the low micromolar range, high in vitro solubility and permeability, and excellent microsomal st

71 mical space, in turn, will also improve drug solubility and pharmacokinetic profiles.

72 Perturbations to viscoadaptation affect solubility and phase separation, suggesting that viscoad

73 However, they have been limited by low solubility and poor stability of active materials.

74 unds such as 13 and 30, which exhibited high solubility and potent efficacy against Gram-negative pat

75 TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency.

76 that play vital roles in maintaining protein solubility and preventing aberrant protein aggregation.

77 he suitable solvent in terms of curcuminoids solubility and proper resolution of peak.

78 tion to BODIPY photocages that imparts water solubility and provides control over cellular permeabili

79 All three MXene systems show unlimited solubility and random distribution of metal elements in

80 complex biological systems; however, protein solubility and sample preparation before MS remain a bot

81 3tDMG shows improved solubility and solution processability as compared to 2t

82 l single-residue mutation resulted in robust solubility and stability of an active ERRbeta ligand-bin

83 fied to incorporate amino-amides to increase solubility and stability while retaining biological acti

84 network robustly maintains misfolded protein solubility and stress resilience through high levels of

85 nd infrared), differently affect the protein solubility and the IgE-binding capacities of both the so

86 near relationship was observed between CO(2) solubility and the moisture-to-protein ratio of experime

87 solution is challenging because of their low solubility and the often hindered cyclodehydrogenation r

88 e; however, they are often restrained by the solubility and the undesired aggregation-caused quenchin

89 vance our understanding of the controls on U solubility and thus improve prediction of U transport in

90 ly used in cancer treatments, but poor water-solubility and toxicity raise serious concerns.

91 However, their application was limited by solubility and undesirable burst drug release.

92 er vapor permeability (WVP), swelling, water solubility and UV-vis light transmittance have also been

93 erties such as low water vapor permeability, solubility and water holding capacity, showing great pot

94 ing U reduction exert a central control on U solubility and, therefore, U transport and its associate

95 ver, cell walls contain fractions of varying solubilities, and a few techniques are available that ca

96 ed lead 13 resolves previous atropisomerism, solubility, and Caco-2 efflux liabilities.

97 the formation of small aggregates, improved solubility, and digestibility with strong gel forming be

98 ures and properties, high conductivity, good solubility, and excellent stability.

99 to control POM self-assembly, stabilization, solubility, and function.

100 different roles in the body depending on its solubility, and in diseased states such as RA, deposited

101 ification of (R)-27, which balanced potency, solubility, and lipophilicity to allow proof-of-concept

102 response, lipophilic efficiency, and aqueous solubility, and lowers cLogP by one log unit compared to

103 a) measurements, considerations of framework solubility, and powder X-ray diffraction analysis.

104 dings reveal key differences in translation, solubility, and protein aggregation of DPRs between c9AL

105 ith desirable results in thickness, opacity, solubility, and water vapor transmission rate (WVTR) ana

106 because it precipitates with calcium as low-solubility apatite minerals.

107 The solubilities are dependent on the nature of the side gro

108 ecules with good chemical stability and high solubility are still desired for high-performance aqueou

109 al novel EP2 antagonists with improved water solubility, brain penetration, high EP2 potency, and sel

110 ical pH-shift process by diminishing protein solubility, but still, the alkaline process version was

111 tunable electronic properties and high water-solubility, but they are often difficult to synthesize a

112 In our effort to enhance its solubility by using natural means, we discovered that un

113 osity, density, surface tension, volatility, solubility, chemical reactivity, and many other importan

114 r of its chemistry-impacting reaction rates, solubility, chemical speciation, and homeostasis.

115 termine the pH-solubility profile, intrinsic solubility, common-ion effect, pK(a), pH(max), and K(sp)

116 hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7

117 es were enabled by a substantial increase in solubility compared to previously analyzed beta-peptoid

118 and significantly (P < 0.05) correlated with solubility, cooking loss and protein digestibility.

119 Our results indicate that water solubility could function as a limiting factor for bioac

120 en for fully layered cases, the large mutual solubility could make the boundary between rock and ice

121 dissolution were obtained using experimental solubility data, which demonstrated that the dissolution

122 It was possible to increase solubility, decrease protein binding, and maintain the h

123 In this study, the solubility, density and viscosity of sorbitol as a sugar

124 p" undesirable properties, and improve their solubility, dispersion, and bioavailability.

125 hance imaging performance by promoting water solubility, eliminating probe self-aggregation, and incr

126 s (water-holding and oil-binding capacities, solubility, emulsifying and foaming properties) of EPSC

127 umin than Finland trityl, and a high aqueous solubility even at acidic pH.

128 eutral molybdate wheels as confirmed by BVS, solubility experiments, and redox titrations.

129 cystine is potentially toxic due to its low solubility, forcing cancer cells with high levels of SLC

130 However, due to their high solubility, gums have been assumed to dissolve before fo

131 s resulting from their poor absorption, poor solubility, high first-pass metabolism, and efficient ef

132 a natural bioactive compound with poor water-solubility, however, the phase solubility test and disso

133 apparent modulus of elasticity and collagen solubility (hydroxyproline release).

134 energy for each quinone, which indicates the solubility in aqueous solution, was calculated at the sa

135 In order to ensure appropriate solubility in aqueous solution, we proved the need for e

136 Curcumin solubility in binary mixtures consisting of ethanol/tria

137 sed rings are realized, which exhibited good solubility in common organic solvents.

138 , morphology, charge on proteins and reduced solubility in comparison to APIc due to processing.

139 , would occur due to greatly enhanced oxygen solubility in lipids, especially near the midplane of li

140 We hypothesized that EGFP's low solubility in mammalian systems must limit the total flu

141 high lattice energy of this salt and its low solubility in many polar aprotic solvents.

142 he phosphine carboxylate while also allowing solubility in organic solvents whereas phosphorus functi

143 We attribute this to enhanced product solubility in the aqueous or solvent fraction of the bio

144 iP) and calnexin/calreticulin, promote FVIII solubility in the ER, where the former is also required

145 glomerates and particle size, improve the Ca solubility in the intestinal media, explaining the simil

146 ntly rescued S-opsin trafficking and M-opsin solubility in the KI retinas.

147 Such a pH change reduces ionic solubility in the suspending media to permit precipitati

148 thiuram disulfide (TETD) molecule shows high solubility in various common organic solvents and achiev

149 rties, structural tunability, stability, and solubility in various media is expected to find applicat

150 NA strand transfer activity and improves its solubility in vitro.

151 arger particles (d(50)27% larger), 12% lower solubility in water and perceptible color changes.

152 R848 is poorly tolerated because of its poor solubility in water and systemic immune activation.

153 However, their low solubility in water limits their use.

154 tion is hampered by its high volatility, low solubility in water, and susceptibility to light, heat a

155 ing capacity, swelling capacity, and protein solubility in water.

156 he films; however, its addition reduced film solubility in water.

157 re due to its atypical temperature dependent solubility in water.

158 ationalized in a decrease of their effective solubilities, in particular for proteins associated with

159 Solubility increased as a function of degree of hydrolys

160 g the molecular structure of azobenzene, the solubility is favorably improved from near zero to 2 M d

161 the FGFR4 potency, metabolic stability, and solubility leading ultimately to the highly selective fi

162 imethylammonium concentration approaches the solubility limit in MAPbBr(3), we observe the disappeara

163 olerant to levels of aromatic acids near the solubility limit were then analyzed by whole genome sequ

164 distributed randomly if they are below their solubility limit, or to form secondary phases if they ar

165 effects of high-entropy alloys; the extended solubility limit, the tendency to form a high-symmetry c

166 appointingly low bio-availability because of solubility-limited absorption.

167 The determination of solubility limits of compounds in water is unprecise and

168 precise and fast determination of intrinsic solubility limits of organic compounds in aqueous soluti

169 ed on potentiometric titrations to determine solubility limits of various organic compounds by exploi

170 n adult animals are close to their intrinsic solubility limits, indeed exceeding them by about 10% on

171 n, it is possible to determine the intrinsic solubility limits, which are independent of the pH value

172 for probing gel transitions outside of bulk solubility limits, with relevant applications ranging fr

173 pressed at concentrations safely below their solubility limits.

174 and functional self-assembly influence these solubility limits.

175 roteins remains challenging due to their low solubility, low abundance, and the complexity of the mem

176 linear AMPs into a new generation with high solubility, low cytotoxicity, potent broad-spectrum ster

177 ntact angle measurements, and water sorption/solubility measurements.

178 pounds act as topoII poison and exhibit good solubility, metabolic (microsomal) stability, and promis

179 l ring and properties such as lipophilicity, solubility, metabolic stability, and free fraction could

180 The 2-oxaadamantane 22, which has a good solubility, microsomal stability, and selectivity for sE

181 elations among chemical compositions, mutual solubilities of constituent elements, phase instability,

182 CH-3-8 is hydrophobic with an aqueous solubility of 0.97 +/- 0.16 mug/mL at pH 7.4.

183 slow binding kinetics, low potency, and poor solubility of 10E8.

184 Of these, 57, with EC(50) = 145 nM and a solubility of 33 muM, showed high clearance in vivo but

185 In contrast, 63, with EC(50) = 162 nM and a solubility of 9 muM, showed lower clearance and seems be

186 s and nanoparticles, that increase the water solubility of anticancer drugs for injection.

187 Removal of the MTS increased solubility of BCO2a when expressed in Escherichia coli a

188 The solubility of both proteins were found to be lower at pH

189 The solubility of carbon dioxide (CO(2)) in the moisture and

190 methodology was applied to overcome the low-solubility of cellulose compounds.

191 at pH 1, 2, 8, 9 and 10; at certain pH, the solubility of CHD protein was higher than that of the FD

192 The poor solubility of chitosan (CS) was improved by succinic anh

193 er mobility that resulted from enhancing the solubility of chlorine by replacing some of the iodine w

194 rature and salt-in-moisture content, whereas solubility of CO(2) increased with increasing pH.

195 r operating temperature, which increases the solubility of common scalants and decreases salt precipi

196 Concerning the high solubility of curcumin in the examined ternary mixtures,

197 d artificial saliva) revealed that the water-solubility of curcumin was prominently improved by inclu

198 d its immediate effect on the morphology and solubility of dissolving species.

199 extrin, a clinical agent used to enhance the solubility of drugs, activates TFEB and inhibits AAA for

200 The solubility of F1, F2, and F3 was >= 95% at pH 7.

201 Hydrolysis improved solubility of faba proteins at acidic and neutral pH, an

202 The nanostructures improve the solubility of food ingredients in vivo, along with enhan

203 The solubility of four novel BTZ compounds (IR 20, IF 274, F

204 very limited current density due to the low solubility of gas reactant(s).

205 is a well-established method to increase the solubility of ionizable drug candidates.

206 Our results also show that despite the low solubility of isoprene in water, aqueous-phase or multip

207 Ion identity and concentration influence the solubility of macromolecules.

208 Asp) and glutamic acid (Glu) can enhance the solubility of many poorly soluble drugs including ciprof

209 First, the binding properties and solubility of metal-mimosine complexes were assessed thr

210 itride appears to be facilitated by the high solubility of nitrogen in manganese metal, while its str

211 excellence, but its high polarity limits the solubility of non-polar compounds.

212 o access synthetically owing to poor aqueous solubility of one or more of the fragments under typical

213 The other is the low solubility of organic substrates, intermediates, and pro

214 solubility were counteracted by increases in solubility of other proteins.

215 ver a six-month time period, and exceptional solubility of over 700 mg/mL in the DMSO formulation sol

216 anoparticles as carriers increases the water-solubility of paclitaxel by 32,000-fold.

217 To address this issue, the solubility of poly(N-isopropylacrylamide), a thermorespo

218 oped a solvent-free method for improving the solubility of quercetin in Coil and enhance its oxidativ

219 pids (0-20 mg/g) was assessed to improve the solubility of quercetin in Coil and enhance its oxidativ

220 Results showed that the solubility of quercetin in Coil increased up to 7.7-fold

221 The solubility of quercetin in Coil was correlated to the ph

222 Finally, the solubility of quercetin in the DESs was higher than in w

223 Also, the solubility of quercetin in water and in the two eutectic

224 As a second aim, the solubility of quercetin was determined.

225 The CO(2) solubility of samples decreased linearly with both incre

226 w guidance on current efforts to enhance the solubility of SGs.

227 Rapid solidification increased the solubility of silicon in aluminum to approximately 5wt%

228 teries (ANIBs) owing to the relatively lower solubility of sodium salts compared to its alkaline cous

229 Poor aqueous solubility of some minor steviol glycosides (SGs) has pr

230 CAGE provided excellent apparent solubility of SRF tosylate (> 500 mg/mL).

231 The difficult synthesis and unfavourable solubility of teixobactin require modifications, yet ins

232 r, their formulation strongly depends on the solubility of the chosen salts, imposing a stringent res

233 mains challenging owing to the extremely low solubility of the ECM.

234 en the two variables caused reduction in the solubility of the films.

235 f fullerenes (C(60)) and thereby improve the solubility of the fullerene in polar solvents (e.g. wate

236 ination, or protodestannylation and increase solubility of the products in organic solvents.

237 ntegration activity and greatly improves the solubility of the protein and nucleoprotein complexes of

238 mechanisms that regulate it, we measured the solubility of the proteome in the mouse Neuro2a cell lin

239 This in turn, deeply reduces the solubility of the surface-bound protein molecules and in

240 More importantly, due to the greater solubility of this derivative in pure water, we show for

241 Furthermore, the water solubility of UDMA/TEG-DVBE resins was reduced approxima

242 Human cells lacking Skd3 exhibit reduced solubility of various mitochondrial proteins, including

243 e of their low molecular weight and relative solubility, oligomers may be particularly pernicious see

244 f the strong dependency of iron oxyhydroxide solubility on pH.

245 The influence of the polymer solubility on the separation efficiency in thermal field

246 ) are poorly known and do not correlate with solubility or extraction measurements commonly used to i

247 tion of the temperature dependency on Hansen solubility parameters.

248 antane group by an oxygen atom increases the solubility, permeability, and stability of three series

249 nce in these applications, and their limited solubility precludes large-scale processing into more us

250 Here we report a successful approach to solubility prediction in organic solvents and water usin

251 Solubility prediction remains a critical challenge in dr

252 ethod by adding a wash buffer with low water solubility prior to the elution step.

253 been proposed to overcome this so-called Wnt solubility problem(4-6).

254 The covalent linkage allowed overcoming solubility problems with the lipophilic vanillin and cin

255 SPA) method to successfully determine the pH-solubility profile, intrinsic solubility, common-ion eff

256 This series of compounds had poor solubility properties and poor permeability, which was a

257 Different cages have different solubilities, reaction rates, and energies required for

258 molecules, a number that exceeds the maximal solubility reported for TGs in PL bilayers (2.8%).

259 These can include low solubility, residual toxicity, susceptibility to proteol

260 n and aggregation, as shown by a decrease in solubility, SDS-PAGE pattern, and Confocal Laser Scannin

261 ad molecules with significant improvement in solubility, selectivity over Na(V)1.5, and CYP2C9 inhibi

262 pophilicity measurements on permeability and solubility, showing that the distribution coefficient lo

263 vercome these limitations by increasing drug solubility, site-targeting, and duration of action.

264 study investigated the water sorption (SOR), solubility (SOL) and cytotoxicity (CYTO) of experimental

265 ons are ubiquitous and known to modulate the solubility, stability, and function of many proteins.

266 by unavoidable side effects as well as poor solubility, stability, and pharmacokinetic properties.

267 The properties of analogues, including solubility, stability, and toxicity, suggest that the BH

268 nomolar concentrations, without resorting to solubility tags or hybridizing templates.

269 th poor water-solubility, however, the phase solubility test and dissolution/disintegration tests (wa

270 ted of ketones and aldehydes and have higher solubility than nonbiological compounds.

271 effect (induced precipitation by decreasing solubility) that PILs exert on these crystallizing speci

272 nds exhibit identical crystal structures and solubilities, the trend in deracemization correlates wit

273 small molecular weight (~500 Da), the water solubility, the ease of functionalization, and the selec

274 I define this CLHZ using lipid solubility theory, diving data, and results from animal

275 s, Kok, and Tijssen combined with the Hansen solubility theory.

276 presents some advantages such as good water solubility, thermal stability, biodegradability, and low

277 to evaluate the changes in protein profile, solubility, thermal, structural (at secondary and tertia

278 ition temperature (T(g)) to <0 degrees C and solubility to <25%, while crystallinity increased to >40

279 mM tungstate was enough to promote tungstate solubility to reach inhibitory concentrations, without p

280 LD had higher collagen solubility, troponin-T degradation products and glycogen

281 wer Tc uptake was explained by higher pyrite solubility under acidic conditions.

282 es and the cellular machinery that maintains solubility undergoes functional decline.

283 f the derivatives displayed improved aqueous solubility (up to 28-fold), thereby addressing a key sho

284 All powders were wettable, and solubility values were in the range of 91-99%.

285 Given this series' low water solubility, various polyethylene glycol derivatives of t

286 A large distribution of solubilities was obtained, containing both molecules tha

287 at concentrations in excess of the amorphous solubility was evaluated.

288 7- and 3.6-fold enhancement in beta-carotene solubility was observed in the presence of 1.5 mg/mL of

289 oor pharmacokinetic properties in human, low solubility, weak permeation, and high metabolism, limiti

290 Three calcium salts with different solubility were used: calcium carbonate (CaC), tricalciu

291 e rule of 5" compounds, has little impact on solubility when log D(7.4) measurements and aromaticity

292 compounds, with encouraging improvements in solubility when pyridyl groups were incorporated.

293 ction scale and shows an outstanding aqueous solubility, which together with its high permeability in

294 were the most deleterious compounds for iron solubility, while phytates and tannins decreased vitamin

295 but suffer from poor chemical definition and solubility, while the chemical synthesis of polysacchari

296 that about one-fifth of the proteome changed solubility with almost all of the increases in insolubil

297 lso controlled by the influence of pH on AFO solubility with an increase in the dissolved inorganic F

298 oderate ago-PAM potency and improved aqueous solubility with therapeutic reduction of intraocular pre

299 ed specific surface areas and size-dependent solubility, with a focus on environmentally-relevant iro

300 lycol substituent provides an enhanced water solubility without compromising the fluorescence ( (f) =