ライフサイエンスコーパス: solubilizing

1 yrin arrays (triads, tetrad, pentad) bearing solubilizing 7-tridecyl (swallowtail) groups is presente

2 rization (nhPHIP) in the organic phase while solubilizing a protein in the aqueous phase.

3 Heparin is capable of solubilizing a subset of collagen-tailed (A12) acetylcho

4 on can have a significant effect on both the solubilizing ability and the selectivity of ionic liquid

5 he different bacterial appeared to enhance P solubilizing activity and overall P availability.

6 The addition of solubilizing addends to the fullerene cage results in a

7 SMA copolymer is a highly efficient membrane-solubilizing agent and that lipid bilayer properties suc

8 Using GO as a solubilizing agent for SWCNTs establishes a new class of

9 , with beta-cyclodextrin being employed as a solubilizing agent for these drugs.

10 HPbetaCD has recently been incorporated as a solubilizing agent in coformulations of ARVs in SIV-infe

11 vior of zonal elution experiments in which a solubilizing agent is present in the mobile phase to aid

12 We hypothesized that the coformulation solubilizing agent Kleptose (2-hydroxypropyl-beta-cyclod

13 Methanol is a common solubilizing agent used to study transmembrane proteins/

14 t of novel applications for this new type of solubilizing agent, and for optimization of the SMA tech

15 -6-fold in the presence of dodecane, a lipid-solubilizing agent, with 50% maximal activation achieved

16 s an indicator, a drug-delivery vector, or a solubilizing agent.

17 e inclusion of nicotinamide as a hydrotropic solubilizing agent.

18 utral conditions with isopropyl alcohol as a solubilizing agent.

19 T315I cells and avoiding the use of DMSO as solubilizing agent.

20 -type molecular containers (1a-1e) to act as solubilizing agents for 19 insoluble drugs including the

21 (benzene, naphthalene) sidewalls, to act as solubilizing agents for hydrocarbons in water is describ

22 Macromolecules can be convenient solubilizing agents for NTs and a structural element of

23 was increased upon addition of carbohydrate solubilizing agents, in particular, 2-hydroxypropyl-beta

24 stored in nonvolatile salt buffers and other solubilizing agents, such as organics or detergents, to

25 fluorinated surfactants over other types of solubilizing agents, with a specific emphasis on their p

26 , we describe a new class of general-purpose solubilizing agents-acyclic cucurbituril-type containers

27 ane-associated proteins and for use of other solubilizing agents.

28 rs, detergents, chaotropic agents, and other solubilizing agents.

29 rs, detergents, chaotropic agents, and other solubilizing agents.

30 actants/detergents, preservatives, and other solubilizing agents.

31 s the bioavailability of mineral-bound Pi by solubilizing Al(3+), Fe(3+), and Ca(2+) phosphates in th

32 Our analysis reveals that the "solubilizing" aliphatic amine forms an intramolecular ex

33 drogen bonding to the oxygen of the adjacent solubilizing alkoxy substituent, provides a novel mechan

34 hese polymers are the incorporation of water solubilizing alkyl functional groups that are integrated

35 tions of the helicene inner rim and multiple solubilizing alkyl groups, is an attractive building blo

36 assic benzodithiophene monomer unit with the solubilizing alkyl side chains C(16) and C(2)C(6) and th

37 us niger and S. himantioides were capable of solubilizing all the insoluble oxides when incorporated

38 es of tetrahydroazepinoindoles with appended solubilizing amine functionalities were synthesized.

39 gioregular poly(3-hexylthiophene) core and a solubilizing, amorphous regiosymmetric poly(3-hexylthiop

40 ulation, we demonstrate a unique approach to solubilizing and administering membrane-bound proteins f

41 By repeatedly solubilizing and depositing a mixture that initially con

42 ene encapsulated by dendrons containing both solubilizing and electroactive moieties.

43 We also provide a proof of principle that solubilizing and entrapping lipophilic substances using

44 We also provide a proof of principle that solubilizing and entrapping lipophilic substances using

45 Difficulties in solubilizing and purifying active pMMO have led to confl

46 Solubilizing and purifying carbon nanotubes remains one

47 We present a method for solubilizing and purifying UDP-Glc:ceramide glucosyltran

48 ellular biofactory depends on technology for solubilizing and refolding proteins that are expressed a

49 After solubilizing and refolding these fusions from inclusion

50 By solubilizing and subfractionating individual connexons f

51 from cationic ligands with the assistance of solubilizing anions and highlights the great potential o

52 In addition to solubilizing antibodies at such high concentrations, IgG

53 lar mycorrhizal fungus (AMF) and a phosphate solubilizing bacteria (PSB) to promote the growth and pr

54 ydroxybutyric acid were incubated with the P solubilizing bacterial strains Enterobacter cloacae, Pse

55 phosphorus (P) availability via a phosphate-solubilizing bacterium (PSB).

56 ing the role of filamentation in a phosphate-solubilizing bacterium.

57 ents, and that the fuzzy coat contributes to solubilizing both types of filament.

58 cationic lipid/DNA complexes were formed by solubilizing cationic liposomes with 1% octylglucoside a

59 alycins that play a well established role in solubilizing cellular fatty acids.

60 evealed that mutants deficient in binding or solubilizing cellulose also exhibit reduced expression o

61 t is represented by trisphenylamine, and the solubilizing chains by N-9-heptadecanyl-substituted pery

62 oribbon, possess phenyl groups with decyloxy solubilizing chains on each corner.

63 nctional groups) and the absence/presence of solubilizing chains.

64 for inactivating proteases, is essential in solubilizing collagen fragments, which significantly con

65 goal was to increase protein availability by solubilizing colloidal calcium phosphate (CCP) and to as

66 Solubilizing concentrations of dodecyl maltoside left th

67 ctyl-beta-D-glucopyranoside) and under fully solubilizing conditions (rhodopsin in a micelle with cos

68 ated that the receptors are sensitive to the solubilizing conditions, which illustrates the potential

69 gp41 or the utilization of nonphysiological solubilizing conditions.

70 al (2S)-ethylhexanol for functionalizing and solubilizing conjugated polymers.

71 trifluoromethyl)phenyl)borate (BAr(F)(-)) as solubilizing counteranions, we report the preparation of

72 Triton X-100 is most effective at solubilizing COX, but it destabilizes COX dimers, even a

73 ecyl ether (C(12)E(8)) are less effective at solubilizing COX.

74 The approach mimics ChIP and requires solubilizing cross-linked complexes with sonication.

75 yl maltoside, or Triton X-100 is the primary solubilizing detergent or the enzyme is dispersed in pho

76 The structure of the solubilizing detergent, however, greatly alters detergen

77 sed to investigate the influence of membrane-solubilizing detergents on GLUT1/lipid/detergent micelle

78 For satisfactorily solubilizing detergents, at concentrations much greater

79 Because of their sensitivity to solubilizing detergents, membrane protein assemblies are

80 re we show that light-gated recruitment of a solubilizing domain, maltose-binding protein (MBP), resu

81 hat methods other than DMSO are employed for solubilizing drugs but, where no alternative exists, res

82 Resveratrol exhibits a clear amyloid-solubilizing effect in this assay, showing no toxicity t

83 The average solubilizing effect of 26% NO saturation was 0.045; much

84 an added benefit of this modification is the solubilizing effect of carbohydrates, in the context of

85 e to inhibit polymerization by measuring the solubilizing effect of iron nitrosyl sickle hemoglobin (

86 lly folded states and early aggregates and a solubilizing effect on the native state.

87 does not benefit patients through any direct solubilizing effect.

88 ligated species do not provide a significant solubilizing effect.

89 irrespective of sequence specificity, has a solubilizing effect.

90 The membrane-solubilizing efficiency of the SMAs, CyclAPols, and Aryl

91 UL12.5 protein were generated by selectively solubilizing either insoluble infected-cell proteins or

92 30% as active as human leukocyte elastase in solubilizing elastin.

93 bled delivery systems usually substitute one solubilizing excipient for another, bringing new issues

94 ally frozen drug micelles containing minimal solubilizing excipient.

95 ochlorine insecticide DDT in the presence of solubilizing factor sodium cholate.

96 stoylated ciliary proteins from the GDI-like solubilizing factor UNC119a/b.

97 that P. aeruginosa could be producing a PQS-solubilizing factor.

98 rd oral suspension formulation compared to a solubilizing formulation and were more active when admin

99 2's eviction from chromatin and supplant the solubilizing function of DNA.

100 co-crystal structure of the lead 4, various solubilizing functional groups were introduced to optimi

101 ded in the design of compounds with tethered solubilizing functionalities designed to reach the solve

102 ility of these methods and the importance of solubilizing functionality, several large PAHs were synt

103 Phosphate solubilizing fungi (PSF) have huge potentials in enhanci

104 trogens attached to the pz periphery; R is a solubilizing group (either propyl (Pr) or 3,4,5-trimetho

105 We introduce a novel siloxane-terminated solubilizing group and demonstrate its effectiveness as

106 An attempt to install a water-solubilizing group at the para-position of the phenoxy g

107 ADC physiochemical properties: addition of a solubilizing group in the linker and the use of an enzym

108 ,3-triazol-4-yl unit, which incorporates the solubilizing group of 3, was accomplished by thermal rea

109 observe the consequences of pai-conjugation, solubilizing group substitution, and formylation of the

110 e carboxamide group of 1 with an added water solubilizing group.

111 easing molecular weight and (ii) appropriate solubilizing-group substitution.

112 2 nM), have been synthesized in which water-solubilizing groups [NHCO(CH(2))nNR(1)R(2), where n = 1

113 her substituted at the 1-position with water-solubilizing groups [NHCO(CH)(n)NR(1)R(2), where n = 1 o

114 atic field generated by the (remote) charged solubilizing groups also plays a significant role in aci

115 characterized by the presence of imidazolium solubilizing groups and an optically active cyanovinyl-l

116 nvolves metal-amide precursors modified with solubilizing groups and oleic acid as the oxygen source.

117 d by C-H...pai interaction between the alkyl solubilizing groups and the nearby placed porphyrin pai-

118 rolyte, Pt-p, which features carboxylic acid solubilizing groups are reported.

119 ns popular strategies to attach polar ligand-solubilizing groups at the exposed terminus of substitue

120 Water-solubilizing groups could be installed conveniently at e

121 to explore the use of phenyls as alternative solubilizing groups for [n]phenacenes.

122 cular modeling studies by implanting various solubilizing groups in phenyl rings A and B.

123 property refinement by the incorporation of solubilizing groups led to the identification of 3-((4-(

124 e investigated the effect of different water-solubilizing groups not only on the photophysical proper

125 Changing the position of the solubilizing groups on an oligomer chain does not preclu

126 Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyr

127 derivatives, the indolizine group with water-solubilizing groups retains a substantial shift toward l

128 s of the same length with and without ethoxy solubilizing groups reveals that both solubilized and un

129 by using taurine-derived carbamates as water solubilizing groups that are cleaved upon protein functi

130 0 wt %) for sensitivity, requiring extensive solubilizing groups that lead to signal-diminishing aggr

131 glet fission and highlight the importance of solubilizing groups to optimize excited-state photophysi

132 and allows selective incorporation of water solubilizing groups to the primary amide in 2 without pr

133 ir aqueous solubility characteristics, water-solubilizing groups were added to some antiproliferative

134 ring multiple fused N-heterocycles and bulky solubilizing groups were prepared via bottom-up solution

135 ith different p-xylene straps and peripheral solubilizing groups were synthesized using a previously

136 Nile Red derivatives that incorporate water-solubilizing groups will tend to fluoresce with good qua

137 structs, interact additionally through their solubilizing groups with N-terminal lid residues that ar

138 ylenediimide dimers bearing long alkyl chain solubilizing groups, bis[1-ethynyl-N,N'-bis(1-hexylhepty

139 zation points, attachment handles, and water-solubilizing groups, on the photochemical properties of

140 depending on the size and shape of the alkyl solubilizing groups.

141 decorated with short PEG chains, serving as solubilizing groups.

142 position of the arylureido moiety with water solubilizing groups.

143 have been reported that include much-needed solubilizing groups.

144 in the peptidic scaffold and the addition of solubilizing groups.

145 While this effect is lost by solubilizing guanylate cyclase, ATP binds the purified,

146 he osmolytes, with some protecting osmolytes solubilizing hydrophobic side chains as well as urea doe

147 Chlorin e6 is capable of solubilizing hydrophobic SPION into stable, water-solubl

148 (v/v) formic acid and 60% (v/v) methanol for solubilizing IMPs and utilizes a separation buffer of 30

149 rent surfactants or organic solvents used in solubilizing individual drugs.

150 veral years ago as an alternative method for solubilizing integral membrane proteins in stable, nativ

151 ectiveness of different lithium salts toward solubilizing intermediates on the surface of zinc metal

152 ulfobetaine (ASB)-16 all appeared capable of solubilizing IPC synthase.

153 tions of styrene were conducted with several solubilizing ligands for the copper(I) halides: 4,4'-di-

154 nherently hydrophobic azobenzenes with water-solubilizing ligands on the same nanoparticulate platfor

155 ans of encapsulation with a silica shell and solubilizing ligands.

156 t of carbohydrate processing are achieved by solubilizing lignin via lowering molecular weight and in

157 Isolating spacers introduced between solubilizing lysine regions and a polyalanine core permi

158 mbrane-bound metalloprotease responsible for solubilizing many pathologically significant membrane su

159 Interestingly solubilizing membrane expressing CFTR in detergents such

160 suggest that DHPC is a better detergent for solubilizing membrane proteins and may be useful in gene

161 Detergents are used most often for solubilizing membrane proteins, but they are associated

162 compatible with detergents commonly used for solubilizing membrane proteins, including dodecylphospho

163 ale lipid bilayers that offer a platform for solubilizing membrane proteins.

164 equestering metals in soils and sediments or solubilizing metals to aid in their extraction.

165 upper rim; and the introduction of the water-solubilizing methylimidazolium groups on the lower rim.

166 idogenic N terminus domain (N) and a charged solubilizing middle region (M).

167 Compounds such as 9m with water-solubilizing moieties at the para position of the B-ring

168 olecular topology, and also demonstrate that solubilizing moieties play a large role in disrupting th

169 Introduction of the charged solubilizing moieties suppresses cellular uptake or adso

170 trongly affected by length, structure of the solubilizing moieties, and pH of the solution.

171 e of amine-modified sulfobetaine anchors and solubilizing motifs on poly(isobutylene-alt-maleic anhyd

172 lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties.

173 ve trafficking of DeltaF508-CFTR, namely the solubilizing mutation F494N/Q637R and DeltaRI (deletion

174 ation in the presence of fewer and different solubilizing mutations.

175 Aspergillus niger was capable of solubilizing natural (fragments and powder) and syntheti

176 inantly the result of oxalate complexing and solubilizing Ni.

177 ar transport, and the subsequent addition of solubilizing, nondissociating detergents generates highe

178 in-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy sid

179 librium states and conditions experienced by solubilizing oil droplets that influence emulsion proper

180 interfacial tensions and Marangoni flows of solubilizing oil-in-water drops.

181 chment sites for high loading capacities and solubilizing oligoether/alkyl groups.

182 isrupts sealed membrane compartments without solubilizing or denaturing the lipid bilayer to allow ma

183 rrent paradigm used to design CPs, where the solubilizing or ionically conducting component is consid

184 s SUMO modification; and (c) introduction of solubilizing or revertant mutations to stabilize F508del

185 Several strategies for solubilizing organic molecules in water are known, but t

186 he data are consistent with lithium chloride solubilizing organozinc reagents from the surface of the

187 less linker for temporarily attaching highly solubilizing peptide sequences ("helping hands") onto in

188 herein describe the development of membrane-solubilizing peptides to directly extract membrane prote

189 tive proteolysis are effective in completely solubilizing PHF, while a variety of denaturants are ine

190 dendrimer growth as well as incorporation of solubilizing piperidine groups.

191 olesterol from the periphery to the liver by solubilizing plasma membrane phospholipid and cholestero

192 gyloxy side chains were used to attach water solubilizing poly(ethylene glycol) chains through a clic

193 s, while the other is used for attachment of solubilizing poly(ethylene oxide) chains.

194 In addition, the feasibility of using lipid-solubilizing polymers for isolating and characterizing A

195 ddress this limitation, we used the superior solubilizing potential of copper (II) gluconate to form

196 ctionation of complex protein mixtures, high solubilizing power for extraction of various types of pr

197 A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrenta

198 All ionic liquids tested have excellent solubilizing properties and vacuum stability compared to

199 thermodynamic, transport, spectroscopic, and solubilizing properties.

200 serve critical functions in proteostasis by solubilizing protein aggregates.

201 nm in diameter after enzymatic cleavage of a solubilizing protein tag.

202 Water is critical for solubilizing reaction components and ligates to Ag(I) un

203 tment of retinal cell membranes with several solubilizing reagents.

204 Computer simulation links ATP's solubilizing role to its ability to modulate protein's s

205 ighly effective phase-transfer catalysts for solubilizing safe and inexpensive metal alkali fluorides

206 quence, and (iii) in-solution removal of the solubilizing sequence using mild aqueous hydrazine to cl

207 mine, (ii) Fmoc-SPPS elongation of a desired solubilizing sequence, and (iii) in-solution removal of

208 nctional group tolerance, accommodating both solubilizing side chains and reactive groups that allow

209 While varying the size and branching of solubilizing side chains in pi-conjugated polymers impac

210 ructure relates to the regiochemistry of the solubilizing side chains on the backbone.

211 by solid state diffusion into the layers of solubilizing side chains without disrupting the conjugat

212 molecular weight distribution, nature of the solubilizing side-chains appended to the backbones, and

213 GS-9620 partially decomposed in the solubilizing solution, so loading and release were not c

214 However, the lack of a general means of solubilizing, stabilizing and structurally characterizin

215 have multiple overlapping mechanisms for re-solubilizing stress granule components.

216 .43 A pi-pi stacking distance with favorable solubilizing substituent orientations.

217 e monomer properties such as core planarity, solubilizing substituent tailorability, and appropriate

218 to facilitate both the introduction of water-solubilizing substituents and the functionalization of t

219 racterization has required the attachment of solubilizing substituents such as tert-butyl.

220 articular, require the complex attachment of solubilizing substituents to enable their handling and p

221 By attaching the appropriate solubilizing substituents, efficient molecular packing w

222 hesize, particularly in the absence of large solubilizing substituents.

223 -based cyanine and squaraine dyes with water-solubilizing sulfonate groups were targeted in this stud

224 prionogenesis by fragmenting prions without solubilizing Sup35, whereas Hsp104 couples Sup35 prion f

225 unsymmetrical perylene diimides containing a solubilizing swallowtail alkyl group and a variety of su

226 the donor group to one imide nitrogen and a solubilizing swallowtail, normally a long (e.g., C(19))

227 studies of processed 45Ti were performed by solubilizing the 45Ti residue in 0.05N HCl, of which 1.2

228 7000-fold from crude cell extracts by first solubilizing the cell membranes with the zwitterionic de

229 rol (LPG), is a very effective detergent for solubilizing the CFTR expressed in both yeast and Sf9 in

230 uggest that this detergent may be useful for solubilizing the CFTR from other sources and for other d

231 on LBC agar suggesting that this molecule is solubilizing the cholesterol micelles in LBC agar.

232 (HFIP) was found to be the best solvent for solubilizing the crude peptides.

233 ate is independent of the detergent used for solubilizing the folded state.

234 he T-domain into the lipid vesicles, without solubilizing the latter.

235 of the membrane-mimetic media often used for solubilizing the membrane proteins.

236 e of a polar environment that was capable of solubilizing the methyl orange into the CO2-rich phase.

237 Furthermore, the potency of LPG in solubilizing the notoriously intractable underglycosylat

238 ly-mediated reductive Fe(III) dissolution is solubilizing the poorly soluble Fe(III) phases to solubl

239 We describe a protocol for solubilizing the recombinant enzyme from inclusion bodie

240 catalyzing the oxidation of Fe(2+) ions and solubilizing the resulting Fe(3+)-oxo mineral.

241 uring the starch content of plant tissues by solubilizing the starch, converting it quantitatively to

242 organic solvent serves an essential role by solubilizing the transition metal catalyst.

243 eases and are generally believed to do so by solubilizing their substrates.

244 ges in their properties and is essential for solubilizing them in common solvents.

245 cids promote absorption of dietary lipids by solubilizing them in mixed micelles.

246 aamphiphilic Pt(II) complexes OPE2-4 bearing solubilizing triethylene glycol (TEG) chains of equal le

247 Solubilizing UA with NaOH avoided this artifact, and thi

248 methyl group in the reduced ring and a water-solubilizing unit at the chlorin 10-position.

249 In one design (FbC1-PO3H2), the water-solubilizing unit is a 1,5-diphosphonopent-3-yl ("swallo

250 In the other design (FbC2-PO3H2), the water-solubilizing unit is a 2,6-bis(phosphonomethoxy)phenyl u

251 guous strings of alanines with no capping or solubilizing units present.

252 ent sUA preparation solutions and found that solubilizing uric acid (UA) by prewarming created errone

253 sts confirmed the efficacy of oxalic acid in solubilizing vanadinite and precipitating lead as oxalat

254 lvent in tandem with the highly fluorinated, solubilizing, weakly coordinating [Al(OR(f))4](-) anion